Mastiff Adoption in Missouri: Mastiff Puppies for Sale in Missouri

Adopt a Mastiff near you in Missouri

Below are our newest added Mastiffs available for adoption in Missouri. To see more adoptable Mastiffs in Missouri, use the search tool below to enter specific criteria!

Smoke

Mastiff/American Bulldog

Male, 7 yrs

Kansas City, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Story

Smoke is a gentle giant who’s ready to fill your home with love, loyalty, and plenty of big-dog snuggles.He’s friendly and outgoing with people, and while he can be a little selective with doggy friends, with the right match he could potentially enjoy a canine companion. At 7 years old and a whopping 150 pounds, Smoke is a true mastiff-sized presence — big in stature and even bigger in heart.He has a nicely balanced energy level. He enjoys playtime (especially a good game of tug!) but is just as happy soaking up attention and relaxing with his people. Smoke is housetrained according to his previous family and already knows a variety of basic commands. He’s smart, eager to please, and would love a home that keeps engaging his mind and continuing his training.He would do best in a home ready for a large, strong dog who wants both playtime and lots of affection — someone excited to share life with him! Smoke is ready to find his forever family and start his next chapter as a cherished member of the household. Come meet this big, lovable boy and see if he’s the perfect match for you!Smoke is neutered, microchipped, up to date on his vaccinations, and ready for his forever home!

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Ivy

Mastiff/Shepherd (Unknown Type)

Female, 5 yrs

Cuba, MO

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

House-trained,

Story

Ivy is housebroken, current on vaccinations and will be spayed before adoption. Food motivated, eager to please and likes to be right by your side. She knows how to sit for a treat.

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Dane

Mastiff

Male, 10 yrs

St. Louis, MO

Size

(when grown) -

Details

Story

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Variya

Mastiff

Female, 11 mos

Kansas City, MO

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Story

10 month old Variya is a friendly, wiggly, silly girl. She loves treats and is happy to learn things for a nice snackie. She also attends the shelter playgroups every morning. She comes spade, up-to-date on her vaccinations and microchip.

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Compton

Mastiff/Labrador Retriever

Male, 3 yrs 1 mo

O'Fallon, MO

Size

(when grown) -

Details

Good with dogs, House-trained,

Story

𝗔𝗗𝗢𝗣𝗧 𝗖𝗢𝗠𝗣𝗧𝗢𝗡 🤍🐷 𝗪𝗲𝗹𝗰𝗼𝗺𝗲 𝘁𝗼 𝘁𝗵𝗲 𝗳𝗮𝗺𝗶𝗹𝘆 Compton 🤍 We promise to find you a 𝒓𝒆𝒂𝒍 𝗳𝘂𝗿𝗲𝘃𝗲𝗿 𝗳𝗮𝗺𝗶𝗹𝘆 this time 🙏 Compton found his way to our city shelter back in January of 2025 as a stray with a collar and leash still attached, but sadly no one came forward 😞 He quickly showed signs of kennel stress, but luckily was sprung by a foster hero, and then what he thought was his furever home…2 months later he was dropped off for dogsitting, the owner blocked the sitter, and never came back for our sweet ham 😭 He was once again adopted again, and later picked up by the Humane Society as a stray and transferred back to CARE. After 𝗮 𝗳𝘂𝗹𝗹 𝘆𝗲𝗮𝗿 𝗼𝗳 𝗯𝗼𝘂𝗻𝗰𝗶𝗻𝗴 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝗸𝗲𝗻𝗻𝗲𝗹𝘀 𝗮𝗻𝗱 𝗵𝗼𝗺𝗲𝘀, Compton is FREE of shelter life, decompressing in a home, and snoring like a grown man 😆 (check out the comments for a video!) This level white noise happens when a shelter dog feels like they can finally relax 🥲 The ONLY reason we were able to help Compton is because a 𝗳𝗼𝘀𝘁𝗲𝗿 𝗵𝗲𝗿𝗼 opened their home 🏡 THANK YOU to all the heroes—you are truly saving a life. All that’s left is to find 𝗳𝘂𝗿𝗲𝘃𝗲𝗿 ♾️👀 _____________________________________________ 𝗚𝗼𝗼𝗱 𝗯𝗼𝘆 𝗾𝘂𝗮𝗹𝗶𝗳𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 𝘀𝗼 𝗳𝗮𝗿: • ~3 yr old ~67lbs happy, hefty hog 🐷 • potty/house trained ✔️ • rides well in the car ✔️ • SUPER food motivated—a fast learner! • AFFECTIONATE! he loves a snuggle • DOG FRIENDLY! • NO CATS ❌ • KID FRIENDLY! hasn’t met tiny hoomans but has done well with the ones he has met!

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Toaster

Mastiff/Cane Corso

Male, Adult

Raytown, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with kids, Not good with dogs, Not good with cats, House-trained,

Story

Hi all! I’m Toaster! My friends call me Toast for short. I’m not really sure how I got my name. Although the more that I think about it, maybe it’s because when you meet me, I will make your heart all warm and toasty? Yes, I think maybe that HAS to be it! Mystery solved! Although since I solve mysteries so well, maybe I should have been named Scooby Doo! Anyhow, before I get distracted, let me tell you some things about me. I’m about 5 years old and they think I’m a mastiff or Cane Corso mix. So I’m kind of a big guy! But that doesn’t mean I have a big head! I mean, PHYSICALLY I do have a big head. What I mean is I don’t have a big head like a big ego. Gosh, sometimes it’s difficult to communicate in human. Really, I’m just a happy guy, who is extremely curious about new things. I love going on walks and checking everything out with my nose. I really love checking out storm drains and sewers. I mean, you never know what might be living in them! I seem to like to meet new people on my walks, too. I usually walk quite nicely on the leash unless I see something I really want to check out, and then I forget not to pull. It’s hard to remember to walk nicely when you seek something really interesting! But I’m more than happy to work on my leash manners a bit. I absolutely love riding in the car, and I am VERY well behaved riding in the car. I also love to play with toys like tennis balls and stuffies. I will admit, I sometimes think I’m the size of a puppy and I often get bouncy like a puppy! And I’ve been known to do zoomies when I get really excited. It seems to make everyone laugh. And I sure like making people laugh. I’ve been known to give big slurpy kisses and to “hug” people when I think they need it. So I hope you like kisses and hugs. I like when humans pet me, but I much prefer booty scratches to head scratches. (I’ll let you in on a little secret; many dogs prefer that!) I think there’s almost nothing as good as a good booty scratch. Except maybe car rides. I’m pretty good at sitting when asked, and I’m learning new things. I just haven’t had a whole lot of training with such requests, but I am receiving some now and I love to learn! Especially when learning is accompanied by some tasty treats! I am NOT a fan of cats. Well, I mean I AM a fan of CHASING cats, but that activity seems to be frowned upon. So I need a home without cats. In fact, I'd like to be your one and only pet, if you don't mind. If you are interested in making your heart feel all Toasty, or want to find out more about me, please call/text The Pet Connection at 913-671-7387.

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Mastiff puppies and dogs in Missouri

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Mastiff puppies and dogs in Missouri

Jump to:

Adopt a Mastiff near you in Missouri

Below are our newest added Mastiffs available for adoption in Missouri. To see more adoptable Mastiffs in Missouri, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Missouri cities

Mastiff shelters & rescues in Missouri

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics