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Mastiff puppies and dogs in Mexico, Missouri

Looking for a Mastiff puppy or dog in Mexico, Missouri? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near Mexico, Missouri Other pups in Mexico, Missouri Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in Mexico, Missouri Mastiff shelters and rescues in Mexico, Missouri Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Mexico, Missouri

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Mexico, Missouri

These Mastiffs are available for adoption close to Mexico, Missouri.
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Izzy

Mastiff Mixed Breed (Large)

Female, 3 yrs 4 mos
Columbia, MO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, Spayed or Neutered,
Story
Meet Izzy, a beautiful 113lb brindle mastiff. Izzy embodies the true nature of a mastiff; calm, gentle, powerful, and fiercely loyal. Izzy is not a fan of strangers, and will ward off anyone she doesn't like with her super power: scary bark. She greets the people that are in her chosen inner circle with a wiggling butt and nub of a tail, but don't be fooled she will drown you in slobber at any given chance. Giving her a treat will result in a drenched hand. Izzy also is a big fan of toys, both chew toys and stuffed animals. Izzy has training needs : Izzy has anxiety surrounding strangers, as is typical of mastiffs who are bred for protection. She needs a quiet home while she can work on being less reactive in situations that might spook her like when strange people approach. She also needs a confident handler that can deal with 113lbs of Izzy. She is incredibly smart and treat motivated. She responds well to positive reinforcement, and needs someone to reward her for staying calm in moments where she feels uncertain. Izzy seems to warm up easier to women, but not so much men. Our behavior team is happy to help anyone interested in taking miss Izzy with a management plan and training.

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Photo of Maxine

Maxine

Mastiff Mixed Breed (Large)

Female, 5 mos
Hawk Point, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered, Shots are up-to-date,
Story
Maxine is a Mastiff mix who may already be a pretty impressive package, but don’t let her size fool you — she is sweet, gentle, and just looking for someone to show her the ropes. She’s still young and has plenty to learn, but with some patience and good training, we think Maxine is going to grow into an absolutely amazing dog. She has the kind of gentle personality that makes you want to root for her, and she deserves a family who will give her the guidance and love she needs to shine. If you have room in your home and heart for a big, lovable girl, Maxine would love to meet you! Maxine's $220 Adoption Fee is a great deal. She is spayed vaccinated, micro-chipped, wormed & current on monthly heartworm preventative. Maxine's estimated month of birth is 4/2026 Visit www.Pals-Pets.org to fill out a Pre-Adoption Questionnaire or call 314.581.6651 to schedule an appointment to meet this pet or any others here at the shelter.

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Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Mexico, Missouri.

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Mastiff puppies and dogs in nearby cities

Mastiff Puppies near me Mastiff in Columbia, MO Mastiff in Fulton, MO Mastiff in Moberly, MO

Related breeds in Mexico, Missouri

Bullmastiffs in Mexico, Missouri Neapolitan Mastiffs in Mexico, Missouri Saint Bernards in Mexico, Missouri

Mastiff shelters & rescues in Mexico, Missouri

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Mexico, Missouri. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

26.7 miles

Central Missouri Humane Society

616 Big Bear Blvd, Columbia, MO 65202

Pet Types: cats, birds, dogs, farm animals, rabbits, reptiles, small animals

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Shelter

41.5 miles

PALS Animal Shelter of Lincoln County, Missouri

4287 Hwy 47 West, Hawk Point, MO 63349

Pet Types: cats, dogs

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If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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