Mastiff Adoption in De Soto, MO: Mastiff Puppies for Sale in De Soto, MO

Adopt a Mastiff near you in De Soto, Missouri

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near De Soto, Missouri

These Mastiffs are available for adoption close to De Soto, Missouri.

Jax

Mastiff

Male, 1 yr 1 mo

Columbia, IL

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Jax is a lovable goofball who does not realize his own size! He is full of puppy energy, loves running and playing, and would do best in a home without small children. He is housebroken, dog selective, and looking for an experienced adopter who can give him structure, exercise, and lots of love.Jax is one year old and weighs 74 pounds.The adoption fee for adult dogs, seven months and older, is $250. All pets are microchipped, up to date on vaccines, and will be altered prior to adoption. If you are interested in meeting a dog, please stop by the shelter during open hours. Dogs may be in a foster home, therefore scheduling an appointment is recommended. If you have an existing dog at home, we recommend bringing it along to meet your possible new family member.helpingstrays.org

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Tiny Tim K 15

Mastiff

Male, 2 yrs

Union, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Spayed or Neutered,

Story

Green Status - Loves to go on walks with everyone.

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Chili Mac

Mastiff

Male, Puppy

St Louis, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Meet Chili Mac! This 11-month-old Cane Corso is a big, lovable goofball with a heart as giant as his paws! Chili Mac is equal parts cuddle bug and class clown — he’ll make you laugh one minute and melt into your lap the next. He can be a little shy when meeting new people, but once he decides you’re cool, he’s all in! He’s great with dogs big and small (seriously — from 6 lbs to 120 lbs!), crate and potty trained, and already knows some basic commands. Due to Chili Mac's size and clumsiness, he would do best in a home with older children. He would also be best with someone who has breed/guardian experience given some mouthy behaviors which are normal for the breed. Chili Mac would love an active home with another dog friend or a human adventure buddy. Whether you’re hiking, road-tripping, or just lounging on the couch- as long as you don’t mind a little drool, he’s ready to be your ride-or-die! If interested, please complete the Adoption Application on our website at www.NeedyPaws.org and we will contact you. Adopters must live within an hour’s drive of St. Louis, MO. Our $295 adoption fee includes up-to-date vaccinations, heartworm testing and preventative, spay/neuter and microchip. We are a 100% foster-based rescue and all of our dogs live in approved foster homes. We are dedicated to finding the best Forever Homes, and will perform home visits and conduct veterinarian and reference checks for each potential adopter. Visit this organization's web site to see any additional information available about this pet.January 27, 2026, 8:03 pm

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Mr. Bojangles

Mastiff Mixed Breed (Large)

Male, 3 yrs 6 mos

St. Louis, MO

Size

(when grown) -

Details

Spayed or Neutered,

Story

Meet Mr. Bojangles, a distinguished male dog around three years old, who brings both class and a dash of drama to the table! He would like to clarify that the vocalizations you hear from his kennel are not barking, but rather his intensive opera training in progress! Once he's out, this fancy-pants gentleman is incredibly chill and sweet, and he walks like a pro—no pulling, unless nature is making an urgent call. Mr. Bojangles is a certified foodie who appreciates a good gourmet treat but is just as happy with a classic peanut-butter bone. Basically, he’s a loyal companion who is effortlessly refined and ready to serenade his way into your heart!

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Meryl Streep

Mastiff Mixed Breed (Medium)

Female, 2 yrs

St. Louis, MO

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,

Story

🩷I learned much about adorable Meryl Streep yesterday as we buddied up and attended CARE’S Adoption Event at “Tower Grove Pride” event. This adorable one and a half year-old pup showed her happy self from the moment she jumped in the car and was the perfect backseat rider. 🩷As we walked to CARE’S tent Meryl walked well on the leash. The event was well attended and this sweet pup was friendly and sweet throughout. As participants of all ages came up to say “Hi” and gave her pets she was gentle to everyone. As other dogs passed she was mostly indifferent being content and enjoying the moment. When this precious girl was tired she laid down and fell fast asleep and stayed like that as the action continued all around her. After her short nap we headed back to the car. This precious, perfect girl made the day’s event fun, happy and totally enjoyable for me her sidekick💕 🩷All I could think is this fabulous pup belongs in a loving home and hopefully soon! Meryl Streep, is a treasure and would be a cherished pup for many families. -Her eye condition is called Cherry Eye and is not serious and will be taken care of by CARES clinic when she’s adopted. 🩷She is at CARE STL for you to meet and possibly fall in love just like me🩷🐾XOXO

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Bagels

Mastiff Mixed Breed (Medium)

Female, 1 yr 3 mos

St. Louis, MO

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with dogs, House-trained, Spayed or Neutered,

Story

Bagels is an adorable 11-month-old Mastiff mix (we suspect there's a little Boxer in her!) who is the very definition of a tiny lap puppy disguised in a big, beautiful body. This goofy girl has absolutely no clue how big she is, and she'll try to climb right onto your lap to melt you with her big brown eyes and sweet face! Bagels is a true Velcro pup who will follow you everywhere, convinced that your personal space is her personal cuddle zone. But with a face this cute, who needs personal space? She's quite smart, too, and is great motivated, which means she's quick to follow commands. Bagels is reliably house-broken (for the most part!) and loves sleeping comfortably on her own couch, going for walks around the neighborhood, and goofing around in the backyard. She's ready to fill an active home with love, snuggles, and endless laughs!

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Mastiff puppies and dogs in De Soto, Missouri

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Mastiff puppies and dogs in De Soto, Missouri

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Adopt a Mastiff near you in De Soto, Missouri

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near De Soto, Missouri

These Mastiffs are available for adoption close to De Soto, Missouri.

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in De Soto, Missouri

Mastiff shelters & rescues in De Soto, Missouri

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics