Mastiff Adoption in South Carolina: Mastiff Puppies for Sale in South Carolina

Adopt a Mastiff near you in South Carolina

Below are our newest added Mastiffs available for adoption in South Carolina. To see more adoptable Mastiffs in South Carolina, use the search tool below to enter specific criteria!

Chase $85 Fostered

Mastiff

Male, 11 mos

Seneca, SC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

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Laila

Mastiff

Female, Adult

Simpsonville, SC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats, House-trained,

Story

She loves kids, but has never met or spent time with babies though. Totally fine with cats and all kinds of little creatures. Good with all dogs, breed, size, etc. not all dogs appreciate her energy and size, so some personalities just don’t click. Tall and stout 95 lb baby with big personality. A velcro doggie who will always say yes to cuddles and no to sleeping anywhere but in bed with you. Food motivated, so very easy to train, just stubborn. Loves being outside, always, no matter what the weather is. Always full of energy and loves meeting new people, but is taking gabapentin as needed for the excitement and some anxiety. Loves car rides, to literally anywhere. Good with long and short trips. loves going to the vet, but hates the groomers. Best to trim her nails yourself lol. She is a true water baby. She loves taking a bath, playing in the rain, swimming in the lake, and has been to the beach.

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Bambi *A PRIORITY PET*

Mastiff/American Bulldog

Female, 9 mos

Columbia, SC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Hi, my name is Bambi, and I’ve been told I’m a strong little pup with a heart full of determination. I’ve been through a lot in my short life, but I don’t let it get me down—I love life too much!My front paws are a little different, and sometimes they buckle when I put weight on them. My back legs didn’t work at all when I was tiny, but now I’m building strength every day. Sometimes I can even stand tall on my back legs for a moment, and my foster mom cheers me on every time. The doctor says there are no limits to what I might accomplish—it’s all up to me!I don’t particularly enjoy my “bike pedaling” exercises (a puppy riding a bike—can you imagine?), but I do them because they help me grow stronger. In between workouts, I love tug-of-war, chewing on my ball, and being curious about the fluffy cats who live with me. I also adore kids and think they’re wonderful.At the end of the day, I like to snuggle close and drift off to sleep with my person nearby. I may move differently than other dogs, but I have the same love, joy, and spirit as any puppy—I just need someone special to believe in me.Could you be the one to cheer me on as I keep discovering all the amazing things I can do?I am a Priority Pet!Pawmetto Lifeline is offering FREE basic medical care for LIFE for Bambi-all included services listed below!Annual exam for life at Pawmetto LifelineCore Vaccines for life at Pawmetto LifelineFree annual HW test for life at Pawmetto LifelineCost of medications plus 10% (*doesn`t include HW/Flea prevention) from Pawmetto LifelineMy adoption fee includes up-to-date vaccinations, dewormer, and heartworm/flea prevention. Plus, a microchip that is already registered to you! What more could you ask for?If my bio shows “Spay/Neutered” with a checkmark, I have already been altered; if you do not see this listed, my surgery is still scheduled and a refundable spay/neuter deposit will be required, which will be returned within 24 hours after my procedure is completed.If you`d like to meet me, please fill out an application on our website, PawmettoLifeline.org.Adoptions are by appointment Tuesday through Thursday. On Fridays and Saturdays, you’re welcome to walk in anytime between 10:00am and 5:00pm. Please note that we’re closed for adoptions on Sundays and Mondays.

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Nala

Mastiff/Labrador Retriever

Female, Young

Blacksburg, SC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Not good with cats, House-trained,

Story

Meet Nala! Breed: mastiff/lab mix. Age: est 4 years, est birthdate 1/22/2021 Weight: approx 65ish lbs. Training: leash, crate and housetrained. She also knows sit and down and eager to learn more. She is very food motivated which is a plus! Good with other dogs/cats? Yes to dogs, but no cats. Good with adults/kids? Nala is very loyal but it's takes her a little bit to warm up to new people. She is protective of her people. She is great with kids, however we feel she would do best in a home without many visitors, or the ability to put her up when you have company. Personality: shy/reserved in New situations. She is playful but also loves to cuddle. Nala is very loyal and protective of the people she loves. She loves to play with other dogs. She LOVES water. Nala is spayed, microchipped, heartworm negative & current on vaccinations and preventatives. If interested in adding Nala to your family, please message for an adoption application! Adoption fee: $75March 7, 2026, 4:10 pm

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Emily

Mastiff/Mixed Breed (Medium)

Female, 4 yrs 2 mos

Lexington, SC

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with kids, Good with dogs, Good with cats, House-trained,

Story

Adopt Emily! 🐾 Emily is a 3 y/o mastiff mix of medium build. She is lower energy and loves to cuddle. While Emily is dog social, she prefers laid back non playful dogs who meet her same energy. She was very undersocialized and it’s hard to say if she ever lived in a home prior to her foster home. She prefers a quiet home where she can feel safe and relax. She struggled with fear more in the beginning than now. She is being fostered by a professional dog trainer so she has come a long way. She did well with her housemate that recently passed away. That has caused her a little anxiety as she misses her very much. 😔 Emily came into Columbia Animal Services as a stray. She was terrified in her kennel and at risk of euthanasia, so the behavior specialist decided to take her home to foster. ♥️ Emily has been well mannered and polite in her foster home and has enjoyed lounging, eating, playing, and doing enrichment activities. Emily’s adoption comes with free behavior coaching services from Columbia K9 training and behavior! 👍 She is about 40 pounds, medium build, spayed, microchipped and fully vetted. She required eye surgery that was done and she has completely healed. She is the perfect lap dog.

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Titan

Mastiff

Male, 11 yrs 10 mos

Hollywood, SC, SC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Titan is a gentle and shy creature who has not been socialized much. He feels quite anxious in unfamiliar environments, yet with time, he could become more comfortable. He has a deep affection for toys. To learn more about this handsome fellow, please fill out an application.

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Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in South Carolina.

Mastiff puppies and dogs in South Carolina

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Below are our newest added Mastiffs available for adoption in South Carolina. To see more adoptable Mastiffs in South Carolina, use the search tool below to enter specific criteria!

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Mastiff puppies and dogs in South Carolina

Jump to:

Adopt a Mastiff near you in South Carolina

Below are our newest added Mastiffs available for adoption in South Carolina. To see more adoptable Mastiffs in South Carolina, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in South Carolina cities

Mastiff shelters & rescues in South Carolina

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics