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Great Dane puppies and dogs in Mesa, Arizona

Looking for a Great Dane puppy or dog in Mesa, Arizona? Adopt a Pet can help you find an adorable Great Dane near you.

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Adopt a Great Dane near you Great Dane in cities near Mesa, Arizona Other pups in Mesa, Arizona Search for a Great Dane puppy or dog near you Browse Great Dane puppies and dogs in nearby cities Browse related breeds in Mesa, Arizona Great Dane shelters and rescues in Mesa, Arizona Learn more about adopting a Great Dane puppy or dog

Adopt a Great Dane near you in Mesa, Arizona

These Great Danes are available in Mesa, Arizona.
Photo of Flora

Flora

Great Dane

Female, Adult
Mesa, AZ
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Not good with dogs, House-trained, Spayed or Neutered,
Story
Flora is a four-year-old Great Dane with a stunning blue coat, a sweet disposition, and a heart full of love. This gorgeous girl is currently in the care of Big Hearts for Big Breeds and is ready to find a forever family that will cherish her as much as she deserves. Flora is wonderful with people and does great with kids, making her an easy companion to welcome into family life. She is kennel trained and enjoys the comforts of home, whether that's relaxing with her favorite people or keeping a watchful eye on the day's activities from a cozy spot nearby. While Flora loves her humans, she prefers to be the only canine in the household. Being your one and only allows her to soak up all the attention, affection, and companionship she craves. Like so many Great Danes, Flora combines elegance and affection in one oversized package. She has the kind of gentle presence that makes a house feel more like home and the loving personality that quickly earns a permanent place in your heart. If you're looking for a beautiful Great Dane who is ready to be your loyal companion, Flora may be the perfect match. Contact Big Hearts for Big Breeds to learn more about this blue-tiful girl and the loving home she's hoping to find.

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Photo of Yuma

Yuma

Great Dane

Male, Adult
Mesa, AZ
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered,
Story
Yuma is a handsome 5-year-old Great Dane in the care of Big Hearts for Big Breeds, and he’s the kind of gentle soul who quietly wins your heart. Neutered, potty trained, and kennel trained, Yuma is a well-mannered boy who does well with other dogs and children. Yuma can be a bit shy at first, preferring to observe and take things in until he knows he’s safe. Once that trust is built, his sweetness shines through — a calm, affectionate Great Dane who simply wants a soft place to land and a family who will offer patience, kindness, and consistency. Yuma is ready for a loving home where he can finally relax and be cherished for the wonderful dog he is.

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Photo of Cliff

Cliff

Great Dane

Male, Young
Mesa, AZ
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
Cliff is a handsome 1½-year-old fawn Great Dane who recently joined the Big Hearts for Big Breeds family in our New Mexico foster program. This sweet young boy is settling in beautifully and is ready to find a forever home where he can continue to thrive. Like many young Danes, Cliff is still growing into his giant frame and doesn't always realize just how big he is! Because of his enthusiastic nature, he would do best with children ages 8 and up who can comfortably enjoy life with a lovable oversized companion. Cliff is potty trained, kennel trained, and has excellent house manners. He gets along well with other dogs and seems to especially enjoy the company of female dogs. He's also cat-friendly, making him a wonderful candidate for many multi-pet households. With his affectionate personality, handsome good looks, and sweet disposition, Cliff is everything people love about young Great Danes. He's looking for a family ready to embrace the fun, loyalty, and occasional goofy moments that come with sharing life with a gentle giant. If you're searching for a well-mannered young Great Dane who's already off to a fantastic start, Cliff may be the perfect addition to your family. Big Hearts for Big Breeds can't wait to help this wonderful boy find the forever home he deserves.

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Special Needs
Photo of Clay

Clay

Great Dane

Male, Puppy
Mesa, AZ
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats, Needs special attention,
Story
Clay is a beautiful Great Dane puppy who came into the care of Big Hearts for Big Breeds at just two months old. With his striking blue eyes and classic double merle coloring, this little guy is impossible not to fall in love with. Like any puppy, Clay is full of curiosity, wonder, and the promise of an exciting future. Because Clay is a double merle, the rescue team is paying close attention to his hearing and vision. Many double merle dogs are born with congenital hearing and/or vision impairments, but we're encouraged by his initial assessments and hopeful that he will not face those challenges. As Clay continues to grow, we'll keep monitoring his development to ensure he has every opportunity to thrive. Right now, Clay is busy doing what puppies do best—learning about the world one adventure at a time. He'll benefit from positive socialization, gentle training, and a family committed to helping him grow into the confident, well-mannered Great Dane he's meant to be. Clay is available through our foster-to-adopt program and will be neutered and receive all age-appropriate vaccinations while in the care of Big Hearts for Big Breeds before his adoption is finalized. Whether he grows into a typical Great Dane or a very special-needs ambassador for the double merle community, one thing is already certain: Clay is deeply loved, incredibly deserving, and ready to find the forever family that will cherish him for exactly who he is.

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Photo of Emerald

Emerald

Great Dane

Female, Adult
Mesa, AZ
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Needs experienced adopter, House-trained, Spayed or Neutered,
Story
Emerald, lovingly known as Emmy, is a 2½-year-old Great Dane with a heart full of love and a bright future ahead. She has recently returned to the care of Big Hearts for Big Breeds after her previous family realized she wasn’t quite the right fit for the structure of their home. While that chapter has closed, Emmy is ready for a fresh start with a family that understands her needs and sees the incredible dog she’s becoming. Emmy is a sweet, affectionate girl who truly thrives with routine, consistency, and clear expectations. She’s the kind of dog who blossoms when she knows what’s expected of her, and she forms deep bonds with the people she trusts. Because she missed out on important socialization early in life, Emmy has worked hard to build her confidence. She successfully completed a board-and-train program where she gained valuable skills and learned to navigate the world with more assurance. She is potty trained, kennel trained, and continues to do best in an environment that provides structure and positive leadership. Emmy would be happiest in a home with older children (14+) and another large, well-mannered dog that can help model appropriate behavior. She can be a bit bossy with canine friends, so adopters with large-breed experience who understand dog dynamics will help set her up for success. With patience, guidance, and a calm, knowledgeable family, Emerald has all the ingredients to become an exceptional companion. Big Hearts for Big Breeds knows her perfect match is out there—someone who will appreciate her intelligence, celebrate her progress, and give her the loving, stable home where she can continue to shine for years to come.

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Photo of Surprise

Surprise

Great Dane

Female, Young
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered,
Story
This beautiful 1.5 year-old Great Dane lives up to her name in the best way! Surprise is full of joy, curiosity, and a knack for making every day feel like a celebration. Surprise has already mastered the art of puppy kisses, wiggly tail wags, and being the star of the show. She’s on the lookout for a family that will shower her with all the best kinds of surprises like belly rubs, adventures, toys, and unconditional love. With a little guidance and a lot of cuddles, Surprise is ready to grow into the loyal, loving companion she’s destined to be.

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Or, how about these Great Danes in cities near Mesa, Arizona

These Great Danes are available for adoption close to Mesa, Arizona.
Photo of Flora

Flora

Great Dane

Female, Adult
Mesa, AZ
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Not good with dogs, House-trained, Spayed or Neutered,
Story
Flora is a four-year-old Great Dane with a stunning blue coat, a sweet disposition, and a heart full of love. This gorgeous girl is currently in the care of Big Hearts for Big Breeds and is ready to find a forever family that will cherish her as much as she deserves. Flora is wonderful with people and does great with kids, making her an easy companion to welcome into family life. She is kennel trained and enjoys the comforts of home, whether that's relaxing with her favorite people or keeping a watchful eye on the day's activities from a cozy spot nearby. While Flora loves her humans, she prefers to be the only canine in the household. Being your one and only allows her to soak up all the attention, affection, and companionship she craves. Like so many Great Danes, Flora combines elegance and affection in one oversized package. She has the kind of gentle presence that makes a house feel more like home and the loving personality that quickly earns a permanent place in your heart. If you're looking for a beautiful Great Dane who is ready to be your loyal companion, Flora may be the perfect match. Contact Big Hearts for Big Breeds to learn more about this blue-tiful girl and the loving home she's hoping to find.

Learn More

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Photo of Yuma

Yuma

Great Dane

Male, Adult
Mesa, AZ
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered,
Story
Yuma is a handsome 5-year-old Great Dane in the care of Big Hearts for Big Breeds, and he’s the kind of gentle soul who quietly wins your heart. Neutered, potty trained, and kennel trained, Yuma is a well-mannered boy who does well with other dogs and children. Yuma can be a bit shy at first, preferring to observe and take things in until he knows he’s safe. Once that trust is built, his sweetness shines through — a calm, affectionate Great Dane who simply wants a soft place to land and a family who will offer patience, kindness, and consistency. Yuma is ready for a loving home where he can finally relax and be cherished for the wonderful dog he is.

Learn More

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Photo of Cliff

Cliff

Great Dane

Male, Young
Mesa, AZ
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
Cliff is a handsome 1½-year-old fawn Great Dane who recently joined the Big Hearts for Big Breeds family in our New Mexico foster program. This sweet young boy is settling in beautifully and is ready to find a forever home where he can continue to thrive. Like many young Danes, Cliff is still growing into his giant frame and doesn't always realize just how big he is! Because of his enthusiastic nature, he would do best with children ages 8 and up who can comfortably enjoy life with a lovable oversized companion. Cliff is potty trained, kennel trained, and has excellent house manners. He gets along well with other dogs and seems to especially enjoy the company of female dogs. He's also cat-friendly, making him a wonderful candidate for many multi-pet households. With his affectionate personality, handsome good looks, and sweet disposition, Cliff is everything people love about young Great Danes. He's looking for a family ready to embrace the fun, loyalty, and occasional goofy moments that come with sharing life with a gentle giant. If you're searching for a well-mannered young Great Dane who's already off to a fantastic start, Cliff may be the perfect addition to your family. Big Hearts for Big Breeds can't wait to help this wonderful boy find the forever home he deserves.

Learn More

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Special Needs
Photo of Clay

Clay

Great Dane

Male, Puppy
Mesa, AZ
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats, Needs special attention,
Story
Clay is a beautiful Great Dane puppy who came into the care of Big Hearts for Big Breeds at just two months old. With his striking blue eyes and classic double merle coloring, this little guy is impossible not to fall in love with. Like any puppy, Clay is full of curiosity, wonder, and the promise of an exciting future. Because Clay is a double merle, the rescue team is paying close attention to his hearing and vision. Many double merle dogs are born with congenital hearing and/or vision impairments, but we're encouraged by his initial assessments and hopeful that he will not face those challenges. As Clay continues to grow, we'll keep monitoring his development to ensure he has every opportunity to thrive. Right now, Clay is busy doing what puppies do best—learning about the world one adventure at a time. He'll benefit from positive socialization, gentle training, and a family committed to helping him grow into the confident, well-mannered Great Dane he's meant to be. Clay is available through our foster-to-adopt program and will be neutered and receive all age-appropriate vaccinations while in the care of Big Hearts for Big Breeds before his adoption is finalized. Whether he grows into a typical Great Dane or a very special-needs ambassador for the double merle community, one thing is already certain: Clay is deeply loved, incredibly deserving, and ready to find the forever family that will cherish him for exactly who he is.

Learn More

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Photo of Surprise

Surprise

Great Dane

Female, Young
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered,
Story
This beautiful 1.5 year-old Great Dane lives up to her name in the best way! Surprise is full of joy, curiosity, and a knack for making every day feel like a celebration. Surprise has already mastered the art of puppy kisses, wiggly tail wags, and being the star of the show. She’s on the lookout for a family that will shower her with all the best kinds of surprises like belly rubs, adventures, toys, and unconditional love. With a little guidance and a lot of cuddles, Surprise is ready to grow into the loyal, loving companion she’s destined to be.

Learn More

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Photo of Pearl

Pearl

Great Dane

Female, Senior
Mesa, AZ
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Not good with cats, House-trained, Spayed or Neutered,
Story
Pearl is a stunning blue Great Dane, around 10 years old, currently in the care of Big Hearts for Big Breeds. As a senior, Pearl is settling into rescue life and discovering the comfort and stability she deserves, one day at a time. Pearl is potty trained, kennel trained, and does well in the car and on leash. She’s wonderful with children and gets along well with other large dogs, but she would do best in a home without cats or small dogs. Pearl is looking for a peaceful, loving home where she can enjoy her golden years surrounded by kindness, comfort, and understanding. If you’re searching for a loyal, steady companion with a soft heart and soulful eyes, Pearl may be the perfect addition to your family.

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These pups are in Mesa, Arizona too!

Below are our newest added Great Danes available for adoption in Mesa, Arizona. To see more adoptable Great Danes in Mesa, Arizona, use the search tool below to enter specific criteria!
Photo of CALLIE

CALLIE

Anatolian Shepherd

Female, 7 yrs 6 mos
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
-

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Photo of Fern

Fern

English Mastiff Irish Wolfhound

Female, Adult
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained,
Story
Fern is a five-year-old Irish Wolfhound, Great Dane, and Mastiff mix with the sweetest sugary face and a personality to match. This one-of-a-kind girl is the kind of dog who makes everyone she meets smile, effortlessly winning hearts with her gentle nature and loving spirit. Now in the care of Big Hearts for Big Breeds, Fern has shown herself to be an absolute treasure. She is wonderful with other dogs, great with cats, and loves kids, making her the kind of companion who fits beautifully into a variety of family dynamics. Whether she's making new friends or simply enjoying quiet time with her people, Fern brings warmth and joy wherever she goes. With her unique blend of giant breeds comes an equally giant heart. She’s affectionate without being demanding, sweet without trying, and has the kind of calm presence that makes every day a little brighter. Her soulful eyes and sugar-dusted face tell the story of a dog who is simply happy to be loved and to love in return. If you've been searching for a loyal best friend who gets along with everyone and has enough love to fill an entire home, Fern may be exactly the companion you've been waiting for. Big Hearts for Big Breeds can't wait to see this special girl find the forever family she so richly deserves.

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Search for a Great Dane puppy or dog

Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in Mesa, Arizona.

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Great Dane puppies and dogs in nearby cities

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Related breeds in Mesa, Arizona

Anatolian Shepherds in Mesa, Arizona Bullmastiffs in Mesa, Arizona Irish Wolfhounds in Mesa, Arizona

Great Dane shelters & rescues in Mesa, Arizona

There are animal shelters and rescues that focus specifically on finding great homes for Great Dane puppies in Mesa, Arizona. Browse these Great Dane rescues and shelters below.

Here are a few organizations closest to you:

Rescue

3.6 miles

Big Hearts for Big Breeds

Mesa, AZ 85202

Pet Types: dogs

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Shelter

10.7 miles

Arizona Animal Welfare League

25 N. 40th Street, Phoenix, AZ 85034

Pet Types: cats, dogs

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Shelter

16.4 miles

Maricopa County Animal Care & Control West Animal Shelter

2500 S. 27th Avenue, Phoenix, AZ 85009

Pet Types: dogs

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Shelter

18.4 miles

Central Arizona Animal Rescue

San Tan Valley, AZ 85142

Pet Types: cats, dogs, rabbits, reptiles

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Rescue

24.4 miles

Regal Dane Rescue

4410 W UNION HILLS DR STE 7-187, GLENDALE, AZ 85308

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Great Dane puppy or dog?

We've got all the info you need on adopting and caring for a Great Dane puppy. Check out the links below for everything you ever wanted to know about Great Dane puppies and adults.

Great Dane basics

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Where do Great Danes come from? How many types of Great Danes are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Great Dane.

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