Mastiff Adoption in North Carolina: Mastiff Puppies for Sale in North Carolina

Adopt a Mastiff near you in North Carolina

Below are our newest added Mastiffs available for adoption in North Carolina. To see more adoptable Mastiffs in North Carolina, use the search tool below to enter specific criteria!

PORKCHOP

Mastiff

Male, 2 yrs

Burlington, NC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Porkchop is a very sweet, smiley boy who loves showing off his good manners. He knows how to sit and shake, and he’s always ready to charm you with that happy face of his. He’s an affectionate, lovable guy who would make a wonderful companion.

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Wynston

Mastiff

Male, Young

High Point, NC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Needs experienced adopter, House-trained,

Story

Wynston came into our lives as a foster, but it didn’t take long for us to fall in love with his sweet and affectionate personality. As he has grown, however, we’ve realized that our home simply doesn’t provide him with the space he deserves, so we are hoping to find him a loving forever home where he can truly thrive. Wynston is a very sweet, loving dog who enjoys being close to the people he trusts. He can be a little skittish at first, particularly around taller individuals, so he may need some patience and reassurance while getting comfortable with someone new. Once he feels safe, his loving personality really comes through. He is both crate trained and house trained. Our biggest priority is finding Wynston a caring home that can give him the space, attention, and love he deserves.

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Needs Home Fast

Enzo

Mastiff

Male, 2 yrs 1 mo

Oxford, NC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Found on 7/6/26 on Olive Grove Church Rd, Creedmoor. Brought to the shelter by citizen at 12:35 pm on 7/11/26. Emaciated and had a large squishy mass on his neck at the time of intake. Friendly but timid. Not wearing a collar.Granville County Animal Shelter919-693-6749animal.shelter@granvillecounty.org

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Leo

Mastiff/Husky

Male, 8 yrs

New Bern, NC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

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Jackson

Mastiff

Male, Young

Greensboro, NC

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, Good with cats, House-trained,

Story

Meet Jackson! He's 98 pounds of cuddly chaos in one sweet package. A great walking and hiking companion if worked with and given lots of encouragement. Great with adult people, other dogs, and cats. We've never had any issue with him being aggressive with any of those. He knows tricks/commands in English and español. He gets a bit jumpy and runs around a lot when excited and is super food motivated. He would come with Collars, a leash, food and water bowls, toys, and two partial bags of food. He is slightly reactive to small kids and some small animals running but is easy to redirect. We love him so much, it hurts our heart to have to do this but he needs attention we unfortunately can't give him. We believe he was abused in his past home and was found as a stray and had little info about him when he was adopted. He needs someone who can give him love and patience with the behaviors that come with an abused dog. He is only a year and 5 months old. Thank you for considering this angel.

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Gisele

Mastiff

Female, 6 yrs 1 mo

Raleigh, NC

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

Meet Gisele, our favorite gentle giant. Through no fault of her own, Gisele found herself in a shelter after what is believed to have been a life spent as a breeder. Once she reached middle age, she was discarded at a pound, and her sweet nature quickly won over shelter staff, who worked hard to get her into rescue. At 5–6 years old, this beautiful brindle Mastiff is impossible not to love. She has only one eye- the other was surgically removed before she arrived but it doesn’t slow her down one bit. This beautiful lady tested heartworm negative at the shelter; however, she is currently being treated for Lyme (showing no signs of illness). Gisele is doing wonderfully with house training and thrives on a consistent routine. While she has had a few pee accidents, she’s making great progress and is well on her way to being fully potty trained. She’s deeply devoted to her people and appears to experience some separation anxiety, likely because she’s finally learning what it feels like to be loved. Although she currently stays in an indestructible crate when left alone, her foster family believes she may eventually do well with more freedom. During the day, she’s happiest curled up at her foster mom’s feet, snoring contentedly while mom works. Gisele lives peacefully with two dogs and even a cat, greeting every person and pet with a wagging tail. Her gentle, affectionate personality makes her a friend to everyone she meets. Despite her size, Gisele is easy to walk on a leash and enjoys short strolls around the neighborhood. She especially loves splashing in the lake near her foster home and takes every opportunity to wade into the water. Gisele has spent years giving to others; now it’s her turn to be cherished. She is a loving, loyal companion looking for a soft place to rest, a family to call her own, and plenty of head scratches. If you’re looking for a sweet, devoted best friend, Gisele may be the happy ending you’ve both been waiting for.

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Mastiff puppies and dogs in North Carolina

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Below are our newest added Mastiffs available for adoption in North Carolina. To see more adoptable Mastiffs in North Carolina, use the search tool below to enter specific criteria!

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Mastiff puppies and dogs in North Carolina

Jump to:

Adopt a Mastiff near you in North Carolina

Below are our newest added Mastiffs available for adoption in North Carolina. To see more adoptable Mastiffs in North Carolina, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in North Carolina cities

Mastiff shelters & rescues in North Carolina

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics