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Great Dane puppies and dogs in Winston Salem, North Carolina

Looking for a Great Dane puppy or dog in Winston Salem, North Carolina? Adopt a Pet can help you find an adorable Great Dane near you.

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Adopt a Great Dane near you Great Dane in cities near Winston Salem, North Carolina Other pups in Winston Salem, North Carolina Search for a Great Dane puppy or dog near you Browse Great Dane puppies and dogs in nearby cities Browse related breeds in Winston Salem, North Carolina Great Dane shelters and rescues in Winston Salem, North Carolina Learn more about adopting a Great Dane puppy or dog

Adopt a Great Dane near you in Winston Salem, North Carolina

We don't see any Great Danes available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Great Danes in cities near Winston Salem, North Carolina

These Great Danes are available for adoption close to Winston Salem, North Carolina.
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Diesel

Great Dane

Male, Senior
Thomasville, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered,
Story
Diesel is a sweet older Great Dane mix dog.  His vet estimated birth date is 2017.  He weighs 77 pounds.  He'd love taking walks and then coming home to nap at your feet.  He can be a little iffy with other dogs, so he'd probably do best as an only dog, or you would need to do a very slow introduction if you have other dogs.  Diesel walks well on a leash. ~Adoption donation $200 . All vetting is up to date. Microchipped and neutered. Also on flea/tick and heartworm preventative. Visit www.ruffloverescue.com/adoption and fill out an application to make this pup a member of your family March 7, 2026, 6:47 pm

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Ghost

Great Dane

Male, 3 yrs
Salisbury, NC
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Ghost, who comes to us from the community. Ghost is a 3-year-old, 122 lb., Great Dane. There's absolutely nothing scary about this ghost- he's a love bug! Ghost is an adorable sweetheart who is sweet, kind, and loving. Ghost is housebroken, and excellent with other dogs, people, and kids. We don't know how he is with cats. He is partially deaf and was born with a deformed cornea (basically half a cornea). He can see straight and down, but he cannot see very well looking upward; his eyes look like a contact lens that is out of place. He definitely doesn't let either of these impairments deter him from living life with enthusiasm and joy. Ghost loves and trusts people with his whole heart. He is neutered, fully vaccinated, and microchipped. Although he may be a bit visually and hearing impaired, Ghost's heart and zeal for life is definitely not. If you would like to meet this gem, please reach out to us for an application.

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Special Needs
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Sven

Great Dane American Pit Bull Terrier

Male, Senior
North Wilkesboro, NC
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats, Needs special attention, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Sven is a sweet, loyal, and affectionate dog who loves being around his people. He enjoys playing, exploring, and spending time outdoors, but he’s just as happy relaxing with his family. He has a fun personality and is always excited to see the people he knows and loves. We are looking for a home that will give Sven the time, patience, and love he deserves. An active family with a securely fenced yard would be ideal. He would do best with someone who is committed to continuing his training and providing him with plenty of exercise and attention. Sven is smart, playful, loving, and eager to be part of a family. We hope to find him a forever home where he will be cherished for the rest of his life.

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These pups are in Winston Salem, North Carolina too!

Below are our newest added Great Danes available for adoption in Winston Salem, North Carolina. To see more adoptable Great Danes in Winston Salem, North Carolina, use the search tool below to enter specific criteria!
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Persia

Anatolian Shepherd

Female
Winston-Salem, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, Spayed or Neutered,
Story
A stray who found herself quickly out of time at a high-kill animal control facility, she is lovely and will make a very nice family pet...She enjoys being near people and playing with dogs in her foster home. Fenced yard preferred; VET'S REFERENCE REQUIRED.July 9, 2026, 2:28 pm

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Search for a Great Dane puppy or dog

Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in Winston Salem, North Carolina.

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Great Dane puppies and dogs in nearby cities

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Related breeds in Winston Salem, North Carolina

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Great Dane shelters & rescues in Winston Salem, North Carolina

There are animal shelters and rescues that focus specifically on finding great homes for Great Dane puppies in Winston Salem, North Carolina. Browse these Great Dane rescues and shelters below.

Here are a few organizations closest to you:

Rescue

19.5 miles

Ruff Love Rescue and Foster Care

P. O. Box 2013, Thomasville, NC 27361

Pet Types: cats, dogs

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Rescue

31.1 miles

Faith Hope and Love Animal Rescue NC

PO Box 4463, Salisbury, NC 28145

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Great Dane puppy or dog?

We've got all the info you need on adopting and caring for a Great Dane puppy. Check out the links below for everything you ever wanted to know about Great Dane puppies and adults.

Great Dane basics

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Where do Great Danes come from? How many types of Great Danes are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Great Dane.

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