Mastiff Adoption in Missouri: Mastiff Puppies for Sale in Missouri

Adopt a Mastiff near you in Missouri

Below are our newest added Mastiffs available for adoption in Missouri. To see more adoptable Mastiffs in Missouri, use the search tool below to enter specific criteria!

Crimson

Mastiff/Mixed Breed (Medium)

Male, 1 yr 6 mos

Springfield, MO

Size

(when grown) -

Details

Story

Meet Crimson! ❤️ Crimson is a striking red Mastiff mix with a big heart to match his impressive presence. At just 1 year and 6 months old, this handsome boy is entering the perfect stage of life—past the tiny puppy phase but still young, playful, and ready to grow with his forever family. Crimson has a gentle, affectionate personality and truly thrives on human companionship. He loves spending time with his people, whether that means going for walks, playing in the yard, or simply relaxing nearby and soaking up attention. Like many Mastiff mixes, Crimson has a loyal and devoted nature, forming strong bonds with those he trusts. He’s a smart young dog who will benefit from continued guidance, structure, and positive reinforcement as he matures into the wonderful companion he’s meant to be. With consistent love and patience, Crimson will blossom into a devoted best friend who will always be by your side. Crimson would do best in a home that understands large breeds and can provide him with the space, love, and commitment he deserves. In return, he promises a lifetime of loyalty, affection, and unforgettable moments. If you’re looking for a handsome, loving companion with a big heart and an even bigger future, Crimson may be the perfect addition to your family. 🐾❤️ Fill out a Match Me form online at: https://www.shelterluv.com/matchme/adopt/CAST/Dog to be preapproved. All C.A.R.E rescue dogs are vaccinated, heart-worm tested, spayed/neutered, and microchipped! So all you need to provide is the love. Our adoption fee is a minimum $150 tax deductible donation. All donations are used for rescue and medical care of animals in need. If you don't have room to take home a pet but want to support our efforts to save animals in need, please consider making a donation. We are not city or state funded and rely solely on private donations that allow us to continue saving lives. To learn more about us or to give a life saving donation please visit http://www.carerescue.org

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Cheese

Mastiff/Mixed Breed (Medium)

Male, 1 yr 6 mos

Springfield, MO

Size

(when grown) -

Details

Story

Meet Cheese — A Big Heart in a Handsome Red Mastiff Mix Cheese is a striking red Mastiff mix who is just 1 year and 6 months old and already full of personality, charm, and love. With his rich reddish coat, soulful eyes, and strong yet gentle presence, Cheese turns heads wherever he goes. But it’s his affectionate nature and loyal heart that truly make him special. Like many Mastiff mixes, Cheese combines strength with sweetness. He’s a young boy who enjoys spending time with his people, whether that means relaxing nearby, soaking up attention, or joining in on a little playtime. He’s still in that fun, youthful stage of life where curiosity and enthusiasm make every day an adventure. Cheese would thrive in a home that appreciates both his playful spirit and his loving, loyal temperament. With continued guidance, patience, and plenty of affection, he’s sure to grow into an incredibly devoted companion. His size may be impressive, but his heart is even bigger. If you’re looking for a handsome young dog who will bring loyalty, warmth, and plenty of love into your life, Cheese might just be the perfect addition to your family. Fill out a Match Me form online at: https://www.shelterluv.com/matchme/adopt/CAST/Dog to be preapproved. All C.A.R.E rescue dogs are vaccinated, heart-worm tested, spayed/neutered, and microchipped! So all you need to provide is the love. Our adoption fee is a minimum $150 tax deductible donation. All donations are used for rescue and medical care of animals in need. If you don't have room to take home a pet but want to support our efforts to save animals in need, please consider making a donation. We are not city or state funded and rely solely on private donations that allow us to continue saving lives. To learn more about us or to give a life saving donation please visit http://www.carerescue.org

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Momma Mia

Mastiff

Female, 5 yrs

Kansas City, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Story

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Ralph BW

Mastiff/Mixed Breed (Large)

Male, 1 yr 1 mo

St Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

Ralph the Derp! Ralph is a huge friendly, enthusiastic, uncoordinated 4-legged energetic goofball! He was rescued from “death row” at a high kill shelter, as a skinny stray with a treatable skin condition. His fur has almost completely grown in & he is now at a healthy weight. This overgrown mastiff/Cane Corso mix pup has no comprehension of his size, leaning into humans for affection or trying to ooze onto laps for cuddles. He is being trained not to jump and not to paw for attention/affection/play because he currently has 85# of mass behind those “congenial” moves. Ralph plays well with dogs of all sizes, but would do best with med-to-larger dogs due to his size & poorly curbed gusto. He hordes toys, taking them all to his chosen dog bed of the day. He likes to carry a special toy “baby” in his mouth when going out in the yard. He does need to be fed in his crate & will guard his empty food bowl from other dogs, unless he is distracted with a toy & led outdoors after meals. He is great on a leash, makes awesome grunty sounds when cuddled, enjoys baths. Ralph will make a great addition to an active family with older children. He is eager to please, food and affection oriented (although a bit stubborn at times), making him an ideal candidate for success with continuation of his training. Please consider adopting the gorgeous big derp into your home. Attributes: In training to avoid jumping/pawing Active family Local adoption fee is $200(in TX) Out of state adoption fee is $450 (includes transport to your area)

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Rain & River

Mastiff/Border Collie

Female, Young

Bolivar, MO

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

River and Rain are both in need of a home they are both females and love to play. The couple that has been raising them is elderly and has fallen down trying to take care of them. They are just two busy body people loving girls that needs an owner that is in more physical shape to take care of them or just one separated to two different homes. They are sisters!

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Bear

Mastiff/Rottweiler

Male, Adult

Waynesville, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Needs experienced adopter, House-trained,

Story

He's 8 years old. We've had him since he was a puppy and he wasn't around many other people so he takes time to warm up to other people and has a hard time with men, usually growling at them. He has warmed up to few men so we believe it's possible for him to live with a man but we recommend caution and to watch out for aggressive behavior. He has separation anxiety and when left alone for too long he may pee or poop on the floor and potentially destroy blinds or scratch doors. He also will get into the trash if it is left out. If he is left in a kennel he will most likely try to break out if he is alone and has hurt himself in the past getting out of kennels. He has been around animals before but isn't good with aggressive or rowdy animals and he is territorial. He did fine in a kennel when there was another dog with him so it may be that he doesn't like being alone. We love him and want to take him with us but we can't take him where we're moving.

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Mastiff puppies and dogs in Missouri

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Below are our newest added Mastiffs available for adoption in Missouri. To see more adoptable Mastiffs in Missouri, use the search tool below to enter specific criteria!

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Mastiff puppies and dogs in Missouri

Jump to:

Adopt a Mastiff near you in Missouri

Below are our newest added Mastiffs available for adoption in Missouri. To see more adoptable Mastiffs in Missouri, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Missouri cities

Mastiff shelters & rescues in Missouri

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics