Mastiff Adoption in Missouri: Mastiff Puppies for Sale in Missouri

Adopt a Mastiff near you in Missouri

Below are our newest added Mastiffs available for adoption in Missouri. To see more adoptable Mastiffs in Missouri, use the search tool below to enter specific criteria!

Gus

Mastiff/Mixed Breed (Large)

Male, Adult

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, House-trained,

Story

Meet Gus! Gus is a charming 3-year-old mastiff mix with a heart as big as his paws. This gentle giant is friendly, outgoing, and absolutely loves people. He gets along wonderfully with other dogs and kids—just be prepared for a little “bull in a china shop” energy when he gets excited! Gus is house-trained, kennel-trained, and making great progress with his leash skills. He’s also an excellent car buddy, happy to settle in and enjoy the ride. If you’re looking for a lovable, goofy companion who brings joy wherever he goes, Gus might just be your perfect match! https://www.shelterluv.com/matchme/adopt/NAF/Dog

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Daisy

Mastiff

Female, Adult

Kansas City, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, House-trained,

Story

Daisy is a Pitbull Mastiff born on Memorial Day 2020. She’s been part of our family since she was a pup. Daisy loves going on walks, cuddling, and playing fetch though she does not always return the toy. She is loving, a gentle girl who loves human touch and company. She can be anxious at times, especially when she spends too much time alone. I have recently gone through a divorce and life is very busy with my son and more work hours. Daisy spends too much time alone and I cannot take her for walks anymore. I cannot give her the life she deserves. It breaks my heart to do this because I do not want to give her up but I know she can do much better and I need to focus on my son and our new life.

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DAPHNE

Mastiff

Female, 4 yrs 1 mo

St. Peters, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Meet Daphne At 4 years old and 106 pounds of pure gentleness, Daphne is a gorgeous Mastiff who’s ready to start a brand-new chapter of her life. She was found by a kind Samaritan who took her in for a few days and quickly discovered just how sweet this big girl really is.It’s clear Daphne hasn’t always known love—she was likely used for breeding—and when you see her, you can tell she still needs to gain a little weight and build her strength back up. But what she lacks in pounds, she makes up for in heart. Every tail wag and lean-in cuddle shows just how much she wants to connect and be loved.Daphne is calm, affectionate, and loves attention from people. She’s the type of dog who will happily spend her day relaxing by your side, soaking up belly rubs and quiet companionship.Because of her size and her gentle-but-strong presence, Daphne would do best in a home with older kids and someone familiar with large or Mastiff-type breeds. She’s low- to medium-energy but will benefit from daily walks, enrichment toys, and positive reinforcement training to help her stay happy and engaged.Daphne did well living with other dogs in her finder’s home, though she preferred to have her person’s attention to herself—so she may do best as the only dog or with slow, structured introductions.She’s food-motivated, takes treats with a soft mouth, and already knows how to “sit.” Most importantly, she’s ready to be loved and treated like family—something she’s been waiting her whole life for.

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Chili Mac

Mastiff

Male, Puppy

St Louis, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, House-trained,

Story

Meet Chili Mac! This 11-month-old Cane Corso is a big, lovable goofball with a heart as giant as his paws! Chili Mac is equal parts cuddle bug and class clown — he’ll make you laugh one minute and melt into your lap the next. He can be a little shy when meeting new people, but once he decides you’re cool, he’s all in! He’s great with dogs big and small (seriously — from 6 lbs to 120 lbs!), crate and potty trained, and already knows some basic commands. Due to Chili Mac's size and clumsiness, he would do best in a home with older children. He would also be best with someone who has breed/guardian experience given some mouthy behaviors which are normal for the breed. Chili Mac would love an active home with another dog friend or a human adventure buddy. Whether you’re hiking, road-tripping, or just lounging on the couch- as long as you don’t mind a little drool, he’s ready to be your ride-or-die! If interested, please complete the Adoption Application on our website at www.NeedyPaws.org and we will contact you. Adopters must live within an hour’s drive of St. Louis, MO. Our $295 adoption fee includes up-to-date vaccinations, heartworm testing and preventative, spay/neuter and microchip. We are a 100% foster-based rescue and all of our dogs live in approved foster homes. We are dedicated to finding the best Forever Homes, and will perform home visits and conduct veterinarian and reference checks for each potential adopter.Visit this organization's web site to see any additional information available about this pet.November 12, 2025, 2:35 pm

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SADIE

Mastiff

Female, 1 yr 1 mo

Maryland Heights, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Hi, I`m Sadie! So, how did I end up here? Well, I once thought I could outsmart a squirrel by mimicking its moves. Long story short, I ended up chasing it right into a fancy garden party, causing a hilarious mess of toppled cakes and tangled ribbons. Next thing I knew, I was here, making everyone laugh with my goofy antics. I`m smart, playful, and full of energy, ready to bring joy and laughter to my new forever home. Why adopt me? Because every day with me is a delightful adventure filled with fun and games! I am looking for a forever family or a family to love me until my forever family finds me. If you decide to fall head over heels in love and cannot part with me that is okay, too! Please call 314-951-1588 for more information!

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Sage

Mastiff

Female, Adult

Saint Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, House-trained,

Story

Hi! Sage is what I believe is an iltalian mastiff mix of some sort. Her exact breed is unknown. Her birthday is 2/24/23. She has never resided in a shelter. She was fostered for 2 months through the Stray Reacue, then adopted by me. I am looking to rehome her solely because she is a very social dog who thrives in a home with multiple humans/dogs. Given my sudden life change, I am no longer able to provide that for her. I have noticed her a bit less happy in a home with just myself and her. Please reach out with any additional questions/concerns!

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Mastiff puppies and dogs in Missouri

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Mastiff puppies and dogs in Missouri

Jump to:

Adopt a Mastiff near you in Missouri

Below are our newest added Mastiffs available for adoption in Missouri. To see more adoptable Mastiffs in Missouri, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Missouri cities

Mastiff shelters & rescues in Missouri

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics