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Cat Vaccines: What Vaccines Do Cats Need?

Here’s what you should know about cat vaccines.

by Naomi Strollo, RVT, CPDT-KA, | February 24, 2024

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Cat Vaccines: What Vaccines Do Cats Need?

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Does your cat really need shots? And if you don’t get them immunized, will they get sick? FPV? FHV1? FeLV? Let’s face it, cat vaccines are confusing. Deciding what’s best for our pets can be a bit of a challenge, especially when you have no idea what all those medical acronyms stand for. But your cat depends on you to decide what medical care is best for them. 

So if you’re considering adopting a cat (or have already adopted one), here’s a breakdown of the core cat shots and why they’re needed to help you make a decision that you feel comfortable and confident with, all while keeping your cat healthy and safe.

Core feline shots

The core vaccines, as recommended by the American Association of Feline Practitioners (AAFP) for kittens and adult cats include the following:

  • Rabies (RV)

  • Feline distemper shot (FVRCP)

    • Feline Calicivirus (FCV)

    • Feline Rhinotracheitis, also known as Herpesvirus (FHV1)

    • Feline Panleukopenia (FPV)

  • Feline Leukemia (FeLV)

Rabies shots for cats

Rabies is a viral infection that spreads quickly through bite wounds and exposure of an open wound from the saliva of an infected animal. Rabies is a serious disease that causes neurological abnormalities, and humans are at risk of getting this deadly infection, so it’s very important for cats (and dogs) to be vaccinated against it. 

Feline distemper shot

The FVRCP vaccine is a combination shot that protects against more than one disease and is commonly known as the feline distemper shot. But this shot actually covers many different diseases, including feline panleukopenia virus, feline calicivirus, and feline rhinotracheitis. Each of these three diseases can be easily transmitted, so it’s important to get your cat vaccinated. Here’s a bit more about each of the diseases this core cat vaccine protects against.

1. Panleukopenia

Panleukopenia, also known as feline distemper, is a highly contagious (to other cats) and potentially lethal virus that causes fever, vomiting, diarrhea, loss of appetite, depression/lethargy, and in some cases, sudden death. Most cats with FPV infection have no signs at all and appear normal. Kittens are particularly susceptible.

FPV is everywhere in the environment. The virus can survive at freezing and room temperatures, and it can even survive certain disinfectants. Worse, the virus is strong and can live for years. The easily transmittable virus can be carried on shoes, paws, bedding, bowls, and litter boxes, infecting cats of any age.

2. Calicivirus

Calicivirus, a highly contagious virus, is a major cause of upper respiratory infection (URI) in cats. Affected cats may have sneezing, eye and nasal discharge, conjunctivitis, lethargy, loss of appetite, sores on the gums and soft tissues of the oral cavity, and lameness. Affected kittens may develop pneumonia. 

The virus spreads through direct contact with the saliva, nasal mucus and eye discharge of infected cats and through aerosol droplets that spread when cats sneeze. 

3. Feline rhinotracheitis

The feline rhinotracheitis, also known as herpesvirus, causes upper respiratory infection (URI) with sneezing, eye and nasal discharge, conjunctivitis, inflammation of the cornea (keratitis), fever, inappetence, and lethargy. Kittens have an increased risk of infection.

The virus is transmitted between cats through direct contact (contact with saliva, eye or nose secretions), inhalation of sneeze droplets (it’s also airborne), sharing food bowls and litter boxes, or contaminated environments. 

Leukemia shot for cats

The FeLV vaccination is considered a core vaccine for all cats less than one year of age. During the early stages, it is common for cats to exhibit no signs of leukemia at all. But over time, an infected cat’s health may progressively deteriorate. Symptoms of leukemia in cats can include loss of appetite, progressive weight loss, poor coat condition, enlarged lymph nodes, persistent fever, pale gums, inflammation of gums, infection of the skin, bladder and upper respiratory, persistent diarrhea, and various eye changes. 

Any close contact with other cats can easily spread this difficult virus. FeLV spreads through the saliva, nasal secretions, feces, urine, and even the milk of infected cats. Casual contact, bite wounds, and nursing can all transmit the infection.

Vaccination schedule for core vaccines

Kittens (under one year of age)

Vaccine

First shot

Second shot

Third shot

FVRCP 

6 to 8 weeks old

10 to 12 weeks old

14 to 16 weeks old

(3 to 4 weeks later from the first shot)

(3-4 weeks later from the second shot) 

Adult Cat (over the age of one or an unknown age)

Vaccine

First vaccination

Second vaccination

Booster vaccination 

Series continues

FVRCP Combination (FPV, FCV, FHV1)

6 to 8 weeks old (or upon intake)

3 to 4 weeks after the first shot

12 months old

Every 3 years

Feline Leukemia Vaccine (FeLV)*

8 weeks old (or upon intake)

3 to 4 weeks after the first shot

12 months old

Rabies

14 to 16 weeks old (or upon intake)

12 months old

Every 1 or 3 years, depending on state laws

*Feline Leukemia Test (FELV) must be done prior to the feline leukemia vaccine. When the FeLV test is negative, then you can proceed with the vaccine. 

Are certain shots for cats optional?

Some shots for cats are optional and are only recommended for cats in a higher-risk environment, such as cats with outdoor access, shelter cats, cats homed with an infected cat, or a multiple-cat household (consisting of eight to 10 cats or more). With these non-core vaccines, the vaccine-specific risk must be weighed against the potential benefit that is unique to each cat’s situation.

Feline leukemia in adult cats

The FeLV vaccine is a non-core vaccine for cats one year of age and older, who have no possibility of exposure to FeLV-infected cats, or other cats with an unknown FeLV status. So if your cat is indoor-only and over one year old, this would be a non-core vaccine. 

Chlamydia felis 

The Chlamydia felis is an optional vaccine that could be considered for cats entering a population of cats, where infection is known to be regularly occurring. The vaccine provides only incomplete protection and has been associated with adverse reactions in three percent of vaccinated cats. It is not recommended as a routine vaccination in low-risk cats. 

Feline immunodeficiency virus (FIV)

FIV is passed to other cats through direct contact (bite wounds and scratches), with outdoor cats and stray cats being the most at risk. The FIV vaccine is no longer available in North America because there were numerous problems, including the vaccine only offering limited protection. Vaccinated cats would often come up false positive when tested for FIV, which could lead to euthanasia if found in a possible stray. For this vaccine, the risks outweigh the benefits.

Feline bordetella bronchiseptica vaccine

The bordetella bronchiseptica shot for cats is an optional vaccine. Bordetella bronchiseptica is a bacteria that is spread between cats in the sneezing secretions of one that is infected. Young kittens are at risk because they develop pneumonia rapidly. Kittens can appear to have no symptoms one day and near death 12 hours later. The good news is that since this is a bacteria, it can be killed with disinfectants. Adult cats rarely get it, and if they do, it’s like the common cold. Kittens are typically only at risk for this in high-volume catteries and breeding locations. Not recommended as a routine vaccination.

Feline infectious peritonitis vaccine (FIP)

FIP vaccination is not usually recommended because the feline infectious peritonitis vaccine is not effective. Although FIP can occur in cats of any age, it is most often seen in young cats (less than two months of age). Early signs of FIP are usually very vague, with fever, lethargy, and reduced appetite. The vaccine is only showing a small percentage of efficacy, and can only be given to kittens over 16 weeks of age, so by the time the kitten could be vaccinated, they have already been exposed to the virus. So, this vaccine has little or no value.

Other shots for cats

Allergy shots for cat allergies 

There is a vaccine for cats that actually helps reduce cat dander-causing allergies in people. This shot will help people with cat allergies to be able to live with cats. The good news is that the vaccine has been well tolerated, but the bad news is it is still in the experimental stage so cat parents looking for relief have longer to wait.

Convenia shots

The convenia shot is an antibiotic injection given by your veterinarian to treat skin infections, wounds, and abscesses. Yep, you read that right — you no longer need to force a pill into your cat. Once shot and done, then sit back and watch them heal. 

Commonly asked questions

Do Indoor cats need to be vaccinated? 

Yes, indoor cats need to be vaccinated. The feline distemper vaccines protect cats from viruses that are airborne and the rabies vaccine is state law. 

What is a distemper shot for cats? 

The distemper shot for cats is a combination vaccine that includes protection against panleukopenia, calicivirus, and rhinotracheitis (also known as herpesvirus). 

How long do rabies shots last for cats? 

The rabies shot for cats lasts for one year after the first injection, and then three years after each subsequent booster shot.

How many series of shots do cats need?

Cats need a series of two distemper vaccines three to four weeks apart if they are older than 16 weeks of age. If they are under 16 weeks of age, they need a series of three distemper vaccines. They would need to return one year later to get a booster. 

What’s a booster shot?

A cat booster shot is an additional dose of a vaccine given after the initial vaccination series. Booster shots prolong a cat’s immune response to diseases.

What is the most important cat vaccine?

The most important vaccine for cats is the rabies vaccine. The rabies shot is actually required by law and is transmissible to humans. 

How much is a rabies shot for a cat?

The cost of a rabies shot for cats varies from location to location. On average, a rabies shot can cost $20 to $30.

Is my cat too old to get shots?

No cat is too old to get shots. Older cats have weakened immune systems and need shots to support being able to fight off different feline viruses. 

References

Feline Vaccines: Benefits and Risks

Vaccination Guidelines for Dogs and Cats

AVMA Feline panleukopenia

Feline Calicivirus

Feline Leukemia Virus

FeLV Vaccine Administration Schedule

Scientists Have Created a Cat-Allergy ’Vaccine’

Naomi Strollo, RVT, CPDT-KA

Naomi Strollo, RVT, CPDT-KA

Naomi Strollo R.V.T, CPDT-KA, has been a Registered Veterinary Technician for over 20 years. Working in general practice and emergency medicine. Having special interest in behavior, she went on to become Fear Free Certified, and a Certified Professional Dog Trainer - Knowledge Assessed (CPDT-KA). She has participated in therapy dog, confirmation, and CGC certifications with her dogs. With positive-reinforcement training, her Akita, Pitbull, and Shiba Inu know how to be friends. Living in Ohio, she enjoys sharing her knowledge through writing contributions.