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Mastiff puppies and dogs in Kentucky

Looking for a Mastiff puppy or dog in Kentucky? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff in Kentucky Search for a Mastiff puppy or dog Mastiff puppies and dogs in Kentucky cities Mastiff shelters and rescues in Kentucky Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Kentucky

Below are our newest added Mastiffs available for adoption in Kentucky. To see more adoptable Mastiffs in Kentucky, use the search tool below to enter specific criteria!
Special Needs
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Zoey

Mastiff

Female, Senior
Mount Vernon, KY
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Needs special attention, Needs experienced adopter, House-trained,
Story
Senior mastiff needs a new home. Sons are getting deployed. I travel for work. She’s an older dog who is very shy. She hides under beds when new people come around. She has never bitten. Anyone loves the outdoors and loves to play. Sleeps inside, but if given a chance would stay outside mostly she currently resides with another mastiff and they get along great has never been around cats. Prefer to adopt with her younger brother, as it would provide her with great comfort.

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Moose

Mastiff

Male, Adult
Mount Vernon, KY
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained,
Story
Need to rehome the sweet loving dog. My sons are in the military and are getting deployed and I travel for work a lot.He is over 200 pounds but he believes he is a lap dog mostly inside but will go outside for brief periods of time. Has a wonderful temperament. Has never bitten anybody or been aggressive to anybody Loves to sleep. Has not chewed on furniture of shoes. Loves stuffed bones and stuffed animals. We have another mastiff and they get along great. They are best buds would prefer to rehome both if possible as they have growing up together.

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Cash

Mastiff

Male, 3 yrs 7 mos
Butler, KY
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
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Story
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Duke

Mastiff

Female Adult
Boston, KY
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with cats,
Story
Free TrainingMeet Duke — Big Heart, Big Energy, Big Need for a Hero Duke is back with us — not because he did anything wrong, but because life threw him a curveball. His longtime companion Duchess began struggling with his rough play, and both were returned. Now Duke is confused, grieving, and howling in his kennel, trying to make sense of it all. This big boy has been through a lot. He’s an oversized puppy at heart — full of love, full of energy, and desperate to connect. He wants to make you happy. He just needs someone who understands that big dogs sometimes come with big feelings and big needs. What Duke Needs:   - A home with no dogs under 75 lbs   - A committed adopter willing to go through our training program   - An experienced handler who understands escape artists and can keep him safe   - Patience, structure, and a whole lot of love   Duke isn’t for everyone. But for the right person, he’ll be everything. If you’ve got the heart, the strength, and the experience to help Duke thrive, he’s waiting — and howling — for you. Duke comes with FREE training with Rosie Dane dog training, thanks to the Pedigree foundation.  If you would like to make Duke a part of the family, fill out an application at www.barktownrescue.org/adopt Www.barktownrescue.org/adopt    The shelter software system requires that we choose a predominant breed or breed mix for our dogs. Visual breed identification in dogs is unreliable so for most of our dogs we are only guessing at the dog's predominant breed or breed mix. We strongly encourage you to select your new pet by looking at each dog's individual personality and pet qualities rather than relying on a breed label that is only our best guess.    Our adoption fees vary from $150 and up.  All of our dogs are up to date on vaccines, heart worm preventives, and flea/tick medication, and will be spayed/neutered prior to adoption. Portions of your adoption fee also help care for the sick and injured animals that we take in.  Thank you for supporting us and considering a rescue dog!    March 16, 2026, 1:20 pm

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Photo of Storm

Storm

Mastiff

Female, Young
Hopkinsville, KY
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained,
Story
Storm came to us from a local shelter and has been an absolute joy to care for. She is the perfect blend of everything we love about the Cane Corso breed—affectionate, calm, loyal, and incredibly intelligent. A Corso experienced handler would be a plus, but she’s eager to please and bonds deeply with her people. She enjoys quiet companionship, steady routines, and will make a wonderful addition to a home that appreciates a gentle giant. If you’re looking for a loyal, loving companion with a heart as big as her paws, Storm might be your girl! 💕

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Kentucky.

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Mastiff puppies and dogs in Kentucky cities

Mastiff Puppies near me Mastiff in Alexandria Mastiff in Ashland Mastiff in Bardstown Mastiff in Bellevue Mastiff in Benton Mastiff in Berea Mastiff in Bowling Green Mastiff in Campbellsville Mastiff in Central City Mastiff in Cold Spring Mastiff in Corbin Mastiff in Covington Mastiff in Cynthiana Mastiff in Danville Mastiff in Dayton Mastiff in Douglass Hills Mastiff in Edgewood Mastiff in Elizabethtown Mastiff in Elsmere Mastiff in Erlanger Mastiff in Flatwoods Mastiff in Florence Mastiff in Fort Mitchell Mastiff in Fort Thomas Mastiff in Frankfort Mastiff in Franklin Mastiff in Ft Wright Mastiff in Georgetown Mastiff in Glasgow Mastiff in Harrodsburg Mastiff in Hazard Mastiff in Henderson Mastiff in Highland Heights Mastiff in Hillview Mastiff in Hopkinsville Mastiff in Hurstbourne Mastiff in Independence Mastiff in Jeffersontown Mastiff in La Grange Mastiff in Lancaster Mastiff in Lawrenceburg Mastiff in Lebanon Mastiff in Leitchfield Mastiff in Lexington Mastiff in London Mastiff in Louisville Mastiff in Ludlow Mastiff in Lyndon Mastiff in Madisonville Mastiff in Mayfield Mastiff in Maysville Mastiff in Middletown Mastiff in Monticello Mastiff in Morehead Mastiff in Mount Sterling Mastiff in Mount Washington Mastiff in Murray Mastiff in Newport Mastiff in Nicholasville Mastiff in Oak Grove Mastiff in Owensboro Mastiff in Paducah Mastiff in Paris Mastiff in Pikeville Mastiff in Princeton Mastiff in Prospect Mastiff in Radcliff Mastiff in Richmond Mastiff in Russellville Mastiff in Scottsville Mastiff in Shelbyville Mastiff in Shepherdsville Mastiff in Shively Mastiff in Somerset Mastiff in St Matthews Mastiff in Taylor Mill Mastiff in Versailles Mastiff in Villa Hills Mastiff in Vine Grove Mastiff in Williamsburg Mastiff in Wilmore Mastiff in Winchester

Mastiff shelters & rescues in Kentucky

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Kentucky. Browse these Mastiff rescues and shelters below.

Here are a few organizations

Shelter

Pendleton County Animal Shelter

1314 Byran Griffin Rd, Butler , KY 41006

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog ?

We've got all the info you need on adopting and caring for a Mastiff puppy . Check out the links below for everything you ever wanted to know about Mastiff puppies and adults .

Mastiff information

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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