Great Dane Adoption in Mississippi: Great Dane Puppies for Sale in Mississippi

Adopt a Great Dane near you in Mississippi

Below are our newest added Great Danes available for adoption in Mississippi. To see more adoptable Great Danes in Mississippi, use the search tool below to enter specific criteria!

Hera (pink collar)

Great Dane

Female, 2 mos

Lucedale, MS

Size

(when grown) -

Details

Story

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MACARONI

Great Dane

Male, Adult

Olive Branch, MS

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with cats, House-trained,

Story

Macaroni is a Great Dane that wants to lounge on the couch with his person. He is 7 years old and weighs 140 pounds. He is house broken. He is always up for a walk around the neighborhood and is moving 0-60 when the leash comes out. He is good with chill cats and enjoys sleeping on his bed or couch after a long day. Macaroni has been around very young foster puppies and done well, but it would be best for him to be the only dog in his new home as he doesn’t do well with other adult dogs that would possibly not be submissive to him. Macaroni needs a family with precious large breed or Great Dane experience. He can be picky with new people and needs someone who can handle his size and preferences. Macaroni is ready to be part of your family and start making the memories you can only experience with him. He is fully vetted. Vetting includes spay/neuter, microchip, rabies and all dog vaccinations. His local adoption fee is $300 for adoptions within the Memphis, TN tristate area. Macaroni’s out of state/not local to the Memphis, TN tristate area adoption fee is $600 and includes the transport to states like PA, CT, NJ, MD, & VA. We use a licensed and registered USDA transport company that will bring Macaroni up north to his new family. You can apply to adopt him today! If you have any questions, please email us at: newbeginnings_animalrescue@yahoo.com You can apply to adopt Macaroni here: www.newbeginningsanimalrescue.net THANK YOU FOR CONSIDERING ADOPTING A RESCUED PET! Visit this organization's web site to see any additional information available about this pet.October 11, 2026, 2:02 pm

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Zeus

Great Dane

Male, Puppy

Tupelo, MS

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Not good with cats, Needs experienced adopter,

Story

He is a really good dog who deserves a loving home. He would do best with a young family or someone who can spend plenty of time with him, because he does not like being left alone for long periods of time. He loves being part of the family, cuddling, and getting lots of attention. He is great with kids and is also crate trained.

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Barlow 060101A

Great Dane/Setter (Unknown Type)

Male, 1 yr 3 mos

Amory, MS

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with kids, Good with dogs, Good with cats, House-trained,

Story

Gentle, friendly, and happy to see anyone: that's Barlow! This long-legged boy came in emaciated, wormy, and full of trash from scavanging the dumpsters just to survive. Severely underweight, Barlow immediately began a slow, gradual feeding regiment to reintroduce his body to real dog food-- small, multiple meals scattered throughout the day, peppered in with occasional crunchy Milkbones for that good boy treat every dog deserves. Barlow isn't at his ideal weight, but he looks exceptional compared to his intake picture (peep in the comments to see how far Barlow has come!) Barlow is a less than one year old Coonhound and Great Dane mix. While he's about 70 pounds, we expect this merle-coated guy to be between 80-100 pounds when he's fully filled out! Barlow would be perfect for a hunting buddy, helping you in the blinds this season to bag that awesome critter. Barlow is still working through food aggression due to his history of starvation, but with patience and proper meals, Barlow would be the perfect pup to be your pal!

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Lexington

Great Dane/Labrador Retriever

Male, Adult

Jackson, MS

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs,

Story

Lexington is a tall, handsome gentle giant with the sweetest soul. This affectionate guy loves being close to his people, going for walks, playing, and—most importantly—TREATS! He’s smart, easy to walk, and has the most adorable habit of leaning his big ol’ body against you for love. Lexington enjoys having his people nearby and would thrive in a home that appreciates a loyal, affectionate companion. He can be selective with other dogs, so slow, proper introductions are important. Give Lexington a little time to settle in, and you’ll discover one incredibly loving best friend. This sweet grey gentleman is ready to trade shelter life for a couch, some snacks, and a family of his very own.October 11, 2026, 7:55 pm

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Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in Mississippi.

Great Dane puppies and dogs in Mississippi

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Below are our newest added Great Danes available for adoption in Mississippi. To see more adoptable Great Danes in Mississippi, use the search tool below to enter specific criteria!

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Great Dane puppies and dogs in Mississippi

Jump to:

Adopt a Great Dane near you in Mississippi

Below are our newest added Great Danes available for adoption in Mississippi. To see more adoptable Great Danes in Mississippi, use the search tool below to enter specific criteria!

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in Mississippi cities

Great Dane shelters & rescues in Mississippi

Looking for a specific shelter or rescue?

Want to learn more about adopting a Great Dane puppy or dog ?

Great Dane information

Great Dane basics