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Mastiff puppies and dogs in South Dakota

Looking for a Mastiff puppy or dog in South Dakota? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff in South Dakota Search for a Mastiff puppy or dog Mastiff puppies and dogs in South Dakota cities Mastiff shelters and rescues in South Dakota Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in South Dakota

Below are our newest added Mastiffs available for adoption in South Dakota. To see more adoptable Mastiffs in South Dakota, use the search tool below to enter specific criteria!
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Lily

Mastiff

Female, 5 yrs 2 mos
Yankton, SD
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained,
Story
Hello, my name is Lily! I am a 5-year-old Mastiff mix looking for my forever home and a family to call my own. I am a sweet, friendly girl with a gentle heart. I can be a little shy when meeting new people at first, but give me a little time and I warm up pretty quickly. Once I know you’re a friend, I love being close to my people and soaking up all the love and attention I can get. I get along great with other dogs, and I even like cats too. I’m also kid friendly, which makes me a wonderful companion for many different kinds of families. Some of my favorite things include going for walks, taking car rides, and spending quality time with the people I love. I am also house trained, so I’m ready to settle right into home life. If you are looking for a loyal, loving companion to share life’s adventures and quiet moments with, I just might be the perfect girl for you. Give Heartland a call to set up a meet and greet — I would love to meet you!

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Photo of Duke

Duke

Mastiff

Male, Young
Rapid City, SD
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with dogs, Needs experienced adopter, House-trained,
Story
Duke is a smart, powerful and loving 155 pound American Mastiff. He came from the breed originator, Flying W Farms in Ohio. He is 18 months old. He has been my constant companion since December 2025, and is very well-trained. He is generally friendly towards people, but he has strong guarding traits, which makes him wary of strangers. He has never been aggressive toward people, but he can be very aggressive with other dogs. This aggressiveness typically shows when any strange dog gets near him and displays teeth, growls, or challenges. If you apply, we can discuss what has happened in the past. Suffice it to say, we no longer go to dog parks and he is not allowed off-leash near other dogs. After consulting with experts, friends and family, I have decided Duke would be better off in a rural or ranch environment where these traits are valued. He is not a dog for novices, and is not an outside dog. He needs to be on a farm, ranch, or large property. He is not a city dog.

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in South Dakota.

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Mastiff puppies and dogs in South Dakota cities

Mastiff Puppies near me Mastiff in Aberdeen Mastiff in Belle Fourche Mastiff in Brandon Mastiff in Brookings Mastiff in Huron Mastiff in Madison Mastiff in Mitchell Mastiff in Pierre Mastiff in Rapid City Mastiff in Sioux Falls Mastiff in Spearfish Mastiff in Sturgis Mastiff in Vermillion Mastiff in Watertown Mastiff in Yankton

Mastiff shelters & rescues in South Dakota

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in South Dakota. Browse these Mastiff rescues and shelters below.

Here are a few organizations

Shelter

Heartland Humane Society

3400 E Highway 50, Yankton , SD 57078

Pet Types: cats, birds, dogs, rabbits, reptiles, small animals

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog ?

We've got all the info you need on adopting and caring for a Mastiff puppy . Check out the links below for everything you ever wanted to know about Mastiff puppies and adults .

Mastiff information

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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