Mastiff Adoption in Adrian, MI: Mastiff Puppies for Sale in Adrian, MI

Adopt a Mastiff near you in Adrian, Michigan

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Adrian, Michigan

These Mastiffs are available for adoption close to Adrian, Michigan.

Mr Woofer

Mastiff

Male, 4 yrs 1 mo

Liberty Center, OH

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Mr Woofers is a 4 to 5 yr old neutered male Mastiff mix. He weighs about 75 lbs. We pulled Woofers from our local animal shelter after he was picked up as a stray. He can be a little cautious when meeting new people but warms up quickly. You can convince him to do anything for a treat. He is lower energy and enjoys just hanging out with his family. He will go for a walk and does occasionally like a good romp in the yard. He has been kind and gentle . He appears to be house trained . He is great with other dogs and children. He hasn't been tested with cats. He is up to date on shots and wormed. He is already neutered. The adoption fee is $400.00. If interested in meeting this cutie, please email heritagefarms08@gmail.com or call the foster at 419-779-0862 . He is being fostered in Ottawa Lake , Michigan. When emailing please include information about you and your family including other pets.

Learn More

Maisy

Mastiff

Female, 5 yrs 11 mos

Belleville, MI

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with dogs, Spayed or Neutered, Shots are up-to-date,

Story

Meet Maisy! Maisy is a 5-year-old Mastiff mix with a heart as big as her paws! She came to us as a stray from Sumpter, severely underweight and clearly having been through a lot. But oh, how far she's come! With time, love, and plenty of good meals, Maisy has transformed into a healthy, happy pup who's ready for her forever home. Despite her tough start, Maisy's outlook on life is nothing short of amazing. She's always wiggly with excitement to see people and has never met a stranger-she's as friendly and affectionate as they come. Her favorite things? Stuffy toys (even if they only last a few minutes), snacks (she's very food motivated), and simply hanging out with her humans. Maisy is still learning the ropes of home life, including potty training and basic manners, but her eagerness to please and strong bond with her people make her a great student. She's mellow by nature and prefers relaxed exploration in the yard over high-energy activities. While she hasn't quite figured out how to "play" just yet, we can tell she's curious and interested-and with time, she might just become a pro! She's currently unsure around other dogs but has done fine in calm playgroups, mostly keeping to herself. If you already have a dog at home, we're still happy to consider a meet-and-greet to see how they might get along. As for cats-we're not sure yet. Maisy would do best in a moderately active home, possibly with older kids and maybe a laid-back dog sibling. Most importantly, she needs a patient and loving family who can help her continue her journey from survivor to spoiled companion. If you're looking for a sweet, soulful, easygoing girl to share your heart and home with-Maisy might just be your perfect match. ---------------------------------------------------------------------------------------------------------------------------------- If you would like to meet Maisy, please submit an application for her on our website https://www.friendsofmichigan.org/adoptable-dogs. She is spayed, up to date on all age appropriate vaccines, microchipped, and on monthly flea & tick prevention. Maisy is currently heartworm positive, and has begun her treatment as of 5/8/25. FMAR covers the full cost of heartworm treatment and works with Home Care Veterinary Services for the treatment. You're still encouraged to apply to adopt Maisy! We'll work closely with you to ensure her treatment continues smoothly and she gets everything she needs to thrive in her new home. Her treatment after adoption would continue through HCVS until successfully completed. Her adoption fee is $250, which helps cover the cost of the medical care she has received. **Please note that the breed listed for each of our dogs is a rough estimate unless DNA results are provided in their Bio. All strays have rough estimates of their age based on the condition of their teeth. Each dog is different, so each adoption is different. Our adoption process might require multiple visits to the shelter before our dogs can go home. Or they may be ready on the first visit. It really depends on the individual dog and the potential adopters. Once we receive your application, the Dog Staff will contact you to discuss meeting our dogs.

Learn More

Bubs

Mastiff

Male, Puppy

Belleville, MI

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

You can fill out an adoption application online on our official website.Meet Bubs Born on January 21, 2026, Bubs is an adorable mastiff mix puppy with a whole lot of growing (and cuddling) ahead of him. With his cute black mask and big, clumsy paws, he may have some Cane Corso or Bullmastiff in the mix—but right now, he’s all puppy energy and sweetness. Bubs is incredibly affectionate and loves being close to his people. He’s the kind of pup who will happily follow you around, flop over for belly rubs, and then bounce right back up for playtime. Curious and gentle, he’s still figuring out the world one sniff (and probably one chew) at a time. Like any young pup, he’s learning his manners and building confidence every day. With a little guidance and a lot of love, Bubs is going to grow into a wonderful, loyal companion. For now, he’s just a big baby with a soft heart and an even softer spot for cuddles.Visit this organization's web site to see any additional information available about this pet.April 28, 2026, 8:18 pm

Learn More

Murphy

Mastiff

Male, Puppy

Northville, MI

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

House-trained, Shots are up-to-date,

Story

Learn More

Bones

Mastiff

Female, 4 yrs

Taylor, MI

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with dogs, Good with cats, House-trained, Shots are up-to-date,

Story

Bones is a big girl with an even bigger heart. Weighing in at around 130 pounds, she may not realize her size—once she trusts you, she’ll happily climb into your lap or wrap you up in a big hug, showering you with sweet chin kisses.She can be shy at first and takes a little time to warm up, but once she does, her affectionate and loyal nature truly shines. Bones is housebroken and well-mannered in the home. She does well around cats, often choosing to ignore them, but she would do best as the only dog so she can soak up all the love and attention she deserves.Loud noises and thunderstorms can be scary for her, so she’ll need a patient, understanding home where she feels safe and secure.Bones is being rehomed through no fault of her own after the passing of her owner. She’s ready to find a loving family who will give her the comfort, stability, and affection she cravesFOCCAS is a foster based, non-profit rescue in Crossville, TN. The adoption fee Includes Age-Appropriate Vaccinations (DA2PPV, Bordetella, Rabies), Deworming, Spay/Neuter, Microchip, Flea/Tick/Heartworm Prevention, and Sheltering. Adult Dogs are Heartworm Tested and Treated as Needed. FOCCAS does not DNA test or guarantee breed. If transport is needed, there are additional fees to cover department of agriculture requirements and transport, the additional fee adds $300 to the adoption fee (any location out of Tennessee, East Coast, Great Lakes or New England regions)Thank You for Your Interest in Adopting a Canine Companion from Foccas-tn.org!To Apply Please Copy and Paste to your browser:https://service.sheltermanager.com/asmservice?account=hb2428&method=online_form_html&formid=41LOCATED IN CROSSVILLE, CUMBERLAND COUNTY, TN. WE CAN TRANSPORT OUT OF STATE, Visit out website for a full list of adoptable pets… https://foccas-tn.org/

Learn More

Hetti

Mastiff Boxer

Female, Adult

Livonia, MI

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

You can fill out an adoption application online on our official website.If interested in any of our animals for adoption, or to foster an animal, please fill out the respective application here to get the process started. Visit our FAQ webpage for commonly asked questions about our adoption/foster process. Meet the magnificent Miss Hetti. She is a playful, energy abundant Mastiff, and likely, boxer mix. She loves tummy rubs, fetch, and Benebone chew toys. Hetti thrives on multiple walks per day however can over heat quickly in higher temps. She is very strong and still learning manners with passing animals so an experienced handler and dog owner is a must. She loves greeting people but due to her size and still puppy behaviors, a house with kids over 12 is preferred. For Hetti to live her best life she should be a solo canine with a large fenced yard and an active owner willing to give her the exercise and attention she needs. Visit this organization's web site to see any additional information available about this pet.Last Day Dog Rescue now microchips all animals before adoption. Microchips are implanted between the animals shoulder blades and are a permanent form of identification. If the animal is ever lost and slips his/her collar/tags the microchip allows the finder to know who to contact if scanned for a microchip. Animals MUST still have a collar with tags on at all times. Per our contract, we take all our animals back if for any reason you can't keep your adopted animal. Please understand the statements about this animal are based upon the foster home's evaluation of the animal. The animal might behave differently (negatively or positively) in your home. While the animal might be good with the current foster’s dogs, cats, children, etc., it may not be with your animal(s) or children. The animal may be housebroken or litter trained in the home of the foster but may relapse in your home. The animal is represented to the public as it performs in the foster home and any statements made regarding the animal are conditional to that foster home setting. Please understand that statements made regarding this animal are simply overviews and are not guaranteed. The Petfinder.com system requires that we choose a predominant breed or breed mix for our animals. Visual breed identification in animals is unreliable so for most of the animals we are only guessing at predominant breed or breed mix. We get to know each animal as an individual and will do our best to describe each of our animals based on personality, not by breed label. Thank you for looking through our list of animals needing forever homes and choosing rescue first. We appreciate you stopping by. March 7, 2026, 8:41 am

Learn More

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Adrian, Michigan.

Mastiff puppies and dogs in Adrian, Michigan

Learn More:

Adopt a Mastiff near you in Adrian, Michigan

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Adrian, Michigan

These Mastiffs are available for adoption close to Adrian, Michigan.

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in Adrian, Michigan

Mastiff shelters & rescues in Adrian, Michigan

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics

Home

Adopt a Dog

Adopt a Mastiff

Michigan

Adrian

Mastiff puppies and dogs in Adrian, Michigan

Learn More:

Adopt a Mastiff near you in Adrian, Michigan

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Adrian, Michigan

These Mastiffs are available for adoption close to Adrian, Michigan.

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in Adrian, Michigan

Mastiff shelters & rescues in Adrian, Michigan

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics