Mastiff Adoption in De Soto, MO: Mastiff Puppies for Sale in De Soto, MO

Adopt a Mastiff near you in De Soto, Missouri

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near De Soto, Missouri

These Mastiffs are available for adoption close to De Soto, Missouri.

Jax

Mastiff

Male, 1 yr

Columbia, IL

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered, Shots are up-to-date,

Story

Jax is one year old and weighs 74 pounds.The adoption fee for adult dogs, seven months and older, is $250. All pets are microchipped, up to date on vaccines, and will be altered prior to adoption. If you are interested in meeting a dog, please stop by the shelter during open hours. Dogs may be in a foster home, therefore scheduling an appointment is recommended. If you have an existing dog at home, we recommend bringing it along to meet your possible new family member.helpingstrays.org

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Chili Mac

Mastiff

Male, Puppy

St Louis, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Meet Chili Mac! This 11-month-old Cane Corso is a big, lovable goofball with a heart as giant as his paws! Chili Mac is equal parts cuddle bug and class clown — he’ll make you laugh one minute and melt into your lap the next. He can be a little shy when meeting new people, but once he decides you’re cool, he’s all in! He’s great with dogs big and small (seriously — from 6 lbs to 120 lbs!), crate and potty trained, and already knows some basic commands. Due to Chili Mac's size and clumsiness, he would do best in a home with older children. He would also be best with someone who has breed/guardian experience given some mouthy behaviors which are normal for the breed. Chili Mac would love an active home with another dog friend or a human adventure buddy. Whether you’re hiking, road-tripping, or just lounging on the couch- as long as you don’t mind a little drool, he’s ready to be your ride-or-die! If interested, please complete the Adoption Application on our website at www.NeedyPaws.org and we will contact you. Adopters must live within an hour’s drive of St. Louis, MO. Our $295 adoption fee includes up-to-date vaccinations, heartworm testing and preventative, spay/neuter and microchip. We are a 100% foster-based rescue and all of our dogs live in approved foster homes. We are dedicated to finding the best Forever Homes, and will perform home visits and conduct veterinarian and reference checks for each potential adopter. Visit this organization's web site to see any additional information available about this pet.December 26, 2025, 1:09 pm

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WALTER

Mastiff

Male, 5 yrs 1 mo

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

Walter is friendly, outgoing, and his happiness is contagious. He walks well on a leash and seems to be potty trained. He knows sit, loves to play with squeekie toys, and wants all the pets.

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Bellatrix

Mastiff

Female, 8 yrs 2 mos

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

Meet Bellatrix – The Gentle Giant with a Harry Potter Twist! Bellatrix may share a name with a famous witch, but don’t worry—she’s all love and loyalty, no dark magic here! This 8-year-old Mastiff is a wise and gentle soul who prefers cuddles over curses and cozy naps over chaos. She absolutely adores people and will happily be your most devoted companion. Bellatrix is potty and crate trained, though she hardly needs her crate it because she’s such a well-mannered lady. Her ideal home? A calm, loving environment where she can relax and feel like the queen of her own Great Hall. She would do best as the only dog in the home. Bellatrix enjoys short strolls, comfy spots like the couch, and being near her favorite humans—she’s basically your very own magical protector. If you’re ready to add a little enchantment (and a lot of love) to your life, Bellatrix is waiting to cast her spell on your heart. Her adoption fee is fully sponsored. Ready to meet Bellatrix? She’s more Hufflepuff than Slytherin—bring her home today! Visit Istodaymydayrescue.org to learn more or fill out an application.

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Gus

Mastiff Mixed Breed (Large)

Male, Adult

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Meet Gus! Gus is a charming 3-year-old mastiff mix with a heart as big as his paws. This gentle giant is friendly, outgoing, and absolutely loves people. He gets along wonderfully with other dogs and kids—just be prepared for a little “bull in a china shop” energy when he gets excited! Gus is house-trained, kennel-trained, and making great progress with his leash skills. He’s also an excellent car buddy, happy to settle in and enjoy the ride. If you’re looking for a lovable, goofy companion who brings joy wherever he goes, Gus might just be your perfect match! https://www.shelterluv.com/matchme/adopt/NAF/Dog

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HARRY

Mastiff

Male, 3 yrs

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

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Mastiff puppies and dogs in De Soto, Missouri

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Adopt a Mastiff near you in De Soto, Missouri

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near De Soto, Missouri

These Mastiffs are available for adoption close to De Soto, Missouri.

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in De Soto, Missouri

Mastiff shelters & rescues in De Soto, Missouri

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics