Mastiff Adoption in Missouri: Mastiff Puppies for Sale in Missouri

Adopt a Mastiff near you in Missouri

Below are our newest added Mastiffs available for adoption in Missouri. To see more adoptable Mastiffs in Missouri, use the search tool below to enter specific criteria!

Frank

English Mastiff/Great Dane

Male, 4 yrs

Cameron, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Needs experienced adopter, House-trained,

Story

Adopt Frank! ☺️ Frank has stolen our hearts!! This sweet guy is the definition of gentle giant. Frank is a 4 year old Mastiff Mix! Originally adopted from KCPP we saw that he does well on a very long walks. Frank does awesome on leash. He is not reactive to bikes or dogs on walks and he pulls very little. Frank knows how to sit and takes treats gently. Frank likes pup cups, and to be told how handsome he is! Frank is about 140 lbs so he will do best with a family that has the strength for him, but also will help him be active. Frank attends playgroups but can be a bit of a nervous nelly, so being with one other dog in the home may be best. He really is such a sweet pea and just wants to love on everyone. Let’s find him his true forever! - 4 years old, 141 lbs - DOG Friendly - House Trained

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Cane

Mastiff

Male, Adult

Centralia, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with cats, House-trained,

Story

Cane is very excited to meet new people. Does have a tendancy to jump up on them. He beleives he is smaller then what he actually is feels the need to be in your space. He needs a person who has time to love him as he needs. He loves to play and chew up his toys. Cane does not bark much. Yes he will when outside and someone walks by the fence with another animal, but he wants to play with them.

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Rooster

Mastiff

Male, Young

Kansas City, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with cats, Needs experienced adopter, House-trained,

Story

Rooster is a very loving boy. He just needs room to run with a yard. Hes good with my 6 year old son. He does growl at other kids especially little girls. Hes is not food aggressive. He loves to play with our German shepard.not sure how he would be with other dogs. Hes getting better on a leash he pulls. He like to chew on anything he can I think because we live in an apartment and he gets bored. Would love to see him go with a family that has time to work with him take him on long walks and a yard to run in.

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Crimson

Mastiff/Mixed Breed (Medium)

Male, 1 yr 8 mos

Springfield, MO

Size

(when grown) -

Details

Good with dogs, House-trained,

Story

Meet Crimson! ❤️ Crimson is a striking red Mastiff mix with a big heart to match his impressive presence. At just 1 year and 6 months old, this handsome boy is entering the perfect stage of life—past the tiny puppy phase but still young, playful, and ready to grow with his forever family. Crimson has a gentle, affectionate personality and truly thrives on human companionship. He loves spending time with his people, whether that means going for walks, playing in the yard, or simply relaxing nearby and soaking up attention. Like many Mastiff mixes, Crimson has a loyal and devoted nature, forming strong bonds with those he trusts. He’s a smart young dog who will benefit from continued guidance, structure, and positive reinforcement as he matures into the wonderful companion he’s meant to be. With consistent love and patience, Crimson will blossom into a devoted best friend who will always be by your side. Crimson would do best in a home that understands large breeds and can provide him with the space, love, and commitment he deserves. In return, he promises a lifetime of loyalty, affection, and unforgettable moments. If you’re looking for a handsome, loving companion with a big heart and an even bigger future, Crimson may be the perfect addition to your family. 🐾❤️ Fill out a Match Me form online at: https://www.shelterluv.com/matchme/adopt/CAST/Dog to be preapproved. All C.A.R.E rescue dogs are vaccinated, heart-worm tested, spayed/neutered, and microchipped! So all you need to provide is the love. Our adoption fee is a minimum $150 tax deductible donation. All donations are used for rescue and medical care of animals in need. If you don't have room to take home a pet but want to support our efforts to save animals in need, please consider making a donation. We are not city or state funded and rely solely on private donations that allow us to continue saving lives. To learn more about us or to give a life saving donation please visit http://www.carerescue.org

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Ralph BW

Mastiff/Mixed Breed (Large)

Male, 1 yr 2 mos

St Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

Ralph the Derp! Ralph is a huge friendly, enthusiastic, uncoordinated 4-legged energetic goofball! He was rescued from “death row” at a high kill shelter, as a skinny stray with a treatable skin condition. His fur has almost completely grown in & he is now at a healthy weight. This overgrown mastiff/Cane Corso mix pup has no comprehension of his size, leaning into humans for affection or trying to ooze onto laps for cuddles. He is being trained not to jump and not to paw for attention/affection/play because he currently has 85# of mass behind those “congenial” moves. Ralph plays well with dogs of all sizes, but would do best with med-to-larger dogs due to his size & poorly curbed gusto. He hordes toys, taking them all to his chosen dog bed of the day. He likes to carry a special toy “baby” in his mouth when going out in the yard. He does need to be fed in his crate & will guard his empty food bowl from other dogs, unless he is distracted with a toy & led outdoors after meals. He is great on a leash, makes awesome grunty sounds when cuddled, enjoys baths. Ralph will make a great addition to an active family with older children. He is eager to please, food and affection oriented (although a bit stubborn at times), making him an ideal candidate for success with continuation of his training. Please consider adopting the gorgeous big derp into your home. Attributes: In training to avoid jumping/pawing Active family He is neutered, microchipped, had recent cherry eye repair and up to date on all vaccines and preventions. Local adoption fee is $200(in TX) Out of state adoption fee is $450 (includes transport to your area)

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Ivy

Mastiff/Shepherd (Unknown Type)

Female, 5 yrs 2 mos

Cuba, MO

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

House-trained,

Story

Ivy is housebroken, current on vaccinations and will be spayed before adoption. Food motivated, eager to please and likes to be right by your side. She knows how to sit for a treat.

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Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Missouri.

Mastiff puppies and dogs in Missouri

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Below are our newest added Mastiffs available for adoption in Missouri. To see more adoptable Mastiffs in Missouri, use the search tool below to enter specific criteria!

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Mastiff puppies and dogs in Missouri

Jump to:

Adopt a Mastiff near you in Missouri

Below are our newest added Mastiffs available for adoption in Missouri. To see more adoptable Mastiffs in Missouri, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Missouri cities

Mastiff shelters & rescues in Missouri

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics