Mastiff Adoption in Iowa: Mastiff Puppies for Sale in Iowa

Adopt a Mastiff near you in Iowa

Below are our newest added Mastiffs available for adoption in Iowa. To see more adoptable Mastiffs in Iowa, use the search tool below to enter specific criteria!

Winter

Mastiff/Mixed Breed (Medium)

Female, 3 mos

Monticello, IA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

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Bandit

Mastiff/Black and Tan Coonhound

Male, Young

Maquoketa, IA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, House-trained,

Story

Bandit is a male mastiff coonhound mix. YOUR NEW COMPANION WILL COME WITH THE FOLLOWING -- spaying or neutering (which must be done before you can take your new family member home), all up-to-date vaccinations including rabies and rabies vaccination tag. *BREED DISCLOSURE: Due to the fact that most of our adoptable pets are strays, we can’t guarantee their breed. We list the pet’s breed as the one that best matches the physical appearance, and the pet may also be listed as a mix when it’s a purebred. COST OF ADOPTION -- Dogs $70 and Cats $55. Cash only please! sorry no checks or credit cards. ADOPTION HOURS -- Tuesday thru Sunday: Noon to 3 pm • Sorry, we're closed on Mondays and Holidays. Jackson County Humane Society 23354 Dark Hollow Road • Maquoketa, IA 52060 Phone: 563-652-5360 • email: jchs.ia.office@gmail.com Please visit us on Facebook! Donations are always greatly needed and appreciated. January 29, 2026, 2:34 pm

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Frost

Mastiff/Mixed Breed (Medium)

Male, 3 mos

Monticello, IA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

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Ziva

Mastiff/Boxer

Female, 11 mos

Council Bluffs, IA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs,

Story

Welcome to rescue, Ziva! She is a mix of Mastiff/Boxer/Hound, born appx Feb 2025. She is a smart girl and full of energy! Ziva is a little sassy sometimes, especially if you're eating and not sharing your food with her! :) Ziva will curl up in your lap for naps. She does well on a leash for walks and likes puzzle games. She really needs to be in a home with another dog to play with. Ziva came to Muddy Paws Parvo+. She was treated and is a healthy girl! The suggested adoption donation for Ziva is $415, which includes a lifetime of free relationship-based training for any behavioral problems (not obedience training). Muddy Paws is a 501c3 non-profit organization meaning that part of your donation MAY be TAX DEDUCTIBLE. We are a 100% volunteer rescue committed to giving animals a second chance at life. All donations go toward that mission. Adoption fees are the primary source of funding for the cost of veterinary care for our animals. In 2022 alone, we provided animal Healthcare totaling over $399,000 covered mainly through adoption fees. Information about the adoption process: All adoptions require a completed ADOPTION APPLICATION. Once your application has completed our prescreen steps, we will put you in touch with the animal’s foster to see if you and the pet are a good match. If so, we will arrange a meeting for you and the animal. The adoptions for all of our animals will take place in the Omaha, NE area and must be done by the adoptive family in person. We do not ship or deliver. Please Note: We are a RESCUE, which is different from a shelter. We conduct veterinary and personal reference checks, and a Home Visit (Virtual in some cases) during the application approval process. We always select the right applicant for each animal, based on the animal’s needs. If you and the animal are not a good match, we will help you select another animal, or we will keep your approved application on file for 6 months. To learn about Muddy Paws Second Chance Rescue or donate to our animals, please visit our website at MuddyPawsSecondChanceRescue.com or our Facebook Page Muddy Paws Second Chance Rescue Inc. If the dog or cat you adopt is older than 6 months of age and not spayed or neutered, you will receive a voucher to alter the pet at Val Verde Animal Hospital in Omaha, at no cost to you. Or you can alter the pet at your own vet and be reimbursed $100 for dogs, and $50 for cats, of total cost. If the dog or cat is younger than 6 months of age, adopter will be responsible for the cost of altering the pet at the vet of their choice. If proof of alter is received by Muddy Paws prior to the pet turning 6 months of age, a reimbursement of $100 for dogs and $50 for cats, will be sent to you to help cover expenses. [Muddy Paws can also suggest a vet with a reduced cost for alters.] All puppies and kittens MUST be spayed or neutered by 6 months of age. All dogs and cats MUST be spayed or neutered no later than one month after adoption is finalized. Thank you in advance for your compliance. ##2539859##

