Mastiff Adoption in Orange, CA: Mastiff Puppies for Sale in Orange, CA

Adopt a Mastiff near you in Orange, California

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Orange, California

These Mastiffs are available for adoption close to Orange, California.

RECON

Mastiff

Male, Adult

Tustin, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

December 12, 2025, 10:40 pm

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Buddy

Mastiff Rottweiler

Male, Puppy

Santa Ana, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with dogs, Not good with cats, Shots are up-to-date,

Story

Buddy was a stray with a broken leg and malnourished. We took him in and took him to the vet to take care of his broken leg. He's very friendly with people, but is very defensive around other pets. He's very sweet and gentle with people.

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Moose - Courtesy Post

Mastiff

Male, Adult

Lake Forest, CA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, House-trained, Spayed or Neutered,

Story

This handsome big guy is Moose, a sweet 2-year-old pup tipping the scales at 97 lbs of love! Moose has had lots of training under his belt and is fully crate trained, walks beautifully on leash, and is great with other dogs.Moose is neutered, up-to-date on vaccines, and ready to find his forever home. While he’s made great progress, Moose is still a bit timid and sensitive, so he’s looking for a calmer household where he can continue to blossom at his own pace. Because of his gentle, shy nature, he’d do best in a home with older kids who understand how to give him space when he needs it.Moose would love a family who can provide a quiet, structured environment where he can feel safe, loved, and part of the pack. If you’re looking for a loyal, kind-hearted companion with a big heart (and paws to match!), Moose may be the one for you! Located in Los Angeles, CAOctober 14, 2025, 1:34 pm

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Dudley-Special Needs - Adopt Me!

Mastiff Labrador Retriever

Male, Adult

Lake Forest, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Dudley is a sweet, affectionate 2-year-old male weighing around 65 lbs. Partially blind and deaf, he doesn’t let that slow him down. He walks nicely on leash and just needs gentle guidance to avoid obstacles — if he loses track, he’ll give your leg a soft “bonk” to reorient himself.Dudley enjoys short walks, stuffed toys, and being outside. After a 20-minute stroll, he’s ready to chill for the rest of the day. He lets you know when he needs to potty and loves foraging for treats as enrichment.He’s social with other dogs (especially if they make physical contact), and he’s currently thriving in a foster home with other dogs, cats, and kids. Dudley also responds to touch cues — a double tap on his bottom means “sit.”Dudley is looking for a patient, loving home to guide him safely and show him how wonderful life can be!December 10, 2025, 5:20 pm

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Brody

Mastiff Pit Bull Terrier

Male, 4 yrs 7 mos

La Habra, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with kids, Good with dogs, Not good with cats, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Hi all! I’m Brody! I’m 4 years old and have been told I’m a total meat head who isn’t always aware just how big he is. I hear everyone calling me a handsome beefcake, which I can only imagine is a good thing. ☺️So far, everyone thinks I’m a mastiff/pit bull mix, hence the beefcake comments, but we’re not 100% sure as we haven’t done a DNA test. Regardless of my breed, I know I’m 100% handsome, because my foster mama tells me every day! 😍 I’ve got a big ole head, and a giant heart to match. 🫶 Not only am I easy on the eyes, but I’m also fully trained! I’ve got my basic obedience down, walk great on a leash and am crate trained. I love ALL dogs, even the littles, and my motto is #BALLISLIFE! I could play ball EVERY DAY and would love a home with a family who will play with me! But not to worry! I’m also perfectly content with some R&R at home and can be a lazy potato. My ideal home would be with a family who is patient and kind. I’ve had a lot happen to me in my 4 years on this earth, so I can be nervous meeting new people. However, I can also warm up really fast, and once you’re in, you’re in forever and we’ll be the bestest friends forever! 👯🤗 I’d also do best in a home with strong leaders, because let’s face it… I don’t like having to make choices. I mean, can ya blame me? Making decisions is a tiring thing, and why spend time doing that when I could be having fun! I’m fully vetted, neutered, current on all vaccines, microchipped and looking for my forever family.

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Henri

Mastiff

Male, 2 yrs

Huntington Beach, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

🥹 Henri will melt your heart! 😌 He's a mellow, loving soul! 😍 He'll snuggle up at your side! ☺️ He just wants your love and affection! ❤️ If Henri is too sweet to pass up, please click here to apply: https://www.treatpetrescue.org/adopt

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These pups are in Orange, California too!

Below are our newest added Mastiffs available for adoption in Orange, California. To see more adoptable Mastiffs in Orange, California, use the search tool below to enter specific criteria!

Bernie

St. Bernard

Male, Adult

Irvine, CA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Meet Bernie — Our Gentle Giant Looking for His Forever Home! Bernie is a 3–4 year old Saint Bernard who survived on the streets for about three weeks before being rescued. Despite his rough start, he is incredibly sweet, gentle, and loving. This big-hearted boy is ready to leave his past behind and find a family who will cherish him. Bernie is a classic St. Bernard — calm, affectionate, and loyal. He enjoys people, loves gentle attention, and just wants to feel safe and loved. He’s looking for a forever home where he can relax, receive consistent care, and finally know what it means to belong. If you have room in your home (and heart!) for this big, lovable companion, Bernie is ready to be your new best friend. He deserves a fresh start and a comfy spot to call his own. &#226&#157&#164&#239&#184&#143 For a complete list of our pets and photos please visit our website fochp.org December 10, 2025, 6:43 pm

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Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Orange, California.

Mastiff puppies and dogs in Orange, California

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Adopt a Mastiff near you in Orange, California

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Orange, California

These Mastiffs are available for adoption close to Orange, California.

These pups are in Orange, California too!

Below are our newest added Mastiffs available for adoption in Orange, California. To see more adoptable Mastiffs in Orange, California, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in Orange, California

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Mastiff basics

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Mastiff puppies and dogs in Orange, California

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Adopt a Mastiff near you in Orange, California

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Orange, California

These Mastiffs are available for adoption close to Orange, California.

These pups are in Orange, California too!

Below are our newest added Mastiffs available for adoption in Orange, California. To see more adoptable Mastiffs in Orange, California, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in Orange, California

Mastiff shelters & rescues in Orange, California

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics