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Mastiff puppies and dogs in Missouri

Looking for a Mastiff puppy or dog in Missouri? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff in Missouri Search for a Mastiff puppy or dog Mastiff puppies and dogs in Missouri cities Mastiff shelters and rescues in Missouri Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Missouri

Below are our newest added Mastiffs available for adoption in Missouri. To see more adoptable Mastiffs in Missouri, use the search tool below to enter specific criteria!
We'll also keep you updated on Kenicke's adoption status with email updates.
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Kenicke

Mastiff

Male, 2 mos
Raytown, MO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats,
Story
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We'll also keep you updated on Leo's adoption status with email updates.
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Leo

Mastiff

Male, 2 mos
Raytown, MO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats,
Story
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We'll also keep you updated on Rizzo's adoption status with email updates.
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Rizzo

Mastiff

Female, 2 mos
Raytown, MO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats,
Story
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We'll also keep you updated on Cane's adoption status with email updates.
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Cane

Mastiff

Male, Adult
Centralia, MO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with cats, House-trained,
Story
Cane is very excited to meet new people. Does have a tendancy to jump up on them. He beleives he is smaller then what he actually is feels the need to be in your space. He needs a person who has time to love him as he needs. He loves to play and chew up his toys. Cane does not bark much. Yes he will when outside and someone walks by the fence with another animal, but he wants to play with them.

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We'll also keep you updated on Zuke's adoption status with email updates.
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Zuke

Mastiff

Male, Adult
St Louis, MO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
House-trained,
Story
  Looking for a loyal companion with a big heart (and an even bigger cuddle game)? This handsome 5-year-old, 120-pound teddy bear might just be your perfect match. This gentle giant is the full package—smart, affectionate, and always ready for fun. He’s the kind of dog who will happily romp around the yard chasing a ball one minute, then curl up beside you like a lap dog the next (yes, all 120 lbs of him). His expressive, squish face and soulful eyes make it pretty clear—he just wants to be close to his people. Personality Highlights:  Smart: Quick learner who loves to engage and figure things out  Playful: Always up for a walk, yard zoomies, or a good game  Toy Lover: Has a soft spot for plush toys—he loves carrying them around and showing them off  Cuddly: A true snuggle bug who gives the best hugs  Loyal: Forms strong bonds and thrives on companionship At five years old, he’s the perfect mix of playful energy and calm companionship—past the wild puppy stage but still full of life and enthusiasm. He enjoys both active time outside and relaxing indoors on a cozy bed (preferably in the same room as you). You’ll often find him proudly trotting around with his favorite soft toy, ball or stick in his mouth. Because of his size, he’d do best in a home that can give him space to stretch out and a family ready to embrace big-dog love. In return, you’ll get endless affection, laughs, and a best friend who’s always happy to see you. If you’re ready for a devoted, playful, snuggly companion (with a love for plush toys), he’s ready to meet you.  If you are interested, complete the  Adoption Application  on our website at  www.NeedyPaws.org  and we will contact you.  Adopters must live within an hour’s drive of St. Louis, MO. Zuke’s adoption fee is $295.00, which includes up-to-date vaccinations, heartworm testing and preventative, spay/neuter and microchip. We are a 100% foster-based rescue and all of our dogs live in approved foster homes. We are dedicated to finding the best Forever Homes, and will perform home visits and conduct veterinarian and reference checks for each potential adopter. Visit this organization's web site to see any additional information available about this pet.April 6, 2026, 11:06 pm

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We'll also keep you updated on Rooster's adoption status with email updates.
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Rooster

Mastiff

Male, Young
Kansas City, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with cats, Needs experienced adopter, House-trained,
Story
Rooster is a very loving boy. He just needs room to run with a yard. Hes good with my 6 year old son. He does growl at other kids especially little girls. Hes is not food aggressive. He loves to play with our German shepard.not sure how he would be with other dogs. Hes getting better on a leash he pulls. He like to chew on anything he can I think because we live in an apartment and he gets bored. Would love to see him go with a family that has time to work with him take him on long walks and a yard to run in.

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Missouri.

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Mastiff puppies and dogs in Missouri cities

Mastiff Puppies near me Mastiff in Arnold Mastiff in Aurora Mastiff in Ballwin Mastiff in Belton Mastiff in Berkeley Mastiff in Black Jack Mastiff in Blue Springs Mastiff in Bolivar Mastiff in Bonne Terre Mastiff in Boonville Mastiff in Bowling Green Mastiff in Branson Mastiff in Breckenridge Hills Mastiff in Brentwood Mastiff in Bridgeton Mastiff in Brookfield Mastiff in Butler Mastiff in Cameron Mastiff in Cape Girardeau Mastiff in Carl Junction Mastiff in Carthage Mastiff in Caruthersville Mastiff in Charleston Mastiff in Chesterfield Mastiff in Chillicothe Mastiff in Clayton Mastiff in Clinton Mastiff in Columbia Mastiff in Creve Coeur Mastiff in Crystal City Mastiff in Dardenne Prairie Mastiff in Desloge Mastiff in De Soto Mastiff in Des Peres Mastiff in Dexter Mastiff in Eldon Mastiff in Ellisville Mastiff in Eureka Mastiff in Excelsior Springs Mastiff in Farmington Mastiff in Ferguson Mastiff in Festus Mastiff in Florissant Mastiff in Fulton Mastiff in Gladstone Mastiff in Grain Valley Mastiff in Grandview Mastiff in Greenwood Mastiff in Hannibal Mastiff in Harrisonville Mastiff in Hazelwood Mastiff in Higginsville Mastiff in Independence Mastiff in Jackson Mastiff in Jefferson City Mastiff in Jennings Mastiff in Joplin Mastiff in Kansas City Mastiff in Kearney Mastiff in Kennett Mastiff in Kirksville Mastiff in Kirkwood Mastiff in Lake St Louis Mastiff in Lamar Mastiff in Lebanon Mastiff in Lees Summit Mastiff in Lexington Mastiff in Liberty Mastiff in Macon Mastiff in Malden Mastiff in Manchester Mastiff in Maplewood Mastiff in Marshall Mastiff in Marshfield Mastiff in Maryland Heights Mastiff in Maryville Mastiff in Mexico Mastiff in Moberly Mastiff in Monett Mastiff in Mountain Grove Mastiff in Mount Vernon Mastiff in Neosho Mastiff in Nevada Mastiff in Nixa Mastiff in Normandy Mastiff in North Kansas City Mastiff in Oak Grove Mastiff in Odessa Mastiff in O Fallon Mastiff in Olivette Mastiff in Osage Beach Mastiff in Overland Mastiff in Ozark Mastiff in Pacific Mastiff in Park Hills Mastiff in Parkville Mastiff in Peculiar Mastiff in Perryville Mastiff in Pevely Mastiff in Platte City Mastiff in Pleasant Hill Mastiff in Poplar Bluff Mastiff in Raymore Mastiff in Raytown Mastiff in Republic Mastiff in Richmond Mastiff in Richmond Heights Mastiff in Rolla Mastiff in Saint Ann Mastiff in Saint Charles Mastiff in Saint Clair Mastiff in Saint Joseph Mastiff in Saint Louis Mastiff in Saint Peters Mastiff in Salem Mastiff in Savannah Mastiff in Scott City Mastiff in Sedalia Mastiff in Sikeston Mastiff in Smithville Mastiff in Springfield Mastiff in Ste Genevieve Mastiff in Sullivan Mastiff in Town and Country Mastiff in Trenton Mastiff in Troy Mastiff in Union Mastiff in University City Mastiff in Valley Park Mastiff in Vandalia Mastiff in Warrensburg Mastiff in Warrenton Mastiff in Washington Mastiff in Webb City Mastiff in Webster Groves Mastiff in Weldon Spring Mastiff in Wentzville Mastiff in West Plains Mastiff in Wildwood

Mastiff shelters & rescues in Missouri

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Missouri. Browse these Mastiff rescues and shelters below.

Here are a few organizations

Rescue

Needy Paws Rescue

St Louis , MO 63125

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog ?

We've got all the info you need on adopting and caring for a Mastiff puppy . Check out the links below for everything you ever wanted to know about Mastiff puppies and adults .

Mastiff information

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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