Mastiff Adoption in De Soto, MO: Mastiff Puppies for Sale in De Soto, MO

Adopt a Mastiff near you in De Soto, Missouri

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near De Soto, Missouri

These Mastiffs are available for adoption close to De Soto, Missouri.

Jax

Mastiff

Male, 1 yr 2 mos

Columbia, IL

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Jax is a lovable goofball who does not realize his own size! He is full of puppy energy, loves running and playing, and would do best in a home without small children. He is housebroken, dog selective, and looking for an experienced adopter who can give him structure, exercise, and lots of love.Jax is one year old and weighs 74 pounds.The adoption fee for adult dogs, seven months and older, is $250. All pets are microchipped, up to date on vaccines, and will be altered prior to adoption. If you are interested in meeting a dog, please stop by the shelter during open hours. Dogs may be in a foster home, therefore scheduling an appointment is recommended. If you have an existing dog at home, we recommend bringing it along to meet your possible new family member.helpingstrays.org

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Chili Mac

Mastiff

Male, Puppy

St Louis, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Chili Mac is currently enrolled in the 12-week Puppies 4 Parole program through the Mo Department of Corrections. He will graduate around May 1st and will be available for adoption at that time. If you are interested in adopting Chili Mac, please complete an application and the foster parent will contact you. Meet Chili Mac! This 11-month-old Cane Corso is a big, lovable goofball with a heart as giant as his paws! Chili Mac is equal parts cuddle bug and class clown — he’ll make you laugh one minute and melt into your lap the next. He can be a little shy when meeting new people, but once he decides you’re cool, he’s all in! He’s great with dogs big and small (seriously — from 6 lbs to 120 lbs!), crate and potty trained, and already knows some basic commands. Due to Chili Mac's size and clumsiness, he would do best in a home with older children. He would also be best with someone who has breed/guardian experience given some mouthy behaviors which are normal for the breed. Chili Mac would love an active home with another dog friend or a human adventure buddy. Whether you’re hiking, road-tripping, or just lounging on the couch- as long as you don’t mind a little drool, he’s ready to be your ride-or-die! If interested, please complete the Adoption Application on our website at www.NeedyPaws.org and we will contact you. Adopters must live within an hour’s drive of St. Louis, MO. Our $295 adoption fee includes up-to-date vaccinations, heartworm testing and preventative, spay/neuter and microchip. We are a 100% foster-based rescue and all of our dogs live in approved foster homes. We are dedicated to finding the best Forever Homes, and will perform home visits and conduct veterinarian and reference checks for each potential adopter.Visit this organization's web site to see any additional information available about this pet.March 8, 2026, 11:22 am

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LUCY

Mastiff

Female, 3 yrs

St. Louis, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Spayed or Neutered,

Story

Lucy is a great dog looking for a forever home. She has lived with children and other dogs, she loves ropes and stuffed toys. She needs plenty of room to roam and prefers a big backyard!

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Meryl Streep

Mastiff Mixed Breed (Medium)

Female, 2 yrs 1 mo

St. Louis, MO

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,

Story

🩷I learned much about adorable Meryl Streep yesterday as we buddied up and attended CARE’S Adoption Event at “Tower Grove Pride” event. This adorable one and a half year-old pup showed her happy self from the moment she jumped in the car and was the perfect backseat rider. 🩷As we walked to CARE’S tent Meryl walked well on the leash. The event was well attended and this sweet pup was friendly and sweet throughout. As participants of all ages came up to say “Hi” and gave her pets she was gentle to everyone. As other dogs passed she was mostly indifferent being content and enjoying the moment. When this precious girl was tired she laid down and fell fast asleep and stayed like that as the action continued all around her. After her short nap we headed back to the car. This precious, perfect girl made the day’s event fun, happy and totally enjoyable for me her sidekick💕 🩷All I could think is this fabulous pup belongs in a loving home and hopefully soon! Meryl Streep, is a treasure and would be a cherished pup for many families. -Her eye condition is called Cherry Eye and is not serious and will be taken care of by CARES clinic when she’s adopted. 🩷She is at CARE STL for you to meet and possibly fall in love just like me🩷🐾XOXO

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Fitzwilliam

Mastiff

Male, 3 yrs 11 mos

St. Louis, MO

Size

(when grown) -

Details

Good with kids, Good with dogs, House-trained, Spayed or Neutered,

Story

Meet Fitzwilliam, a handsome and incredibly loyal companion who is ready to find his "person." Whether you call him Fitz or Fitzy, he is a dog who truly listens; he responds beautifully to his name, soft whistles, and kiss sounds. While he might take a quiet 24 hours to assess a new environment, once that bond is formed, it is unbreakable. He is a "velcro dog" in the best way, often waiting for his favorite humans to sit down and relax before he finally settles into his own bed for the night. Fitzwilliam is a brilliant, observant boy with a problem-solving mind that will constantly impress you. He has even figured out how to operate lever-style door handles and pocket doors! This intelligence makes him a joy to engage with; he already knows "sit" and is eager to learn more. When he’s feeling playful, he showcases a silly side with joyful zoomies or "boxer-style" wrestling moves on the floor. Despite his athletic side, he is a gentleman at heart who is remarkably gentle with children, often approaching quietly for a sniff and a polite pat. A true homebody, Fitz loves the finer things in life—specifically cozy dog beds with high sides or cushioned bolsters. He is a relaxed presence in the house and is very content to snooze the day away once he’s had his exercise. He is also a star in his crate; once he settles in with a treat-filled Kong, he is calm and quiet, making him an easy roommate. His loyalty is perhaps his most impressive trait. In busy situations, he looks to his owners for guidance and stays by their side rather than wandering off. He’s the perfect partner for someone who enjoys a nice walk to the woods and appreciates a dog who truly values the connection they share. If you’re looking for a sweet, smart, and devoted friend to share your home with, Fitzwilliam is waiting to meet you.

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Bagels

Mastiff Mixed Breed (Medium)

Female, 1 yr 4 mos

St. Louis, MO

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with dogs, House-trained, Spayed or Neutered,

Story

Bagels is an adorable 11-month-old Mastiff mix (we suspect there's a little Boxer in her!) who is the very definition of a tiny lap puppy disguised in a big, beautiful body. This goofy girl has absolutely no clue how big she is, and she'll try to climb right onto your lap to melt you with her big brown eyes and sweet face! Bagels is a true Velcro pup who will follow you everywhere, convinced that your personal space is her personal cuddle zone. But with a face this cute, who needs personal space? She's quite smart, too, and is great motivated, which means she's quick to follow commands. Bagels is reliably house-broken (for the most part!) and loves sleeping comfortably on her own couch, going for walks around the neighborhood, and goofing around in the backyard. She's ready to fill an active home with love, snuggles, and endless laughs!

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Mastiff puppies and dogs in De Soto, Missouri

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Mastiff puppies and dogs in De Soto, Missouri

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Adopt a Mastiff near you in De Soto, Missouri

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near De Soto, Missouri

These Mastiffs are available for adoption close to De Soto, Missouri.

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in De Soto, Missouri

Mastiff shelters & rescues in De Soto, Missouri

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics