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Great Dane puppies and dogs in South Carolina

Looking for a Great Dane puppy or dog in South Carolina? Adopt a Pet can help you find an adorable Great Dane near you.

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Adopt a Great Dane in South Carolina Search for a Great Dane puppy or dog Great Dane puppies and dogs in South Carolina cities Great Dane shelters and rescues in South Carolina Learn more about adopting a Great Dane puppy or dog

Adopt a Great Dane near you in South Carolina

Below are our newest added Great Danes available for adoption in South Carolina. To see more adoptable Great Danes in South Carolina, use the search tool below to enter specific criteria!
We'll also keep you updated on Moose's adoption status with email updates.
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Moose

Great Dane

Male, Young
Aiken, SC
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained,
Story
Moose is a wonderful young Great Dane. Like all Great Danes, he doesn’t have a mean bone in his body. He’s loving, playful, and goofy, and gets along with other dogs. He’s small for a Dane, only weighing about 100 pounds. Unfortunately that’s still too much for my wife too handle due to health issues. Moose is a little over 18 months old so he’s still filling out and has many good years ahead. He’s fully housebroken and is crate trained. We will also give his crate to help ease the transition. He has not been fixed yet because we wanted him to be fully grown before getting him fixed. We’ve had many Great Danes over the years and they are a wonderful breed. We’ve just reached the age that they’re becoming too much.

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We'll also keep you updated on Titan's adoption status with email updates.
Needs Home Fast
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Titan

Great Dane/Labrador Retriever

Male, 2 yrs
Pickens, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
Meet Titan, the Big Loveable TornadoTitan is a two year old, 70lb Great Dane Lab mix who is neutered, heartworm negative, and dog friendly. He’s packed with enthusiasm, big feelings, and absolutely zero manners — the definition of a work in progress. Titan needs an active home ready to channel his energy, teach him the ropes, and laugh along the way. Meet Titan today and help this gentle giant-in-training become the amazing dog he’s meant to be.

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We'll also keep you updated on Rosie's adoption status with email updates.
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Rosie

Great Dane

Female, Adult
Okatie, SC
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Needs experienced adopter, House-trained,
Story
Rosie is a majestically beautiful girl. She loves walks and cuddles. Her favorite is kisses and hugs. If you are interested, you MUST have Great Dane experience. She can be a bit much for some dogs. Noah's Arks Rescue is all about giving an Abused Animal a second chance at life and to experience what true love is. We take animals that have been tortured, abused, and neglected and supply the emergency medical care required to get them well. We then provide rehab physically and mentally to prepare them for their new home and new life. We are located in Ridgeland, SC., and are by appointment only. All of our dogs are at our Rehabilitation Center either in hospice care or being loved on by staff until we find them forever homes. Please call 843.540.6755 or email NoahsArksRescues@mac.com with any questions. If you are interested, please fill out our Adoption Application at https://www.noahs-arks.net/nar-application. We do adopt out of state and will arrange transports. Our dogs are not allowed to fly cargo at any time.

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We'll also keep you updated on Cleopatra's adoption status with email updates.
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Cleopatra

Great Dane

Female, Adult
Travelers Rest, SC
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with kids, Not good with dogs, Not good with cats, House-trained,
Story
Hello this is so hard to do but I think it’s in the best interest of Cleopatra who is a sweet lap dog girl who I think needs a quieter more predictable environment, where she can be the baby that she is. I feel bad that she is living with us when she is clearly not comfortable. We adopted her at 2 years old and she has always had a skittish nature but she has gotten progressively less tolerant of living with our other animals and is very jumpy and nervous to the point where it can start conflict. I hope to find her a better fit before something happens that i can not fix. If you have the space for this timid beauty please consider reaching out. I’d like to see her happy and relaxed.

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We'll also keep you updated on Scooby's adoption status with email updates.
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Scooby

Great Dane

Male, Adult
Ware Shoals, SC
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, Needs experienced adopter,
Story
Scooby is a little over three years old. He’s is very sweet and loving. He has loads of energy and loves to run and play with other dogs. He is however food aggressive with other dogs. Other than that he does great with all other animals. He needs a loving home with somebody who can get him out and exercise him regularly as needed.

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We'll also keep you updated on Wallen's adoption status with email updates.
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Wallen

Great Dane

Male, Adult
Hilton Head, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
Wallen is a charming two-year-old Great Dane mix who tips the scales at a healthy 66 pounds. Wallen is the epitome of sweetness, always ready to shower you with affection and brighten your day with his playful antics. His intelligence shines through in everything he does, making him quick to learn new tricks and commands, especially when treats are involved. Wallen's playful nature makes him a joy to be around, whether he's chasing after a ball or simply enjoying a romp in the yard. With his combination of smarts, sweetness, and playfulness, Wallen is sure to become a beloved member of the family.December 29, 2025, 1:18 pm

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Search for a Great Dane puppy or dog

Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in South Carolina.

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Great Dane puppies and dogs in South Carolina cities

Great Dane Puppies near me Great Dane in Abbeville Great Dane in Aiken Great Dane in Anderson Great Dane in Barnwell Great Dane in Batesburg Leesville Great Dane in Beaufort Great Dane in Belton Great Dane in Bennettsville Great Dane in Bluffton Great Dane in Camden Great Dane in Cayce Great Dane in Charleston Great Dane in Cheraw Great Dane in Chester Great Dane in Clemson Great Dane in Clinton Great Dane in Clover Great Dane in Columbia Great Dane in Conway Great Dane in Darlington Great Dane in Dillon Great Dane in Easley Great Dane in Edgefield Great Dane in Florence Great Dane in Fort Mill Great Dane in Fountain Inn Great Dane in Gaffney Great Dane in Georgetown Great Dane in Goose Creek Great Dane in Greenville Great Dane in Greenwood Great Dane in Greer Great Dane in Hanahan Great Dane in Hartsville Great Dane in Hilton Head Island Great Dane in Hollywood Great Dane in Irmo Great Dane in Isle of Palms Great Dane in Lake City Great Dane in Lancaster Great Dane in Laurens Great Dane in Lexington Great Dane in Marion Great Dane in Mauldin Great Dane in Moncks Corner Great Dane in Mount Pleasant Great Dane in Mullins Great Dane in Myrtle Beach Great Dane in Newberry Great Dane in North Augusta Great Dane in North Charleston Great Dane in North Myrtle Beach Great Dane in Orangeburg Great Dane in Port Royal Great Dane in Rock Hill Great Dane in Seneca Great Dane in Simpsonville Great Dane in Spartanburg Great Dane in Summerville Great Dane in Sumter Great Dane in Surfside Beach Great Dane in Tega Cay Great Dane in Travelers Rest Great Dane in Union Great Dane in Walterboro Great Dane in West Columbia Great Dane in York

Great Dane shelters & rescues in South Carolina

There are animal shelters and rescues that focus specifically on finding great homes for Great Dane puppies in South Carolina. Browse these Great Dane rescues and shelters below.

Here are a few organizations

Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Great Dane puppy or dog ?

We've got all the info you need on adopting and caring for a Great Dane puppy . Check out the links below for everything you ever wanted to know about Great Dane puppies and adults .

Great Dane information

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Where do Great Danes come from? How many types of Great Danes are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Great Dane.

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