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Great Dane puppies and dogs in Middletown, Pennsylvania

Looking for a Great Dane puppy or dog in Middletown, Pennsylvania? Adopt a Pet can help you find an adorable Great Dane near you.

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Adopt a Great Dane near you in Middletown, Pennsylvania

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These Great Danes are available for adoption close to Middletown, Pennsylvania.
Photo of Celeste

Celeste

Great Dane Catahoula Leopard Dog

Female, Adult
Harrisburg, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Not good with dogs, Not good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
PLEASE NOTE! Unless stated otherwise, our dogs and puppies are located in Arkansas, and transported to the north/northeast once adopted. We do occasionally have dogs/puppies placed in foster homes in the north/northeast. In the cases where the pet is somewhere other than Arkansas, it will be noted beside the name of the pet.8/12/26 WAIVED ADOPTION FEE!! Celeste cant stay in rescue forever, she really needs to find her forever home! Shes holding up a spot for others in need, plus she deserves a home of her own. PLEASE SHARE!!She needs hundreds of shares to help get her seen!She needs to be the only dog in the home. She can go for walks and such and pass by other dogs, but cant live with other dogs. It is VERY hard to find homes for dogs who need to be the only pet in the home. Her foster has many other dogs of her own, due to this, Celeste has to stay in a utility room in the garage (a nice doggy suite) with plenty of outside time, but she deserves to be in a home, with a family. She loves people!! She is all the things. A stunning beauty, heartwarmingly affectionate, and playfully mischievous in the most innocent way. She follows some basic commands such as sit, is house trained, and very food motivated. We do not know her breed. We only have her looks/size to go by. Great Dane, Catahoula, Lab? We dont know for sure but we do know shes a beauty!Shes about 80 pounds, one and a half years old. We have so many more pictures and videos but can only put 6 on this website. Please email us or visit our Facebook to see more pics and videos. Link to our facebook:https://www.facebook.com/adoptastrayrescueorg?mibextid=wwXIfr&mibextid=wwXIfrShe is spayed, vaccinated, microchipped, and is current on flea/tick/heartworm prevention. Located in Arkansas. She can be adopted locally, but transport is available to the New England area as well. Adopter must be able to pick up or arrange for someone to pick up for them in MD, PA, NJ, or CT on Saturdays.To apply, please fill out the adoption app: https://form.jotform.com/212690945239059email apps.aasr@gmail.com with any questions.Visit this organization's web site to see any additional information available about this pet.Our typical adoption fee for puppies younger than 6 months old is $400, and for older puppies and adults, the usual fee is $350. This includes microchip, spay/neuter,  up to date on age appropriate vaccinations, dewormings, flea/tick treatment, and heartworm test (if over 6 months old) as well as heartworm treatment if they test positive. There is a transport fee of $150 per dog, depending on the transporter. We use Pack Leaders Rescue Dog Transport most often, but also use Hearts Transport as well on occasion. Please visit our Facebook page too! https://www.facebook.com/adoptastrayrescueorg For more info regarding adopting, email apps.aasr@gmail.com Thank you for considering one of our rescue babies!August 30, 2026, 12:58 pm
Photo of Gelo

Gelo

Great Dane

Male, Young
Harrisburg, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
-
Story
You can fill out an adoption application online on our official website. Fill out an Adoption Application Certified good boy in training, professional smuggle seeker. Meet Mr. New-Kid-On-The-Block Gelo! He's sweet, loves people, and is still figuring out this whole "pet life" thing. Big wins so far: Kid approved ✅ Great with kids Road trip buddy ✅ Rode in the truck like a gentleman, chilling in the back with my daughter. Dog-friendly-ish ✅ Says hi politely to most pups. Got a little side eye for a recently neutered Great Pyrenees that stopped by, but who can blame him? Gelo is still working on his leash skills because squirrel! and learning that sidewalks aren't a buffet of smells. Kennel manners? Leveling up fast. He’s using the dog door like a pro. Medically? Gelo is all good. He just finished his antibiotics, so he's fresh, healthy, and ready to roll. Above all, this dude is a total love bug. Pets, scratches, attention -- Gelo's here for all of it. Gelo is new, so we're still. unlocking new levels of his personality, but early reviews say: 5 stars, would snuggle again. Looking for a sweet, goofy co-pilot who's ready to learn and love? Gelo's your guy. Visit this organization's web site to see any additional information available about this pet. Application Fees, Adoption Donations and Rescue Policy: Please know that 100% of our fees and donations pay for the costs of rescuing dogs. These include but are not limited to pull fees from shelters, veterinary examinations, vaccinations, medications and care, microchips, neuter/spay surgeries, heartworm treatments, behavior evaluations, and foster care, as needed. Important notes before applying. Approved adopters must have their primary residence in one of the following states: Delaware, Maryland, Michigan, New Jersey, Ohio, Pennsylvania, West Virginia, Virginia, and parts of North Carolina and Kentucky. You must be at least 21 years of age to apply and legally sign our contract for adoption. Applications must be completed by the homeowner.  We do not adopt giant breed dogs to renters. If you are renting, and you are applying to adopt a dog that is not a giant breed, permission to adopt an animal must be obtained from the landlord or property owner. We do not adopt giant breed dogs to homes with children under 6 years of age. Homes with children should have a fenced yard. Applications will be denied if anyone residing in the household has a record indicating drug/alcohol abuse, theft, or violence. Pets currently in the applicant's home must have a history of appropriate veterinary care. Homes with intact dogs will not be approved for adoption.  Proof of any of the following exceptions is required: The intact dog is a working member of a law enforcement, or search and rescue/recovery team. The intact dog is registered under the auspices of the American Kennel Club and is actively being shown. A veterinarian has determined the sterilization procedure would harm the intact dog.  We believe in Force Free Training Methods and do not approve of methods or devices using pain or force to control the dog, or to deter undesirable behavior.  Homes with highly varnished steps must have carpeting, securely fixed stair treads, or a non-skid surface. **We encourage you to remediate potential safety issues while your application is under review, prior to the home visit. ​Any inside steps to which the dog(s) have access, must have carpeting, securely fixed stair treads, or a non-skid surface. Homes with highly varnished floors must have non-slip area rugs or mats wherever your animal walks or rests frequently.  **Puppy Adoption Policy** To ensure proper house training and socialization, puppies will only be adopted to homes where an adult will not be away more than an hour per day, per month of age of the puppy, up to 6 months. Certain large-breed dogs should not be sterilized prior to 12 - 18 months of age.  If you adopt an intact puppy, you will sign an adoption contract agreeing to have the dog sterilized at your expense at the time your veterinarian recommends. Proof of sterilization must be provided to Mastiffs To Mutts Rescue as soon as the procedure is completed.  If the puppy is not sterilized as required, Mastiffs To Mutts Rescue reserves the right to claim legal ownership of the dog.  For additional information please review our FAQs or contact mastiffstomutts@gmail.com **Mastiffs To Mutts Rescue reserves the right to approve or deny any adoption that occurs through this organization without disclosure.  We reserve the right to make exceptions for special circumstances. **PA Kennel License: 05845   August 28, 2026, 5:09 pm
Photo of Journey

Journey

Great Dane

Female, Adult
Mechanicsburg, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with kids, Not good with dogs, Not good with cats, Spayed or Neutered,
Story
Journey's story didn't start out easy. Found as a stray in the South, she ended up in a high-kill shelter. She was heartbreakingly thin, covered in open wounds, and had clearly been through more than any dog should. Believed to be around 3 years old—or perhaps even younger—Journey desperately needed someone to give her a chance. That chance came when Molly's Place stepped in. They brought her to Pennsylvania and began the journey that inspired her name. With patience, expert care, and lots of love, Journey has made an incredible transformation. Today, Journey is the stunning 108# Great Dane she was always meant to be! The days of being skin and bones are behind her. After a month of healing, her wounds have completely recovered, she's filled out beautifully, and her joyful spirit shines brighter every day. Journey is a happy, HAPPY, energetic, and affectionate girl who is ready to find the loving family she's been waiting for. She gets along well with adults and no kids due to her enthusiastic Great Dane body and tail has a mind of its own!  She is wanting all your love and attention, so she does have to be the only animal in the home as well. Her house-training status is currently unknown. Since found as a stray, a 6 ft fenced yard is required.  Journey has overcome so much and is more than ready for the next chapter of her life. Could that chapter be with you? Applications are now being accepted, so don't wait too long. Journey is ready to leap into your heart—and maybe even your lap—and finally find the forever home she deserves. Kennel License #7198 To submit an adoption application, visit mollysplacerescue.org. Fill the form out completely, print, scan and email back to mollysplace@verizon.net. You must obtain pre-approval prior to visiting the dog or cat. Adoptions fees include the following:    spay/neuter surgery,  microchip and registration,  age appropriate vaccinations,  initial dewormings,  Activyl for fleas,  tested for FeLV and FIV (cats only),  bubble bath prior to going home (dogs only) WE do not "HOLD" animals without an approved application and a non-refundable/non-transferable paid adoption fee.  Adoptions are on a first come, first serve basis.  We can not send extra pictures.  WE do not ship, you must pick up the pet.  Kitties must be transported in a secure cat carrier.   Pooches require a "martingale" collar and a non-retractable leash. Visit this organization's web site to see any additional information available about this pet.August 23, 2026, 2:55 pm
Photo of Duchess

Duchess

Great Dane

Female, Adult
York, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Duchess is a good pet. She lost her brother Duke last year to health issues. She has exhibited none of those issues. She is approximately 6 years old. She is up to date on shots and I have her medical records. I wish to rehome her due to a family life event.
Photo of Dolly

Dolly

Great Dane Labrador Retriever

Female, Adult
Westminster, MD
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Not good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
You can fill out an adoption application online on our official website.All of the animals posted on our site have been temperament tested. While not all are in the immediate area, once we have processed and approved your application, we will move the dog to our adoptive area for you to meet, greet and hopefully adopt. Sometimes we will have more than one application on a dog. That does not mean it automatically goes to another family but you should be aware of the fact that until you are approved and set up for the meet/greet.. the dog could get adopted by another applicant.Dolly has large Great Dane genes grafted onto a somewhat smaller body. Not that anyone would ever call her small, but you would say she's a manageable size, which is perfect. If you love the Dane look, but aren't sure you could handle a full size model, we have Dolly waiting for you. She is currently only 60 lbs., but that is a bit deceiving, as she is very underweight. We would like to see at least 15 lbs. more on her ribs and we are working on it. She is now getting top quality groceries, something she has never had before. Still a young dog,  she is in the process of learning about how to deal with the world around her and she is learning fast. Her foster has some comments to help you understand this 'dog-in-progress. 'She’s nervous around new people and things. She does warm up after a bit. Her initial reaction to people that she doesn’t know is to low growl. She is trying to tell everyone to give her a moment to process the new information. I don’t recommend a house with cats or small animals. She’ tries to chase down all the birds,  and squirrels when we’re outside. I’m fairly confident her life prior to rescue wasn’t a good one. It's heartbreaking seeing a good dog trying to cope with a world she was never shown. UPDATE:I have had her for a month now, and she is learning! I took her to the vet today, and while she was nervous, she did not growl. So there has been improvement on that aspect. She wasn’t super outgoing and wanting everyone’s attention, so definitely stand by the slower to warm up to strangers. I highly suspect she’s been abused. She is highly intelligent and learns new things really fast.  She really has the potential to be an excellent dog, and wants to be loved and please her person. MORE UPDATE: Since being here at my house over a month now I have some new insights into her. She is not dog friendly with all dogs.  She's OK with my male dog, but not so happy with my female.  I've been working on getting her to ignore people on walks and she's doing better. She doesn't like it if strangers get too close when we are out.  In the yard. she's definitely going to need at least a 6 foot fence to keep her safely secured.  I will say, she is house trained and does let you know when she needs to go out. She also does very well in her kennel. She is very smart, and can learn things pretty quickly. She has all her shots and is ready and waiting for the person or family who like bigger dogs, but aren't ready for an actual Goliath. Dolly is a good girl! She is hoping you will want to help her be a good dog and come for her soon.   If you are interested in Dolly, please fill out an application at: https://reachoutrescue.rescuegroups.org/forms/form?formid=4588    Or contact: rorrcanine@gmail.com   *** Click here to sponsor this dog! ***Visit this organization's web site to see any additional information available about this pet.August 30, 2026, 5:36 pm
Photo of Duke - Bonded Pair with Lulu

Duke - Bonded Pair with Lulu

Great Dane

Male, Young
Reading, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
-
Story
BONDED PAIR WITH LULU! PLEASE SEE LISTING FOR LULU! LULU AND DUKE MAY POTENTIALLY BE ADOPTED SEPARATELY, BUT IT IS PREFERRED THAT THEY ARE ADOPTED TOGETHER! Duke and Lulu are a bonded pair who came into rescue following the death of their owner and loss of their home. As expected after all the changes in their environment and family dynamic the past six months, they seek lots of attention. Both are affectionate, playful and eager to please and would do well in a structured environment with humans who can give them the time and attention they need. Duke seems to be the strong silent type – sitting back observing and taking his cues from Lulu. He warms up right away, while she needs a little time to get comfortable with new people. Both travel in the car extremely well, are crate trained, and have lived peacefully with several inside/outside cats. Their roommates/caretakers report they have high prey drive and do not like Chihuahuas. As far as exposure to children, they have only encountered a 12YO nephew a few times. They both listen considerably well,but could use general manners reinforcement and leash work. If you’re looking to add a pair of loveable, entertaining, in-your-face Danes to your family, then these two are for you! Stay tuned for updates. Please include your home area code and a phone number where a volunteer can reach you when contacting us about an adoption. DUKE UPDATE APRIL 2026 Duke has been moved to a NJ foster home and will begin treatment for heartworm, sadly Duke tested positive for Heartworm but not to worry, he will start treatment soon and then will be ready for adoption! Duke is a lovely boy, so friendly and a cuddle bug. He is being spoiled in his foster home until he starts the injections to kill the heartworms, then will have to go on crate rest. Fortunately, Duke is crate trained and learning to walk nicely on a leash. His first vet visit went well, he made lots of friends at his new vet office. Keep your eye on this one, once ready, Duke will be an amazing addition to any home. For more information on this dog and our adoption policies, visit MAGDRL at https://www.magdrl.org. MAGDRL adopts Great Danes in NY, NJ, PA, MD, DE, DC, VA, & WV.

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Great Dane shelters & rescues in Middletown, Pennsylvania

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Rescue

7.4 miles

Adopt A Stray - PA transport

Harrisburg, PA 17105

Pet Types: dogs

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Rescue

7.5 miles

Mastiffs To Mutts - Central PA

Harrisburg, PA 17109

Pet Types: dogs

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Rescue

14 miles

Mollys Place Rescue

PO Box 328, Mechanicsburg, PA 17055

Pet Types: cats, dogs

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Rescue

42.5 miles

Reach Out Rescue & Resources

P. O. Box 542, Westminster, MD 21158

Pet Types: cats, dogs

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Great Dane basics

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