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Reacher

Mastiff/Mixed Breed (Medium)

Male, 1 yr 3 mos

Monticello, IA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, Good with cats,

Story

Reacher is a 1-year-old male Mastiff mix who was surrendered to us through no fault of his own. He spent the first year of his life in a loving home, but life can change quickly, and his owners had to make the heartbreaking decision to bring him back to the shelter. Now, Reacher is waiting patiently in a foster home until his forever family finds him. Reacher is an absolute lover and cuddler, with lots of puppy still left in him. He does need some time to warm up to new people and may shake until he feels safe, but once he trusts you, his affectionate and gentle nature shines through. He bonds deeply with his people and thrives on companionship. He is fantastic with kids and truly enjoys being part of family life—jumping on the trampoline, playing in the hose, fetch, cuddling, dressing up, and simply being included. Reacher does well with other dogs of all sizes and loves to play. He has shown interest in hamsters and guinea pigs, but does not seem bothered by cats. Reacher is still learning proper leash manners, but walks well without pulling. He loves car rides and rides calmly with his seat belt on. This handsome guy currently weighs around 115 lbs, and while he is large and impressive, his heart is even bigger. We believe he is a Mastiff mix, possibly Cane Corso or Great Dane, and he carries himself with the gentle, affectionate demeanor these breeds are known for. Reacher is very smart and food motivated, especially when fruits and veggies are involved. He rings a bell to let you know when he wants to go outside—and when he’s ready to come back in. He knows basic commands, including “wait” before going out, and is known to mimic what he sees you do (opening doors, baby gates, snack cabinets, etc.). He is fully house trained. Reacher does have some separation anxiety, but it has improved greatly over time. He is not a fan of being kenneled, though it is actively being worked on, as being crate trained helps with transitions—especially when someone new enters the home. Reacher must be an indoor family member. He thrives on closeness, routine, and being part of his people’s daily lives, and would diminish in any other setting. Rehoming Reacher has absolutely nothing to do with him—he is nearly perfect. He is simply looking for the loving, committed home he deserves.

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Big Momma

Mastiff

Female, Senior

Burlington, IA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids,

Story

Big Momma is a 5 year old female Mastiff. Big Momma is of course a big pretty gal, she is soft, and cuddly too. She is pretty good at moving around at her own speed..dont rush her lol, and just as funny as can be when she tilts her head at you. Just imagine laying your head next to hers... such a big face to gaze into! Her friend Sherry would love to go with her too, so please check her out, they are happily bonded together and we plan to keep it that way. Our adoption hours are Tuesday-Friday 3-6PM and 1-5PM on the weekends. We are located in Burlington, Iowa. All dog adoptions include a health exam, Rabies, DHPP and Distemper vaccinations, Heartworm check, Sterilization and post surgical pain medication. All cat adoptions include A health check up, FLV and FiV screening, FVRCP and rabies vaccinations, sterilization with pain medications. Please visit our website desmoinescountyhumanesociety.org for more info on any pet listed or to view all of our adoptable pets.

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Below are our newest added Mastiffs available for adoption in Iowa. To see more adoptable Mastiffs in Iowa, use the search tool below to enter specific criteria!

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Mastiff puppies and dogs in Iowa

Jump to:

Adopt a Mastiff near you in Iowa

Below are our newest added Mastiffs available for adoption in Iowa. To see more adoptable Mastiffs in Iowa, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Iowa cities

Mastiff shelters & rescues in Iowa

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics