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Mastiff puppies and dogs in South Carolina

Looking for a Mastiff puppy or dog in South Carolina? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff in South Carolina Search for a Mastiff puppy or dog Mastiff puppies and dogs in South Carolina cities Mastiff shelters and rescues in South Carolina Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in South Carolina

Below are our newest added Mastiffs available for adoption in South Carolina. To see more adoptable Mastiffs in South Carolina, use the search tool below to enter specific criteria!
We'll also keep you updated on Rumsey's adoption status with email updates.
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Rumsey

Mastiff/Mixed Breed (Medium)

Male, 2 yrs
Greenville, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
Found Address Rosalee Dr Piedmont, SC 29673 Greenville

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We'll also keep you updated on 90851a Goliath's adoption status with email updates.
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90851a Goliath

Mastiff

Male, 1 yr 8 mos
North Charleston, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
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We'll also keep you updated on Bugs URGENT SUPER HERO NEEDED!'s adoption status with email updates.
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Bugs URGENT SUPER HERO NEEDED!

Mastiff/American Staffordshire Terrier

Male, Young
columbia, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, House-trained,
Story
Meet Bugs, URGENT HELP NEEDED FIR THIS SUPER SWEET BUT SCARED BOY! After all the progress Bugs has made in just a short amount of time he is still at risk of being euthanized It's one of the hardest things for staff & volunteers. Sometimes love isn't enough, love can't save them from an overcrowded shelter where animals keep pouring in. We are hoping this touches someone heart this boy deserves so more. Can’t imagine what’s he’s been through. We hope this newfound confidence wasn't for nothing & Bugs absolutely did his part, and now he needs your help.PLEASE HIRRY TEXT KAREN 4136298152

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We'll also keep you updated on Nala's adoption status with email updates.
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Nala

Mastiff/Labrador Retriever

Female, Young
Blacksburg, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Not good with cats, House-trained,
Story
Meet Nala! Breed: mastiff/lab mix. Age: est 4 years, est birthdate 1/22/2021 Weight: approx 65ish lbs. Training: leash, crate and housetrained. She also knows sit and down and eager to learn more. She is very food motivated which is a plus! Good with other dogs/cats? Yes to dogs, but no cats. Good with adults/kids? Nala is very loyal but it's takes her a little bit to warm up to new people. She is protective of her people. She is great with kids, however we feel she would do best in a home without many visitors, or the ability to put her up when you have company. Personality: shy/reserved in New situations. She is playful but also loves to cuddle. Nala is very loyal and protective of the people she loves. She loves to play with other dogs. She LOVES water. Nala is spayed, microchipped, heartworm negative & current on vaccinations and preventatives. If interested in adding Nala to your family, please message for an adoption application! Adoption fee: $75September 28, 2025, 7:06 pm

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We'll also keep you updated on Emily's adoption status with email updates.
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Emily

Mastiff/Mixed Breed (Medium)

Female, 3 yrs 11 mos
Lexington, SC
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained,
Story
Adopt Emily! 🐾 Emily is a 3 y/o mastiff mix of medium build. She is lower energy and loves to cuddle. While Emily is dog social, she prefers laid back non playful dogs who meet her same energy. She was very undersocialized and it’s hard to say if she ever lived in a home prior to her foster home. She prefers a quiet home where she can feel safe and relax. She struggled with fear more in the beginning than now. She is being fostered by a professional dog trainer so she has come a long way. She did well with her housemate that recently passed away. That has caused her a little anxiety as she misses her very much. 😔 Emily came into Columbia Animal Services as a stray. She was terrified in her kennel and at risk of euthanasia, so the behavior specialist decided to take her home to foster. ♥️ Emily has been well mannered and polite in her foster home and has enjoyed lounging, eating, playing, and doing enrichment activities. Emily’s adoption comes with free behavior coaching services from Columbia K9 training and behavior! 👍 She is about 40 pounds, medium build, spayed, microchipped and fully vetted. She required eye surgery that was done and she has completely healed. She is the perfect lap dog.

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We'll also keep you updated on Titan's adoption status with email updates.
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Titan

Mastiff

Male, 11 yrs 7 mos
Hollywood, SC, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
Titan is a gentle and shy creature who has not been socialized much. He feels quite anxious in unfamiliar environments, yet with time, he could become more comfortable. He has a deep affection for toys. To learn more about this handsome fellow, please fill out an application.

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in South Carolina.

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Mastiff puppies and dogs in South Carolina cities

Mastiff Puppies near me Mastiff in Abbeville Mastiff in Aiken Mastiff in Anderson Mastiff in Barnwell Mastiff in Batesburg Leesville Mastiff in Beaufort Mastiff in Belton Mastiff in Bennettsville Mastiff in Bluffton Mastiff in Camden Mastiff in Cayce Mastiff in Charleston Mastiff in Cheraw Mastiff in Chester Mastiff in Clemson Mastiff in Clinton Mastiff in Clover Mastiff in Columbia Mastiff in Conway Mastiff in Darlington Mastiff in Dillon Mastiff in Easley Mastiff in Edgefield Mastiff in Florence Mastiff in Fort Mill Mastiff in Fountain Inn Mastiff in Gaffney Mastiff in Georgetown Mastiff in Goose Creek Mastiff in Greenville Mastiff in Greenwood Mastiff in Greer Mastiff in Hanahan Mastiff in Hartsville Mastiff in Hilton Head Island Mastiff in Hollywood Mastiff in Irmo Mastiff in Isle of Palms Mastiff in Lake City Mastiff in Lancaster Mastiff in Laurens Mastiff in Lexington Mastiff in Marion Mastiff in Mauldin Mastiff in Moncks Corner Mastiff in Mount Pleasant Mastiff in Mullins Mastiff in Myrtle Beach Mastiff in Newberry Mastiff in North Augusta Mastiff in North Charleston Mastiff in North Myrtle Beach Mastiff in Orangeburg Mastiff in Port Royal Mastiff in Rock Hill Mastiff in Seneca Mastiff in Simpsonville Mastiff in Spartanburg Mastiff in Summerville Mastiff in Sumter Mastiff in Surfside Beach Mastiff in Tega Cay Mastiff in Travelers Rest Mastiff in Union Mastiff in Walterboro Mastiff in West Columbia Mastiff in York

Mastiff shelters & rescues in South Carolina

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in South Carolina. Browse these Mastiff rescues and shelters below.

Here are a few organizations

Shelter

Greenville County Animal Care Services

328 Furman Hall Rd, Greenville , SC 29609

Pet Types: cats, dogs

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Rescue

Mercy Rescue Haven

Blacksburg , SC 29702

Pet Types: cats, dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog ?

We've got all the info you need on adopting and caring for a Mastiff puppy . Check out the links below for everything you ever wanted to know about Mastiff puppies and adults .

Mastiff information

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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