Mastiff Adoption in Irvine, CA: Mastiff Puppies for Sale in Irvine, CA

Adopt a Mastiff near you in Irvine, California

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Irvine, California

These Mastiffs are available for adoption close to Irvine, California.

Buddy

Mastiff Rottweiler

Male, Puppy

Santa Ana, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with dogs, Not good with cats, Shots are up-to-date,

Story

Buddy was a stray with a broken leg and malnourished. We took him in and took him to the vet to take care of his broken leg. He's very friendly with people, but is very defensive around other pets. He's very sweet and gentle with people.

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Moose - Courtesy Post

Mastiff

Male, Adult

Lake Forest, CA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, House-trained, Spayed or Neutered,

Story

This handsome big guy is Moose, a sweet 2-year-old pup tipping the scales at 97 lbs of love! Moose has had lots of training under his belt and is fully crate trained, walks beautifully on leash, and is great with other dogs.Moose is neutered, up-to-date on vaccines, and ready to find his forever home. While he’s made great progress, Moose is still a bit timid and sensitive, so he’s looking for a calmer household where he can continue to blossom at his own pace. Because of his gentle, shy nature, he’d do best in a home with older kids who understand how to give him space when he needs it.Moose would love a family who can provide a quiet, structured environment where he can feel safe, loved, and part of the pack. If you’re looking for a loyal, kind-hearted companion with a big heart (and paws to match!), Moose may be the one for you! Located in Los Angeles, CAOctober 14, 2025, 1:34 pm

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Dudley-Special Needs - Adopt Me!

Mastiff Labrador Retriever

Male, Adult

Lake Forest, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Dudley is a sweet, affectionate 2-year-old male weighing around 65 lbs. Partially blind and deaf, he doesn’t let that slow him down. He walks nicely on leash and just needs gentle guidance to avoid obstacles — if he loses track, he’ll give your leg a soft “bonk” to reorient himself.Dudley enjoys short walks, stuffed toys, and being outside. After a 20-minute stroll, he’s ready to chill for the rest of the day. He lets you know when he needs to potty and loves foraging for treats as enrichment.He’s social with other dogs (especially if they make physical contact), and he’s currently thriving in a foster home with other dogs, cats, and kids. Dudley also responds to touch cues — a double tap on his bottom means “sit.”Dudley is looking for a patient, loving home to guide him safely and show him how wonderful life can be!December 10, 2025, 5:20 pm

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Butch

Mastiff Mastiff

Male, Senior

Mission Viejo, CA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

This sweet senior boy was found wandering in Northern California, and despite his big size, he’s truly just a gentle giant. He’s a white mastiff mix who wants nothing more than to be near his people. At his age, he’s not too active — a bit of arthritis has slowed him down — but he still enjoys short sniff walks and quiet time in the sun. He’s fully potty trained, knows a few simple commands, and has the best manners. He gets along great with smaller dogs and does fine with bigger ones too, as long as introductions are done slowly. What he really needs is someone who’s home most of the time and ready to give him the companionship he’s been missing. He’s not looking for adventure anymore — just love, warmth, and a cozy spot to rest his head. If you’ve got room in your heart and home for a loyal old friend who just wants to be loved, this gentle soul would be forever grateful.December 6, 2025, 6:54 pm

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Edam

Mastiff

Male, Adult

Newport Beach, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Not good with dogs, Not good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

This is a courtesy post on behalf of our partners at Maui Humane Society. Edam is available for adoption and can fly ANYWHERE Hawaiian or Alaska Airlines flies. If you are interested in adopting Edam, please contact us and we will put you in touch with the appropriate contacts at Maui Humane! My name is Edam! The Coast Guard found me at the park, I'd say it was a daring rescue at sea but in actuality I was just lounging on the grass. I'm Edam, a 5-year old boy who's seemingly had a rough past. See I was found with a serious leg injury, a collar so tight I have indents in my neck and my jaw is a little crooked but despite all this I'm happy-go-lucky, very loving, optimistic and thrilled to be here. The shelter is like the Four Seasons compared to where I've been! I enjoy going on walks, chewing on bones, playing in the yard, munching on snacks and getting attention from my humans. I was named Edam because it's a popular cheese that everyone likes, just like me! Ok, I'm ready to close the book on the first chapter of my life and start a new one - will you please be in my story? MY FOSTER HOME SAYS THIS ABOUT ME: Edam is a good boy who just want to be loved, he's very affectionate, eager to please and loves to give sweet kisses. His favorite things are stuffed Kongs, cuddling on the bed, eating cheese and hot dogs, and jumping in anyone's open truck tailgate! He is housebroken, he gets along with our dog, he knows sit, crate and wait and he's a mellow guy. To get pets he likes to sit in the back seat of the car with his front paws on the ground and his big head on the center console.

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Henri

Mastiff

Male, 2 yrs

Huntington Beach, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

🥹 Henri will melt your heart! 😌 He's a mellow, loving soul! 😍 He'll snuggle up at your side! ☺️ He just wants your love and affection! ❤️ If Henri is too sweet to pass up, please click here to apply: https://www.treatpetrescue.org/adopt

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Mastiff puppies and dogs in Irvine, California

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Adopt a Mastiff near you in Irvine, California

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Irvine, California

These Mastiffs are available for adoption close to Irvine, California.

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in Irvine, California

Mastiff shelters & rescues in Irvine, California

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics