Great Dane Adoption in Pennsylvania: Great Dane Puppies for Sale in Pennsylvania

Adopt a Great Dane near you in Pennsylvania

Below are our newest added Great Danes available for adoption in Pennsylvania. To see more adoptable Great Danes in Pennsylvania, use the search tool below to enter specific criteria!

Ceasar

Great Dane/Pit Bull Terrier

Male, 5 yrs

Somerset, PA

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with dogs, House-trained,

Story

Meet Ceasar, a 5-year-old Great Dane/Pit Mix with a heart as big as he is! This sweet and lovable boy absolutely adores people and never turns down the chance to give hugs or soak up all the pets he can get. Ceasar came to us as a stray from Johnstown, and he has quickly won everyone over with his goofy, silly personality that keeps us laughing every day. Ceasar is very food motivated, which makes him eager to learn and easy to bond with. He appears to do well with other dogs, but we do require a meet and greet with any potential canine housemates to ensure everyone is a good fit. We are currently unsure how Ceasar feels about cats, but we would be happy to cat test him upon request. If you’re looking for a big, affectionate goofball who will happily be your shadow and best friend, Ceasar may be the perfect match for you!

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Ozzie

Great Dane

Male, 2 mos

Sinking Spring, PA

Size

(when grown) -

Details

Good with dogs, Good with cats,

Story

This handsome “little” guy truly needs no introduction. We can hear the crowd chanting… Ozzie Ozzie OZZIE!!!! 👀🗣️❤️ That’s right our adorable Great Dane Ozzie is finally ready to find his happily ever after home! ❤️🐾 As many of you recall Ozzie was born in our care when his mama was surrendered and no one knew she was pregnant. And who can forget when he was just a few weeks old and a terrible accident happened that left him with a massive goose egg on his nogging and his foster mama franticly rushing him to not one but two emergency vets where he was given the absolute best care. ❤️‍🩹 And after a few days in an oxygen tank, being put on meds for swelling and tons of TLC he was finally able to come home. We spent weeks continuing his meds and working with him all the while encountering another hiccup. Ozzie wasn’t interested in eating and was not putting on weight. So back to the vet we went for bloodwork and a fecal to find out Ozzie had an overabundance of round worms taking up residency in his belly. 🪱 After two treatments of dewormer and lots of bribing with any and every food under the sun, we are happy to announce that he is doing amazingly well. He has been consistently gaining weight and is filling out, finally! No more nasty little worms giving him an upset belly. Ozzie is now 10 weeks old and so stinking adorable! He is a typical puppy… sleep, poop, play, eat and repeat! He loves playing with the other dogs in his foster home as well as toys (and shoes) of all kinds. He loves exploring the backyard and running around with the other dogs, even if it isn’t the most graceful at times. He is content to find a dog bed and lay down and chew a toy or take a nap. He is a snuggle bug, he enjoys being snuggled and held. Ozzie is eating like a champ now, a mix of dry large breed puppy food and wet puppy food. We no longer need to bribe him with naughty things to get him to eat. He has been doing really well with going potty outside, he does still have accidents but that is expected of such a young puppy. He also sleeps wonderfully through the night in an open xpen. We do have music playing for him when ever he is in his xpen, as well as some toys. We really haven’t started him with leach walking yet, so this is something his new family will need to work on. Ozzie has had his first round of vaccinations and will need two more rounds of distemper and his rabies when he is old enough. He is microchipped and on preventatives. Due to his young age and breed, he is not altered and will be adopted out on a neuter contract that comes with an additional fee on top of his adoption fee. This fee is 100% fully refundable when the contract is followed, he will need to be neutered as well as have gastropexy surgery within a set timeframe. He has had follow-ups appointments over the past weeks and the vet notes that he has mild exophthalmos and mild ataxia, both have gotten better with each visit. His foster family will gladly provide more information for potential applicants. What does the ideal family look like for our superstar? His forever family will need to have large breed experience. They will need to understand the cost of caring for a large breed dog; the amount of food he eats on a daily basis in itself is hefty. A fenced in yard would definitely be an added perk. And another friendly, playful companion for him would be greatly appreciated. 🐾If you feel this handsome guy would make an amazing addition to your family, apply today!🐾 www.zoeshouserescue.com Ozzie is being fostered near Reading, PA and potential adopters will need to be willing to come to this area for a meet and greet. Any residential dogs will also need to be able to attend the meet and greet. Zoe’s House Rescue Kennel License 9117 Sinking Spring, PA 19608

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Celeste

Great Dane/Catahoula Leopard Dog

Female, Adult

Harrisburg, PA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, House-trained,

Story

PLEASE NOTE! Unless stated otherwise, our dogs and puppies are located in Arkansas, and transported to the north/northeast once adopted. We do occasionally have dogs/puppies placed in foster homes in the north/northeast. In the cases where the pet is somewhere other than Arkansas, it will be noted beside the name of the pet. CELESTE This girl had waited too long and us holding up a spot for others in need. Please share! She is all the things. A stunning beauty, heartwarmingly affectionate, and playfully mischievous in the most innocent way. She follows some basic commands such as “sit”, is house trained, and very food motivated. We believe her to be a Great Dane mix, with possibly a dash of Mastiff thrown in there. Maybe some Catahoula? We don’t know for sure. At about 80 lbs and just over a year old, she could still grow some. She is spayed, vaccinated, microchipped, and is current on flea/tick/heartworm prevention. Located in Arkansas. She can be adopted locally, but transport is available to the New England area as well. Adopter must be able to pick up or arrange for someone to pick up for them in PA, NY, or CT on Saturdays. To apply, please fill out the adoption app: https://form.jotform.com/212690945239059 email: apps.aasr@gmail.com with any questions. Visit this organization's web site to see any additional information available about this pet.Our typical adoption fee for puppies younger than 6 months old is $400, and for older puppies and adults, the usual fee is $350. This includes microchip, spay/neuter, up to date on age appropriate vaccinations, dewormings, flea/tick treatment, and heartworm test (if over 6 months old) as well as heartworm treatment if they test positive. There is a transport fee of $150 per dog, depending on the transporter. We use Pack Leaders Rescue Dog Transport most often, but also use Hearts Transport as well on occasion. Please visit our Facebook page too! https://www.facebook.com/adoptastrayrescueorg For more info regarding adopting, email apps.aasr@gmail.com Thank you for considering one of our rescue babies!May 11, 2026, 8:13 pm

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Harley

Great Dane

Female, 4 yrs 3 mos

Sinking Spring, PA

Size

(when grown) -

Details

Story

Meet Harley 🤍  Miss Harley is a 4-year-old Great Dane who came to us as a former mill mama and, shortly after arriving, surprised us with one last litter. Now that her puppies are grown, she’s ready to find a home of her own. She is incredibly kind, gentle, and absolutely stunning - but more importantly, she’s a dog who deserves patience and understanding as she continues to grow and feel safe. Harley thrives with other dogs. They bring out her playful, silly side (zoomies included!), and she would do best in a home with a canine companion. Outside is her happy place - she loves sunshine, walks, and playtime. She would do best in a secure fenced-in yard where she can feel safe and free. Inside, she’s still learning to feel comfortable and will need time and consistency. Harley can be fearful of men and will need slow, respectful introductions. She’s made progress, but her adopter must be committed to continuing that journey. She’s looking for a family willing to meet her where she is and show her that life can be safe and full of love. Harley is housebroken, crate trained, spayed, and up to date on vaccines and preventatives. If you’re experienced, patient, and have a dog who needs a best friend… Harley might be your girl 🤍

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Jasper

Great Dane

Male, 3 yrs

Media, PA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, Good with cats, House-trained,

Story

Meet Jasper He is a loving Dane mix ready to bring joy and love into your life. He's vaccinated,neutered and adores pets, kids, and playful companions. Jasper is gentle, loyal, and loves treats. Although stairs are a challenge, he walks well on a leash. Apply today at www.hindeanimalrescueteam.org to welcome him into your family.

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Casper

Great Dane

Male, 3 yrs

Media, PA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats, House-trained,

Story

Casper, a majestic Dane mix with a heart of gold, dreams of finding his forever friend! With his vaccines up to date and neutered. Casper’s a loving boy and is convinced he's a lap dog (even at 85 lbs). This 3 year old can’t get enough affection. Casper's wonderful with children, who enjoys playtime and other pets. As with many dogs, Casper gets excited on leash walks and pulls a bit. Apply now at www.hindeanimalrescueteam.org to offer this loving dog a second chance at happiness!

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Great Dane puppies and dogs in Pennsylvania

Jump to:

Adopt a Great Dane near you in Pennsylvania

Below are our newest added Great Danes available for adoption in Pennsylvania. To see more adoptable Great Danes in Pennsylvania, use the search tool below to enter specific criteria!

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in Pennsylvania cities

Great Dane shelters & rescues in Pennsylvania

Looking for a specific shelter or rescue?

Want to learn more about adopting a Great Dane puppy or dog ?

Great Dane information

Great Dane basics