Mastiff Adoption in Ste Genevieve, MO: Mastiff Puppies for Sale in Ste Genevieve, MO

Adopt a Mastiff near you in Ste Genevieve, Missouri

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Ste Genevieve, Missouri

These Mastiffs are available for adoption close to Ste Genevieve, Missouri.

Jax

Mastiff

Male, 1 yr

Columbia, IL

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Jax is a lovable goofball who does not realize his own size! He is full of puppy energy, loves running and playing, and would do best in a home without small children. He is housebroken, dog selective, and looking for an experienced adopter who can give him structure, exercise, and lots of love.Jax is one year old and weighs 74 pounds.The adoption fee for adult dogs, seven months and older, is $250. All pets are microchipped, up to date on vaccines, and will be altered prior to adoption. If you are interested in meeting a dog, please stop by the shelter during open hours. Dogs may be in a foster home, therefore scheduling an appointment is recommended. If you have an existing dog at home, we recommend bringing it along to meet your possible new family member.helpingstrays.org

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Derek

Mastiff American Pit Bull Terrier

Male, 2 yrs 2 mos

Belleville, IL

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

Derek is a lovable 2-year-old mastiff mix with a big ol’ blocky build and an even bigger personality. This sweet, even-tempered dude is friendly, goofy, and always ready for fun. He’s got plenty of energy and absolutely lives for his zoomie sessions—watching him take off is guaranteed to make you smile. Derek is also great with other dogs and would love a furry friend to romp around with. If you’re looking for a joyful, silly, good-natured companion, Derek is your guy!

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Chili Mac

Mastiff

Male, Puppy

St Louis, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Meet Chili Mac! This 11-month-old Cane Corso is a big, lovable goofball with a heart as giant as his paws! Chili Mac is equal parts cuddle bug and class clown — he’ll make you laugh one minute and melt into your lap the next. He can be a little shy when meeting new people, but once he decides you’re cool, he’s all in! He’s great with dogs big and small (seriously — from 6 lbs to 120 lbs!), crate and potty trained, and already knows some basic commands. Due to Chili Mac's size and clumsiness, he would do best in a home with older children. He would also be best with someone who has breed/guardian experience given some mouthy behaviors which are normal for the breed. Chili Mac would love an active home with another dog friend or a human adventure buddy. Whether you’re hiking, road-tripping, or just lounging on the couch- as long as you don’t mind a little drool, he’s ready to be your ride-or-die! If interested, please complete the Adoption Application on our website at www.NeedyPaws.org and we will contact you. Adopters must live within an hour’s drive of St. Louis, MO. Our $295 adoption fee includes up-to-date vaccinations, heartworm testing and preventative, spay/neuter and microchip. We are a 100% foster-based rescue and all of our dogs live in approved foster homes. We are dedicated to finding the best Forever Homes, and will perform home visits and conduct veterinarian and reference checks for each potential adopter. Visit this organization's web site to see any additional information available about this pet.December 26, 2025, 1:09 pm

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Gus

Mastiff Mixed Breed (Large)

Male, Adult

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Meet Gus! Gus is a charming 3-year-old mastiff mix with a heart as big as his paws. This gentle giant is friendly, outgoing, and absolutely loves people. He gets along wonderfully with other dogs and kids—just be prepared for a little “bull in a china shop” energy when he gets excited! Gus is house-trained, kennel-trained, and making great progress with his leash skills. He’s also an excellent car buddy, happy to settle in and enjoy the ride. If you’re looking for a lovable, goofy companion who brings joy wherever he goes, Gus might just be your perfect match! https://www.shelterluv.com/matchme/adopt/NAF/Dog

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Big Dog

Mastiff

Male, 3 yrs 5 mos

East ST Louis, IL

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Spayed or Neutered,

Story

This pet's adoption fee is sponsored by the Zach Schneider Memorial Fund, created in memory of Zach Schneider, who loved pets and fostered for Gateway Pet Guardians. Waived fees are sponsored by the Zach Schneider Memorial Fund, created in memory of Zach Schneider, who loved pets and fostered for Gateway Pet Guardians! Meet Big Dog — Big Sweetness, Big Fun, Big Love! Big Dog lives up to his name in every way—he’s large, he’s lovable, and he’s overflowing with joy. This gentle giant has a heart to match his size, and around here, we lovingly call him Big Sweetness because that’s exactly what he is. Despite his impressive stature, Big Dog is all softness on the inside. While we think he'd do best as the only dog in a home, he’s affectionate, friendly, and eager to make connections with every human he meets. Whether he’s leaning in for pets, flashing his goofy grin, or trotting around with those oversized paws, he brings an irresistible charm that wins people over instantly. And let’s talk about the fun—because Big Dog brings that in a big way, too. He’s playful, spirited, and always ready for an adventure. From giant-sized zoomies to joyful tail wags that practically create a breeze, he knows how to keep life lively and full of laughter. If you’re searching for a dog who will fill your home with love, laughter, and big-hearted companionship, Big Dog is ready to take up space in your house and your heart. Come meet him—he’s Big Everything you could want in a best friend. If you are interested in a meet and greet for adoption for Big Dog, please fill out an application on our website at www.gatewaypets.org/adopt. If you are interested in learning more about Big Dog or the adoption process at GPG, please email placement@gatewaypets.org All of our dogs and cats will be microchipped, spayed or neutered, and up-to-date on vaccinations at the time of adoption. For more photos of Big Dog, follow us on Facebook Gateway Pet Guardians and Instagram @gatewaypets ... #gpgBig Dog. To view other adoptable pets from our shelter, please visit, www.gatewaypets.org/adopt. Gateway Pet Guardians is proud to offer a variety of mixed breed dogs available for adoption. However, please keep in mind that we rarely know the genetic background of the animals we rescue and, as such, we cannot guarantee the exact breed combinations found within this dog. Therefore, we do not know his/her actual genetic makeup. Just know that this dog is probably a variety of several different breeds that have combined to create one very amazing and unique animal.

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Hippie

Mastiff

Female, 9 mos

East ST Louis, IL

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Story

This pet's adoption fee is sponsored by the Zach Schneider Memorial Fund, created in memory of Zach Schneider, who loved pets and fostered for Gateway Pet Guardians. Big Girl = Big Love! Hippie is all peace and love, baby! Every square inch of her screams "I love you, do you love me too?!" We just adore her friendly disposition and outgoing personality. If you're looking for a true bestie, Hippie is definitely the right fit for you. If you are interested in a meet and greet for adoption for Hippie, please fill out an application on our website at www.gatewaypets.org/adopt. If you are interested in learning more about Hippie or the adoption process at GPG, please email placement@gatewaypets.org All of our dogs and cats will be microchipped, spayed or neutered, and up-to-date on vaccinations at the time of adoption. For more photos of Hippie, follow us on Facebook Gateway Pet Guardians and Instagram @gatewaypets ... #gpgHippie. To view other adoptable pets from our shelter, please visit, www.gatewaypets.org/adopt. Gateway Pet Guardians is proud to offer a variety of mixed breed dogs available for adoption. However, please keep in mind that we rarely know the genetic background of the animals we rescue and, as such, we cannot guarantee the exact breed combinations found within this dog. Therefore, we do not know his/her actual genetic makeup. Just know that this dog is probably a variety of several different breeds that have combined to create one very amazing and unique animal.

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Mastiff puppies and dogs in Ste Genevieve, Missouri

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Mastiff puppies and dogs in Ste Genevieve, Missouri

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Adopt a Mastiff near you in Ste Genevieve, Missouri

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Ste Genevieve, Missouri

These Mastiffs are available for adoption close to Ste Genevieve, Missouri.

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in Ste Genevieve, Missouri

Mastiff shelters & rescues in Ste Genevieve, Missouri

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics