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Mastiff puppies and dogs in North Carolina

Looking for a Mastiff puppy or dog in North Carolina? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff in North Carolina Search for a Mastiff puppy or dog Mastiff puppies and dogs in North Carolina cities Mastiff shelters and rescues in North Carolina Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in North Carolina

Below are our newest added Mastiffs available for adoption in North Carolina. To see more adoptable Mastiffs in North Carolina, use the search tool below to enter specific criteria!
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BOBO

Mastiff

Male, 1 yr
Chapel Hill, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
I am a sweet dog that arrived at OCAS as a stray. I was very underweight and had some other medical concerns. The care team at the shelter is helping me gain weight and they are providing lots of TLC. If you`d like to help me and other pets that enter the shelter with medical issues, please consider making a donation to the shelter. The Community Giving Fund is an easy way to donate online. Thank you!

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PORKCHOP

Mastiff

Male, 2 yrs 1 mo
Burlington, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
Porkchop is a very sweet, smiley boy who loves showing off his good manners. He knows how to sit and shake, and he’s always ready to charm you with that happy face of his. He’s an affectionate, lovable guy who would make a wonderful companion.

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Photo of Bruce

Bruce

Mastiff

Male, 6 yrs 11 mos
Newport, NC
Size
(when grown) -
Details
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Story
💙 Meet this handsome hunk of love named Bruce! 💙 Bruce came into the shelter as a stray on August 29, 2026. Sadly, his owner never came to reclaim him, so now this big, beautiful boy is waiting for someone to give him the forever home he deserves. 🐾 Bruce is a BIG BOY, weighing in at a whopping 110 pounds — but don't let his size fool you! This handsome guy is absolutely full of love and has a whole lot of it to share. ❤️ At 6 years and 11 months old, Bruce is entering his golden years, but he still has plenty of pep in his step and so much life and love left to give. He's already neutered and up to date on his vaccinations, too! What Bruce deserves now is a wonderful, loving home where he can spend his golden years being spoiled, cherished, and reminded every day just how special he is. 🥰🏡 Bruce is ready and excited to begin his next chapter with someone who will love him for the amazing dog he is. Could YOU be the person he's been waiting for? 💙 Stop by for a visit with handsome Bruce and see if this 110-pound hunk of love might just be your perfect match! 🐶❤️

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Photo of Big Leo

Big Leo

Mastiff/Husky

Male, 8 yrs 1 mo
New Bern, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
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Needs Home Fast
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ACE

Mastiff

Male, 1 yr 7 mos
Newton, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
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Photo of Misty

Misty

Mastiff/Mixed Breed (Medium)

Female, 2 yrs 8 mos
Rutherfordton, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in North Carolina.

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Mastiff puppies and dogs in North Carolina cities

Mastiff Puppies near me Mastiff in Aberdeen Mastiff in Albemarle Mastiff in Angier Mastiff in Apex Mastiff in Archdale Mastiff in Asheboro Mastiff in Asheville Mastiff in Ayden Mastiff in Belmont Mastiff in Bessemer City Mastiff in Black Mountain Mastiff in Boiling Spring Lakes Mastiff in Boone Mastiff in Brevard Mastiff in Burlington Mastiff in Butner Mastiff in Carolina Beach Mastiff in Carrboro Mastiff in Cary Mastiff in Chapel Hill Mastiff in Charlotte Mastiff in Cherryville Mastiff in Clayton Mastiff in Clemmons Mastiff in Clinton Mastiff in Concord Mastiff in Conover Mastiff in Cornelius Mastiff in Davidson Mastiff in Dunn Mastiff in Durham Mastiff in Eden Mastiff in Edenton Mastiff in Elizabeth City Mastiff in Elon Mastiff in Erwin Mastiff in Fairview Mastiff in Farmville Mastiff in Fayetteville Mastiff in Fletcher Mastiff in Forest City Mastiff in Fuquay Varina Mastiff in Garner Mastiff in Gastonia Mastiff in Gibsonville Mastiff in Goldsboro Mastiff in Graham Mastiff in Granite Falls Mastiff in Greensboro Mastiff in Greenville Mastiff in Hamlet Mastiff in Harrisburg Mastiff in Havelock Mastiff in Henderson Mastiff in Hendersonville Mastiff in Hickory Mastiff in High Point Mastiff in Hillsborough Mastiff in Holly Springs Mastiff in Hope Mills Mastiff in Huntersville Mastiff in Indian Trail Mastiff in Jacksonville Mastiff in Kannapolis Mastiff in Kernersville Mastiff in Kill Devil Hills Mastiff in King Mastiff in Kings Mountain Mastiff in Kinston Mastiff in Knightdale Mastiff in Laurinburg Mastiff in Leland Mastiff in Lenoir Mastiff in Lewisville Mastiff in Lexington Mastiff in Lincolnton Mastiff in Lumberton Mastiff in Maggie Valley Mastiff in Marion Mastiff in Matthews Mastiff in Mebane Mastiff in Mills River Mastiff in Mint Hill Mastiff in Mocksville Mastiff in Monroe Mastiff in Mooresville Mastiff in Morehead City Mastiff in Morganton Mastiff in Morrisville Mastiff in Mount Airy Mastiff in Mount Holly Mastiff in Mount Olive Mastiff in Nashville Mastiff in New Bern Mastiff in Newport Mastiff in Newton Mastiff in Oak Island Mastiff in Oak Ridge Mastiff in Oxford Mastiff in Pinehurst Mastiff in Pineville Mastiff in Pleasant Garden Mastiff in Raleigh Mastiff in Reidsville Mastiff in Roanoke Rapids Mastiff in Rockingham Mastiff in Rocky Mount Mastiff in Roxboro Mastiff in Salisbury Mastiff in Sanford Mastiff in Sawmills Mastiff in Selma Mastiff in Shelby Mastiff in Siler City Mastiff in Smithfield Mastiff in Southern Pines Mastiff in Spring Lake Mastiff in Stallings Mastiff in Statesville Mastiff in Summerfield Mastiff in Tarboro Mastiff in Thomasville Mastiff in Trinity Mastiff in Unionville Mastiff in Valdese Mastiff in Wadesboro Mastiff in Wake Forest Mastiff in Walkertown Mastiff in Washington Mastiff in Waynesville Mastiff in Weddington Mastiff in Wendell Mastiff in Whiteville Mastiff in Williamston Mastiff in Wilmington Mastiff in Wilson Mastiff in Winston Salem Mastiff in Winterville Mastiff in Woodfin Mastiff in Zebulon

Mastiff shelters & rescues in North Carolina

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in North Carolina. Browse these Mastiff rescues and shelters below.

Here are a few organizations

Shelter

Carteret County Humane Society & Animal Shelter

853 Hibbs Rd, Newport , NC 28570

Pet Types: cats, birds, dogs, farm animals, rabbits, small animals

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Shelter

Craven-Pamlico Animal Services

1639 Old Airport Road, New Bern , NC 28562

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog ?

We've got all the info you need on adopting and caring for a Mastiff puppy . Check out the links below for everything you ever wanted to know about Mastiff puppies and adults .

Mastiff information

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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