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Mastiff puppies and dogs in Missouri

Looking for a Mastiff puppy or dog in Missouri? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff in Missouri Search for a Mastiff puppy or dog Mastiff puppies and dogs in Missouri cities Mastiff shelters and rescues in Missouri Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Missouri

Below are our newest added Mastiffs available for adoption in Missouri. To see more adoptable Mastiffs in Missouri, use the search tool below to enter specific criteria!
Photo of BAILEY

BAILEY

Mastiff

Female, 2 yrs
St. Louis, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
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Sweet Jolene

Mastiff/Mixed Breed (Large)

Female, 2 yrs
St. Louis, MO
Size
(when grown) -
Details
Good with cats,
Story
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Diego JuM

Mastiff/Mixed Breed (Large)

Male, 2 yrs 1 mo
St Louis, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs,
Story
I'm Diego, a striking 2-year-old chocolate and blond brindle Mastiff mix, and I've got the heart of an adventurer! 🐕 At 63 pounds of pure energy and loyalty, I'm already neutered and crate trained—ready to be your partner in crime. I thrive with active owners who can match my enthusiasm, and I'm fantastic with other dogs, so playdates are always a go! If you're looking for a friendly, energetic companion who'll stick by your side through thick and thin, come meet me today. 💪❤️ Local adoption fee is $300 (in TX) Out of state adoption fee is $550 (includes transport to your area)

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Photo of Duke

Duke

Mastiff/Boxer

Male, Senior
Saint Joseph, MO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Not good with cats,
Story
🐾 Meet Duke - Sweet & Energetic Looking for a Forever Home! He is a loyal companion with a wonderful personality, looking for an active home where he can thrive. He is a Boxer / Bully mix blend with a beautiful short fawn coat and a classic dark muzzle. He loves outdoor adventures, playtime, and long walks. He does not like being inside. Needs a family that can provide regular exercise and mental stimulation. Secure Yard: A fenced yard or open country fields is preferred so he can burn off his energy safely. Responds wonderfully to structured routines and positive reinforcement training, His owner passed in June I have been trying to take care of him but it's just became too much for me.

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Photo of Izzy

Izzy

Mastiff/Mixed Breed (Large)

Female, 3 yrs 3 mos
Columbia, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats,
Story
Izzy is a sweet, gentle giant. She is more nervous around men than women. She loves treats and seems very smart! Izzy is looking for a mature home where someone has experience with large breed dogs.

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Photo of Pancho

Pancho

Mastiff/Shar Pei

Male, Senior
Stover, MO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, House-trained,
Story
You can fill out an adoption application online on our official website.Poor old man was roaming in town from house to house just looking for a kind human to help. Nails were long and curled, double ear infection and severe flea dermis. He’s healed up, gets some hot spots once in awhile but otherwise loves to play fetch. Carrying a slobbery ball around is his favorite thing to do! Pancho answers better to Tank and is possibly a Kangle breed. We are only guessing what breed he is but definitely a large breed. He would be very happy as the only dog and loves to be inside near a fan and/or AC.Visit this organization's web site to see any additional information available about this pet.September 7, 2026, 8:17 pm

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Missouri.

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Mastiff puppies and dogs in Missouri cities

Mastiff Puppies near me Mastiff in Arnold Mastiff in Aurora Mastiff in Ballwin Mastiff in Belton Mastiff in Berkeley Mastiff in Black Jack Mastiff in Blue Springs Mastiff in Bolivar Mastiff in Bonne Terre Mastiff in Boonville Mastiff in Bowling Green Mastiff in Branson Mastiff in Breckenridge Hills Mastiff in Brentwood Mastiff in Bridgeton Mastiff in Brookfield Mastiff in Butler Mastiff in Cameron Mastiff in Cape Girardeau Mastiff in Carl Junction Mastiff in Carthage Mastiff in Caruthersville Mastiff in Charleston Mastiff in Chesterfield Mastiff in Chillicothe Mastiff in Clayton Mastiff in Clinton Mastiff in Columbia Mastiff in Creve Coeur Mastiff in Crystal City Mastiff in Dardenne Prairie Mastiff in Desloge Mastiff in De Soto Mastiff in Des Peres Mastiff in Dexter Mastiff in Eldon Mastiff in Ellisville Mastiff in Eureka Mastiff in Excelsior Springs Mastiff in Farmington Mastiff in Ferguson Mastiff in Festus Mastiff in Florissant Mastiff in Fulton Mastiff in Gladstone Mastiff in Grain Valley Mastiff in Grandview Mastiff in Greenwood Mastiff in Hannibal Mastiff in Harrisonville Mastiff in Hazelwood Mastiff in Higginsville Mastiff in Independence Mastiff in Jackson Mastiff in Jefferson City Mastiff in Jennings Mastiff in Joplin Mastiff in Kansas City Mastiff in Kearney Mastiff in Kennett Mastiff in Kirksville Mastiff in Kirkwood Mastiff in Lake St Louis Mastiff in Lamar Mastiff in Lebanon Mastiff in Lees Summit Mastiff in Lexington Mastiff in Liberty Mastiff in Macon Mastiff in Malden Mastiff in Manchester Mastiff in Maplewood Mastiff in Marshall Mastiff in Marshfield Mastiff in Maryland Heights Mastiff in Maryville Mastiff in Mexico Mastiff in Moberly Mastiff in Monett Mastiff in Mountain Grove Mastiff in Mount Vernon Mastiff in Neosho Mastiff in Nevada Mastiff in Nixa Mastiff in Normandy Mastiff in North Kansas City Mastiff in Oak Grove Mastiff in Odessa Mastiff in O Fallon Mastiff in Olivette Mastiff in Osage Beach Mastiff in Overland Mastiff in Ozark Mastiff in Pacific Mastiff in Park Hills Mastiff in Parkville Mastiff in Peculiar Mastiff in Perryville Mastiff in Pevely Mastiff in Platte City Mastiff in Pleasant Hill Mastiff in Poplar Bluff Mastiff in Raymore Mastiff in Raytown Mastiff in Republic Mastiff in Richmond Mastiff in Richmond Heights Mastiff in Rolla Mastiff in Saint Ann Mastiff in Saint Charles Mastiff in Saint Clair Mastiff in Saint Joseph Mastiff in Saint Louis Mastiff in Saint Peters Mastiff in Salem Mastiff in Savannah Mastiff in Scott City Mastiff in Sedalia Mastiff in Sikeston Mastiff in Smithville Mastiff in Springfield Mastiff in Ste Genevieve Mastiff in Sullivan Mastiff in Town and Country Mastiff in Trenton Mastiff in Troy Mastiff in Union Mastiff in University City Mastiff in Valley Park Mastiff in Vandalia Mastiff in Warrensburg Mastiff in Warrenton Mastiff in Washington Mastiff in Webb City Mastiff in Webster Groves Mastiff in Weldon Spring Mastiff in Wentzville Mastiff in West Plains Mastiff in Wildwood

Mastiff shelters & rescues in Missouri

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Missouri. Browse these Mastiff rescues and shelters below.

Here are a few organizations

Shelter

Central Missouri Humane Society

616 Big Bear Blvd, Columbia , MO 65202

Pet Types: cats, birds, dogs, farm animals, rabbits, reptiles, small animals

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Rescue

Stover Animal Rescue

709 West 4th Street, PO Box 332, Stover , MO 65078

Pet Types: cats, dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog ?

We've got all the info you need on adopting and caring for a Mastiff puppy . Check out the links below for everything you ever wanted to know about Mastiff puppies and adults .

Mastiff information

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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