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Great Dane puppies and dogs in Lancaster, South Carolina

Looking for a Great Dane puppy or dog in Lancaster, South Carolina? Adopt a Pet can help you find an adorable Great Dane near you.

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Adopt a Great Dane near you in Lancaster, South Carolina

We don't see any Great Danes available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Great Danes in cities near Lancaster, South Carolina

These Great Danes are available for adoption close to Lancaster, South Carolina.
We'll also keep you updated on Milo's adoption status with email updates.
Photo of Milo

Milo

Great Dane Catahoula Leopard Dog

Male, Puppy
Rock Hill, SC
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Shots are up-to-date,
Story
Milo is a 15-week-old puppy with a gentle soul, wiggly puppy energy, and so much love to give. After a difficult start to life—being neglected and treated poorly for not looking like his siblings—Milo is ready for a fresh beginning with a family who will cherish him. He’s a shy boy at first, but once he feels safe, Milo will give you his whole heart. He’s a total cuddle bug who wants to be as close to you as possible and will happily follow you from room to room. With his long legs and bouncy hops, he moves like a little kangaroo and brings constant smiles with his goofy, clumsy charm. Milo loves other dogs, enjoys playtime, and is learning the ropes in his foster home. He’s working on basic training, doing well with leash walks, sleeps in his crate at night, and looks to his older foster brother for confidence and guidance. Milo needs a patient, loving home that will help him continue building confidence and show him that he is finally safe and loved—exactly as he is. 🐾💙 --- To apply to adopt, please follow the steps for adoption on HalfwayThereRescue.com/Adoption-Process and apply directly here: https://fs26.formsite.com/htrnp/a2k3lsooud/index.html
We'll also keep you updated on Espresso Martini's adoption status with email updates.
Photo of Espresso Martini

Espresso Martini

Great Dane

Female, 1 yr 1 mo
Chester, SC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, Needs experienced adopter, House-trained, Spayed or Neutered,
Story
Meet Espresso Martini, the fabulous one-year-old Great Dane who is ready to bring a splash of joy into your life! This lovely lady weighs in at a solid 112 pounds of pure love and affection. Just imagine those big, gentle paws and soulful eyes gazing up at you, ready to share a snuggle or two! 🐾💖 Espresso Martini is not just a pretty face; she’s a smart cookie who’s eager to please! With her training already underway, she’s learning leash manners and is both house and crate trained. That’s right, this girl is a fast learner, and she’s ready to impress you! Plus, she gets along wonderfully with other dogs and children, making her the perfect addition to any family. Just picture all the joyful moments you’ll share together! 🐶✨ And here's a little fun fact: Great Danes are known for their gentle demeanor, often earning them the title of "gentle giants." Espresso Martini embodies this beautifully! 🖤 So, if you’re looking for a big-hearted companion who loves to snuggle and play, Espresso Martini is your girl. Want to be a part of her incredible journey? Every animal deserves a happy ending, and this one starts with you! Espresso Martini is waiting for you to come meet her! Apply for the pet here: https://tinyurl.com/3u7r9sh7
We'll also keep you updated on THOR's adoption status with email updates.
Photo of THOR

THOR

Great Dane Labrador Retriever

Male, Adult
Charlotte, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
House-trained, Spayed or Neutered, Shots are up-to-date,
Story
  Thor is a one-year-old Great Dane and Lab mix weighing 71 pounds, and his story already reads like the opening scene of a movie. Found running loose through a Tennessee neighborhood, this big, beautiful boy was moments away from tragedy when fate—and a young dog lover—stepped in. Twice Thor ran in front of her car, and instead of driving on, she stopped, opened her door, and called to him. Without hesitation, Thor leapt into the back seat as if he knew his life was about to change. And it did.   With no collar and no microchip, Thor became part of Critter Cavalry Rescue and stayed with the very woman who saved him. From the moment he was safe, his true nature began to shine. Thor is strikingly handsome, with chiseled features and expressive ears that nearly stand straight up, giving him a regal, alert look—like a show dog who wandered off the Westminster runway and into a superhero origin story.   But don’t let the model looks fool you. Thor is pure joy wrapped in a giant puppy body. He tosses toys into the air, pounces on squeaky treasures, and delights in balls and stuffed animals with the enthusiasm of a dog who is still discovering how fun life can be. He doesn’t quite realize how big or strong he is yet, but his heart is gentle and his spirit is eager.   Thor is intelligent, focused, and deeply people-oriented. When you work with him, he locks onto you completely, especially if treats are involved, which makes training both effective and fun. He is wonderful with other dogs, showing no dominance or alpha behavior, just friendly curiosity and easygoing charm. Recently neutered, Thor is still growing and will likely fill out into a solid 90-pound adult over the next year.   He is housebroken and currently learning that being alone doesn’t mean being abandoned, as crates aren’t quite his favorite place. Thor simply loves people and wants to be near them, soaking in companionship and reassurance. His liver-and-black coat shifts with the sunlight, turning heads wherever he goes, and making him unforgettable long after he’s passed by.   Thor is the kind of dog who comes into your life once and leaves a permanent mark on your heart. He is waiting for someone to guide him, shape him, and grow with him into the extraordinary companion he is clearly meant to be.     If you are interested in making this big boy a big part of your life please write to Critter Cavalry Rescue at ccrtennessee@gmail.com. Tell us where you live, city and state.   We adopt to Tennessee where our rescue is based and he is being fostered, but we also transport to the Northeast   PLEASE NOTE:  Our dogs are transported from Tennessee to meeting places in the states where we have posted.  Further information about us is given on our Adopt-A-Pet site.  The adoption fees vary and will be provided as well as noted on the application you receive.  Contact us at 615-661-5333 or ccrnewengland@gmail.comJanuary 24, 2026, 5:58 pm
We'll also keep you updated on Slim Jim's adoption status with email updates.
Needs Home Fast
Photo of Slim Jim

Slim Jim

Great Dane

Male, 2 yrs
Gastonia, NC
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
-
Story
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We'll also keep you updated on Hera's adoption status with email updates.
Photo of Hera

Hera

Great Dane

Female, Adult
Stanley, NC
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Hera is a 2 year old gentle giant. She loves to cuddle and relax. She can be shy at times but overall has a good temperament. She weighs 125 lbs and she definitely doesn’t know that she is a giant dog. We are hopeful to rehome Hera to a loving home that can be more attentive to her.

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Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in Lancaster, South Carolina.

Great Dane puppies and dogs in nearby cities

Related breeds in Lancaster, South Carolina

Great Dane shelters & rescues in Lancaster, South Carolina

There are animal shelters and rescues that focus specifically on finding great homes for Great Dane puppies in Lancaster, South Carolina. Browse these Great Dane rescues and shelters below.

Here are a few organizations closest to you:

Rescue

24.5 miles

Halfway There Rescue

Rock Hill, SC 29732

Pet Types: dogs

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Rescue

27.9 miles

Country Acres Rescue

Chester, SC 29706

Pet Types: dogs

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Rescue

31.3 miles

Critter Cavalry Rescue -NC

Charlotte, NC 28201

Pet Types: cats, dogs

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Shelter

44 miles

Gaston County Animal Care and Enforcement

1491 Business Park Court, Gastonia, NC 28052

Pet Types: cats, dogs

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Want to learn more about adopting a Great Dane puppy or dog?

We've got all the info you need on adopting and caring for a Great Dane puppy. Check out the links below for everything you ever wanted to know about Great Dane puppies and adults.

Great Dane basics

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Where do Great Danes come from? How many types of Great Danes are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Great Dane.

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