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Mastiff puppies and dogs in South Carolina

Looking for a Mastiff puppy or dog in South Carolina? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff in South Carolina Search for a Mastiff puppy or dog Mastiff puppies and dogs in South Carolina cities Mastiff shelters and rescues in South Carolina Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in South Carolina

Below are our newest added Mastiffs available for adoption in South Carolina. To see more adoptable Mastiffs in South Carolina, use the search tool below to enter specific criteria!
We'll also keep you updated on Sadie's adoption status with email updates.
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Sadie

Mastiff

Female, 3 yrs
Abbeville, SC
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
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We'll also keep you updated on Monster Paws's adoption status with email updates.
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Monster Paws

Mastiff

Female, Adult
Williamston, SC
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, House-trained,
Story
Monster Paws is a 115lb female 3yr old Boerboel (South African Mastiff) looking for a forever home. She came into foster care after her owner suffered a brain injury and could no longer care for her. She a low energy, calm companion and would thrive in a peaceful home. Crate trained and house trained. Great with kids, other dogs of all sizes, cats, and even chickens. Giant breed experience preferred. Detailed secondary application required and vet references will be checked.

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We'll also keep you updated on 89383A Goliath's adoption status with email updates.
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89383A Goliath

Mastiff

Male, 1 yr 7 mos
North Charleston, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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We'll also keep you updated on Bear's adoption status with email updates.
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Bear

Mastiff

Female, 10 yrs 3 mos
Anderson, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
Meet Bear! Bear is a 10 year old Mastiff mix. Bear is looking for a forever cuddle buddy.Some fun facts about Bear :Profession : Ultimate cuddle bugFavorite hobby : Stealing your heartFavorite song : Forever youngStop by and ask about Bear at Anderson Paws from 12pm to 5pm on M,T,TH,F,SA!

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We'll also keep you updated on Bugs URGENT SUPER HERO NEEDED!'s adoption status with email updates.
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Bugs URGENT SUPER HERO NEEDED!

Mastiff/American Staffordshire Terrier

Male, Young
columbia, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, House-trained,
Story
Meet Bugs, URGENT HELP NEEDED FIR THIS SUPER SWEET BUT SCARED BOY! After all the progress Bugs has made in just a short amount of time he is still at risk of being euthanized It's one of the hardest things for staff & volunteers. Sometimes love isn't enough, love can't save them from an overcrowded shelter where animals keep pouring in. We are hoping this touches someone heart this boy deserves so more. Can’t imagine what’s he’s been through. We hope this newfound confidence wasn't for nothing & Bugs absolutely did his part, and now he needs your help.PLEASE HIRRY TEXT KAREN 4136298152

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We'll also keep you updated on Nala's adoption status with email updates.
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Nala

Mastiff/Labrador Retriever

Female, Young
Blacksburg, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Not good with cats, House-trained,
Story
Meet Nala! Breed: mastiff/lab mix. Age: est 4 years, est birthdate 1/22/2021 Weight: approx 65ish lbs. Training: leash, crate and housetrained. She also knows sit and down and eager to learn more. She is very food motivated which is a plus! Good with other dogs/cats? Yes to dogs, but no cats. Good with adults/kids? Nala is very loyal but it's takes her a little bit to warm up to new people. She is protective of her people. She is great with kids, however we feel she would do best in a home without many visitors, or the ability to put her up when you have company. Personality: shy/reserved in New situations. She is playful but also loves to cuddle. Nala is very loyal and protective of the people she loves. She loves to play with other dogs. She LOVES water. Nala is spayed, microchipped, heartworm negative & current on vaccinations and preventatives. If interested in adding Nala to your family, please message for an adoption application! Adoption fee: $75September 28, 2025, 7:06 pm

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in South Carolina.

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Mastiff puppies and dogs in South Carolina cities

Mastiff Puppies near me Mastiff in Abbeville Mastiff in Aiken Mastiff in Anderson Mastiff in Barnwell Mastiff in Batesburg Leesville Mastiff in Beaufort Mastiff in Belton Mastiff in Bennettsville Mastiff in Bluffton Mastiff in Camden Mastiff in Cayce Mastiff in Charleston Mastiff in Cheraw Mastiff in Chester Mastiff in Clemson Mastiff in Clinton Mastiff in Clover Mastiff in Columbia Mastiff in Conway Mastiff in Darlington Mastiff in Dillon Mastiff in Easley Mastiff in Edgefield Mastiff in Florence Mastiff in Fort Mill Mastiff in Fountain Inn Mastiff in Gaffney Mastiff in Georgetown Mastiff in Goose Creek Mastiff in Greenville Mastiff in Greenwood Mastiff in Greer Mastiff in Hanahan Mastiff in Hartsville Mastiff in Hilton Head Island Mastiff in Hollywood Mastiff in Irmo Mastiff in Isle of Palms Mastiff in Lake City Mastiff in Lancaster Mastiff in Laurens Mastiff in Lexington Mastiff in Marion Mastiff in Mauldin Mastiff in Moncks Corner Mastiff in Mount Pleasant Mastiff in Mullins Mastiff in Myrtle Beach Mastiff in Newberry Mastiff in North Augusta Mastiff in North Charleston Mastiff in North Myrtle Beach Mastiff in Orangeburg Mastiff in Port Royal Mastiff in Rock Hill Mastiff in Seneca Mastiff in Simpsonville Mastiff in Spartanburg Mastiff in Summerville Mastiff in Sumter Mastiff in Surfside Beach Mastiff in Tega Cay Mastiff in Travelers Rest Mastiff in Union Mastiff in Walterboro Mastiff in West Columbia Mastiff in York

Mastiff shelters & rescues in South Carolina

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in South Carolina. Browse these Mastiff rescues and shelters below.

Here are a few organizations

Shelter

Charleston Animal Society

2455 Remount Road, North Charleston , SC 29406

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Shelter

Hallie Hill Animal Sanctuary

5604 New Road, Hollywood, SC , SC 29449

Pet Types: cats, dogs, small animals

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog ?

We've got all the info you need on adopting and caring for a Mastiff puppy . Check out the links below for everything you ever wanted to know about Mastiff puppies and adults .

Mastiff information

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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