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Mastiff puppies and dogs in Missouri

Looking for a Mastiff puppy or dog in Missouri? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff in Missouri Search for a Mastiff puppy or dog Mastiff puppies and dogs in Missouri cities Mastiff shelters and rescues in Missouri Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Missouri

Below are our newest added Mastiffs available for adoption in Missouri. To see more adoptable Mastiffs in Missouri, use the search tool below to enter specific criteria!
We'll also keep you updated on Smoke's adoption status with email updates.
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Smoke

Mastiff/American Bulldog

Male, 7 yrs
Kansas City, MO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
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Story
Smoke is a gentle giant who’s ready to fill your home with love, loyalty, and plenty of big-dog snuggles.He’s friendly and outgoing with people, and while he can be a little selective with doggy friends, with the right match he could potentially enjoy a canine companion. At 7 years old and a whopping 150 pounds, Smoke is a true mastiff-sized presence — big in stature and even bigger in heart.He has a nicely balanced energy level. He enjoys playtime (especially a good game of tug!) but is just as happy soaking up attention and relaxing with his people. Smoke is housetrained according to his previous family and already knows a variety of basic commands. He’s smart, eager to please, and would love a home that keeps engaging his mind and continuing his training.He would do best in a home ready for a large, strong dog who wants both playtime and lots of affection — someone excited to share life with him! Smoke is ready to find his forever family and start his next chapter as a cherished member of the household. Come meet this big, lovable boy and see if he’s the perfect match for you!Smoke is neutered, microchipped, up to date on his vaccinations, and ready for his forever home!

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We'll also keep you updated on Ivy's adoption status with email updates.
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Ivy

Mastiff/Shepherd (Unknown Type)

Female, 5 yrs
Cuba, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
House-trained,
Story
Ivy is housebroken, current on vaccinations and will be spayed before adoption. Food motivated, eager to please and likes to be right by your side. She knows how to sit for a treat.

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We'll also keep you updated on Reverie's adoption status with email updates.
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Reverie

Mastiff

Female, 2 yrs
Kansas City, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
2 year old Reverie enjoys the company of other dogs and seems to be a more introverted girl. She does love a nice snackie and she knows some basic commands. She is spayed, up-to-date on her vaccinations and microchip.

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We'll also keep you updated on Dane's adoption status with email updates.
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Dane

Mastiff

Male, 10 yrs
St. Louis, MO
Size
(when grown) -
Details
-
Story
-

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We'll also keep you updated on Variya's adoption status with email updates.
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Variya

Mastiff

Female, 10 mos
Kansas City, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
-
Story
10 month old Variya is a friendly, wiggly, silly girl. She loves treats and is happy to learn things for a nice snackie. She also attends the shelter playgroups every morning. She comes spade, up-to-date on her vaccinations and microchip.

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We'll also keep you updated on Compton 's adoption status with email updates.
Photo of Compton

Compton

Mastiff/Labrador Retriever

Male, 3 yrs 1 mo
O'Fallon, MO
Size
(when grown) -
Details
Good with dogs, House-trained,
Story
𝗔𝗗𝗢𝗣𝗧 𝗖𝗢𝗠𝗣𝗧𝗢𝗡 🤍🐷 𝗪𝗲𝗹𝗰𝗼𝗺𝗲 𝘁𝗼 𝘁𝗵𝗲 𝗳𝗮𝗺𝗶𝗹𝘆 Compton 🤍 We promise to find you a 𝒓𝒆𝒂𝒍 𝗳𝘂𝗿𝗲𝘃𝗲𝗿 𝗳𝗮𝗺𝗶𝗹𝘆 this time 🙏 Compton found his way to our city shelter back in January of 2025 as a stray with a collar and leash still attached, but sadly no one came forward 😞 He quickly showed signs of kennel stress, but luckily was sprung by a foster hero, and then what he thought was his furever home…2 months later he was dropped off for dogsitting, the owner blocked the sitter, and never came back for our sweet ham 😭 He was once again adopted again, and later picked up by the Humane Society as a stray and transferred back to CARE. After 𝗮 𝗳𝘂𝗹𝗹 𝘆𝗲𝗮𝗿 𝗼𝗳 𝗯𝗼𝘂𝗻𝗰𝗶𝗻𝗴 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝗸𝗲𝗻𝗻𝗲𝗹𝘀 𝗮𝗻𝗱 𝗵𝗼𝗺𝗲𝘀, Compton is FREE of shelter life, decompressing in a home, and snoring like a grown man 😆 (check out the comments for a video!) This level white noise happens when a shelter dog feels like they can finally relax 🥲 The ONLY reason we were able to help Compton is because a 𝗳𝗼𝘀𝘁𝗲𝗿 𝗵𝗲𝗿𝗼 opened their home 🏡 THANK YOU to all the heroes—you are truly saving a life. All that’s left is to find 𝗳𝘂𝗿𝗲𝘃𝗲𝗿 ♾️👀 _____________________________________________ 𝗚𝗼𝗼𝗱 𝗯𝗼𝘆 𝗾𝘂𝗮𝗹𝗶𝗳𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 𝘀𝗼 𝗳𝗮𝗿: • ~3 yr old ~67lbs happy, hefty hog 🐷 • potty/house trained ✔️ • rides well in the car ✔️ • SUPER food motivated—a fast learner! • AFFECTIONATE! he loves a snuggle • DOG FRIENDLY! • NO CATS ❌ • KID FRIENDLY! hasn’t met tiny hoomans but has done well with the ones he has met!

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Missouri.

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Mastiff puppies and dogs in Missouri cities

Mastiff Puppies near me Mastiff in Arnold Mastiff in Aurora Mastiff in Ballwin Mastiff in Belton Mastiff in Berkeley Mastiff in Black Jack Mastiff in Blue Springs Mastiff in Bolivar Mastiff in Bonne Terre Mastiff in Boonville Mastiff in Bowling Green Mastiff in Branson Mastiff in Breckenridge Hills Mastiff in Brentwood Mastiff in Bridgeton Mastiff in Brookfield Mastiff in Butler Mastiff in Cameron Mastiff in Cape Girardeau Mastiff in Carl Junction Mastiff in Carthage Mastiff in Caruthersville Mastiff in Charleston Mastiff in Chesterfield Mastiff in Chillicothe Mastiff in Clayton Mastiff in Clinton Mastiff in Columbia Mastiff in Creve Coeur Mastiff in Crystal City Mastiff in Dardenne Prairie Mastiff in Desloge Mastiff in De Soto Mastiff in Des Peres Mastiff in Dexter Mastiff in Eldon Mastiff in Ellisville Mastiff in Eureka Mastiff in Excelsior Springs Mastiff in Farmington Mastiff in Ferguson Mastiff in Festus Mastiff in Florissant Mastiff in Fulton Mastiff in Gladstone Mastiff in Grain Valley Mastiff in Grandview Mastiff in Greenwood Mastiff in Hannibal Mastiff in Harrisonville Mastiff in Hazelwood Mastiff in Higginsville Mastiff in Independence Mastiff in Jackson Mastiff in Jefferson City Mastiff in Jennings Mastiff in Joplin Mastiff in Kansas City Mastiff in Kearney Mastiff in Kennett Mastiff in Kirksville Mastiff in Kirkwood Mastiff in Lake St Louis Mastiff in Lamar Mastiff in Lebanon Mastiff in Lees Summit Mastiff in Lexington Mastiff in Liberty Mastiff in Macon Mastiff in Malden Mastiff in Manchester Mastiff in Maplewood Mastiff in Marshall Mastiff in Marshfield Mastiff in Maryland Heights Mastiff in Maryville Mastiff in Mexico Mastiff in Moberly Mastiff in Monett Mastiff in Mountain Grove Mastiff in Mount Vernon Mastiff in Neosho Mastiff in Nevada Mastiff in Nixa Mastiff in Normandy Mastiff in North Kansas City Mastiff in Oak Grove Mastiff in Odessa Mastiff in O Fallon Mastiff in Olivette Mastiff in Osage Beach Mastiff in Overland Mastiff in Ozark Mastiff in Pacific Mastiff in Park Hills Mastiff in Parkville Mastiff in Peculiar Mastiff in Perryville Mastiff in Pevely Mastiff in Platte City Mastiff in Pleasant Hill Mastiff in Poplar Bluff Mastiff in Raymore Mastiff in Raytown Mastiff in Republic Mastiff in Richmond Mastiff in Richmond Heights Mastiff in Rolla Mastiff in Saint Ann Mastiff in Saint Charles Mastiff in Saint Clair Mastiff in Saint Joseph Mastiff in Saint Louis Mastiff in Saint Peters Mastiff in Salem Mastiff in Savannah Mastiff in Scott City Mastiff in Sedalia Mastiff in Sikeston Mastiff in Smithville Mastiff in Springfield Mastiff in Ste Genevieve Mastiff in Sullivan Mastiff in Town and Country Mastiff in Trenton Mastiff in Troy Mastiff in Union Mastiff in University City Mastiff in Valley Park Mastiff in Vandalia Mastiff in Warrensburg Mastiff in Warrenton Mastiff in Washington Mastiff in Webb City Mastiff in Webster Groves Mastiff in Weldon Spring Mastiff in Wentzville Mastiff in West Plains Mastiff in Wildwood

Mastiff shelters & rescues in Missouri

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Missouri. Browse these Mastiff rescues and shelters below.

Here are a few organizations

Rescue

Gods Dogs Rescue of TX for St Louis Transport Stop

St Louis , MO 63146

Pet Types: dogs

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Shelter

CARE STL

2700 Walnut Place, St. Louis , MO 63103

Pet Types: cats, birds, dogs, farm animals, rabbits, small animals

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Rescue

Needy Paws Rescue

St Louis , MO 63125

Pet Types: dogs

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Rescue

Unleashed Potential Animal Rescue

O'Fallon , MO 63366

Pet Types: dogs

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Shelter

Cuba Mo Animal Control

224 Enterprise Drive, Cuba , MO 65453

Pet Types: cats, dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog ?

We've got all the info you need on adopting and caring for a Mastiff puppy . Check out the links below for everything you ever wanted to know about Mastiff puppies and adults .

Mastiff information

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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