Great Dane Adoption in South Carolina: Great Dane Puppies for Sale in South Carolina

Adopt a Great Dane near you in South Carolina

Below are our newest added Great Danes available for adoption in South Carolina. To see more adoptable Great Danes in South Carolina, use the search tool below to enter specific criteria!

Chapel

Great Dane/Labrador Retriever

Male, 1 yr 1 mo

EFFINGHAM, SC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Story

PLEASE NOTEA pre-adoption form must be completed in person at the shelter.If the animal is already spayed or neutered, they can be adopted and go home the same day. This will be clearly noted in their description.Once your pre-adoption process is complete, we will schedule a spay/neuter appointment, typically within 10 days. You will be able to bring your new pet home once the procedure has been completed.At this time, all adoption fees are being waived.If you have any questions about your application, please contact the Florence County Animal Shelter directly at 843-665-3053.

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Tito

Great Dane

Male, 5 mos

Greenville, SC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

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Nebula

Great Dane

Female

greenville, SC

Size

(when grown) -

Details

Story

Meet Nebula! Nebula is a stunning, black-and-white Great Dane who is every bit as celestial and vast as her name suggests. If you are looking for a "velcro dog" who doesn't realize she’s the size of a small pony, Nebula is ready to fill your home with love (and probably a little bit of drool). The Basics: • Breed: Great Dane • Personality: Gentle, soulful, and incredibly affectionate • Social Style: Great with dogs of all sizes; indifferent to cats • Favorite Hobby: Sunbathing in the grass and perfecting the "lean" against her favorite humans. Her Personality: Nebula is the definition of a "gentle giant." She has a calm, observant nature and spends much of her day lounging in the yard, soaking up the sun, and watching the world go by with those expressive, soulful eyes. While she looks majestic, she is a total sweetheart who thrives on human companionship. She is a professional at the "Great Dane Lean"—her way of giving a hug—and will happily sit at your feet (or on them) just to be close to you. Friends & Family One of Nebula’s best qualities is her social grace. She is a social butterfly who gets along famously with other dogs, whether they are fellow giants or pint-sized companions. When it comes to feline friends, she is completely indifferent to cats, making her a peaceful addition to a multi-pet household. Nebula is looking for a family that understands the giant-breed lifestyle. She would love: • A Yard to Lounge In: She enjoys her outdoor time, whether she’s sitting tall like a statue or stretched out for a nap in the grass. • Pet Siblings: She’d be happy to have a canine brother or sister to hang out with. • Plenty of Couch Space: Let’s be honest, she’s going to want to share the furniture with you. • Gentle Guidance: She is a sensitive soul who responds best to soft words and plenty of treats. She is spayed, microchipped, dewormed, and current with all vaccines (as appropriate for her age) and on flea and heartworm prevention. Nebula is currently being fostered in South Carolina. ADOPT NEBULA!! www.LuckyPupRescueSC.com The adoption fee is $375.00 and we require a vet check and home visit. May 15, 2026, 5:30 pm

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Wallen

Great Dane

Male, Adult

Hilton Head, SC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Wallen is a charming three-year-old Great Dane mix who tips the scales at a healthy 62 pounds. Wallen is the epitome of sweetness, always ready to shower you with affection and brighten your day with his playful antics. His intelligence shines through in everything he does, making him quick to learn new tricks and commands, especially when treats are involved. Wallen's playful nature makes him a joy to be around, whether he's chasing after a ball or simply enjoying a romp in the yard. With his combination of smarts, sweetness, and playfulness, Wallen is sure to become a beloved member of the family.May 16, 2026, 2:38 pm

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Brynn

Great Dane

Female, < 1 month

Williamston, SC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, House-trained,

Story

Apply for the pet here: https://tinyurl.com/4t36cxak

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Hemi

Great Dane

Male, 7 yrs

Williamston, SC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, House-trained,

Story

Apply for the pet here: https://tinyurl.com/bvp75t4y

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Great Dane puppies and dogs in South Carolina

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Below are our newest added Great Danes available for adoption in South Carolina. To see more adoptable Great Danes in South Carolina, use the search tool below to enter specific criteria!

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Great Dane puppies and dogs in South Carolina

Jump to:

Adopt a Great Dane near you in South Carolina

Below are our newest added Great Danes available for adoption in South Carolina. To see more adoptable Great Danes in South Carolina, use the search tool below to enter specific criteria!

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in South Carolina cities

Great Dane shelters & rescues in South Carolina

Looking for a specific shelter or rescue?

Want to learn more about adopting a Great Dane puppy or dog ?

Great Dane information

Great Dane basics