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Mastiff puppies and dogs in South Carolina

Looking for a Mastiff puppy or dog in South Carolina? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff in South Carolina Search for a Mastiff puppy or dog Mastiff puppies and dogs in South Carolina cities Mastiff shelters and rescues in South Carolina Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in South Carolina

Below are our newest added Mastiffs available for adoption in South Carolina. To see more adoptable Mastiffs in South Carolina, use the search tool below to enter specific criteria!
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95530a Dakota

Mastiff

Female, 1 yr 6 mos
North Charleston, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
Meet this sweet lady! This beautiful Mastiff mix is a big girl with an even bigger heart! She is an absolute sweetheart who loves nothing more than spending time with her people. Give her some pets, offer her a tasty treat, and she’ll be your best friend in no time!She enjoys getting out for walks, having fun and playing, but she also knows how to slow things down. When playtime is over, she is always ready for some serious cuddle time! She’s the kind of dog who would love to be part of a family where she can enjoy daily walks, plenty of affection, tasty treats, and a cozy spot to relax with her favorite people.If you’ve been looking for a sweet, affectionate, playful big girl to add to your family, this lovely Mastiff mix could be the one you’ve been waiting for!

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Photo of Maximus

Maximus

Mastiff

Male, 8 yrs 8 mos
Spartanburg, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
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Special Needs
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Hooch Tiggy

Mastiff/Bullmastiff

Male, 8 yrs 11 mos
Anderson, SC
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Needs special attention,
Story
Tiggy is a Hospice senior boy. He is a very nervous guy who came into a shelter a bag of bones. Tiggy was transferred to Pawsitive Impact as a Hospice dog. He has had a severe ear infection cleaned out by the vet under anesthesia, a wound on his foot, three teeth removed and needs to have eyelid surgery. Tiggy is not adoptable but he is an expensive Foster. Please visit our website to donate to Tiggy's end of Life Care.

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SeaSmoke

Mastiff/Mixed Breed (Medium)

Male, 2 yrs 1 mo
Hardeeville, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, Not good with cats,
Story
Let's talk about Seasmoke.Is Seasmoke the smartest dog you've ever met? Probably not.Will he be your marathon training partner? Also no.Will he spend hours mastering advanced tricks, solving puzzles, or applying to medical school? Definitely not.But if you're looking for an easygoing, lovable giant who appreciates the simple things in life, Seasmoke is absolutely your guy.This young adult Mastiff has life pretty much figured out. A comfy spot to nap? Perfect. A leisurely stroll? Sounds great. Some snacks? Even better. A family to love? That's the dream. Seasmoke isn't interested in overcomplicating things, and honestly, there's something admirable about that.Like many Mastiffs, he's a laid-back soul who would much rather hang out with his people than create chaos. He's sweet, gentle, and happy to take life one nap at a time. While some dogs are constantly looking for their next adventure, Seasmoke is busy perfecting the art of relaxation.If your ideal companion is a calm, low-maintenance boy who asks for little more than a comfortable place to lounge and some affection from his favorite humans, Seasmoke may just be your perfect match.Sometimes the best dogs aren't the fastest, smartest, or most athletic. Sometimes they're the ones who remind us to slow down and enjoy life's simple pleasures. Seasmoke has mastered that lesson already. ❤️🐾Adoption hours are Wednesday through Sunday from 11 a.m. to 4 p.m. Come meet Seasmoke and see why this gentle giant is impossible not to love.Adoption Hours are Wednesday through Sunday from 11 AM to 4 PM. You do not need an appointment to come by and meet animals during adoption hours.

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Photo of Jolene

Jolene

Mastiff

Female, 7 yrs 4 mos
Conway, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, Needs experienced adopter, House-trained,
Story
Meet Jolene- a natural at all things- loyalty, protection, play time, nap time AND natural instinct for service dog work. Jolene came from neglect and abuse yet still shows loyalty and protection of her persons. As a Boerboel, Experience with this breed is REQUIRED. They are not ideal for first timers esp as adults.

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Photo of Dreamfyre

Dreamfyre

Mastiff/Mixed Breed (Medium)

Female, 4 yrs 5 mos
Hardeeville, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats,
Story
Dreamfyre is proof that first impressions aren't always the whole story.When you first meet this young adult Mastiff girl, she'll likely have plenty to say about it. Dreamfyre isn't shy about announcing her arrival or sharing her opinions with the world. But give her a few minutes, and you'll discover that beneath all that commentary is exactly what Mastiff lovers adore—a sweet, gentle, low-key companion who would much rather relax by your side than cause any trouble.Once she's comfortable, Dreamfyre settles into classic Mastiff mode: calm, easygoing, and happy to simply be part of the family. She enjoys spending time with her people, takes life's little adventures in stride, and has a wonderfully affectionate nature.Dreamfyre also plays well with other dogs and enjoys canine companionship, making her a great option for a home with another friendly pup. Whether she's hanging out with her dog friends or lounging around the house, she approaches life with the laid-back attitude that makes Mastiffs such beloved companions.If you've been searching for a big dog with an even bigger heart, Dreamfyre may be exactly what you're looking for. Just be prepared to listen to her introduction—she likes to make sure everyone knows she's arrived before settling in for a nap! ❤️🐾Adoption hours are Wednesday through Sunday from 11 a.m. to 4 p.m. Come meet Dreamfyre and see why we can't help but adore this gentle giant.Adoption Hours are Wednesday through Sunday from 11 AM to 4 PM. You do not need an appointment to come by and meet animals during adoption hours.

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in South Carolina.

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Mastiff puppies and dogs in South Carolina cities

Mastiff Puppies near me Mastiff in Abbeville Mastiff in Aiken Mastiff in Anderson Mastiff in Barnwell Mastiff in Batesburg Leesville Mastiff in Beaufort Mastiff in Belton Mastiff in Bennettsville Mastiff in Bluffton Mastiff in Camden Mastiff in Cayce Mastiff in Charleston Mastiff in Cheraw Mastiff in Chester Mastiff in Clemson Mastiff in Clinton Mastiff in Clover Mastiff in Columbia Mastiff in Conway Mastiff in Darlington Mastiff in Dillon Mastiff in Easley Mastiff in Edgefield Mastiff in Florence Mastiff in Fort Mill Mastiff in Fountain Inn Mastiff in Gaffney Mastiff in Georgetown Mastiff in Goose Creek Mastiff in Greenville Mastiff in Greenwood Mastiff in Greer Mastiff in Hanahan Mastiff in Hartsville Mastiff in Hilton Head Island Mastiff in Hollywood Mastiff in Irmo Mastiff in Isle of Palms Mastiff in Lake City Mastiff in Lancaster Mastiff in Laurens Mastiff in Lexington Mastiff in Marion Mastiff in Mauldin Mastiff in Moncks Corner Mastiff in Mount Pleasant Mastiff in Mullins Mastiff in Myrtle Beach Mastiff in Newberry Mastiff in North Augusta Mastiff in North Charleston Mastiff in North Myrtle Beach Mastiff in Orangeburg Mastiff in Port Royal Mastiff in Rock Hill Mastiff in Seneca Mastiff in Simpsonville Mastiff in Spartanburg Mastiff in Summerville Mastiff in Sumter Mastiff in Surfside Beach Mastiff in Tega Cay Mastiff in Travelers Rest Mastiff in Union Mastiff in Walterboro Mastiff in West Columbia Mastiff in York

Mastiff shelters & rescues in South Carolina

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in South Carolina. Browse these Mastiff rescues and shelters below.

Here are a few organizations

Shelter

Marion County Animal Shelter

123 Dog and Cat Court, Mullins , SC 29574

Pet Types: cats, dogs

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Rescue

Haven Paws Dog Rescue

Conway , SC 29526

Pet Types: dogs

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Shelter

Charleston Animal Society

2455 Remount Road, North Charleston , SC 29406

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

We Are Zeus Inc

PO BOX 1851, Lexington , SC 29072

Pet Types: cats, dogs

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Shelter

Hallie Hill Animal Sanctuary

5604 New Road, Hollywood, SC , SC 29449

Pet Types: cats, dogs, small animals

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog ?

We've got all the info you need on adopting and caring for a Mastiff puppy . Check out the links below for everything you ever wanted to know about Mastiff puppies and adults .

Mastiff information

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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