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Mastiff puppies and dogs in Danville, Kentucky

Looking for a Mastiff puppy or dog in Danville, Kentucky? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you in Danville, Kentucky

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Danville, Kentucky

These Mastiffs are available for adoption close to Danville, Kentucky.
Photo of Waylon

Waylon

Mastiff Boxer

Male, Adult
Richmond, KY
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Not good with kids, Good with dogs, House-trained, Shots are up-to-date,
Story
Waylon is has a lot of energy and needs room to run all day. With our growing family, we don’t have to time or space to exercise him like he needs. He’s not aggressive around little kids, but he will knock them over and play-nip at them. He loves to play and be around people. We would like to rehome him as soon as possible due to a new baby arriving soon and would be willing to help with neutering costs if that is a deal breaker.
Photo of Rose

Rose

Mastiff American Bulldog

Female, Adult
Lexington, KY
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Not good with dogs, Not good with cats, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Rose was our son's dog and he passed away quite suddenly. She is loving and sweet. She is used to being indoors and is very well house trained. She is okay around other dogs except ones on leashes. We do not know why this is a problem. She comes with leashes, harness, and collar. We will provide food and treats for a month. We do not want to have to put Rosie down but we are 80ish and unable to handle her and our current dog. We just want someone to love her and take care of her. She is up to date on all vaccinations . She hates loud noises especially thunder storms. We have gummy treats that contain a calming agent for her. That helps and we will give a supply of those.
Photo of Duke

Duke

Mastiff

Female Adult
Boston, KY
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with cats, Spayed or Neutered, Shots are up-to-date,
Story
Free TrainingMeet Duke — Big Heart, Big Energy, Big Need for a Hero Duke is back with us — not because he did anything wrong, but because life threw him a curveball. His longtime companion Duchess began struggling with his rough play, and both were returned. Now Duke is confused, grieving, and howling in his kennel, trying to make sense of it all. This big boy has been through a lot. He’s an oversized puppy at heart — full of love, full of energy, and desperate to connect. He wants to make you happy. He just needs someone who understands that big dogs sometimes come with big feelings and big needs. What Duke Needs:   - A home with no dogs under 75 lbs   - A committed adopter willing to go through our training program   - An experienced handler who understands escape artists and can keep him safe   - Patience, structure, and a whole lot of love   Duke isn’t for everyone. But for the right person, he’ll be everything. If you’ve got the heart, the strength, and the experience to help Duke thrive, he’s waiting — and howling — for you. Duke comes with FREE training with Rosie Dane dog training, thanks to the Pedigree foundation.  If you would like to make Duke a part of the family, fill out an application at www.barktownrescue.org/adopt Www.barktownrescue.org/adopt    The shelter software system requires that we choose a predominant breed or breed mix for our dogs. Visual breed identification in dogs is unreliable so for most of our dogs we are only guessing at the dog's predominant breed or breed mix. We strongly encourage you to select your new pet by looking at each dog's individual personality and pet qualities rather than relying on a breed label that is only our best guess.    Our adoption fees vary from $150 and up.  All of our dogs are up to date on vaccines, heart worm preventives, and flea/tick medication, and will be spayed/neutered prior to adoption. Portions of your adoption fee also help care for the sick and injured animals that we take in.  Thank you for supporting us and considering a rescue dog!    August 21, 2026, 11:41 am
Photo of Mollie Cookie

Mollie Cookie

St. Bernard Mastiff

Female, Adult
Nicholasville, KY
Size
(when grown) -
Details
Good with dogs, Spayed or Neutered,
Story
Meet Mollie! This sweet girl has a gentle, easygoing personality and loves spending time with both her canine friends and her favorite people. She's happy to enjoy playtime with other dogs, but she's just as content taking calm, leisurely walks by your side. Mollie would make a wonderful companion for someone looking for a loving, loyal dog who appreciates both fun and quiet moments. If you're searching for a kind-hearted best friend, Mollie is ready to meet you! Primary Color: Brown Secondary Color: White Weight: 85 Age: 6yrs 6mths 3wks

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Mastiff shelters & rescues in Danville, Kentucky

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Danville, Kentucky. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Rescue

47.8 miles

Barktown Rescue

295 Petersburg Road, Boston, KY 40107

Pet Types: cats, dogs

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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