Mastiff Adoption in Iowa: Mastiff Puppies for Sale in Iowa

Adopt a Mastiff near you in Iowa

Below are our newest added Mastiffs available for adoption in Iowa. To see more adoptable Mastiffs in Iowa, use the search tool below to enter specific criteria!

Duke

Mastiff

Male, 7 mos

Ottumwa, IA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Story

Learn More

Gnarley

Mastiff

Female, 4 yrs 5 mos

Fort Madison, IA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

If you have ANY QUESTIONS or are truly interested in adopting any animal from PAW Animal Shelter Please, fillout an adoption application FIRST! WE are a high intake No Kill Shelter ran by a staff of 4 and do not always have time to answer every question asked by so many. If you are a good fit for the animal you are interested in -we will call to speak with you, If we feel you are not a good fit , we will contact you about other pets that may be a good fit for your home. Many people are losing the opportunity to adopt the animal they want because they fail to put in an application and the pet was adopted before we could answer your email. .If you have applied for an animal in our facility and have not received a response within 7 days, PLEASE call or contact us again. Though we do our best in trying to answer all emails in a timely manner, sometimes things get away from us, get lost or misplaced. It is never our intention to ignore a request about an adoptable animal in our facility. Sandy Brown, Director, PAW Animal Shelter 319-372-2274 ##2005617##

Learn More

Princess

Mastiff/German Shepherd Dog

Female, Young

Ames, IA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats, House-trained,

Story

Hello everyone! Her name is Princess, my daughter picked it out! We got her from a friend when she was a very tiny puppy, and momma and papa dog had a large liter! Princess's birthday is December 12th, so she is just over 3 years old now! She is a Mastiff, German Shephard Mix is what we were told the parents were. Princess is great with kids of all ages, and other pets indoor and outdoor! Also cats or dogs! Currently she lives with a family friend and does wonderful with their kids, and cats! Princess loves to go on walks, and run around! An ideal place for her is somewhere she can get some exercise! Whether that means yard or trips to a dog park, she loves both! Princess is kennel trained, and house trained, meaning she can stay in or out of kennel when family isn't home! Her temperament is very friendly, calm, chill, and likes to take her naps too! She is also a curious dog, and likes to look outside and watch the world go by!

Learn More

Hesta

Mastiff/Mixed Breed (Medium)

Female, 1 yr

Council Bluffs, IA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Learn More

Winter

Mastiff/Mixed Breed (Medium)

Female, 3 mos

Monticello, IA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

Just like her name, Winter is pure magic. This 4-month-old Mastiff mix is wrapped in a stunning brindle coat, paired with the sweetest, most soulful eyes you’ve ever seen. And those big paws? Let’s just say she’s going to be a large dot on the growth chart — but that just means there’s more of her to love, cuddle, and adore. Winter is a very sweet girl who is still discovering the world around her. She can be a little shy at first as she figures things out, but the moment she realizes she’s safe with you, she melts into a total lovebug. She adores people, actively seeks affection, and hands out kisses like freshly fallen snow — generously and often! This curious girl has an independent streak, too. When she’s feeling brave, she’ll happily explore wherever her (not-so) little body takes her. She loves playtime with other dogs — especially wrestling matches and a good game of tug-of-war! She gets along with dogs of all sizes (though big dogs can feel a bit intimidating at first). She also does well with cats and is wonderful with kids. Winter is an overall happy, joyful puppy who’s learning the ropes of growing up. Potty training is still a work in progress, and she’s nearly mastered crate training. Like many large breed pups, she’s working on not jumping when she gets excited — she just has so much happiness to share! Winter would thrive in any loving home ready to raise a large breed puppy. In return, she promises a lifetime of loyalty, endless snuggles, and more kisses than you ever thought possible. If you’re ready to add a little extra warmth to your winter season (and every season after), Winter is ready to be your forever snowflake.

Learn More

Bandit

Mastiff/Black and Tan Coonhound

Male, Young

Maquoketa, IA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, House-trained,

Story

Bandit is a male mastiff coonhound mix. YOUR NEW COMPANION WILL COME WITH THE FOLLOWING -- spaying or neutering (which must be done before you can take your new family member home), all up-to-date vaccinations including rabies and rabies vaccination tag. *BREED DISCLOSURE: Due to the fact that most of our adoptable pets are strays, we can’t guarantee their breed. We list the pet’s breed as the one that best matches the physical appearance, and the pet may also be listed as a mix when it’s a purebred. COST OF ADOPTION -- Dogs $70 and Cats $55. Cash only please! sorry no checks or credit cards. ADOPTION HOURS -- Tuesday thru Sunday: Noon to 3 pm • Sorry, we're closed on Mondays and Holidays. Jackson County Humane Society 23354 Dark Hollow Road • Maquoketa, IA 52060 Phone: 563-652-5360 • email: jchs.ia.office@gmail.com Please visit us on Facebook! Donations are always greatly needed and appreciated. February 10, 2026, 2:54 pm

Learn More

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Iowa.

Mastiff puppies and dogs in Iowa

Jump to:

Adopt a Mastiff near you in Iowa

Below are our newest added Mastiffs available for adoption in Iowa. To see more adoptable Mastiffs in Iowa, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Iowa cities

Mastiff shelters & rescues in Iowa

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics

Home

Adopt a Dog

Adopt a Mastiff

Iowa

Mastiff puppies and dogs in Iowa

Jump to:

Adopt a Mastiff near you in Iowa

Below are our newest added Mastiffs available for adoption in Iowa. To see more adoptable Mastiffs in Iowa, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Iowa cities

Mastiff shelters & rescues in Iowa

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics