Great Dane Adoption in North Carolina: Great Dane Puppies for Sale in North Carolina

Adopt a Great Dane near you in North Carolina

Below are our newest added Great Danes available for adoption in North Carolina. To see more adoptable Great Danes in North Carolina, use the search tool below to enter specific criteria!

Spinelli

Great Dane/Mixed Breed (Medium)

Male, 3 mos

Columbus, NC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Story

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Grayven

Great Dane

Male, Adult

Flat Rock, NC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, Needs experienced adopter, House-trained,

Story

Grayven is a big boy and is still growing. He’s almost 2. He’s goofy and aloof. He gets along with other dogs his size (large or X Large breed) and loves to tug of war with a braided rope. Chew on flavored pet safe bones and ruff house with his pack. We have 5 other dogs and all but 1 are seniors. Grayven wants to play. They wear out relatively quickly. He’s good on a leash with a pinch collar (just to keep his attention on his training). He doesn’t pull but has long legs and walks fast. We simply Cannot give him the time and energy he desires and deserves. He is my husbands dog and would do well in a home where the male is alpha.

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Brinkley

Great Dane/Cane Corso

Female, 5 mos

Charlotte, NC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, House-trained,

Story

Meet Brinkley! At just 5 months old, Brinkley is a beautiful Great Dane/Cane Corso mix weighing 42 pounds, with an estimated adult weight of 80–90 pounds. This sweet girl came to rescue at only 5 weeks old alongside her brother after being surrendered. While her brother has already found his forever home, Brinkley is patiently waiting for her special family. Brinkley is a gentle, chill puppy who absolutely lives for snuggles. If you’re looking for a big baby who loves to cuddle, she’s your girl! She also enjoys squeaky toys and chasing balls, but her favorite place is right next to (or leaning on!) her person. In the mornings, she loves to jump up for back snuggles and soak up all the affection she can get! Because she’s still gaining confidence, Brinkley can be shy and nervous with strangers and takes a little time to warm up. Once she trusts you, though, she bonds deeply and loves wholeheartedly. Patience and kindness will be key to helping her blossom into the confident companion she’s meant to be. Brinkley does wonderfully with other dogs but hasn’t been around cats yet. She has been around several adults and does great, though she may need slow introductions to new people. She has no aggression issues, she is mostly house trained, and she is fully crate trained. She will need more support at getting comfortable walking on a leash, so her future family should be prepared to continue positive, gentle leash training. If you’re looking for a loyal, loving companion who will truly bond with you, and you’re ready to help a sweet, sensitive girl grow into her very best self, Brinkley is your girl!

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Romeo

Great Dane/Mixed Breed (Medium)

Male, 7 mos

Greensboro, NC

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Story

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Athena

Great Dane

Female, 5 yrs 6 mos

Salisbury, NC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats, House-trained,

Story

Meet Athena, who comes to us from the community. She was listed for sale on Facebook Marketplace with her siblings and after they were unable to sell her, she came to us. Athena is a 5–6-year-old, 85.5 lb., Great Dane. Athena hasn't met a stranger. She loves other dogs, is kid and cat friendly, and seems to be housebroken. She is spayed, fully vaccinated, and microchipped. This lovely lady boasts a gentle demeanor that will capture your heart. Her friendly, playful nature is matched only by her wonderful manners, making transitions from house to car to leash walking a delight. Athena's recent vet visit confirmed that she’s in excellent health. Though she may be petite for a Great Dane, her current 85.5 pounds is a little underweight; therefore, she gets to enjoy a few extra groceries! And we would also like to report that she was so well-behaved at the vet's office and such a good girl during her nail trim.

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Nina

Great Dane

Female, Puppy

Iron Station, NC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, Good with cats, House-trained,

Story

Get ready to meet your new best friend, Nina!!! This 6–7 month old Great Dane beauty is all puppy charm wrapped up in a big, lovable package! Rescued from a shelter and ready for her happily-ever-after, she’s bursting with personality and joy. She’s super social, incredibly outgoing, and loves being around people. Toys? Yes, please! Playtime is her favorite time, and she brings nonstop fun wherever she goes. Despite her growing Great Dane size, she’s gentle and does wonderfully with dogs of all sizes—and even cats! She’s crate trained and appears to be housebroken, making her well on her way to being the perfect house companion. If you’re looking for a playful, affectionate, larger-than-life best friend to fill your home with love and laughter, this sweet girl is ready to meet you! . Nina is being fostered in Asheville NC. If interested in adopting you can email us at info@greatdanefriends.com for an application. Since Nina LOVES to play and zoom and fenced yard is required to keep this active puppy safe *****Great Dane Friends of Ruff Love covers NC and surrounding states for adoptions. We require a fenced yard (exceptions made on a case by case basis - NO exceptions for puppies or deaf/vision impaired dogs - no invisible fencing), that stairs in the home be covered with some sort of slip resistant material to prevent injury, that all other animals in the home be up to date on vaccinations as well as spayed/neutered and that all dogs live inside as a part of the family. Our approval process consists of an application, vet and reference checks, phone interview and house check. Please email us for an application or if you have any questions.***** February 14, 2026, 12:07 pm

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Great Dane puppies and dogs in North Carolina

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Below are our newest added Great Danes available for adoption in North Carolina. To see more adoptable Great Danes in North Carolina, use the search tool below to enter specific criteria!

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Great Dane puppies and dogs in North Carolina

Jump to:

Adopt a Great Dane near you in North Carolina

Below are our newest added Great Danes available for adoption in North Carolina. To see more adoptable Great Danes in North Carolina, use the search tool below to enter specific criteria!

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in North Carolina cities

Great Dane shelters & rescues in North Carolina

Looking for a specific shelter or rescue?

Want to learn more about adopting a Great Dane puppy or dog ?

Great Dane information

Great Dane basics