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Mastiff puppies and dogs in South Carolina

Looking for a Mastiff puppy or dog in South Carolina? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff in South Carolina Search for a Mastiff puppy or dog Mastiff puppies and dogs in South Carolina cities Mastiff shelters and rescues in South Carolina Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in South Carolina

Below are our newest added Mastiffs available for adoption in South Carolina. To see more adoptable Mastiffs in South Carolina, use the search tool below to enter specific criteria!
We'll also keep you updated on Dottie's adoption status with email updates.
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Dottie

Mastiff

Female, Puppy
Rock Hill, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs,
Story
Meet Miss Dottie! Dottie is a 10-week-old mastiff mix weighing in at 12 pounds 8 ounces (as of 11/17/25). She’s a sweet, spunky puppy who loves everyone she meets! Dottie is great with dogs, cats, and kids, and she’s already sleeping through the night like a champ. She’s currently working on her potty training and doing well for her age. Dottie is in her teething era, so she’ll need plenty of chew toys, treats, and fun activities to keep her busy. If you’re looking for a lovable, happy little girl who will grow into a wonderful companion, Dottie is your girl. --- To apply to adopt, please follow the steps for adoption on HalfwayThereRescue.com/Adoption-Process and apply directly here: https://fs26.formsite.com/htrnp/a2k3lsooud/index.html

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We'll also keep you updated on Ralphie's adoption status with email updates.
Needs Home Fast
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Ralphie

Mastiff

Male, 5 yrs
Pickens, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
Ralphie, the Holiday Classic with a Big Heart!Ralphie is a 5-year-old, 56lb Tri-Color Bulldog Blend who’s neutered, heartworm Positive, and dog friendly. He knows “sit” and loves being part of the fun — think less Red Ryder BB gun and more big squishy Christmas ham. Ralphie’s all about cozy cuddles, soft blankets, and celebrating life’s simple joys.

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We'll also keep you updated on Bear's adoption status with email updates.
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Bear

Mastiff

Female, 10 yrs 2 mos
Anderson, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
Meet Bear! Bear is a 10 year old Mastiff mix. Bear is looking for a forever cuddle buddy.Some fun facts about Bear :Profession : Ultimate cuddle bugFavorite hobby : Stealing your heartFavorite song : Forever youngStop by and ask about Bear at Anderson Paws from 12pm to 5pm on M,T,TH,F,SA!

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We'll also keep you updated on Bugs URGENT SUPER HERO NEEDED!'s adoption status with email updates.
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Bugs URGENT SUPER HERO NEEDED!

Mastiff/American Staffordshire Terrier

Male, Young
columbia, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, House-trained,
Story
Meet Bugs, URGENT HELP NEEDED FIR THIS SUPER SWEET BUT SCARED BOY! After all the progress Bugs has made in just a short amount of time he is still at risk of being euthanized It's one of the hardest things for staff & volunteers. Sometimes love isn't enough, love can't save them from an overcrowded shelter where animals keep pouring in. We are hoping this touches someone heart this boy deserves so more. Can’t imagine what’s he’s been through. We hope this newfound confidence wasn't for nothing & Bugs absolutely did his part, and now he needs your help.PLEASE HIRRY TEXT KAREN 4136298152

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We'll also keep you updated on Nala's adoption status with email updates.
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Nala

Mastiff/Labrador Retriever

Female, Young
Blacksburg, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Not good with cats, House-trained,
Story
Meet Nala! Breed: mastiff/lab mix. Age: est 4 years, est birthdate 1/22/2021 Weight: approx 65ish lbs. Training: leash, crate and housetrained. She also knows sit and down and eager to learn more. She is very food motivated which is a plus! Good with other dogs/cats? Yes to dogs, but no cats. Good with adults/kids? Nala is very loyal but it's takes her a little bit to warm up to new people. She is protective of her people. She is great with kids, however we feel she would do best in a home without many visitors, or the ability to put her up when you have company. Personality: shy/reserved in New situations. She is playful but also loves to cuddle. Nala is very loyal and protective of the people she loves. She loves to play with other dogs. She LOVES water. Nala is spayed, microchipped, heartworm negative & current on vaccinations and preventatives. If interested in adding Nala to your family, please message for an adoption application! Adoption fee: $75September 28, 2025, 7:06 pm

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We'll also keep you updated on Charlie Brown's adoption status with email updates.
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Charlie Brown

Mastiff

Male, 7 yrs 9 mos
Irmo, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
Charlie Brown is a lovable Mastiff mix who is in search of a forever home. This boy is truly a gentle giant. Despite being found abandoned when his previous owners moved away, Charlie Brown has shown immense resilience and is healing beautifully from his past environment.He`s as calm as they come. He has a serene demeanor that makes him an ideal companion for any household. Whether it’s young children, other dogs, or even cats, Charlie Brown gets along with everyone! What desires most is human companionship. Charlie`s knees are a bit achy so he is on a good join supplement. If you`re looking for a running partner, CB isn`t the right pup for you. He`d love nothing more than to be your couch potato buddy, offering warmth and love in exchange for a cozy spot by your side. 6 yrs 90 lb. Neuter, vaccines, microchip provided.

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in South Carolina.

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Mastiff puppies and dogs in South Carolina cities

Mastiff Puppies near me Mastiff in Abbeville Mastiff in Aiken Mastiff in Anderson Mastiff in Barnwell Mastiff in Batesburg Leesville Mastiff in Beaufort Mastiff in Belton Mastiff in Bennettsville Mastiff in Bluffton Mastiff in Camden Mastiff in Cayce Mastiff in Charleston Mastiff in Cheraw Mastiff in Chester Mastiff in Clemson Mastiff in Clinton Mastiff in Clover Mastiff in Columbia Mastiff in Conway Mastiff in Darlington Mastiff in Dillon Mastiff in Easley Mastiff in Edgefield Mastiff in Florence Mastiff in Fort Mill Mastiff in Fountain Inn Mastiff in Gaffney Mastiff in Georgetown Mastiff in Goose Creek Mastiff in Greenville Mastiff in Greenwood Mastiff in Greer Mastiff in Hanahan Mastiff in Hartsville Mastiff in Hilton Head Island Mastiff in Hollywood Mastiff in Irmo Mastiff in Isle of Palms Mastiff in Lake City Mastiff in Lancaster Mastiff in Laurens Mastiff in Lexington Mastiff in Marion Mastiff in Mauldin Mastiff in Moncks Corner Mastiff in Mount Pleasant Mastiff in Mullins Mastiff in Myrtle Beach Mastiff in Newberry Mastiff in North Augusta Mastiff in North Charleston Mastiff in North Myrtle Beach Mastiff in Orangeburg Mastiff in Port Royal Mastiff in Rock Hill Mastiff in Seneca Mastiff in Simpsonville Mastiff in Spartanburg Mastiff in Summerville Mastiff in Sumter Mastiff in Surfside Beach Mastiff in Tega Cay Mastiff in Travelers Rest Mastiff in Union Mastiff in Walterboro Mastiff in West Columbia Mastiff in York

Mastiff shelters & rescues in South Carolina

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in South Carolina. Browse these Mastiff rescues and shelters below.

Here are a few organizations

Shelter

Hallie Hill Animal Sanctuary

5604 New Road, Hollywood, SC , SC 29449

Pet Types: cats, dogs, small animals

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog ?

We've got all the info you need on adopting and caring for a Mastiff puppy . Check out the links below for everything you ever wanted to know about Mastiff puppies and adults .

Mastiff information

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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