Mastiff Adoption in Santa Ana, CA: Mastiff Puppies for Sale in Santa Ana, CA

Adopt a Mastiff near you in Santa Ana, California

These Mastiffs are available in Santa Ana, California.

Buddy

Mastiff Rottweiler

Male, Puppy

Santa Ana, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with dogs, Not good with cats, Shots are up-to-date,

Story

Buddy was a stray with a broken leg and malnourished. We took him in and took him to the vet to take care of his broken leg. He's very friendly with people, but is very defensive around other pets. He's very sweet and gentle with people.

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Or, how about these Mastiffs in cities near Santa Ana, California

These Mastiffs are available for adoption close to Santa Ana, California.

Buddy

Mastiff Rottweiler

Male, Puppy

Santa Ana, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with dogs, Not good with cats, Shots are up-to-date,

Story

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Henri

Mastiff

Male, 2 yrs

Huntington Beach, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

🥹 Henri will melt your heart! 😌 He's a mellow, loving soul! 😍 He'll snuggle up at your side! ☺️ He just wants your love and affection! ❤️ If Henri is too sweet to pass up, please click here to apply: https://www.treatpetrescue.org/adopt

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RECON

Mastiff

Male, Adult

Tustin, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

December 17, 2025, 7:17 pm

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Edam

Mastiff

Male, Adult

Newport Beach, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Not good with dogs, Not good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

This is a courtesy post on behalf of our partners at Maui Humane Society. Edam is available for adoption and can fly ANYWHERE Hawaiian or Alaska Airlines flies. If you are interested in adopting Edam, please contact us and we will put you in touch with the appropriate contacts at Maui Humane! My name is Edam! The Coast Guard found me at the park, I'd say it was a daring rescue at sea but in actuality I was just lounging on the grass. I'm Edam, a 5-year old boy who's seemingly had a rough past. See I was found with a serious leg injury, a collar so tight I have indents in my neck and my jaw is a little crooked but despite all this I'm happy-go-lucky, very loving, optimistic and thrilled to be here. The shelter is like the Four Seasons compared to where I've been! I enjoy going on walks, chewing on bones, playing in the yard, munching on snacks and getting attention from my humans. I was named Edam because it's a popular cheese that everyone likes, just like me! Ok, I'm ready to close the book on the first chapter of my life and start a new one - will you please be in my story? MY FOSTER HOME SAYS THIS ABOUT ME: Edam is a good boy who just want to be loved, he's very affectionate, eager to please and loves to give sweet kisses. His favorite things are stuffed Kongs, cuddling on the bed, eating cheese and hot dogs, and jumping in anyone's open truck tailgate! He is housebroken, he gets along with our dog, he knows sit, crate and wait and he's a mellow guy. To get pets he likes to sit in the back seat of the car with his front paws on the ground and his big head on the center console.

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Brody

Mastiff Pit Bull Terrier

Male, 4 yrs 8 mos

La Habra, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with kids, Good with dogs, Not good with cats, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Hi all! I’m Brody! I’m 4 years old and have been told I’m a total meat head who isn’t always aware just how big he is. I hear everyone calling me a handsome beefcake, which I can only imagine is a good thing. ☺️So far, everyone thinks I’m a mastiff/pit bull mix, hence the beefcake comments, but we’re not 100% sure as we haven’t done a DNA test. Regardless of my breed, I know I’m 100% handsome, because my foster mama tells me every day! 😍 I’ve got a big ole head, and a giant heart to match. 🫶 Not only am I easy on the eyes, but I’m also fully trained! I’ve got my basic obedience down, walk great on a leash and am crate trained. I love ALL dogs, even the littles, and my motto is #BALLISLIFE! I could play ball EVERY DAY and would love a home with a family who will play with me! But not to worry! I’m also perfectly content with some R&R at home and can be a lazy potato. My ideal home would be with a family who is patient and kind. I’ve had a lot happen to me in my 4 years on this earth, so I can be nervous meeting new people. However, I can also warm up really fast, and once you’re in, you’re in forever and we’ll be the bestest friends forever! 👯🤗 I’d also do best in a home with strong leaders, because let’s face it… I don’t like having to make choices. I mean, can ya blame me? Making decisions is a tiring thing, and why spend time doing that when I could be having fun! I’m fully vetted, neutered, current on all vaccines, microchipped and looking for my forever family.

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Moose - Courtesy Post

Mastiff

Male, Adult

Lake Forest, CA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, House-trained, Spayed or Neutered,

Story

This handsome big guy is Moose, a sweet 2-year-old pup tipping the scales at 97 lbs of love! Moose has had lots of training under his belt and is fully crate trained, walks beautifully on leash, and is great with other dogs.Moose is neutered, up-to-date on vaccines, and ready to find his forever home. While he’s made great progress, Moose is still a bit timid and sensitive, so he’s looking for a calmer household where he can continue to blossom at his own pace. Because of his gentle, shy nature, he’d do best in a home with older kids who understand how to give him space when he needs it.Moose would love a family who can provide a quiet, structured environment where he can feel safe, loved, and part of the pack. If you’re looking for a loyal, kind-hearted companion with a big heart (and paws to match!), Moose may be the one for you! Located in Los Angeles, CAOctober 14, 2025, 1:34 pm

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Mastiff puppies and dogs in Santa Ana, California

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Mastiff puppies and dogs in Santa Ana, California

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Adopt a Mastiff near you in Santa Ana, California

These Mastiffs are available in Santa Ana, California.

Or, how about these Mastiffs in cities near Santa Ana, California

These Mastiffs are available for adoption close to Santa Ana, California.

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in Santa Ana, California

Mastiff shelters & rescues in Santa Ana, California

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics