Great Dane Adoption in Greenville, SC: Great Dane Puppies for Sale in Greenville, SC

Adopt a Great Dane near you in Greenville, South Carolina

We don't see any Great Danes available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Great Danes in cities near Greenville, South Carolina

These Great Danes are available for adoption close to Greenville, South Carolina.

Cleopatra

Great Dane

Female, Adult

Travelers Rest, SC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Not good with kids, Not good with dogs, Not good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Hello this is so hard to do but I think it’s in the best interest of Cleopatra who is a sweet lap dog girl who I think needs a quieter more predictable environment, where she can be the baby that she is. I feel bad that she is living with us when she is clearly not comfortable. We adopted her at 2 years old and she has always had a skittish nature but she has gotten progressively less tolerant of living with our other animals and is very jumpy and nervous to the point where it can start conflict. I hope to find her a better fit before something happens that i can not fix. If you have the space for this timid beauty please consider reaching out. I’d like to see her happy and relaxed.

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Needs Home Fast

Titan

Great Dane Labrador Retriever

Male, 2 yrs

Pickens, SC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Meet Titan, the Big Loveable TornadoTitan is a two year old, 70lb Great Dane Lab mix who is neutered, heartworm negative, and dog friendly. He’s packed with enthusiasm, big feelings, and absolutely zero manners — the definition of a work in progress. Titan needs an active home ready to channel his energy, teach him the ropes, and laugh along the way. Meet Titan today and help this gentle giant-in-training become the amazing dog he’s meant to be.

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Groot

Great Dane

Male, Young

Spartanburg, SC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Groot: ✔️Lovable ✔️Funny ✔️Good snuggler ✔️Plays fetch ✔️Likes to meet new people ✔️Smushy face ✔️Gets along with most other dogs ✔️Silly ears ✔️80 pounds ✔️Guaranteed to make you laugh Housebroken, crate-trained, up to date on shots, and neutered. Born in November, 2019.

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Scooby

Great Dane

Male, Adult

Ware Shoals, SC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, Good with cats, Needs experienced adopter,

Story

Scooby is a little over three years old. He’s is very sweet and loving. He has loads of energy and loves to run and play with other dogs. He is however food aggressive with other dogs. Other than that he does great with all other animals. He needs a loving home with somebody who can get him out and exercise him regularly as needed.

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These pups are in Greenville, South Carolina too!

Below are our newest added Great Danes available for adoption in Greenville, South Carolina. To see more adoptable Great Danes in Greenville, South Carolina, use the search tool below to enter specific criteria!

Hattie - PLEASE READ ALL INFORMATION

Anatolian Shepherd

Female, 1 yr 3 mos

Greenville, SC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, Good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

**It is very important to reserach the breed if you are not familiar with them, as livestock guardians have their own set of idiosyncracies that need to be considered. Reminder: Anatolians are NOT German Shepherds, but instead are a very different breed. SOCIAL MEDIA HASHTAG: #hattietheanatolianshepherd AGE: 1.5yrsWEIGHT: 90-100lbsWORKING LGD: NODOGS: GoodDOG RESTRICTIONS: NO same sized femalesCATS: Unknown but may be too playful for themCHILDREN: Uncertain but may unintentionally knock down small childrenOTHER ANIMALS: Unknown (birds, chickens, livestock, exotics, etc)FENCED YARD REQUIRED: YesGOOD OFF LEASH: NO - ROAMER/RUNNERGROOMING/SHEDDING NEEDS: HighMEDICAL ISSUES: NoneMEDICATIONS: Anti-anxiety medsSPECIAL NEEDS: Can clear fences so can't be left alone outside; can break out of cratesANXIETY: Some separation anxiety; combination of medication and canine friends helps significantly.BARKING: HighEXPERIENCED OWNER NEEDED: YesCRATE TRAINED: No - breaks out; makes anxiousHOUSE TRAINED: Not completely; needs continued work but is almost there!GOOD IN CAR: Yes; can get excited sometimesFUN FACTS: Hattie is the girl that everyone loves, stealing the show wherever she goes. She's a big hit with everyone and she, in return, adores all. She can sometimes get too excited and hug with enthusiasm, but we're working on that because she's a big girl who is still growing. Hattie loves dogs and would be very lonely and more anxious without them. She has a heart of gold and really cares about her people and friends, sticking by your side as you go through your daily adventures. Hattie enjoys hugs, gives very gentle kisses and takes her treats/meds gently, as well..to boot, she's an excellent alarm clock, so you'll never oversleep! She loves to play and run around the yard with her best buds, tongue hanging out and incredibly happy; a playful buddy would make her very happy, for she would be very sad as an only dog. **It is very important to research the Anatolian Shepherd breed if you are not very familiar with them, as they are not a breed for everyone. While Hattie is a lovely, gentle, happy girl, the breed does have it's own idiosyncracies that need to be understood and considered, such as running, roaming, barking, and other animals.***Hattie will need to be surpervised while outdoors during the transition to her new home. She will also need to continue house training and her anti-anxiety meds, to which she has responded very well. She is a strong girl, so her new family must be comfortable with this. A 6ft fence is required, and she can never be trusted off leash, even for short distances. ##2355048##

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Special Needs

Theo - PLEASE READ ALL INFORMATION

Anatolian Shepherd

Male, 4 yrs 11 mos

Greenville, SC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Needs special attention, Spayed or Neutered, Shots are up-to-date,

Story

AGE: Approx 4yrsWEIGHT: 120lbsWORKING LGD: NO - family pet only DOGS: GoodDOG RESTRICTIONS: NO Large or XL males CATS: UnknownCHILDREN: UnknownOTHER ANIMALS (birds, farm animals, etc): Unknown FENCED YARD REQUIRED: Yes - 6ft GOOD OFF LEASH: No - ROAMER/RUNNER GROOMING/SHEDDING NEEDS: HighMEDICAL ISSUES: Was a light heartworm positive but has been treated and now heartworm negative. MEDICATIONS: Anxiety meds for separation anxiety SPECIAL NEEDS: Severely abused. Will require patience, compassion, and committment. Zero aggression - A very kind dog but terribly afraid of people and tries to get away. ANXIETY: Very afraid of people and will run and/or hide. Afraid of storms but just wants to be with you.BARKING: High - Extremely LOUD EXPERIENCED OWNER NEEDED: Yes CRATE TRAINED: Yes but will break out HOUSE TRAINED: Yes GOOD IN CAR: Yes. Afraid. FUN FACTS: Theo was severely abused. Upon entry into rescue he hid in a corner, his back to us, and shook hard. He's come a long way, however, and does well meeting people, but he is slow to approach. He has developed separtion anxiety and is currently taking medication for that so he doesn't get into anything while nobody is home - otherwise he's extremely well behaved. He loves his people very much, and is devoted. Due to his fears, however, especially with changes into a new home, he will require commitment, devotion, compassion, and patience. He will not be a dog that is snuggly and kissy or wrapped up in his new family, due to his need to learn to trust. He will take a significant amount of time to learn and to establish acceptance of his new life, but he is SO worth it. Theo is a VERY KIND and GENTLE dog with a soft, loving heart. He has absolutely ZERO aggression. He's also highly intelligent. He requires a 6ft fence for playtime and to be on a leash at ALL times when not in the fenced area due to his fears and his breed - NO EXCEPTIONS. He will also need someone who can handle his strength for times when he might be afraid on a leash. Theo loves his canine companions and would be unhappy in a home without other dogs, but he will need gentle introductions b/c he'll be afraid. No dominant males, please. He loves to play and highly depends on his canine friends. Theo LOVES treats and food, and he is very mild mannered when taking them from you. He loves his morning and evening treat and runs to the kitchen and sits handsomely when he knows it's time. He's a fun boy with a tremendous smile, and he also talks to you at times. Theo is devoted to those he loves and appreciates their kindness. He is a lovely boy with an innocent and very sweet disposition. ##1311506##

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Auggie

Anatolian Shepherd

Male

greenville, SC

Size

(when grown) -

Details

Spayed or Neutered,

Story

Meet Auggie! Auggie is a dog’s dog. He absolutely adores other pups and will happily shadow them all day—Penny is his idol! While he loves humans (especially teens), dogs are his favorite companions. With cats, he’s a “live and let live” kind of guy. With kids, he’s gentle but clumsy—think giant toddler energy. Auggie is looking for a family who can keep up with his big brain, bigger body, and biggest heart. He’ll thrive in a home with another playful pup, a tall fence, and humans who don’t mind being adored (after his dog buddy, of course). If you’re ready to bring home a loyal shadow, a high-jump champion, and a goofy best friend rolled into one, Auggie is waiting for you! He is neutered, dewormed, microchipped, current with all vaccines (as appropriate for his age) and on flea and heartworm prevention. Auggie is currently being fostered in South Carolina. ADOPT AUGGIE!! www.LuckyPupRescueSC.com The adoption fee is $375.00 and we require a vet check and home visit. August 20, 2025, 12:33 pm

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Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in Greenville, South Carolina.

Great Dane puppies and dogs in Greenville, South Carolina

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Adopt a Great Dane near you in Greenville, South Carolina

We don't see any Great Danes available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Great Danes in cities near Greenville, South Carolina

These Great Danes are available for adoption close to Greenville, South Carolina.

These pups are in Greenville, South Carolina too!

Below are our newest added Great Danes available for adoption in Greenville, South Carolina. To see more adoptable Great Danes in Greenville, South Carolina, use the search tool below to enter specific criteria!

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Great Dane puppies and dogs in Greenville, South Carolina

Learn More:

Adopt a Great Dane near you in Greenville, South Carolina

We don't see any Great Danes available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Great Danes in cities near Greenville, South Carolina

These Great Danes are available for adoption close to Greenville, South Carolina.

These pups are in Greenville, South Carolina too!

Below are our newest added Great Danes available for adoption in Greenville, South Carolina. To see more adoptable Great Danes in Greenville, South Carolina, use the search tool below to enter specific criteria!

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in nearby cities

Related breeds in Greenville, South Carolina

Great Dane shelters & rescues in Greenville, South Carolina

Looking for a specific shelter or rescue?

Want to learn more about adopting a Great Dane puppy or dog?

Great Dane basics

Great Dane basics