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Mastiff puppies and dogs in Massachusetts

Looking for a Mastiff puppy or dog in Massachusetts? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you in Massachusetts

Below are our newest added Mastiffs available for adoption in Massachusetts. To see more adoptable Mastiffs in Massachusetts, use the search tool below to enter specific criteria!
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DUKE

Mastiff

Male, 1 yr 6 mos
Boston, MA
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
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Story
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Photo of Nova

Nova

Mastiff/American Pit Bull Terrier

Female, Adult
Easthampton, MA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained,
Story
Nova is a 6 year old dog looking for a loving home. Good with other dogs and cats. House trained and nows all basic commands. She does get seasonal allergies. She is very sweet and loving. Is a window barker
Photo of King Kong

King Kong

Mastiff

Male, 11 mos
Worcester, MA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
Move over, Godzilla… there`s a new lovable giant in town! Meet King Kong, a goofy, dorky Mastiff mix puppy who is still trying to figure out what to do with all those legs, paws, and that BIG personality! He`s basically a walking, wiggling, wrestling machine with a heart of gold and absolutely no concept of personal space. We think King Kong would LOVE a canine buddy who enjoys playing, romping, and wrestling. He has enjoyed playing with other dogs at the shelter. Another fun-loving dog could be just his kind of partner in crime!Fair warning: this big boy is still working on his manners. He jumps up with enthusiasm and can knock people around without meaning to, so he`ll need an adopter who is physically able to safely handle and walk a strong, growing pup. If there are to be kids in the home should be teenagers.Looking for a whole lot of puppy silliness wrapped in one giant package? King Kong is ready to bring the laughs, the love, and possibly a few bruises to your lifeIf you are interested in adopting King Kong please come to the shelter on Mondays, Wednesdays and Thursdays during our walk-in adoption hours of 12-4pm
Photo of Silvio

Silvio

Mastiff/Great Pyrenees

Male, Young
Shrewsbury, MA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained,
Story
Silvio is the best boy. He is so loving, loves cuddles... and any kind of attention. He thinks hes small - still has puppy energy. He turned 3 in January 2026. I have no complaints with him whatsoever... rehoming him breaks our hearts, but he deserves better than the circumstances were facing. He needs room to stretch his legs and exercise on a regular basis. He loves playing in snow, he is so funny when he gets the zoomies lol. He is just the best!! He does so well at dogs parks, we take him almost every day. Gentle giant but protective over his family. He's not the biggest fan of strangers getting too close to us or our home but once they let him sniff & say hi its fine. I would love to be able to visit him occasionally. But he does need more than I can provide at this point so this must be done. You will love every second with him. He keeps life interesting thats for sure. He needs someone with time & energy.

Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Massachusetts.

Mastiff puppies and dogs in Massachusetts cities

Mastiff shelters & rescues in Massachusetts

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Massachusetts. Browse these Mastiff rescues and shelters below.

Here are a few organizations

Shelter

Animal Rescue League of Boston

10 Chandler Street, Boston , MA 02116

Pet Types: cats, birds, dogs, rabbits, small animals

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Shelter

Worcester Animal Rescue League

139 Holden St., Worcester , MA 01606

Pet Types: cats, dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog ?

We've got all the info you need on adopting and caring for a Mastiff puppy . Check out the links below for everything you ever wanted to know about Mastiff puppies and adults .

Mastiff information

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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