Great Dane Adoption in Pennsylvania: Great Dane Puppies for Sale in Pennsylvania

Adopt a Great Dane near you in Pennsylvania

Below are our newest added Great Danes available for adoption in Pennsylvania. To see more adoptable Great Danes in Pennsylvania, use the search tool below to enter specific criteria!

Odette

Great Dane

Female, 2 yrs

Lancaster, PA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Here is Odette! This younger gal is here as a stray and ready for her next adventure! She is a very large energetic pup with lots to say. She would thrive in an active household and would benefit from some basic obedience training. She is open to living with children who can handle her energetic nature. She could potentially get along with another dog as long as they are tolerant of her playfulness. We are not aware of how she will do around cats. If you have space in your home and are ready for an adventure come meet Odette!---If you are interested in adopting, please come prepared --bring a photo ID, proof of address, and everyone in the home including resident dogs with vaccination history. We are open daily 12-6pm.---The Pennsylvania SPCA - Lancaster Center848 S. Prince St. Lancaster PA 17603Kennel #16516717-917-6979lancaster@pspca.org

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Santa Monica

Great Dane/Labrador Retriever

Female, 2 mos

Eighty Four, PA

Size

(when grown) Small 25 lbs (11 kg) or less

Details

Story

Hi!My name is Santa Monica, I am a happy 2 month old Labrador/Great Dane mix, weighing 10 pounds. I was the smallest in my litter, but I am getting stronger everyday. I love to play, run and wrestle with my siblings. I would a family that could take me on adventures, and show me the good life. I will need to meet all humans and canines in the family before adoption.

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Cooper

Great Dane/Pointer

Male, 1 yr

Quakertown, PA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats, House-trained,

Story

Meet Cooper! Hes a 1 year old Great Dane/Pointer mix with the sweetest personality and the cutest goofy side. Cooper is friendly, affectionate, and loves being part of whatever youre doing. He enjoys toys, chew bones, and hanging out with his people, but he also has a playful side and would love another dog to romp around with or a couple of walks each day to burn off some energy. He walks well on a leash and is doing great with both crate training and house training. Cooper gets along wonderfully with other dogs, cats, and kids, making him an easy fit for many different kinds of families. He's neutered, fully vaccinated, and ready to find a forever home of his own.

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Celeste

Great Dane/Catahoula Leopard Dog

Female, Adult

Harrisburg, PA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Not good with dogs, Not good with cats, House-trained,

Story

PLEASE NOTE! Unless stated otherwise, our dogs and puppies are located in Arkansas, and transported to the north/northeast once adopted. We do occasionally have dogs/puppies placed in foster homes in the north/northeast. In the cases where the pet is somewhere other than Arkansas, it will be noted beside the name of the pet.9/4/26 WAIVED ADOPTION FEE!! Celeste cant stay in rescue forever, she really needs to find her forever home! Shes holding up a spot for others in need, plus she deserves a home of her own. PLEASE SHARE!!She needs to be the only dog in the home. She can go for walks and such and pass by other dogs, but cant live with other dogs. It is VERY hard to find homes for dogs who need to be the only pet in the home. She loves people!! She is all the things. A stunning beauty, heartwarmingly affectionate, and playfully mischievous in the most innocent way. She follows some basic commands such as sit, is house trained, and very food motivated. We do not know her breed. We only have her looks/size to go by. Great Dane, Catahoula, Lab? We dont know for sure but we do know shes a beauty!Shes about 80 pounds, one and a half years old. We have so many more pictures and videos but can only put 4 on this website. Please email us or visit our Facebook to see more pics and videos. Link to our facebook:https://www.facebook.com/adoptastrayrescueorg?mibextid=wwXIfr&mibextid=wwXIfrShe is spayed, vaccinated, microchipped, and is current on flea/tick/heartworm prevention. Located in New England. To apply, please fill out the adoption app: https://form.jotform.com/212690945239059email apps.aasr@gmail.com with any questions.Visit this organization's web site to see any additional information available about this pet.Our typical adoption fee for puppies younger than 6 months old is $400, and for older puppies and adults, the usual fee is $350. This includes microchip, spay/neuter, up to date on age appropriate vaccinations, dewormings, flea/tick treatment, and heartworm test (if over 6 months old) as well as heartworm treatment if they test positive. There is a transport fee of $150 per dog, depending on the transporter. We use Pack Leaders Rescue Dog Transport most often, but also use Hearts Transport as well on occasion. Please visit our Facebook page too! https://www.facebook.com/adoptastrayrescueorg For more info regarding adopting, email apps.aasr@gmail.com Thank you for considering one of our rescue babies!September 6, 2026, 11:30 am

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Jethro

Great Dane

Male, Young

Willow Grove, PA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Not good with dogs, Good with cats, House-trained,

Story

We got Jethro when he was 9 weeks old we all ready had a 5yr old Alaskan malamute they got along great until about a month ago and I guess Jethro got to his alpha stage and decided he did not like Opie our Alaskan malamute anymore so we've had to separate them they are both male dogs so we had Jethro neutered to see if that would help but it hasn't Jethro is great behavior wise around everything else except Opie so at this point we need to just rehome home he is such a great dog very affectionate with all humans

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Grant

Great Dane

Male, Adult

Nanticoke, PA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Story

🐾Meet Grant!🐾 Grant is a 1-year-and-5-month-old Great Dane looking for a loving new home. ❤️ He is very friendly, sweet, and great with kids. He has a gentle personality and loves being around people. I'm hoping to find him a new home as soon as possible, but most importantly, I want to make sure he goes to a caring family who will love and take good care of him. If you're genuinely interested in giving Grant a good home, please reach out for more information. 🐶❤️

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Great Dane puppies and dogs in Pennsylvania

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Below are our newest added Great Danes available for adoption in Pennsylvania. To see more adoptable Great Danes in Pennsylvania, use the search tool below to enter specific criteria!

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Great Dane puppies and dogs in Pennsylvania

Jump to:

Adopt a Great Dane near you in Pennsylvania

Below are our newest added Great Danes available for adoption in Pennsylvania. To see more adoptable Great Danes in Pennsylvania, use the search tool below to enter specific criteria!

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in Pennsylvania cities

Great Dane shelters & rescues in Pennsylvania

Looking for a specific shelter or rescue?

Want to learn more about adopting a Great Dane puppy or dog ?

Great Dane information

Great Dane basics