Neapolitan Mastiff Adoption in Saint Louis, MO: Neapolitan Mastiff Puppies for Sale in Saint Louis, MO

Adopt a Neapolitan Mastiff near you in Saint Louis, Missouri

We don't see any Neapolitan Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Neapolitan Mastiffs in cities near Saint Louis, Missouri

These Neapolitan Mastiffs are available for adoption close to Saint Louis, Missouri.

Gianna

Neapolitan Mastiff

Female, Young

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

You can fill out an adoption application online on our official website.We partnered with Bull Mastiff Rescuers Inc. who recently saved this unique beauty from being passed around in Michigan. Her double cherry eye has been removed and spay completed, so she is set to find a loving foster home with someone experienced in caring for Neos. We know Gianna plays well with another large male dog but we're still getting to know her personality and specific needs, so stay tuned for more updates. She’s a sweet girl, and we’re committed to finding the perfect match for her. Are you ready to give her the love and care she deserves?Visit this organization's web site to see any additional information available about this pet.December 28, 2024, 12:57 pm

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Anita

Neapolitan Mastiff

Female, Adult

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with kids, Good with dogs, House-trained, Spayed or Neutered,

Story

You can fill out an adoption application online on our official website.Miss Anita found herself abandoned in her owners garage went they moved. Several neighborhoods around her rallied to help her. Finally, a couple took her in to try and get her the right home on social media. When that didn't work they came to Mastino Rescue, Inc., to help and find her a home. She has been spayed and on 8/13/24 she had her cherry eye surgery removal. Anita is a great girl, loves her male foster but it took a couple days for her to warm up to her female foster. She will need time to settle into a new home. With slow introductions she started playing with her male foster Neo brother. If you are looking for a beautiful tawny girl, have the time/patience for Anita please go to our website at Mastino-rescue-inc.org and complete a family profile. Anita is being fostered in Arizona but to the perfect home transportation assistance can be provided. Visit this organization's web site to see any additional information available about this pet.November 5, 2024, 10:33 am

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Gracie

Neapolitan Mastiff

Female, Adult

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with kids, Not good with dogs, Not good with cats, House-trained,

Story

You can fill out an adoption application online on our official website.Gracie was another one that came to us from an Arkansas Shelter basically at the same time as Adolfo. She is another one that is severely underweight and heartworm possible. On June 24th, 2024 she will be receiving one of two back to back injections for HW treatment, the second on the 25th. In a month or went she get to be a healthy weight and under our Vets recommendation she will be spayed. Gracie wishes to be the only pet in the home, there seems to be no negotiating on that front. She requests the full attention of her humans. On the plus side, she loves car rides and won't leave your side on or off leash. If you believe you are the perfect match for our beautiful approximately 5 year old girl please go to our website at mastino-rescue-inc.org and complete a family profile. You won't be disappointed with this girl. Visit this organization's web site to see any additional information available about this pet.November 5, 2024, 10:33 am

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Bettina

Neapolitan Mastiff

Female, Adult

St. Louis, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Spayed or Neutered,

Story

You can fill out an adoption application online on our official website. Bettina was found as a stray and was brought into a Florida shelter before coming to Mastino Rescue. She is around 4-5 years old, and has recovered from heartworm, double cherry eye suurgery, entropion surgery, and spay surgery. She's an absolute gem and ready to find her forever home! We encourage you to apply for Bettina if you're interested: https://www.mastino-rescue-inc.org/familyprofile Visit this organization's web site to see any additional information available about this pet.November 5, 2024, 10:33 am

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Rinaldo

Neapolitan Mastiff

Male, Young

St. Louis, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

House-trained, Spayed or Neutered,

Story

You can fill out an adoption application online on our official website.UPDATE: Rinaldo's fur and weight is looking amazing thanks to the TLC he has received from his foster Mom. He is sweet and sassy, housebroken, has learned how to delicately take treats, manners when it comes to eating, and learning how to trust people. He loves his Vet but protective of his home, just like any good Neo should be. His only downfall is he does not do well with other dogs. So there will be no exceptions, RINALDO WILL BE THE ONLY PET IN THE HOME. A quiet home in the country is the perfect forever for our handsome boy. Please meet Rinaldo. An approximately 2 year old blue Neapolitan Mastiff. He found himself in a Houston Texas high kill shelter being brought in as a stray. A caring person in Arkansas saw his post which reminded her of a dog she owned and passed away. Having no idea he was a Neapolitan Mastiff had him shipped to her. When he arrived she realized she was not equipped to care for him. On June 29th, 2025, Rinaldo arrived at his foster home in Virginia. He is heart worm positive and his slow kill treatment has already started. His rear end is being treated for the flea infestation he suffered from. Underweight at just 118 pounds his foster will definitely be putting groceries on that solid Mastino frame. He knows sit and down but his leash manners surely need to be worked on which our foster is more than experienced to handle. We know he rides well in a vehicle and seems to be a happy boy. We will do updates on our Facebook page as they come in from his foster home. If you are interested in Rinaldo or any of the other Neos in need please go to our website and check them out. Any questions please don't hesitate to ask. MRI is just as excited as Rinaldo to find his forever home. Mastino-rescue-inc.org Visit this organization's web site to see any additional information available about this pet.October 13, 2025, 5:57 pm

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Livia

Neapolitan Mastiff

Female, Adult

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, Not good with cats, House-trained, Spayed or Neutered,

Story

You can fill out an adoption application online on our official website. Our Royal Mastino, Livia, is doing well in her experienced foster home, but continues to dream of a family and home of her own. Princess Livia (as she prefers to be called) is a fit 3 years old typical strong willed female Neapolitan Mastiff. She balances out her play time with heavily snoring napping. Preferably somewhere with a soft bed or thick blanket. Livia is housebroken and crate trained, though she will give you side-eye if the crate contains insufficient treats to lure her in. She is indeed a princess. Her ideal home would have a large male dog to play with and a fenced yard. Livia loves to patrol her yard snuffling and watching for anything new going on in her neighborhood. She is learning there is enough food and human attention in her foster homes so that she doesn't need to resource guard. She loves belly rubs, rump scratches and neck wrinkle massages and doesn't hesitate to request them from her favorite people. Due to her forward attitude and roughness Livia needs to be the ONLY PET in the household, NO EXCEPTIONS. She is learning leash manners as she is very strong on the leash when distracted. Livia is a lovely girl that bonds quickly with whomever she claims as her person. Visit this organization's web site to see any additional information available about this pet.October 17, 2025, 4:53 pm

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These pups are in Saint Louis, Missouri too!

Below are our newest added Neapolitan Mastiffs available for adoption in Saint Louis, Missouri. To see more adoptable Neapolitan Mastiffs in Saint Louis, Missouri, use the search tool below to enter specific criteria!

Fred

Great Dane

Male, 2 yrs 7 mos

St. Louis, MO

Size

(when grown) -

Details

Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Hey! I'm Fred. I'm a 2.5 year old Great Dane mix with a fun personality. I'm a bit of a goofball- typical for most Danes. I seem to do good with other dogs and recently became the father to 7 little pups. Thankfully, my parenting days are done and over with. I'm hoping for a loving family to take me home. If you're interested in adopting me, fill out an adoption application online at www.polkcountyhumanesociety.org/adopt where you will also find a link to reserve me for an appointment. Some pets are in foster homes or may already have an appointment scheduled, so the appointment is important to make sure I will be available to meet you when you come. Polk County Humane Society is located in Bolivar, Missouri, but also makes transports to the Denver, CO, Des Moines, IA and St. Louis areas twice monthly. For potential adopters in those areas, we can do a virtual visit using FaceTime or another app. Just request an appointment using the same link, but note that you want the visit to be virtual. We will call you at the time of the visit once it is confirmed. For long distance transports to Colorado and Iowa, there is an additional $100 fee to cover the cost of the transport ($65) and a health certificate from a veterinarian ($35). For transports to St. Louis, the additional fee is $50 to help cover gas. Going that last mile home for our sweet pets! All of our pets are neutered or spayed, have vaccinations appropriate for their age, treated with flea/tick/heartworm prevention, dewormed and dogs are also microchipped. #adoptdontshop ##2565696##

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Mae

Bullmastiff

Female, Adult

St Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

BASICS: Bullmastiff / female / 5 years old CHILDREN: Yes CATS: Unknown DOGS: Male dogs over 30lbs, with slow introduction and supervision PERSONALITY: Medium energy level; Very sweet and affectionate; Enjoys taking naps in the sun or on the couch, exploring outdoors in the yard, walking the neighborhood and LOVES hanging out with people. Loves men! TRAINING: Housebroken, leash trained, knows basic obedience and how to use a dog door SPECIAL NEEDS: None VETTING: Fully vaccinated, spayed, microchipped Ready to give Mae the forever home of her dreams? Fill out our Adoption Application, located The Bullpen Way Station & Sanctuary under the 'work with us' tab. We highly recommend that our potential adopters fill out an online application as soon as possible, as it greatly expedites the process of finding the right dog for your situation. Our dogs are available for adoption nationwide but preference is given to adopters willing to do an in-person meeting. Please understand that our dogs are not adopted on a first-come, first-served basis, but rather we strive for a "perfect placement" so we know that they will not be failed again.

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Panda

Great Dane Boxer

Male, 2 yrs 2 mos

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

WE ARE A TX-BASED RESCUE. THIS DOG IS CURRENTLY LOCATED IN TX AND WILL BE TRANSPORTED UPON ADOPTION. Please fill out an adoption application at haydudeequine.org 🐾 Pleased to meet you - I’m Panda! 🐾 Part marshmallow, part zoomie machine, and 100% good boy. I came in on the skinnier side (hey, rescue life isn’t exactly a buffet), but I’m filling out nicely thanks to regular meals, snacks and love... lots and lots of love!! At 2yrs and 70lbs I’m already the total package: housebroken, crate trained, and doggy-door certified. I love people of all sizes, though my big, playful energy is better matched with bigger kids and medium-to-large doggie siblings. Small pups might find my enthusiasm a little…extra. But don’t worry—I’m a gentleman and happily back off if another dog says “nah, bro.” (Even Chad’s grumpy old pit bull approves.) My hobbies? Oh, just the usual—water splashing, toy stealing (ahem…sharing), and epic backyard zoomies. I walk like a dream on leash and would love to be your partner for strolls, hikes, or jogs. Underneath all the silliness, I’m a soft-hearted guy who just wants a family to call my own. Someone to laugh at my antics, throw my toys, and remind me every day that I’m finally home. 🖤🤍 Apply today at haydudeequine.org and get ready to add a little Panda-monium to your life. I promise it comes with lots and lots of cherished moments and unlimited cuddles!!!

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Adopt a Neapolitan Mastiff near you in Saint Louis, Missouri

We don't see any Neapolitan Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Neapolitan Mastiffs in cities near Saint Louis, Missouri

These Neapolitan Mastiffs are available for adoption close to Saint Louis, Missouri.

These pups are in Saint Louis, Missouri too!

Below are our newest added Neapolitan Mastiffs available for adoption in Saint Louis, Missouri. To see more adoptable Neapolitan Mastiffs in Saint Louis, Missouri, use the search tool below to enter specific criteria!

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Neapolitan Mastiff basics

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Neapolitan Mastiff puppies and dogs in Saint Louis, Missouri

Learn More:

Adopt a Neapolitan Mastiff near you in Saint Louis, Missouri

We don't see any Neapolitan Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Neapolitan Mastiffs in cities near Saint Louis, Missouri

These Neapolitan Mastiffs are available for adoption close to Saint Louis, Missouri.

These pups are in Saint Louis, Missouri too!

Below are our newest added Neapolitan Mastiffs available for adoption in Saint Louis, Missouri. To see more adoptable Neapolitan Mastiffs in Saint Louis, Missouri, use the search tool below to enter specific criteria!

Search for a Neapolitan Mastiff puppy or dog

Neapolitan Mastiff puppies and dogs in nearby cities

Related breeds in Saint Louis, Missouri

Neapolitan Mastiff shelters & rescues in Saint Louis, Missouri

Looking for a specific shelter or rescue?

Want to learn more about adopting a Neapolitan Mastiff puppy or dog?

Neapolitan Mastiff basics

Neapolitan Mastiff basics