Mastiff Adoption in Missouri: Mastiff Puppies for Sale in Missouri

Adopt a Mastiff near you in Missouri

Below are our newest added Mastiffs available for adoption in Missouri. To see more adoptable Mastiffs in Missouri, use the search tool below to enter specific criteria!

Sweet Jolene

Mastiff/Mixed Breed (Large)

Female, 2 yrs

St. Louis, MO

Size

(when grown) -

Details

Good with cats,

Story

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Diego JuM

Mastiff/Mixed Breed (Large)

Male, 2 yrs 1 mo

St Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs,

Story

I'm Diego, a striking 2-year-old chocolate and blond brindle Mastiff mix, and I've got the heart of an adventurer! 🐕 At 63 pounds of pure energy and loyalty, I'm already neutered and crate trained—ready to be your partner in crime. I thrive with active owners who can match my enthusiasm, and I'm fantastic with other dogs, so playdates are always a go! If you're looking for a friendly, energetic companion who'll stick by your side through thick and thin, come meet me today. 💪❤️ Local adoption fee is $300 (in TX) Out of state adoption fee is $550 (includes transport to your area)

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Duke

Mastiff/Boxer

Male, Senior

Saint Joseph, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, Not good with cats,

Story

🐾 Meet Duke - Sweet & Energetic Looking for a Forever Home! He is a loyal companion with a wonderful personality, looking for an active home where he can thrive. He is a Boxer / Bully mix blend with a beautiful short fawn coat and a classic dark muzzle. He loves outdoor adventures, playtime, and long walks. He does not like being inside. Needs a family that can provide regular exercise and mental stimulation. Secure Yard: A fenced yard or open country fields is preferred so he can burn off his energy safely. Responds wonderfully to structured routines and positive reinforcement training, His owner passed in June I have been trying to take care of him but it's just became too much for me.

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Izzy

Mastiff/Mixed Breed (Large)

Female, 3 yrs 3 mos

Columbia, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

Meet Izzy, a beautiful 113lb brindle mastiff. Izzy embodies the true nature of a mastiff; calm, gentle, powerful, and fiercely loyal. Izzy is not a fan of strangers, and will ward off anyone she doesn't like with her super power: scary bark. She greets the people that are in her chosen inner circle with a wiggling butt and nub of a tail, but don't be fooled she will drown you in slobber at any given chance. Giving her a treat will result in a drenched hand. Izzy also is a big fan of toys, both chew toys and stuffed animals. Izzy has training needs : Izzy has anxiety surrounding strangers, as is typical of mastiffs who are bred for protection. She needs a quiet home while she can work on being less reactive in situations that might spook her like when strange people approach. She also needs a confident handler that can deal with 113lbs of Izzy. She is incredibly smart and treat motivated. She responds well to positive reinforcement, and needs someone to reward her for staying calm in moments where she feels uncertain. Izzy seems to warm up easier to women, but not so much men. Our behavior team is happy to help anyone interested in taking miss Izzy with a management plan and training.

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Pancho

Mastiff/Shar Pei

Male, Senior

Stover, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, House-trained,

Story

You can fill out an adoption application online on our official website.Poor old man was roaming in town from house to house just looking for a kind human to help. Nails were long and curled, double ear infection and severe flea dermis. He’s healed up, gets some hot spots once in awhile but otherwise loves to play fetch. Carrying a slobbery ball around is his favorite thing to do! Pancho answers better to Tank and is possibly a Kangle breed. We are only guessing what breed he is but definitely a large breed. He would be very happy as the only dog and loves to be inside near a fan and/or AC.Visit this organization's web site to see any additional information available about this pet.September 7, 2026, 8:17 pm

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Special Needs

Bitsie

Mastiff

Female, 8 yrs 10 mos

Independence, MO

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with kids, Needs special attention, House-trained,

Story

Bitsie, an 8-year-old mastiff mix who needed a new home after her owner passed away. She had been living in very poor conditions and arrived obese, with severe foot infections, patchy hair, and other health issues. Although our building was full, ABF helped by arranging veterinary care, providing supplies, and eventually placing her in temporary foster care. Over several months, Bitsie underwent extensive testing and treatment for a persistent bacterial and staph infection in her feet, as well as a UTI and hyperthyroidism. After multiple medication adjustments and specialist visits, her condition gradually improved. As of October, her infection has drastically decreased, her pain has subsided, she is now thriving on a maintenance regimen. She's transformed into a healthier, happier dog. Bitsie continues her Thyro tabs for her hyperthyroidism and Ketoconazole and Sporimune to maintain the care of her feet. Bitsie for the first time is like a puppy. She is enjoying life. She has always given sloppy kisses, but even more now that she feels good. Bitsie runs around the yard, tossing her toys up in the air, chasing balls and rolling in the grass. She also loves car rides and thinks she is a lapdog. I know she has had a long journey to get where she is today and may have to continue some medications, but we are still going to hold out hope that someday she can have her own family. She is very strong, active, smart and wants to please you. Bitsie needs a family that can train her and love her for the rest of her life.

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Mastiff puppies and dogs in Missouri

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Below are our newest added Mastiffs available for adoption in Missouri. To see more adoptable Mastiffs in Missouri, use the search tool below to enter specific criteria!

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Mastiff puppies and dogs in Missouri

Jump to:

Adopt a Mastiff near you in Missouri

Below are our newest added Mastiffs available for adoption in Missouri. To see more adoptable Mastiffs in Missouri, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Missouri cities

Mastiff shelters & rescues in Missouri

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics