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Mastiff puppies and dogs in Simi Valley, California

Looking for a Mastiff puppy or dog in Simi Valley, California? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near Simi Valley, California Other pups in Simi Valley, California Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in Simi Valley, California Mastiff shelters and rescues in Simi Valley, California Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Simi Valley, California

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Simi Valley, California

These Mastiffs are available for adoption close to Simi Valley, California.
Special Needs
Photo of Cheddar

Cheddar

Mastiff

Male, 1 yr
Agoura Hilla, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, Needs special attention, Spayed or Neutered,
Story
Meet Cheddar! Cheddar is a 1 year old, 79 pound Mastiff mix with a heart as big as he is! This goofy, happy boy loves everyone he meets and gets along great with other dogs. Cheddar is a very special boy who is deaf, and he’ll need an adopter who is willing to understand him, and learn how to communicate with him in ways that work for him. This doesn’t stop him from being the loving, playful, silly boy that he is, it just means his forever family will need to take a little extra time to understand his world. We know the right person will see that his deafness is just one small part of what makes Cheddar so special. Cheddar is already catching on to his basic commands and is learning to sit politely for treats. He’s eager to please and would thrive with an adopter who is excited to continue his training, build a strong bond with him, and help him grow into the best boy he can be. When it’s time to play, Cheddar is all in! He loves having fun, but once he’s gotten his energy out, he’s more than happy to curl up on the couch and be your favorite cuddle buddy. Cheddar is up to date on vaccinations, microchipped, and neutered, so he’s ready to head home with his forever family. If you’re looking for a sweet, lovable companion who will fill your home with laughter, love, and plenty of goofy moments, Cheddar is your guy!

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Needs Home Fast
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FAMOUS

Mastiff

Male, 6 yrs 2 mos
Chatsworth, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Spayed or Neutered,
Story
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Needs Home Fast
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RICH

Mastiff

Male, 6 yrs 2 mos
Chatsworth, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
-

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NALA

Mastiff Rhodesian Ridgeback

Female, Young
Woodland Hills, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered,
Story
Meet Nala – A Gentle Soul with a Heart of Gold Nala is a beautiful Boerboel/Rhodesian mix with a heart just as big as her smile. Rescued from Stanislaus Animal Services, she’s been given a second chance—and now she’s ready to find the forever home she truly deserves. At around 3 years old and 65 lbs, Nala is the perfect mix of playful, affectionate, and loving. She’s spayed, fully vaccinated, and microchipped—completely ready to start her next chapter. Nala absolutely loves being around people and thrives on companionship. She has a sweet and loving nature and gets along well with other dogs, making her a wonderful fit for many homes. She’s currently working with trainers and continuing to build confidence and social skills—showing every day just how much potential she has to be an incredible lifelong companion. All Nala needs now is someone to give her the love and stability she’s been waiting for.  Nala is available for: • Adoption • Foster-to-Adopt If you’re ready to open your heart to a loyal, loving dog, Nala is ready to meet you. Please contact the rescue for more information and to schedule a meet-and-greet.                         August 21, 2026, 11:14 pm

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*NAGEE

Mastiff Boxer

Male, 6 yrs 3 mos
Camarillo, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
-

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Needs Home Fast
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MOUSE

Mastiff Great Dane

Male, 3 yrs 4 mos
Van Nuys, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Spayed or Neutered,
Story
-

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Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Simi Valley, California.

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Mastiff puppies and dogs in nearby cities

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Related breeds in Simi Valley, California

Bullmastiffs in Simi Valley, California Neapolitan Mastiffs in Simi Valley, California Saint Bernards in Simi Valley, California

Mastiff shelters & rescues in Simi Valley, California

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Simi Valley, California. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

8.2 miles

Eastwood Ranch Foundation

28260 Dorothy Dr., Agoura Hilla, CA 91301

Pet Types: cats, dogs

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Shelter

8.9 miles

West Valley Animal Care Center - Los Angeles Animal Services

20655 Plummer Street, Chatsworth, CA 91311

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

10.5 miles

Melita's Dream Animal Rescue

21200 Oxnard St, #6492, Woodland Hills, CA 91365

Pet Types: dogs

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Shelter

15.6 miles

Ventura County Animal Services

600 Aviation Drive, Camarillo, CA 93010

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Shelter

18 miles

East Valley Animal Care Center - Los Angeles Animal Services

14409 Vanowen Street, Van Nuys, CA 91405

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Shelter

19.6 miles

Santa Paula Animal Rescue Center

705 E. Santa Barbara Street, Santa Paula, CA 93060

Pet Types: cats, dogs, rabbits, small animals

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Rescue

20.5 miles

Hank's Legacy Foundation

canyon country, CA 91387

Pet Types: cats, dogs

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Rescue

22.7 miles

Philozoia Animal Rescue

Santa Monica, CA 90401

Pet Types: dogs

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Shelter

24.7 miles

West L.A. Animal Care Center - Los Angeles Animal Services

11361 West Pico Blvd, Los Angeles, CA 90064

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

24.8 miles

Ace of Hearts Dog Rescue - CA

PO Box 2357, Beverly Hills, CA 90213

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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