Adopt

Neapolitan Mastiff puppies and dogs in Denver, Colorado

Looking for a Neapolitan Mastiff puppy or dog in Denver, Colorado? Adopt a Pet can help you find an adorable Neapolitan Mastiff near you.

Picture of Neapolitan Mastiff

Adopt a Neapolitan Mastiff near you in Denver, Colorado

These Neapolitan Mastiffs are available in Denver, Colorado.
We'll also keep you updated on Zen's adoption status with email updates.
Photo of Zen

Zen

Neapolitan Mastiff Mastiff

Male, 7 yrs 3 mos
Boulder, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with dogs, Needs experienced adopter, Spayed or Neutered, Shots are up-to-date,
Story
Zen is a 6-year-old male Neo Mastiff mix who’s as big-hearted as he is big in stature. Rescued from a shelter after his previous owners surrendered him for being “too big,” Zen is now on the hunt for his forever home where he can truly shine. Zen is a sweet, playful giant with a lot of energy for his breed. He’s very intelligent and learns quickly, making him a joy to train. However, Zen prefers to be the only dog in the home; he can get jealous and aggressive with other dogs, wanting all the attention for himself. When he's your one and only, he’s incredibly loving and will shower you with affection. Though he’s not reactive to other dogs on leash, Zen does best in a home without canine companions. He appreciates careful introductions to new people, especially those who approach unexpectedly. Zen’s ideal owner will be someone experienced with his breed and capable of continuing his training and socialization. If you’re ready to welcome a devoted and energetic companion into your life, Zen could be the perfect fit. He’s looking for a loving home where he can be the center of attention and enjoy all the love he has to give!
We'll also keep you updated on Moose's adoption status with email updates.
Photo of Moose

Moose

Neapolitan Mastiff Neapolitan Mastiff

Male, 9 mos
Denver, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, Spayed or Neutered,
Story
Meet Moose! ✔️good with kids ✔️ good with dogs ✔️ neutered The most beautiful, stunning, perfectly well behaved gentle giant !! Moose is in doggy daycare and has proven himself a perfect gentleman. He was actually purchased from a breeder as a puppy, and the family has a baby on the way, and do not have the time to commit to moose, which is why they trusted us to find him a wonderful and suitable forever home. He's neutered, UTD on vaccines , microchipped , walks beautifully on leash and eats 8 cups of food a day! https://new.shelterluv.com/matchme/adopt/BCAR/Dog Transport is an additional $185

Or, how about these Neapolitan Mastiffs in cities near Denver, Colorado

These Neapolitan Mastiffs are available for adoption close to Denver, Colorado.
We'll also keep you updated on Zen's adoption status with email updates.
Photo of Zen

Zen

Neapolitan Mastiff Mastiff

Male, 7 yrs 3 mos
Boulder, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with dogs, Needs experienced adopter, Spayed or Neutered, Shots are up-to-date,
Story
Zen is a 6-year-old male Neo Mastiff mix who’s as big-hearted as he is big in stature. Rescued from a shelter after his previous owners surrendered him for being “too big,” Zen is now on the hunt for his forever home where he can truly shine. Zen is a sweet, playful giant with a lot of energy for his breed. He’s very intelligent and learns quickly, making him a joy to train. However, Zen prefers to be the only dog in the home; he can get jealous and aggressive with other dogs, wanting all the attention for himself. When he's your one and only, he’s incredibly loving and will shower you with affection. Though he’s not reactive to other dogs on leash, Zen does best in a home without canine companions. He appreciates careful introductions to new people, especially those who approach unexpectedly. Zen’s ideal owner will be someone experienced with his breed and capable of continuing his training and socialization. If you’re ready to welcome a devoted and energetic companion into your life, Zen could be the perfect fit. He’s looking for a loving home where he can be the center of attention and enjoy all the love he has to give!
We'll also keep you updated on Moose's adoption status with email updates.
Photo of Moose

Moose

Neapolitan Mastiff Neapolitan Mastiff

Male, 9 mos
Denver, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, Spayed or Neutered,
Story
Meet Moose! ✔️good with kids ✔️ good with dogs ✔️ neutered The most beautiful, stunning, perfectly well behaved gentle giant !! Moose is in doggy daycare and has proven himself a perfect gentleman. He was actually purchased from a breeder as a puppy, and the family has a baby on the way, and do not have the time to commit to moose, which is why they trusted us to find him a wonderful and suitable forever home. He's neutered, UTD on vaccines , microchipped , walks beautifully on leash and eats 8 cups of food a day! https://new.shelterluv.com/matchme/adopt/BCAR/Dog Transport is an additional $185
We'll also keep you updated on Gina's adoption status with email updates.
Photo of Gina

Gina

Neapolitan Mastiff Cane Corso

Female, 8 mos
Boulder, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained, Shots are up-to-date,
Story
She is 80% neopolitan mastiff and 20% Cane Corso. She is 7 Months old and 90 pounds. She is a very wiggly and happy puppy with so much extra skin and the cutest butt wrinkles you have ever seen. She was born from a pregnant neopolitan mother we rescued from the shelter and when we got the DNA back and found out the puppies were 100% mastiff that was pretty exciting! She is great with other dogs, she likes to play a lot and she has been around small dogs but she may play a little rough for tiny ones. She has been around cats but occasionally tries to chase. She is extremely affectionate and cuddly. She is crate trained and pretty well potty trained. To excellent home only, please tell me about yourself.

These pups are in Denver, Colorado too!

Below are our newest added Neapolitan Mastiffs available for adoption in Denver, Colorado. To see more adoptable Neapolitan Mastiffs in Denver, Colorado, use the search tool below to enter specific criteria!
We'll also keep you updated on Chevy's adoption status with email updates.
Photo of Chevy

Chevy

Great Dane

Female, Adult
Lakewood, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with kids, Not good with dogs, Not good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
For more information about this Dane, please visit our website at https://rmgreatdane.org. Adoption Applications link can be found on the home page. Updated 11-17-2025 Meet Chevy, a stunning merle Great Dane with a soft heart, a goofy spirit, and a journey that’s taken a lot of courage. At 5 years old, Chevy has made incredible progress in professional training, and she’s ready to find a patient, experienced family who can continue helping her grow. Personality Chevy is a shy girl at first, especially with new people and new experiences. She startles easily and can be fearful, but once she feels safe, her true personality shines. With her trusted humans, she transforms into a big, affectionate snugglebug who loves belly rubs, couch cuddles, and lounging on her back like a silly, happy seal. She’s a Velcro dog, a world-class leaner, and will happily wiggle right into your lap if you let her. She’s playful too—zoomies, rolling in the grass, and ripping squeakers out of toys are among her favorite hobbies. Training & Progress Chevy is house trained, crate trained, and knows all her basics: sit, down, come, stay, and off. She’s very treat-motivated and responds beautifully in controlled training environments. Her biggest challenge is her fear of people and dogs. Outdoors, she may bark, snap, or lunge when scared—and strangers, sudden noises, or unfamiliar dogs can be overwhelming. But with a professional trainer, she has been calm, neutral, and noticeably improving. Her foster family reports consistent progress, especially with careful, structured introductions. Chevy will absolutely thrive with a family committed to continuing her positive-reinforcement training, managing her environment, and helping her confidence grow at her pace. Ideal Home Chevy’s perfect family will offer: A quiet, predictable home with minimal surprises A fenced yard or outdoor space for zoomies and grass-rolling No other dogs or pets   Adults only, or possibly older dog-savvy teens Experience with fearful or reactive dogs (or willingness to learn) Compassion, structure, patience, and consistency She bonds deeply with her people and can be anxious when separated, but she’s getting much better about calmly settling in her kennel when home alone. Other Good Stuff LOVES car rides and will hop right into the back seat without hesitation Non-destructive in the home (other than defeating her kennel bedding!) Sleeps in the bed and loves snuggling Very gentle with food—she’ll wait for permission before eating Healthy overall, with one tooth (a fang) that will need removal &#226&#157&#164&#239&#184&#143 Why You’ll Love Her Chevy is an incredibly loving, sensitive girl who just needs someone that believes in her. She may take weeks to fully settle in, but once she does, she gives her whole heart. Her goofy zoomies, her wiggly cuddle demands, her brave steps forward in training—these moments will make you fall in love with her over and over. If you’re looking for a devoted companion and are ready to help a sweet, fearful Dane blossom into her best self, Chevy may be the dog you’ve been waiting for. More about Chevy: Great Dane Experience Required Housetrained:Yes  Crate trained: Yes Needs a calm home – dog savvy adults and teens only No dogs – has shown reactivity from a distance No cats – high prey drive Professional training in process Fearful and anxious around new people – needs slow introductions Are you interested in adopting or fostering-to-adopt Chevy, reach out to Candice at placements@rmgreatdane.org.December 30, 2025, 1:01 pm
We'll also keep you updated on Loki's adoption status with email updates.
Photo of Loki

Loki

Great Dane

Male, 4 yrs 1 mo
Denver, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
 Meet Loki At 135 pounds of pure love and personality, Loki is a 4-year-old Great Dane looking for his forever home! He’s a big sweetheart who’s powered by snuggles and thrives when he can be close to his people—so he’s hoping to find a human who works from home and doesn’t mind a constant cuddle buddy. Despite his size, Loki still gets the zoomies and loves to romp around when the mood strikes! He’s crate and potty trained, though he’ll let you know (loudly!) if he’s put in a crate without a comfy bed—this guy loves his cozy spots. Loki can be a little cautious when meeting new people and may growl at first, but once he warms up, he’s full of affection—offering endless kisses, hugs, and heart-melting loyalty.He would do well in a home with or without another dog. Because of his size and sensitive nature, a home with Great Dane experience is highly recommended. Loki also has a high prey drive, so consistent leash training is a must to help him stay focused and safe on walks. If you’re looking for a big-hearted companion who will fill your home with love, laughter, and the occasional zoomie, Loki might just be your perfect match. ##2565971##
We'll also keep you updated on Duke's adoption status with email updates.
Photo of Duke

Duke

Great Dane

Male, Young
Boulder, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Spayed or Neutered, Shots are up-to-date,
Story
Meet Duke! Duke is a new rescue to Ace of Hearts and we are still learning more about him! What we do know is that he is very timid right now and still learning to trust his people... however, like your typical dane he has been nothing but gentle and friendly for this entire process.

Search for a Neapolitan Mastiff puppy or dog

Use the search tool below to browse adoptable Neapolitan Mastiff puppies and adults Neapolitan Mastiff in Denver, Colorado.

Neapolitan Mastiff puppies and dogs in nearby cities

Related breeds in Denver, Colorado

Neapolitan Mastiff shelters & rescues in Denver, Colorado

There are animal shelters and rescues that focus specifically on finding great homes for Neapolitan Mastiff puppies in Denver, Colorado. Browse these Neapolitan Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Rescue

6 miles

Ace of Hearts Dog Rescue - CO Transport Stop

711 Walnut St, Boulder, CO 80203

Pet Types: dogs

More an arrow icon

Rescue

25.1 miles

Redline Rescue

Boulder, CO 80301

Pet Types: cats, dogs

More an arrow icon

Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

magnifying glass with cat and dog

Want to learn more about adopting a Neapolitan Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Neapolitan Mastiff puppy. Check out the links below for everything you ever wanted to know about Neapolitan Mastiff puppies and adults.

Neapolitan Mastiff basics

clipboard with list

Where do Neapolitan Mastiffs come from? How many types of Neapolitan Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Neapolitan Mastiff.

Learn More an arrow icon