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Mastiff puppies and dogs in North Carolina

Looking for a Mastiff puppy or dog in North Carolina? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff in North Carolina Search for a Mastiff puppy or dog Mastiff puppies and dogs in North Carolina cities Mastiff shelters and rescues in North Carolina Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in North Carolina

Below are our newest added Mastiffs available for adoption in North Carolina. To see more adoptable Mastiffs in North Carolina, use the search tool below to enter specific criteria!
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A018448

Mastiff

Male, 8 mos
Shelby, NC
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
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Story
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BOBO

Mastiff

Male, 1 yr 1 mo
Chapel Hill, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
I am a sweet dog that arrived at OCAS as a stray. I was very underweight and had some other medical concerns. The care team at the shelter is helping me gain weight and they are providing lots of TLC. I am young and eager to learn. I`ll make a great addition to some lucky home!If you`d like to help me and other pets that enter the shelter with medical issues, please consider making a donation to the shelter. The Community Giving Fund is an easy way to donate online. Thank you!Insights from my adventure buddies and foster friends:Bobo is a lovely pup who can seem shy and fearful at first, but his true personality shines through very quickly. Underneath that initial shyness is a playful, energetic dog who loves spending time playing with you and with other dogs. He loves any toy he can chew on and is extremely food-motivated, which made it easy to teach him `sit` and `up` in no time. Given how smart he is, you could realistically teach him just about anything. He`s at the perfect age to be adopted and shaped by his forever family, since he picks up on patterns very quickly. As an energetic pup, he`ll need a family willing to commit some time to developing and stimulating his mind through structured play. He is very funny! Somehow, he`s always making you laugh.

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Cricket

Mastiff

Male, Adult
Boone, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained,
Story
Are you hoping to find an older dog with a calm, goofy personality who wants to be your very best friend? Are you hoping for a dog who is not destructive, but respectful of your space and already house trained? Cricket was found dying in a ditch six months ago. I brought him home, and he has come an incredibly long way since then. He was heartworm positive when I found him. He completed treatment through Watauga Vet and is now clear to go for walks, hikes, and play with other dogs. He will need to remain on heartworm prevention for the rest of his life. * He is in good health now and has a dental cleaning scheduled for October 9. * He is wonderful with other animals, including cats and dogs, and he is gentle with children. * He is housebroken and has been incredibly easy to train. * He would be a really fun dog for someone who wants to continue training, take him on short walks (around 30 minutes), or simply have a big goofy companion * His tongue is always sticking out!

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Riscoe

Mastiff

Male, Adult
Charlotte, NC
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Needs experienced adopter, House-trained,
Story
Playful loving and protective. Needs a yard and space to run.

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PORKCHOP

Mastiff

Male, 2 yrs 2 mos
Burlington, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
Porkchop is a very sweet, smiley boy who loves showing off his good manners. He knows how to sit and shake, and he’s always ready to charm you with that happy face of his. He’s an affectionate, lovable guy who would make a wonderful companion.

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Photo of Bruce

Bruce

Mastiff

Male, 7 yrs
Newport, NC
Size
(when grown) -
Details
-
Story
💙 Meet this handsome hunk of love named Bruce! 💙 Bruce came into the shelter as a stray on August 29, 2026. Sadly, his owner never came to reclaim him, so now this big, beautiful boy is waiting for someone to give him the forever home he deserves. 🐾 Bruce is a BIG BOY, weighing in at a whopping 110 pounds — but don't let his size fool you! This handsome guy is absolutely full of love and has a whole lot of it to share. ❤️ At 6 years and 11 months old, Bruce is entering his golden years, but he still has plenty of pep in his step and so much life and love left to give. He's already neutered and up to date on his vaccinations, too! What Bruce deserves now is a wonderful, loving home where he can spend his golden years being spoiled, cherished, and reminded every day just how special he is. 🥰🏡 Bruce is ready and excited to begin his next chapter with someone who will love him for the amazing dog he is. Could YOU be the person he's been waiting for? 💙 Stop by for a visit with handsome Bruce and see if this 110-pound hunk of love might just be your perfect match! 🐶❤️

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in North Carolina.

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Mastiff puppies and dogs in North Carolina cities

Mastiff Puppies near me Mastiff in Aberdeen Mastiff in Albemarle Mastiff in Angier Mastiff in Apex Mastiff in Archdale Mastiff in Asheboro Mastiff in Asheville Mastiff in Ayden Mastiff in Belmont Mastiff in Bessemer City Mastiff in Black Mountain Mastiff in Boiling Spring Lakes Mastiff in Boone Mastiff in Brevard Mastiff in Burlington Mastiff in Butner Mastiff in Carolina Beach Mastiff in Carrboro Mastiff in Cary Mastiff in Chapel Hill Mastiff in Charlotte Mastiff in Cherryville Mastiff in Clayton Mastiff in Clemmons Mastiff in Clinton Mastiff in Concord Mastiff in Conover Mastiff in Cornelius Mastiff in Davidson Mastiff in Dunn Mastiff in Durham Mastiff in Eden Mastiff in Edenton Mastiff in Elizabeth City Mastiff in Elon Mastiff in Erwin Mastiff in Fairview Mastiff in Farmville Mastiff in Fayetteville Mastiff in Fletcher Mastiff in Forest City Mastiff in Fuquay Varina Mastiff in Garner Mastiff in Gastonia Mastiff in Gibsonville Mastiff in Goldsboro Mastiff in Graham Mastiff in Granite Falls Mastiff in Greensboro Mastiff in Greenville Mastiff in Hamlet Mastiff in Harrisburg Mastiff in Havelock Mastiff in Henderson Mastiff in Hendersonville Mastiff in Hickory Mastiff in High Point Mastiff in Hillsborough Mastiff in Holly Springs Mastiff in Hope Mills Mastiff in Huntersville Mastiff in Indian Trail Mastiff in Jacksonville Mastiff in Kannapolis Mastiff in Kernersville Mastiff in Kill Devil Hills Mastiff in King Mastiff in Kings Mountain Mastiff in Kinston Mastiff in Knightdale Mastiff in Laurinburg Mastiff in Leland Mastiff in Lenoir Mastiff in Lewisville Mastiff in Lexington Mastiff in Lincolnton Mastiff in Lumberton Mastiff in Maggie Valley Mastiff in Marion Mastiff in Matthews Mastiff in Mebane Mastiff in Mills River Mastiff in Mint Hill Mastiff in Mocksville Mastiff in Monroe Mastiff in Mooresville Mastiff in Morehead City Mastiff in Morganton Mastiff in Morrisville Mastiff in Mount Airy Mastiff in Mount Holly Mastiff in Mount Olive Mastiff in Nashville Mastiff in New Bern Mastiff in Newport Mastiff in Newton Mastiff in Oak Island Mastiff in Oak Ridge Mastiff in Oxford Mastiff in Pinehurst Mastiff in Pineville Mastiff in Pleasant Garden Mastiff in Raleigh Mastiff in Reidsville Mastiff in Roanoke Rapids Mastiff in Rockingham Mastiff in Rocky Mount Mastiff in Roxboro Mastiff in Salisbury Mastiff in Sanford Mastiff in Sawmills Mastiff in Selma Mastiff in Shelby Mastiff in Siler City Mastiff in Smithfield Mastiff in Southern Pines Mastiff in Spring Lake Mastiff in Stallings Mastiff in Statesville Mastiff in Summerfield Mastiff in Tarboro Mastiff in Thomasville Mastiff in Trinity Mastiff in Unionville Mastiff in Valdese Mastiff in Wadesboro Mastiff in Wake Forest Mastiff in Walkertown Mastiff in Washington Mastiff in Waynesville Mastiff in Weddington Mastiff in Wendell Mastiff in Whiteville Mastiff in Williamston Mastiff in Wilmington Mastiff in Wilson Mastiff in Winston Salem Mastiff in Winterville Mastiff in Woodfin Mastiff in Zebulon

Mastiff shelters & rescues in North Carolina

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in North Carolina. Browse these Mastiff rescues and shelters below.

Here are a few organizations

Shelter

Burlington Animal Services

221 Stone Quarry Rd, Burlington , NC 27217

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Shelter

Orange County Animal Services

1601 Eubanks Road, Chapel Hill , NC 27516

Pet Types: cats, dogs, rabbits, small animals

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Shelter

Cleveland County Animal Services

1601 Airport Rd, Shelby , NC 28150

Pet Types: cats, dogs

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Rescue

Carolina Animal Network

Wendell , NC 27591

Pet Types: cats, dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog ?

We've got all the info you need on adopting and caring for a Mastiff puppy . Check out the links below for everything you ever wanted to know about Mastiff puppies and adults .

Mastiff information

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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