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Mastiff puppies and dogs in Simi Valley, California

Looking for a Mastiff puppy or dog in Simi Valley, California? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near Simi Valley, California Other pups in Simi Valley, California Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in Simi Valley, California Mastiff shelters and rescues in Simi Valley, California Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Simi Valley, California

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Simi Valley, California

These Mastiffs are available for adoption close to Simi Valley, California.
We'll also keep you updated on DEACON's adoption status with email updates.
Needs Home Fast
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DEACON

Mastiff Labrador Retriever

Male, 3 yrs 1 mo
Agoura, CA
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Spayed or Neutered,
Story
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We'll also keep you updated on ANGEL's adoption status with email updates.
Needs Home Fast
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ANGEL

Mastiff

Male, 3 yrs
Chatsworth, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
-

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We'll also keep you updated on Booker fka Sabook/Harley's adoption status with email updates.
Photo of Booker fka Sabook/Harley

Booker fka Sabook/Harley

Mastiff Mixed Breed (Large)

Male, 6 yrs 9 mos
Los Angeles, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Needs experienced adopter, Spayed or Neutered, Shots are up-to-date,
Story
Harley is a handsome dude who would love to be your one and only buddy. He has a messy story. A flaky woman pulled him out of a city shelter on a whim and then realized her senior dog and Harley were not going to be a good match. She was not up for really giving it a decent effort. She put him in boarding and walked away. He was eventually brought to us at our rescue ranch where he is currently living. He sees other dogs through the yard with no response but we definitely feel he is going to be best/happiest as an only dog. He’s happy to go on walks but he’s also just as happy to have a yard to sunbathe, toss around his toys and just watch over everything. He is not a guard dog. Have not seen him show any signs of being protective. He’s basically a big layback dude.

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We'll also keep you updated on SNOOPY's adoption status with email updates.
Needs Home Fast
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SNOOPY

Mastiff Cane Corso

Female, 9 mos
Chatsworth, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
-

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We'll also keep you updated on Ethel's adoption status with email updates.
Photo of Ethel

Ethel

Mastiff

Female, 2 yrs 8 mos
Woodland Hills, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
THIS IS A COURTESY POSTING, IF YOU ARE INTERESTED IN THIS DOG, PLEASE SEE CONTACT INFORMATION BELOW Ethel is a 2-1/2 year old Mastiff that was rescued from a very neglectful owner who starved her sister to death. She has been to a trainer for rehabilitation and is doing very well now. The Donor can no longer afford to keep her; she must find another place to go. At first meeting, you can notice traces of distrust and sadness in her eyes however, after a few minutes of interaction when she recognizes intention to offer love, she reveals her noble nature and expresses affection generously. She is a bit insecure in unfamiliar environments but very well-behaved. Tranquility defines her, she enjoys receiving affection and sunbathing during naps. As a typical Mastiff, Ethel possesses a guarding instinct which can cause her to react to passersby when she is home, outdoors she doesn’t care. She does get along with both dogs and humans, her preference is for peaceful surroundings, and her behavior reflects her desire for calmness and stability. Ethel weighs about 90 lbs, she is up to date on vaccines, spayed, housetrained and well-behaved. If you are interested in a companion that will be happy to spend long hours relaxing, Ethel is your girl. If you are interested in her, please contact Ronnie at (310) 804-1555.

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We'll also keep you updated on ZEUS's adoption status with email updates.
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ZEUS

Mastiff

Male, Young
Woodland Hills, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered,
Story
Meet Zeus!  Zeus is a handsome 3.5-year-old Cane Corso who was rescued alongside his sister, Zeus, from the West Valley Animal Shelter. This gentle giant weighs about 96 lbs and is full of love to give. Zeus is: &#226&#156&#133 Neutered &#226&#156&#133 Vaccinated &#226&#156&#133 Microchipped Scheduled for cherry eye surgery (both eyes) Zeus has a sweet, friendly personality. He does well with people and can get along with other dogs with proper introductions. Due to his size and breed, Zeus would do best in a home with experience handling Mastiff or other large breeds. If you’re interested in adopting or fostering to adopt Zeus, please contact the rescue. He’s ready to find his forever home where he can thrive and be loved!November 16, 2025, 2:02 am

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Simi Valley, California.

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Mastiff puppies and dogs in nearby cities

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Related breeds in Simi Valley, California

Bullmastiffs in Simi Valley, California Neapolitan Mastiffs in Simi Valley, California Saint Bernards in Simi Valley, California

Mastiff shelters & rescues in Simi Valley, California

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Simi Valley, California. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

8.2 miles

Los Angeles County: Agoura

29525 Agoura Rd., Agoura, CA 91301

Pet Types: cats, dogs, rabbits, small animals

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Shelter

8.9 miles

West Valley Animal Care Center - Los Angeles Animal Services

20655 Plummer Street, Chatsworth, CA 91311

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

8.9 miles

LA Animal Rescue

Los Angeles, CA 91311

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

9.5 miles

Adopt Me Rescue

21943 Ventura Blvd, Woodland Hills, CA 91367

Pet Types: dogs

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Rescue

10.5 miles

Melita's Dream Animal Rescue

21200 Oxnard St, #6492, Woodland Hills, CA 91365

Pet Types: dogs

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Shelter

15.2 miles

Los Angeles County: Castaic

31044 N. Charlie Canyon Rd., Castaic, CA 91384

Pet Types: cats, dogs, rabbits, small animals

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Shelter

15.6 miles

Ventura County Animal Services

600 Aviation Drive, Camarillo, CA 93010

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

16.9 miles

WEACT

Santa Clarita, CA 91354

Pet Types: dogs

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Shelter

17.8 miles

Paws for Life K9 Rescue

15321 Brand Blvd., Mission Hills, CA 91345

Pet Types: dogs

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Shelter

18 miles

East Valley Animal Care Center - Los Angeles Animal Services

14409 Vanowen Street, Van Nuys, CA 91405

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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