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Mastiff puppies and dogs in Irvine, California

Looking for a Mastiff puppy or dog in Irvine, California? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near Irvine, California Other pups in Irvine, California Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in Irvine, California Mastiff shelters and rescues in Irvine, California Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Irvine, California

These Mastiffs are available in Irvine, California.
Photo of RIVER

RIVER

Mastiff

Male, 1 yr
Irvine, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
Boo! Did I scare you? Don’t worry, I’m just River, your friendly neighborhood gentle giant! I may be a BIG boy, but underneath all this dog is an even bigger sweetheart with a goofy personality that’s sure to keep you laughing. I’m looking for a forever home with family members ages 16 and up who have plenty of love to give and don’t mind having a giant goofball around. So, what do you say? Skip the tricks, I’ve got all the treats (and cuddles) you could ever need!

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Or, how about these Mastiffs in cities near Irvine, California

These Mastiffs are available for adoption close to Irvine, California.
Photo of INDIANA

INDIANA

Mastiff

Male, Adult
Tustin, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
November 11, 2026, 1:51 pm

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Photo of Baby Huey

Baby Huey

Mastiff

Male, 4 yrs 9 mos
Tustin, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Spayed or Neutered,
Story
-

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Photo of RIVER

RIVER

Mastiff

Male, 1 yr
Irvine, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
Boo! Did I scare you? Don’t worry, I’m just River, your friendly neighborhood gentle giant! I may be a BIG boy, but underneath all this dog is an even bigger sweetheart with a goofy personality that’s sure to keep you laughing. I’m looking for a forever home with family members ages 16 and up who have plenty of love to give and don’t mind having a giant goofball around. So, what do you say? Skip the tricks, I’ve got all the treats (and cuddles) you could ever need!

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Photo of Moose (Courtesy Post) - Adopt Me!

Moose (Courtesy Post) - Adopt Me!

Mastiff

Male, Adult
Lake Forest, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, House-trained, Spayed or Neutered,
Story
This handsome big guy is Moose, a sweet 2-year-old pup tipping the scales at 97 lbs of love! Moose has had lots of training under his belt and is fully crate trained, walks beautifully on leash, and is great with other dogs.Moose is neutered, up-to-date on vaccines, and ready to find his forever home. While he’s made great progress, Moose is still a bit timid and sensitive, so he’s looking for a calmer household where he can continue to blossom at his own pace. Because of his gentle, shy nature, he’d do best in a home with older kids who understand how to give him space when he needs it.Moose would love a family who can provide a quiet, structured environment where he can feel safe, loved, and part of the pack. If you’re looking for a loyal, kind-hearted companion with a big heart (and paws to match!), Moose may be the one for you! Located in Los Angeles, CAMarch 7, 2026, 3:29 pm

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Photo of Charlie

Charlie

Mastiff

Male, 2 yrs
Huntington Beach, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Charlie is a loving and gentle boy! He likes to go on walks and cuddle with people. He is being trained by Redemption Tails, and his adoption includes a consultation.

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Photo of COLEMAN

COLEMAN

Mastiff

Male, 1 yr
Corona, CA
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
-
Story
11/3/26 Dog was adopted and returned in 24hours. Per the adopter, living situation changed. Return was not a result of the dogs behavior. 10/23/26 11:19 Showing increased signs of kennel stress. Leash biting and jumping up at hander. Difficult for staff and volunteers to get in/out of kennel. Young dog growing up in shelter system. Becoming increasingy frustrated due to prolonged confinement.

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Irvine, California.

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Mastiff puppies and dogs in nearby cities

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Related breeds in Irvine, California

Bullmastiffs in Irvine, California Neapolitan Mastiffs in Irvine, California Saint Bernards in Irvine, California

Mastiff shelters & rescues in Irvine, California

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Irvine, California. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Rescue

2.4 miles

No Stray Left Behind

Tustin, CA 92782

Pet Types: dogs

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Shelter

2.4 miles

OC Animal Care

1630 Victory Road, Tustin, CA 92782

Pet Types: cats, birds, dogs, rabbits, reptiles, small animals

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Shelter

3.4 miles

Irvine Animal Care Center

6443 Oak Canyon, Irvine, CA 92618

Pet Types: cats, birds, dogs, rabbits, small animals

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Rescue

8.1 miles

The Little Red Dog, Inc

Lake Forest, CA 92630

Pet Types: cats, dogs, rabbits, small animals

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Rescue

13.7 miles

TREAT Pet Rescue

Huntington Beach, CA 92646

Pet Types: cats, dogs

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Shelter

15.2 miles

Corona Animal Shelter

1330 Magnolia Ave, Corona, CA 92879

Pet Types: cats, birds, dogs, rabbits, reptiles, small animals

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Shelter

20.7 miles

Inland Valley Humane Society & S.P.C.A.

500 Humane Way, Pomona, CA 91766

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Shelter

21.6 miles

Long Beach Animal Care Services

7700 E Spring St., Long Beach, CA 90815

Pet Types: cats, birds, dogs, rabbits, small animals

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Shelter

21.7 miles

West End Shelter for Animals

Ontario, CA 91761

Pet Types: cats, dogs

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Shelter

23.4 miles

Mary S. Roberts Pet Adoption Center

6165 Industrial Avenue, Riverside, CA 92504

Pet Types: cats, dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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