Great Dane Adoption in South Carolina: Great Dane Puppies for Sale in South Carolina

Adopt a Great Dane near you in South Carolina

Below are our newest added Great Danes available for adoption in South Carolina. To see more adoptable Great Danes in South Carolina, use the search tool below to enter specific criteria!

88624a Muffin - Adoption Amba

Great Dane

Male, 10 mos

North Charleston, SC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Muffin is in the Adoption Ambassador Foster Program. Foster families take dogs that are available for adoption into their homes and help them get adopted. This is what his foster is saying about him: Meet Muffin! If you are looking for a professional snuggle buddy, then Muffin is the perfect one for you! While he loves taking a good nap, he is a pro at play time! All he needs is a good stick of any size to have a good time! But he will never say no to a delicious treat or a squeaky toy! Muffin loves people and things of all sizes, and he will make sure to tell everyone! Except he does not like anything that makes a loud noise inside the house (vacuum cleaner, hair dryer, etc) but with a little bit of love he will give them a chance! If you offer up a car ride to him, he will not say no and will be your passenger prince! He is a gentle giant with a big heart, loud voice, and is so excited to go to his forever home!Interested in Muffin?! Contact Senior Director of Adoptions, Courtney Gumienny, cgumienny@charlestonanimalsociety.org or 843-329-1577.

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Espresso Martini

Great Dane

Female, 1 yr 1 mo

Chester, SC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats, Needs experienced adopter, House-trained,

Story

Meet Espresso Martini, the fabulous one-year-old Great Dane who is ready to bring a splash of joy into your life! This lovely lady weighs in at a solid 112 pounds of pure love and affection. Just imagine those big, gentle paws and soulful eyes gazing up at you, ready to share a snuggle or two! 🐾💖 Espresso Martini is not just a pretty face; she’s a smart cookie who’s eager to please! With her training already underway, she’s learning leash manners and is both house and crate trained. That’s right, this girl is a fast learner, and she’s ready to impress you! Plus, she gets along wonderfully with other dogs and children, making her the perfect addition to any family. Just picture all the joyful moments you’ll share together! 🐶✨ And here's a little fun fact: Great Danes are known for their gentle demeanor, often earning them the title of "gentle giants." Espresso Martini embodies this beautifully! 🖤 So, if you’re looking for a big-hearted companion who loves to snuggle and play, Espresso Martini is your girl. Want to be a part of her incredible journey? Every animal deserves a happy ending, and this one starts with you! Espresso Martini is waiting for you to come meet her! Apply for the pet here: https://tinyurl.com/3u7r9sh7

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Athena

Great Dane/Mixed Breed (Medium)

Female, 7 mos

Union, SC

Size

(when grown) -

Details

Story

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Athena

Great Dane/Mixed Breed (Medium)

Female, 7 mos

Union, SC

Size

(when grown) -

Details

Story

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Milo

Great Dane/Catahoula Leopard Dog

Male, Puppy

Rock Hill, SC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs,

Story

Milo is a 15-week-old puppy with a gentle soul, wiggly puppy energy, and so much love to give. After a difficult start to life—being neglected and treated poorly for not looking like his siblings—Milo is ready for a fresh beginning with a family who will cherish him. He’s a shy boy at first, but once he feels safe, Milo will give you his whole heart. He’s a total cuddle bug who wants to be as close to you as possible and will happily follow you from room to room. With his long legs and bouncy hops, he moves like a little kangaroo and brings constant smiles with his goofy, clumsy charm. Milo loves other dogs, enjoys playtime, and is learning the ropes in his foster home. He’s working on basic training, doing well with leash walks, sleeps in his crate at night, and looks to his older foster brother for confidence and guidance. Milo needs a patient, loving home that will help him continue building confidence and show him that he is finally safe and loved—exactly as he is. 🐾💙 --- To apply to adopt, please follow the steps for adoption on HalfwayThereRescue.com/Adoption-Process and apply directly here: https://fs26.formsite.com/htrnp/a2k3lsooud/index.html

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Domino 🐾

Great Dane/Mixed Breed (Medium)

Male, 7 yrs 10 mos

Greenville, SC

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Story

Meet Domino! This clever, confident boy greets you with playful excitement—pouncing around with joy without jumping on you. Domino is highly treat-motivated and shows off skills like sit, paw/shake, and even catching treats mid-air. He loves toys and stays focused during play, often striking an adorable play bow with his butt in the air. Goofy, playful, and smart, Domino is ready to bring fun and smiles to his future home. Leash Manners: Some pull Tricks: Sit, Treat Catching, Paw/Shake Toy Preference: Tennis ball, tug toy, plush squeaky toy More Fun Facts: Pounces on toys when playing Personality Key Descriptors: Clever, Confident, Goofy, Playful Love Language: Yummy treats, fun toys & playtime Energy-o-Meter (0–15): 9/15 Adoption includes vaccines, deworming, flea treatment, microchip, heartworm test, spay/neuter unless medically prohibited. The adoption fee is $35. Want to meet me? Call/text 864-467-3985 to set up a one-on-one VIP appointment or stop by Monday–Saturday, 12–5.

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Great Dane puppies and dogs in South Carolina

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Great Dane puppies and dogs in South Carolina

Jump to:

Adopt a Great Dane near you in South Carolina

Below are our newest added Great Danes available for adoption in South Carolina. To see more adoptable Great Danes in South Carolina, use the search tool below to enter specific criteria!

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in South Carolina cities

Great Dane shelters & rescues in South Carolina

Looking for a specific shelter or rescue?

Want to learn more about adopting a Great Dane puppy or dog ?

Great Dane information

Great Dane basics