Great Dane Adoption in South Carolina: Great Dane Puppies for Sale in South Carolina

Adopt a Great Dane near you in South Carolina

Below are our newest added Great Danes available for adoption in South Carolina. To see more adoptable Great Danes in South Carolina, use the search tool below to enter specific criteria!

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Marmaduke

Great Dane

Male, 2 yrs

Lancaster, SC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Story

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Milo

Great Dane/Catahoula Leopard Dog

Male, Puppy

Rock Hill, SC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs,

Story

Milo is a 15-week-old puppy with a gentle soul, wiggly puppy energy, and so much love to give. After a difficult start to life—being neglected and treated poorly for not looking like his siblings—Milo is ready for a fresh beginning with a family who will cherish him. He’s a shy boy at first, but once he feels safe, Milo will give you his whole heart. He’s a total cuddle bug who wants to be as close to you as possible and will happily follow you from room to room. With his long legs and bouncy hops, he moves like a little kangaroo and brings constant smiles with his goofy, clumsy charm. Milo loves other dogs, enjoys playtime, and is learning the ropes in his foster home. He’s working on basic training, doing well with leash walks, sleeps in his crate at night, and looks to his older foster brother for confidence and guidance. Milo needs a patient, loving home that will help him continue building confidence and show him that he is finally safe and loved—exactly as he is. 🐾💙 --- To apply to adopt, please follow the steps for adoption on HalfwayThereRescue.com/Adoption-Process and apply directly here: https://fs26.formsite.com/htrnp/a2k3lsooud/index.html

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Domino

Great Dane/Mixed Breed (Medium)

Male, 7 yrs 9 mos

Greenville, SC

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Story

Meet Domino! This clever, confident boy greets you with playful excitement—pouncing around with joy without jumping on you. Domino is highly treat-motivated and shows off skills like sit, paw/shake, and even catching treats mid-air. He loves toys and stays focused during play, often striking an adorable play bow with his butt in the air. Goofy, playful, and smart, Domino is ready to bring fun and smiles to his future home. Leash Manners: Some pull Tricks: Sit, Treat Catching, Paw/Shake Toy Preference: Tennis ball, tug toy, plush squeaky toy More Fun Facts: Pounces on toys when playing Personality Key Descriptors: Clever, Confident, Goofy, Playful Love Language: Yummy treats, fun toys & playtime Energy-o-Meter (0–15): 9/15 Adoption includes vaccines, deworming, flea treatment, microchip, heartworm test, spay/neuter unless medically prohibited. The adoption fee is $35. Want to meet me? Call/text 864-467-3985 to set up a one-on-one VIP appointment or stop by Monday–Saturday, 12–5.

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Rosie

Great Dane

Female, Adult

Okatie, SC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Needs experienced adopter, House-trained,

Story

Rosie is a majestically beautiful girl. She loves walks and cuddles. Her favorite is kisses and hugs. If you are interested, you MUST have Great Dane experience. She can be a bit much for some dogs. Noah's Arks Rescue is all about giving an Abused Animal a second chance at life and to experience what true love is. We take animals that have been tortured, abused, and neglected and supply the emergency medical care required to get them well. We then provide rehab physically and mentally to prepare them for their new home and new life. We are located in Ridgeland, SC., and are by appointment only. All of our dogs are at our Rehabilitation Center either in hospice care or being loved on by staff until we find them forever homes. Please call 843.540.6755 or email NoahsArksRescues@mac.com with any questions. If you are interested, please fill out our Adoption Application at https://www.noahs-arks.net/nar-application. We do adopt out of state and will arrange transports. Our dogs are not allowed to fly cargo at any time.

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Cleopatra

Great Dane

Female, Adult

Travelers Rest, SC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Not good with kids, Not good with dogs, Not good with cats, House-trained,

Story

Hello this is so hard to do but I think it’s in the best interest of Cleopatra who is a sweet lap dog girl who I think needs a quieter more predictable environment, where she can be the baby that she is. I feel bad that she is living with us when she is clearly not comfortable. We adopted her at 2 years old and she has always had a skittish nature but she has gotten progressively less tolerant of living with our other animals and is very jumpy and nervous to the point where it can start conflict. I hope to find her a better fit before something happens that i can not fix. If you have the space for this timid beauty please consider reaching out. I’d like to see her happy and relaxed.

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Wallen

Great Dane

Male, Adult

Hilton Head, SC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Wallen is a charming two-year-old Great Dane mix who tips the scales at a healthy 66 pounds. Wallen is the epitome of sweetness, always ready to shower you with affection and brighten your day with his playful antics. His intelligence shines through in everything he does, making him quick to learn new tricks and commands, especially when treats are involved. Wallen's playful nature makes him a joy to be around, whether he's chasing after a ball or simply enjoying a romp in the yard. With his combination of smarts, sweetness, and playfulness, Wallen is sure to become a beloved member of the family.December 29, 2025, 1:18 pm

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Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in South Carolina.

Great Dane puppies and dogs in South Carolina

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Adopt a Great Dane near you in South Carolina

Below are our newest added Great Danes available for adoption in South Carolina. To see more adoptable Great Danes in South Carolina, use the search tool below to enter specific criteria!

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Great Dane puppies and dogs in South Carolina cities

Great Dane shelters & rescues in South Carolina

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Great Dane puppies and dogs in South Carolina

Jump to:

Adopt a Great Dane near you in South Carolina

Below are our newest added Great Danes available for adoption in South Carolina. To see more adoptable Great Danes in South Carolina, use the search tool below to enter specific criteria!

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in South Carolina cities

Great Dane shelters & rescues in South Carolina

Looking for a specific shelter or rescue?

Want to learn more about adopting a Great Dane puppy or dog ?

Great Dane information

Great Dane basics