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Mastiff puppies and dogs in Simpsonville, South Carolina

Looking for a Mastiff puppy or dog in Simpsonville, South Carolina? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near Simpsonville, South Carolina Other pups in Simpsonville, South Carolina Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in Simpsonville, South Carolina Mastiff shelters and rescues in Simpsonville, South Carolina Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Simpsonville, South Carolina

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Simpsonville, South Carolina

These Mastiffs are available for adoption close to Simpsonville, South Carolina.
We'll also keep you updated on Ralphie's adoption status with email updates.
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Ralphie

Mastiff

Male, 5 yrs 1 mo
Pickens, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
Ralphie, the Holiday Classic with a Big Heart!Ralphie is a 5-year-old, 56lb Tri-Color Bulldog Blend who’s neutered, heartworm Positive, and dog friendly. He knows “sit” and loves being part of the fun — think less Red Ryder BB gun and more big squishy Christmas ham. Ralphie’s all about cozy cuddles, soft blankets, and celebrating life’s simple joys.

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We'll also keep you updated on Nala's adoption status with email updates.
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Nala

Mastiff Labrador Retriever

Female, Young
Blacksburg, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Not good with cats, House-trained, Spayed or Neutered,
Story
Meet Nala! Breed: mastiff/lab mix. Age: est 4 years, est birthdate 1/22/2021 Weight: approx 65ish lbs. Training: leash, crate and housetrained. She also knows sit and down and eager to learn more. She is very food motivated which is a plus! Good with other dogs/cats? Yes to dogs, but no cats. Good with adults/kids? Nala is very loyal but it's takes her a little bit to warm up to new people. She is protective of her people. She is great with kids, however we feel she would do best in a home without many visitors, or the ability to put her up when you have company. Personality: shy/reserved in New situations. She is playful but also loves to cuddle. Nala is very loyal and protective of the people she loves. She loves to play with other dogs. She LOVES water. Nala is spayed, microchipped, heartworm negative & current on vaccinations and preventatives. If interested in adding Nala to your family, please message for an adoption application! Adoption fee: $75September 28, 2025, 7:06 pm

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We'll also keep you updated on Bear's adoption status with email updates.
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Bear

Mastiff

Female, 10 yrs 2 mos
Anderson, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
Meet Bear! Bear is a 10 year old Mastiff mix. Bear is looking for a forever cuddle buddy.Some fun facts about Bear :Profession : Ultimate cuddle bugFavorite hobby : Stealing your heartFavorite song : Forever youngStop by and ask about Bear at Anderson Paws from 12pm to 5pm on M,T,TH,F,SA!

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Mastiff puppies and dogs in nearby cities

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Related breeds in Simpsonville, South Carolina

Bullmastiffs in Simpsonville, South Carolina Neapolitan Mastiffs in Simpsonville, South Carolina Saint Bernards in Simpsonville, South Carolina

Mastiff shelters & rescues in Simpsonville, South Carolina

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Simpsonville, South Carolina. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

34.7 miles

Pickens County SC Animal Shelter

193 County Farm Rd, Pickens, SC 29671

Pet Types: birds, dogs, farm animals, rabbits, reptiles, small animals

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Rescue

42.3 miles

Mercy Rescue Haven

Blacksburg, SC 29702

Pet Types: cats, dogs

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Shelter

42.8 miles

Anderson County PAWS

1320 Hwy 29 South, Anderson, SC 29626

Pet Types: cats, dogs, rabbits, small animals

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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