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Mastiff puppies and dogs in Mississippi

Looking for a Mastiff puppy or dog in Mississippi? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff in Mississippi Search for a Mastiff puppy or dog Mastiff puppies and dogs in Mississippi cities Mastiff shelters and rescues in Mississippi Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Mississippi

Below are our newest added Mastiffs available for adoption in Mississippi. To see more adoptable Mastiffs in Mississippi, use the search tool below to enter specific criteria!
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Monica

Mastiff/American Bulldog

Female, 3 yrs 2 mos
Hattiesburg, MS
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
One of staff members had the following to say about Monica: "If I had to describe Monica in three words, I'd say: squishy, smoochy, and smiley. Monica loves to be doted on and will return the affection with a big smile and a sloppy smooch. She loves going for walks, but the real way to her heart is playtime. Nothing brings her more joy than de-fluffing a stuffed animal, cleaning every speck of peanut butter off a Kong, or romping around our play yards with her friends. If you're looking for a dog to chase the blues away, Monica is ready to be your ray of sunshine!"

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PUMPKIN

Mastiff

Female, Young
Olive Branch, MS
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained,
Story
Pumpkin is a big, beautiful Mastiff mix who is about one year old and weighs around 115 pounds. She’s a loving, playful girl who enjoys treats and spending time outside. Pumpkin can be a little shy at first, so her adopters will need to be patient and give her time to feel comfortable. Once she warms up, she’s incredibly sweet and affectionate. She is crate trained and housebroken, and she walks well on a leash. Pumpkin enjoys walks around the neighborhood and trips to the park. After a day of fun, she’s happiest snuggling on the couch with her people. Despite her big size, Pumpkin is calm, quiet, and gentle — the perfect companion for someone looking for a loyal and loving friend. She is fully vetted. Vetting includes spay/neuter, microchip, rabies and all dog vaccinations.  Her local adoption fee is $300 for adoptions within the Memphis, TN tristate area.   Pumpkin’s out of state/not local to Memphis, TN tristate area adoption fee is $600 and includes the transport to states like PA, CT, NJ, MD, & VA. We use a licensed and registered USDA transport company that will bring Pumpkin up north to her new family.  You can apply to adopt her today!     If you have any questions, please email us at: newbeginnings_animalrescue@yahoo.com   You can apply to adopt Pumpkin here: www.newbeginningsanimalrescue.net   THANK YOU FOR CONSIDERING ADOPTING A RESCUED PET! Visit this organization's web site to see any additional information available about this pet.August 3, 2026, 9:16 pm

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Sully

Mastiff/Boxer

Male, Senior
Jackson, MS
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
Every morning, Sully clocks in for his favorite job: Neighborhood Watch. From the end of his kennel row, he keeps an eye on everyone who comes around the corner, making sure he doesn't miss a single visitor. He's always hoping today will be the day someone stops and says, 'Hey, Sully... I've been looking for you!' Until then, he'll keep his tail ready, his smile on, and his suitcase packed for the greatest adventure of all—a forever home.August 3, 2026, 11:46 pm

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Slim

Mastiff

Male, Adult
Jackson, MS
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
Hi! I'm Slim... and before you ask... yes, I smile this big all the time. Life is just better when you're happy, and I try my best to prove that every single day. I love toys, I love stretching my legs on a walk, and I'm always ready to make a new friend. People say my smile is contagious. I hope they're right, because I'd love to spend my days making someone smile, too. If you're looking for a loyal sidekick with a goofy personality and a heart as big as that grin, I think we should meet. I promise I'll bring the smile... you just bring the leash.August 3, 2026, 11:46 pm

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Presley

Mastiff

Female, Adult
Jackson, MS
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats,
Story
Sweet girl, friendly, playful, even tempered, enjoys being outside, and is ready for her next adventure! She likes water and being in a playgroup.August 3, 2026, 11:46 pm

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Hercules

Mastiff

Male, Adult
Jackson, MS
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with dogs, Not good with cats,
Story
Hercules – Small Name? Not a Chance! This Hercules may not wear a cape, but he does have superpowers—like melting hearts with his wiggly tail and lighting up every room with his happy, goofy grin. He’s affectionate, leash-trained, and loves getting out to explore the world by your side. Whether it’s a walk through the neighborhood or just soaking up attention, Hercules is all in. He’s still working on his “hero training” (he’s been known to pull a little Houdini act now and then), so he’ll need a home ready to guide him and keep him safely contained. But with consistency and love, this boy is going to be an absolute superstar. If you’re looking for a loyal sidekick with a big personality and an even bigger heart… Hercules is ready to save the day.August 3, 2026, 11:46 pm

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Mississippi.

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Mastiff puppies and dogs in Mississippi cities

Mastiff Puppies near me Mastiff in Aberdeen Mastiff in Amory Mastiff in Batesville Mastiff in Bay St Louis Mastiff in Biloxi Mastiff in Booneville Mastiff in Brandon Mastiff in Brookhaven Mastiff in Canton Mastiff in Carthage Mastiff in Clarksdale Mastiff in Cleveland Mastiff in Clinton Mastiff in Columbia Mastiff in Columbus Mastiff in Corinth Mastiff in Crystal Springs Mastiff in Diberville Mastiff in Ellisville Mastiff in Flowood Mastiff in Forest Mastiff in Gautier Mastiff in Greenville Mastiff in Greenwood Mastiff in Grenada Mastiff in Gulfport Mastiff in Hattiesburg Mastiff in Hazlehurst Mastiff in Hernando Mastiff in Holly Springs Mastiff in Horn Lake Mastiff in Indianola Mastiff in Jackson Mastiff in Kosciusko Mastiff in Laurel Mastiff in Leland Mastiff in Long Beach Mastiff in Louisville Mastiff in Madison Mastiff in Magee Mastiff in McComb Mastiff in Meridian Mastiff in Moss Point Mastiff in Natchez Mastiff in New Albany Mastiff in Ocean Springs Mastiff in Olive Branch Mastiff in Oxford Mastiff in Pascagoula Mastiff in Pearl Mastiff in Petal Mastiff in Philadelphia Mastiff in Picayune Mastiff in Pontotoc Mastiff in Richland Mastiff in Ridgeland Mastiff in Ripley Mastiff in Senatobia Mastiff in Southaven Mastiff in Starkville Mastiff in Tupelo Mastiff in Vicksburg Mastiff in Waveland Mastiff in Waynesboro Mastiff in West Point Mastiff in Wiggins Mastiff in Winona Mastiff in Yazoo City

Mastiff shelters & rescues in Mississippi

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Mississippi. Browse these Mastiff rescues and shelters below.

Here are a few organizations

Rescue

New Beginnings Animal Rescue

Olive Branch , MS 38654

Pet Types: cats, dogs, rabbits

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Shelter

Cleveland-Bolivar County Animal Shelter

200 West Carpenter Street, Cleveland , MS 38732

Pet Types: cats, birds, dogs, rabbits, small animals

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog ?

We've got all the info you need on adopting and caring for a Mastiff puppy . Check out the links below for everything you ever wanted to know about Mastiff puppies and adults .

Mastiff information

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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