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Mastiff puppies and dogs in South Carolina

Looking for a Mastiff puppy or dog in South Carolina? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff in South Carolina Search for a Mastiff puppy or dog Mastiff puppies and dogs in South Carolina cities Mastiff shelters and rescues in South Carolina Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in South Carolina

Below are our newest added Mastiffs available for adoption in South Carolina. To see more adoptable Mastiffs in South Carolina, use the search tool below to enter specific criteria!
We'll also keep you updated on Smoke's adoption status with email updates.
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Smoke

Mastiff/Mixed Breed (Medium)

Male, 1 yr
Greenville, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
Found Address Zet Ct SC 29611 Greenville

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We'll also keep you updated on Big Boi's adoption status with email updates.
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Big Boi

Mastiff/Mastiff

Male, 4 yrs
Union, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained,
Story
🐾 Meet Big Boii 🐾 This big handsome hunk is approximately 4 years old and 100% certified gentle giant 💙 Big Boii may be HEARTWORM POSITIVE , but don’t let that fool you — his heart is FULL of love. He’s sweet as honey, a giant snuggle bug, and will literally sing you to sleep with his adorable personality. 🎶 ✨ Dog friendly ✨ Kid friendly ✨ Great off leash ✨ Professional cuddle expert Big Boii is looking for a rescue willing to give this lovable mastiff the second chance he deserves. He’s got the size of a giant but the soul of a teddy bear. 🐻 Please help us find this big baby his happily ever after. 🛟💙 #RescueNeeded #MeetBigBoii #GentleGiant #AdoptDontShop

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We'll also keep you updated on SeaSmoke's adoption status with email updates.
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SeaSmoke

Mastiff/Mixed Breed (Medium)

Male, 1 yr 8 mos
Hardeeville, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, Not good with cats,
Story
Adoption Hours are Thursday through Sunday from noon to 5pm. You do not need an appointment to come by and meet animals during adoption hours.

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We'll also keep you updated on Dreamfyre's adoption status with email updates.
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Dreamfyre

Mastiff/Mixed Breed (Medium)

Female, 4 yrs 1 mo
Hardeeville, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
Adoption Hours are Thursday through Sunday from noon to 5pm. You do not need an appointment to come by and meet animals during adoption hours.

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We'll also keep you updated on Mufasa's adoption status with email updates.
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Mufasa

Mastiff

Male, 3 yrs
Mullins, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Not good with cats,
Story
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We'll also keep you updated on Houndini's adoption status with email updates.
Photo of Houndini

Houndini

Mastiff/Mixed Breed (Medium)

Male, 1 yr 7 mos
Greenville, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
Houndini is an adventurous, athletic pup who greets the world with excitement—expect a joyful, bouncy hello! He’s a curious explorer who loves sniffing around and checking everything out. While he enjoys toys and treats, he can get a little distracted by all the fun happening around him. Houndini is sweet, playful, and always ready for affection and attention. Leash Manners: Strong Pull Tricks: None Toy Preference: Plush squeaky toys; also enjoys wandering and sniffing More Fun Facts: Very strong pull but a sweet dog; playful and social; may get distracted easily; enjoys treats like cheese and hot dogs but may ignore them if something more exciting is happening Personality Key Descriptors: Adventurous, Athletic, Curious, Playful Love Language: Loving pets, yummy treats Energy-o-Meter (0–15): 10 Adoption includes vaccines, deworming, flea treatment, microchip, heartworm test, and spay/neuter unless medically prohibited. The adoption fee is $35. Want to meet me? Call/text 864-467-3985 to set up a one-on-one VIP appointment or stop by Monday - Saturday 12-5.

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in South Carolina.

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Mastiff puppies and dogs in South Carolina cities

Mastiff Puppies near me Mastiff in Abbeville Mastiff in Aiken Mastiff in Anderson Mastiff in Barnwell Mastiff in Batesburg Leesville Mastiff in Beaufort Mastiff in Belton Mastiff in Bennettsville Mastiff in Bluffton Mastiff in Camden Mastiff in Cayce Mastiff in Charleston Mastiff in Cheraw Mastiff in Chester Mastiff in Clemson Mastiff in Clinton Mastiff in Clover Mastiff in Columbia Mastiff in Conway Mastiff in Darlington Mastiff in Dillon Mastiff in Easley Mastiff in Edgefield Mastiff in Florence Mastiff in Fort Mill Mastiff in Fountain Inn Mastiff in Gaffney Mastiff in Georgetown Mastiff in Goose Creek Mastiff in Greenville Mastiff in Greenwood Mastiff in Greer Mastiff in Hanahan Mastiff in Hartsville Mastiff in Hilton Head Island Mastiff in Hollywood Mastiff in Irmo Mastiff in Isle of Palms Mastiff in Lake City Mastiff in Lancaster Mastiff in Laurens Mastiff in Lexington Mastiff in Marion Mastiff in Mauldin Mastiff in Moncks Corner Mastiff in Mount Pleasant Mastiff in Mullins Mastiff in Myrtle Beach Mastiff in Newberry Mastiff in North Augusta Mastiff in North Charleston Mastiff in North Myrtle Beach Mastiff in Orangeburg Mastiff in Port Royal Mastiff in Rock Hill Mastiff in Seneca Mastiff in Simpsonville Mastiff in Spartanburg Mastiff in Summerville Mastiff in Sumter Mastiff in Surfside Beach Mastiff in Tega Cay Mastiff in Travelers Rest Mastiff in Union Mastiff in Walterboro Mastiff in West Columbia Mastiff in York

Mastiff shelters & rescues in South Carolina

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in South Carolina. Browse these Mastiff rescues and shelters below.

Here are a few organizations

Shelter

Pawmetto Lifeline

1275 Bower Parkway, Columbia , SC 29212

Pet Types: cats, dogs

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Rescue

We Are Zeus Inc

PO BOX 1851, Lexington , SC 29072

Pet Types: cats, dogs

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Shelter

Union County Animal Shelter

1647 Jonesville Hwy, Union , SC 29379

Pet Types: cats, dogs

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Rescue

Mercy Rescue Haven

Blacksburg , SC 29702

Pet Types: cats, dogs

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Shelter

Marion County Animal Shelter

123 Dog and Cat Court, Mullins , SC 29574

Pet Types: cats, dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog ?

We've got all the info you need on adopting and caring for a Mastiff puppy . Check out the links below for everything you ever wanted to know about Mastiff puppies and adults .

Mastiff information

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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