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Great Dane puppies and dogs in Iowa

Looking for a Great Dane puppy or dog in Iowa? Adopt a Pet can help you find an adorable Great Dane near you.

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Adopt a Great Dane near you in Iowa

Below are our newest added Great Danes available for adoption in Iowa. To see more adoptable Great Danes in Iowa, use the search tool below to enter specific criteria!
We'll also keep you updated on Sequoia's adoption status with email updates.
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Sequoia

Great Dane/Rottweiler

Female, Puppy
South Amana, IA
Size
(when grown) Small 25 lbs (11 kg) or less
Details
Good with kids, Good with dogs,
Story
You can fill out an adoption application online on our official website.Sequoia and her adorable 8 littermates are a Great Dane/Rottweiler mix, and we also have a picture of their parents posted here on their profile.  The puppies have all been given "National Park" themed names!  They are from a local Iowa County family that had an accidental litter, and they recently reached out to Safe Haven asking for help with their 9 puppies that were born on 11/03/2025. There are 5 males and 4 females - with 7 of the puppies being black and 2 being tan.  We think they are all incredibly adorable and sweet, but suspect the two tan puppies will be chosen quickly - there is one male (Rocky) and one female (Sierra). These puppies have definitely been very well cared for and socialized, and came into Safe Haven on 12/17 to be examined by our veterinarian and receive their initial set of (6 week old) puppy vaccinations, deworming, and a microchip.  They returned to their home for now to continue nursing for a few more weeks and get proper socialization from their mom.  On January 1st they will return to Safe Haven for a puppy vaccine booster, as well as a kennel cough vaccine, another round of deworming, monthly heartworm and flea/tick preventative - and at this point the puppies will be just over 8 weeks old and will be weaned and be ready for adoption.  We are starting the process now of finding adoptive families in hopes that they will be able to go home soon after the first of the year.   Due to these puppies being a large breed puppy mix they will be adopted out on a spay/neuter contract - which means their adoptive families will sign a contract stating the puppies will be spayed/neutered by the time they are 9 months old. Families will be required to bring their puppy back to Safe Haven for us to spay/neuter when the puppy is between 6 to 9 months old, at no additional cost. The other option for each adoptive family would be to have the surgery done with their veterinarian at the family's own cost, and provide us proof of that surgery once complete. The ideal adoptive family will be committed to taking a puppy obedience class to get started on the right foot - they will need a family that can commit to continue proper socialization and also all the work that goes into house-training a puppy, which requires a lot of patience and persistence with working on a schedule. Puppies need to be taken outside frequently - as often as every 3 to 4 hours in the beginning. So an ideal home for these puppies will be one where they won't have long periods of time during the day spent alone during the first few months, so they can have the best chance of successful housetraining and have years of wonderful love and devotion to focus on!  If you are interested in adopting Sequoia (one of the female black puppies) or one of her littermates, please fill out an adoption application as the first step of the adoption process.  If you know you would like a certain puppy please describe the specific puppy on the application. Once the application has been approved, a Safe Haven volunteer will be in contact to set up the adoption. Visit this organization's web site to see any additional information available about this pet.December 23, 2025, 10:18 am

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We'll also keep you updated on Donatello's adoption status with email updates.
Photo of Donatello

Donatello

Great Dane

Male, Adult
Des Moines, IA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
-
Story
HOW TO ADOPT: This animal is available for adoption by appointment. To schedule a time to meet this animal, please email meetme@arl-iowa.org.---- A lounger who can't get enough pets and wants to be touching his people at all times! - Likes toys and chews he can spending lots of time licking and chewing on; seems to prefer those to squeak or tug toys - Loves running around in his foster family's yard - Knows sit and shake, walks nicely on a leash, and is treat-motivated - Fully housetrained in his foster home and also does well in his crate; just remember that any dog may need time to get used to a new routine - Seems to feel more comfortable in his kennel/crate when his foster family is not home - His foster family says he tends to get nervous on car rides - Can be an introvert around other dogs and may prefer one-on-one interactions or smaller groups of dog friends who have a similar play style; may not be comfortable at dog parks or at large, dog-friendly events (dog intro recommended) - Young, noisy or busy children can be too much for him (mature home recommended) All adoptable dogs and puppies are spayed/neutered, microchipped and up to date on vaccinations (rabies and DA2PPV as appropriate for their age)The ARL's shelter software requires that we choose a primary breed for our dogs. Visual breed identification in dogs is unreliable, so for most dogs we are only guessing at primary breed. We get to know each dog as an individual and do our best to describe each of our dogs based on personality, not breed label. Primary Color: Black Secondary Color: White Weight: 85.5 Age: 3yrs 1mths 2wks

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We'll also keep you updated on Arches's adoption status with email updates.
Photo of Arches

Arches

Great Dane/Rottweiler

Male, Puppy
South Amana, IA
Size
(when grown) Small 25 lbs (11 kg) or less
Details
Good with kids, Good with dogs,
Story
You can fill out an adoption application online on our official website.Arches and his adorable 8 littermates are a Great Dane/Rottweiler mix, and we also have a picture of their parents posted here on their profile.  The puppies have all been given 'National Park' themed names!  They are from a local Iowa County family that had an accidental litter, and they recently reached out to Safe Haven asking for help with their 9 puppies that were born on 11/03/2025. There are 5 males and 4 females - with 7 of the puppies being black and 2 being tan.  We think they are all incredibly adorable and sweet, but suspect the two tan puppies will be chosen quickly - there is one male (Rocky) and one female (Sierra).These puppies have definitely been very well cared for and socialized, and came into Safe Haven on 12/17 to be examined by our veterinarian and receive their initial set of (6 week old) puppy vaccinations, deworming, and a microchip.  They returned to their home for now to continue nursing for a few more weeks and get proper socialization from their mom.  On January 1st they will return to Safe Haven for a puppy vaccine booster, as well as a kennel cough vaccine, another round of deworming, monthly heartworm and flea/tick preventative - and at this point the puppies will be just over 8 weeks old and will be weaned and be ready for adoption.  We are starting the process now of finding adoptive families in hopes that they will be able to go home soon after the first of the year.  Due to these puppies being a large breed puppy mix they will be adopted out on a spay/neuter contract - which means their adoptive families will sign a contract stating the puppies will be spayed/neutered by the time they are 9 months old. Families will be required to bring their puppy back to Safe Haven for us to spay/neuter when the puppy is between 6 to 9 months old, at no additional cost. The other option for each adoptive family would be to have the surgery done with their veterinarian at the family's own cost, and provide us proof of that surgery once complete.The ideal adoptive family will be committed to taking a puppy obedience class to get started on the right foot - they will need a family that can commit to continue proper socialization and also all the work that goes into house-training a puppy, which requires a lot of patience and persistence with working on a schedule. Puppies need to be taken outside frequently - as often as every 3 to 4 hours in the beginning. So an ideal home for these puppies will be one where they won't have long periods of time during the day spent alone during the first few months, so they can have the best chance of successful housetraining and have years of wonderful love and devotion to focus on! If you are interested in adopting Arches (one of the male black puppies) or one of his littermates, please fill out an adoption application as the first step of the adoption process.  If you know you would like a certain puppy please describe the specific puppy on the application. Once the application has been approved, a Safe Haven volunteer will be in contact to set up the adoption. Visit this organization's web site to see any additional information available about this pet.December 21, 2025, 1:50 pm

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We'll also keep you updated on Rainier's adoption status with email updates.
Photo of Rainier

Rainier

Great Dane/Rottweiler

Male, Puppy
South Amana, IA
Size
(when grown) Small 25 lbs (11 kg) or less
Details
Good with kids, Good with dogs,
Story
You can fill out an adoption application online on our official website.Rainier and his adorable 8 littermates are a Great Dane/Rottweiler mix, and we also have a picture of their parents posted here on their profile.  The puppies have all been given 'National Park' themed names!  They are from a local Iowa County family that had an accidental litter, and they recently reached out to Safe Haven asking for help with their 9 puppies that were born on 11/03/2025. There are 5 males and 4 females - with 7 of the puppies being black and 2 being tan.  We think they are all incredibly adorable and sweet, but suspect the two tan puppies will be chosen quickly - there is one male (Rocky) and one female (Sierra).These puppies have definitely been very well cared for and socialized, and came into Safe Haven on 12/17 to be examined by our veterinarian and receive their initial set of (6 week old) puppy vaccinations, deworming, and a microchip.  They returned to their home for now to continue nursing for a few more weeks and get proper socialization from their mom.  On January 1st they will return to Safe Haven for a puppy vaccine booster, as well as a kennel cough vaccine, another round of deworming, monthly heartworm and flea/tick preventative - and at this point the puppies will be just over 8 weeks old and will be weaned and be ready for adoption.  We are starting the process now of finding adoptive families in hopes that they will be able to go home soon after the first of the year.  Due to these puppies being a large breed puppy mix they will be adopted out on a spay/neuter contract - which means their adoptive families will sign a contract stating the puppies will be spayed/neutered by the time they are 9 months old. Families will be required to bring their puppy back to Safe Haven for us to spay/neuter when the puppy is between 6 to 9 months old, at no additional cost. The other option for each adoptive family would be to have the surgery done with their veterinarian at the family's own cost, and provide us proof of that surgery once complete.The ideal adoptive family will be committed to taking a puppy obedience class to get started on the right foot - they will need a family that can commit to continue proper socialization and also all the work that goes into house-training a puppy, which requires a lot of patience and persistence with working on a schedule. Puppies need to be taken outside frequently - as often as every 3 to 4 hours in the beginning. So an ideal home for these puppies will be one where they won't have long periods of time during the day spent alone during the first few months, so they can have the best chance of successful housetraining and have years of wonderful love and devotion to focus on! If you are interested in adopting Rainier (one of the male black puppies) or one of his littermates, please fill out an adoption application as the first step of the adoption process.  If you know you would like a certain puppy please describe the specific puppy on the application. Once the application has been approved, a Safe Haven volunteer will be in contact to set up the adoption. Visit this organization's web site to see any additional information available about this pet.December 21, 2025, 1:27 pm

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We'll also keep you updated on Zion's adoption status with email updates.
Photo of Zion

Zion

Great Dane/Rottweiler

Male, Puppy
South Amana, IA
Size
(when grown) Small 25 lbs (11 kg) or less
Details
Good with kids, Good with dogs,
Story
You can fill out an adoption application online on our official website.Zion and his adorable 8 littermates are a Great Dane/Rottweiler mix, and we also have a picture of their parents posted here on their profile.  The puppies have all been given 'National Park' themed names!  They are from a local Iowa County family that had an accidental litter, and they recently reached out to Safe Haven asking for help with their 9 puppies that were born on 11/03/2025. There are 5 males and 4 females - with 7 of the puppies being black and 2 being tan.  We think they are all incredibly adorable and sweet, but suspect the two tan puppies will be chosen quickly - there is one male (Rocky) and one female (Sierra).These puppies have definitely been very well cared for and socialized, and came into Safe Haven on 12/17 to be examined by our veterinarian and receive their initial set of (6 week old) puppy vaccinations, deworming, and a microchip.  They returned to their home for now to continue nursing for a few more weeks and get proper socialization from their mom.  On January 1st they will return to Safe Haven for a puppy vaccine booster, as well as a kennel cough vaccine, another round of deworming, monthly heartworm and flea/tick preventative - and at this point the puppies will be just over 8 weeks old and will be weaned and be ready for adoption.  We are starting the process now of finding adoptive families in hopes that they will be able to go home soon after the first of the year.  Due to these puppies being a large breed puppy mix they will be adopted out on a spay/neuter contract - which means their adoptive families will sign a contract stating the puppies will be spayed/neutered by the time they are 9 months old. Families will be required to bring their puppy back to Safe Haven for us to spay/neuter when the puppy is between 6 to 9 months old, at no additional cost. The other option for each adoptive family would be to have the surgery done with their veterinarian at the family's own cost, and provide us proof of that surgery once complete.The ideal adoptive family will be committed to taking a puppy obedience class to get started on the right foot - they will need a family that can commit to continue proper socialization and also all the work that goes into house-training a puppy, which requires a lot of patience and persistence with working on a schedule. Puppies need to be taken outside frequently - as often as every 3 to 4 hours in the beginning. So an ideal home for these puppies will be one where they won't have long periods of time during the day spent alone during the first few months, so they can have the best chance of successful housetraining and have years of wonderful love and devotion to focus on! If you are interested in adopting Zion (one of the male black puppies) or one of his littermates, please fill out an adoption application as the first step of the adoption process.  If you know you would like a certain puppy please describe the specific puppy on the application. Once the application has been approved, a Safe Haven volunteer will be in contact to set up the adoption. Visit this organization's web site to see any additional information available about this pet.December 21, 2025, 1:50 pm

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We'll also keep you updated on Denali's adoption status with email updates.
Photo of Denali

Denali

Great Dane/Rottweiler

Male, Puppy
South Amana, IA
Size
(when grown) Small 25 lbs (11 kg) or less
Details
Good with kids, Good with dogs,
Story
You can fill out an adoption application online on our official website.Denali and his adorable 8 littermates are a Great Dane/Rottweiler mix, and we also have a picture of their parents posted here on their profile.  The puppies have all been given 'National Park' themed names!  They are from a local Iowa County family that had an accidental litter, and they recently reached out to Safe Haven asking for help with their 9 puppies that were born on 11/03/2025. There are 5 males and 4 females - with 7 of the puppies being black and 2 being tan.  We think they are all incredibly adorable and sweet, but suspect the two tan puppies will be chosen quickly - there is one male (Rocky) and one female (Sierra).These puppies have definitely been very well cared for and socialized, and came into Safe Haven on 12/17 to be examined by our veterinarian and receive their initial set of (6 week old) puppy vaccinations, deworming, and a microchip.  They returned to their home for now to continue nursing for a few more weeks and get proper socialization from their mom.  On January 1st they will return to Safe Haven for a puppy vaccine booster, as well as a kennel cough vaccine, another round of deworming, monthly heartworm and flea/tick preventative - and at this point the puppies will be just over 8 weeks old and will be weaned and be ready for adoption.  We are starting the process now of finding adoptive families in hopes that they will be able to go home soon after the first of the year.  Due to these puppies being a large breed puppy mix they will be adopted out on a spay/neuter contract - which means their adoptive families will sign a contract stating the puppies will be spayed/neutered by the time they are 9 months old. Families will be required to bring their puppy back to Safe Haven for us to spay/neuter when the puppy is between 6 to 9 months old, at no additional cost. The other option for each adoptive family would be to have the surgery done with their veterinarian at the family's own cost, and provide us proof of that surgery once complete.The ideal adoptive family will be committed to taking a puppy obedience class to get started on the right foot - they will need a family that can commit to continue proper socialization and also all the work that goes into house-training a puppy, which requires a lot of patience and persistence with working on a schedule. Puppies need to be taken outside frequently - as often as every 3 to 4 hours in the beginning. So an ideal home for these puppies will be one where they won't have long periods of time during the day spent alone during the first few months, so they can have the best chance of successful housetraining and have years of wonderful love and devotion to focus on! If you are interested in adopting Denali (one of the male black puppies) or one of his littermates, please fill out an adoption application as the first step of the adoption process.  If you know you would like a certain puppy please describe the specific puppy on the application. Once the application has been approved, a Safe Haven volunteer will be in contact to set up the adoption. Visit this organization's web site to see any additional information available about this pet.December 21, 2025, 1:27 pm

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Search for a Great Dane puppy or dog

Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in Iowa.

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Great Dane puppies and dogs in Iowa cities

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Great Dane shelters & rescues in Iowa

There are animal shelters and rescues that focus specifically on finding great homes for Great Dane puppies in Iowa. Browse these Great Dane rescues and shelters below.

Here are a few organizations

Rescue

Safe Haven of Iowa County

2783 Highway 6 Trail, South Amana , IA 52334

Pet Types: cats, dogs

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Shelter

PAW (Protectors of Animal Welfare) Animal Shelter

2031 48th Street, Fort Madison , IA 52627

Pet Types: cats, dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Great Dane puppy or dog ?

We've got all the info you need on adopting and caring for a Great Dane puppy . Check out the links below for everything you ever wanted to know about Great Dane puppies and adults .

Great Dane information

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Where do Great Danes come from? How many types of Great Danes are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Great Dane.

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