Neapolitan Mastiff Adoption in Irvine, CA: Neapolitan Mastiff Puppies for Sale in Irvine, CA

Adopt a Neapolitan Mastiff near you in Irvine, California

We don't see any Neapolitan Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Neapolitan Mastiffs in cities near Irvine, California

These Neapolitan Mastiffs are available for adoption close to Irvine, California.

White

Neapolitan Mastiff Boxer

Male

Costa Mesa, CA

Size

(when grown) -

Details

Story

Meet White! His mom is a Boxer who was abandoned on the streets and about to gime birth any day. These babies habe had a great start to life in a lobing foster home with mom and siblings. At 8 weeks old they are now ready to complete a family of their own. We did a DNA test, which showed half Boxer, 30 percent Neapolitan Mastiff and 20 percent Cane Corso. He will do best with a family or person familiar with the breeds and is committed to socializing and training himJune 22, 2025, 10:15 pm

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Red

Neapolitan Mastiff Yorkie, Yorkshire Terrier

Female, Puppy

Costa Mesa, CA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Story

Meet Red! Her mom is a Boxer who was abandoned on the streets and about to gime birth any day. These babies habe had a great start to life in a lobing foster home with mom and siblings. At 8 weeks old they are now ready to complete a family of their own. We did a DNA test, which showed half Boxer, 30 percent Neapolitan Mastiff and 20 percent Cane Corso. She will do best with a family or person familiar with the breeds and is committed to socializing and training her. June 22, 2025, 10:15 pm

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Orange

Neapolitan Mastiff Boxer

Male

Costa Mesa, CA

Size

(when grown) -

Details

Story

Meet Orange! His mom is a Boxer who was abandoned on the streets and about to gime birth any day. These babies habe had a great start to life in a lobing foster home with mom and siblings. At 8 weeks old they are now ready to complete a family of their own. We did a DNA test, which showed half Boxer, 30 percent Neapolitan Mastiff and 20 percent Cane Corso. He will do best with a family or person familiar with the breeds and is committed to socializing and training himJune 22, 2025, 10:15 pm

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Zen

Neapolitan Mastiff Mastiff

Male, 5 yrs 2 mos

Beverly Hills, CA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Not good with kids, Good with dogs, Not good with cats, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Zen is a 4-year-old male Neo Mastiff mix who’s as big-hearted as he is big in stature. Rescued from a shelter after his previous owners surrendered him for being “too big,” Zen is now on the hunt for his forever home where he can truly shine. Zen is a sweet, playful giant with a lot of energy for his breed. He’s very intelligent and learns quickly, making him a joy to train. However, Zen prefers to be the only dog in the home; he can get jealous and aggressive with other dogs, wanting all the attention for himself. When he's your one and only, he’s incredibly loving and will shower you with affection. Though he’s not reactive to other dogs on leash, Zen does best in a home without canine companions. He appreciates careful introductions to new people, especially those who approach unexpectedly. Zen’s ideal owner will be someone experienced with his breed and capable of continuing his training and socialization. If you’re ready to welcome a devoted and energetic companion into your life, Zen could be the perfect fit. He’s looking for a loving home where he can be the center of attention and enjoy all the love he has to give!

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Napoleon

Neapolitan Mastiff American Bulldog

Male, Adult

Vista, CA

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with kids, Good with dogs, House-trained, Shots are up-to-date,

Story

Great dog, can’t keep due to having a baby.

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These pups are in Irvine, California too!

Below are our newest added Neapolitan Mastiffs available for adoption in Irvine, California. To see more adoptable Neapolitan Mastiffs in Irvine, California, use the search tool below to enter specific criteria!

LYLA

Great Dane

Female, 4 yrs

Irvine, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

Hi, I’m Lyla. I’m a gentle soul looking for a loving home. I am friendly but a little shy at first, so I may take some time to warm up to new faces and truly appreciate patience and understanding. Once I feel secure, my affectionate nature really shines, and I can be a devoted companion. I would do best in a calm, quiet home that can provide ongoing socialization and a loving environment, allowing me to settle in at my own pace. In return, I`ll work hard to be a loyal and loving companion.

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PHOENIX

Great Dane

Male, 2 yrs 4 mos

Irvine, CA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Spayed or Neutered,

Story

Hi, I’m Phoenix. I am a friendly, energetic dog who loves to play and learn new tricks. I am a large dog, weighing almost 100 lbs, and sometimes I don’t realize my own strength. This can be challenging for my handlers, especially since I had no formal leash training before. Fortunately, I do well with walking aids and plenty of treats. I would thrive in a single-dog home with someone experienced with my size or breed. I do best with plenty of exercise, attention, and consistent training. With the right guidance, I can channel my energy positively and become a loyal, loving companion.Check out this video of my off-site walk:

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Adopt a Neapolitan Mastiff near you in Irvine, California

We don't see any Neapolitan Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Neapolitan Mastiffs in cities near Irvine, California

These Neapolitan Mastiffs are available for adoption close to Irvine, California.

These pups are in Irvine, California too!

Below are our newest added Neapolitan Mastiffs available for adoption in Irvine, California. To see more adoptable Neapolitan Mastiffs in Irvine, California, use the search tool below to enter specific criteria!

Search for a Neapolitan Mastiff puppy or dog

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Neapolitan Mastiff basics

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Neapolitan Mastiff puppies and dogs in Irvine, California

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Adopt a Neapolitan Mastiff near you in Irvine, California

We don't see any Neapolitan Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Neapolitan Mastiffs in cities near Irvine, California

These Neapolitan Mastiffs are available for adoption close to Irvine, California.

These pups are in Irvine, California too!

Below are our newest added Neapolitan Mastiffs available for adoption in Irvine, California. To see more adoptable Neapolitan Mastiffs in Irvine, California, use the search tool below to enter specific criteria!

Search for a Neapolitan Mastiff puppy or dog

Neapolitan Mastiff puppies and dogs in nearby cities

Related breeds in Irvine, California

Neapolitan Mastiff shelters & rescues in Irvine, California

Looking for a specific shelter or rescue?

Want to learn more about adopting a Neapolitan Mastiff puppy or dog?

Neapolitan Mastiff basics

Neapolitan Mastiff basics