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Mastiff puppies and dogs in North Carolina

Looking for a Mastiff puppy or dog in North Carolina? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff in North Carolina Search for a Mastiff puppy or dog Mastiff puppies and dogs in North Carolina cities Mastiff shelters and rescues in North Carolina Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in North Carolina

Below are our newest added Mastiffs available for adoption in North Carolina. To see more adoptable Mastiffs in North Carolina, use the search tool below to enter specific criteria!
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Soulful Sora

Mastiff

Female, Adult
Raleigh, NC
Size
(when grown) -
Details
-
Story
Primary Color: Brindle- Black Weight: 71 Age: 3yrs 0mths 0wks

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BOBO

Mastiff

Male, 1 yr 2 mos
Chapel Hill, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
I am a sweet dog that arrived at OCAS as a stray. I was very underweight and had some other medical concerns. The care team at the shelter is helping me gain weight and they are providing lots of TLC. I am young and eager to learn. I`ll make a great addition to some lucky home!If you`d like to help me and other pets that enter the shelter with medical issues, please consider making a donation to the shelter. The Community Giving Fund is an easy way to donate online. Thank you!Insights from my adventure buddies and foster friends:Bobo is a lovely pup who can seem shy and fearful at first, but his true personality shines through very quickly. Underneath that initial shyness is a playful, energetic dog who loves spending time playing with you and with other dogs. He loves any toy he can chew on and is extremely food-motivated, which made it easy to teach him `sit` and `up` in no time. Given how smart he is, you could realistically teach him just about anything. He`s at the perfect age to be adopted and shaped by his forever family, since he picks up on patterns very quickly. As an energetic pup, he`ll need a family willing to commit some time to developing and stimulating his mind through structured play. He is very funny! Somehow, he`s always making you laugh. Poor Bobo is having a tough time being in the shelter. He will need training and plenty of time to adjust which is understandable. We went to Blackwood Farm Park. We got to the first picnic table on the far field. He did enjoy basking in the sun! He enjoys being away from everyone and I get that. It was nice when it was just the two of us sitting in the sun and nobody else in sight!

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Photo of Buford

Buford

Mastiff/Bloodhound

Male, 3 yrs
North Wilkesboro, NC
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
-
Story
Meet Buford, aka Bo, an extra-large sweetheart who truly embodies the term `gentle giant.` He is a possible Bloodhound or Mastiff mix around 3 years old and is a whopping 92 pounds! Despite his impressive size and strength, he is incredibly soft-hearted with a patient demeanor that makes him a wonderful greeter for everyone he meets. Buford is a social butterfly who gets along great with everyone he comes across (so long as they don’t mind his intimidating size.) He loves to run and play with other dogs or all sizes. The few cats he has met haven’t been fond of him but he doesn’t seem to pay them much attention either. Buford is a very big boy and is very strong. He loves being around people and kids but isn’t aware of his size compared to others and will easily knock you over if you aren`t prepared. His ideal day involves sunning outside and having plenty of space get out his occasional zoomies. A home with a large yard where he can stretch his legs, and a nice cushioned couch or dog bed to nap on, is his version of paradise. Buford is house and crate trained and loves having a pile of blankets to sleep on. If you are looking for a loyal, sturdy, and affectionate cuddle bug, Buford is more than ready to meet you! Buford has, microchipped, and kept current on vaccines and preventions. He is due to be neutered on 11/17 and will be ready for his forever home afterwards. If you’re committed to adopting a rescue pup, an application is the first step: https://humanesocietyofwilkes.org/adopt/application. You can expect an email response within a week of approval. For questions you can email julianshumate@gmail.com

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Mia

Mastiff

Female, 3 yrs 8 mos
Greenville, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
-

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Pongo

Mastiff

Female
Thomasville, NC
Size
(when grown) -
Details
Good with dogs,
Story
Pongo came to Ruff Love Rescue after his owner died.  At first he was scared, confused and reserved, but he can warmed up to the volunteers at the rescue.  He might need some time to warm up with his new family, especially men at first.  But he is a gentle giant.  He is good with most dogs.  He is crate trained and probably will housetrain easily, if he isn't already housetrained.  He loves affection and pets.  He would just like a home where he can lay his head, take leisurely walks and be loved.  Pongo's adoption fee is $300.  He is fully vetted, neutered, microchipped, and up-to-date on immunizations.  Adopt Pongo through RuffLoveRescue.com/adopt  Ruff Love Rescue is located in Thomasville, NCNovember 12, 2026, 1:35 pm

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Photo of Zeke

Zeke

Mastiff/Mixed Breed (Large)

Male, 4 yrs
Jacksonville, NC
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
Location Found: Cow Horn Rd, Richlands

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Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in North Carolina.

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Mastiff puppies and dogs in North Carolina cities

Mastiff Puppies near me Mastiff in Aberdeen Mastiff in Albemarle Mastiff in Angier Mastiff in Apex Mastiff in Archdale Mastiff in Asheboro Mastiff in Asheville Mastiff in Ayden Mastiff in Belmont Mastiff in Bessemer City Mastiff in Black Mountain Mastiff in Boiling Spring Lakes Mastiff in Boone Mastiff in Brevard Mastiff in Burlington Mastiff in Butner Mastiff in Carolina Beach Mastiff in Carrboro Mastiff in Cary Mastiff in Chapel Hill Mastiff in Charlotte Mastiff in Cherryville Mastiff in Clayton Mastiff in Clemmons Mastiff in Clinton Mastiff in Concord Mastiff in Conover Mastiff in Cornelius Mastiff in Davidson Mastiff in Dunn Mastiff in Durham Mastiff in Eden Mastiff in Edenton Mastiff in Elizabeth City Mastiff in Elon Mastiff in Erwin Mastiff in Fairview Mastiff in Farmville Mastiff in Fayetteville Mastiff in Fletcher Mastiff in Forest City Mastiff in Fuquay Varina Mastiff in Garner Mastiff in Gastonia Mastiff in Gibsonville Mastiff in Goldsboro Mastiff in Graham Mastiff in Granite Falls Mastiff in Greensboro Mastiff in Greenville Mastiff in Hamlet Mastiff in Harrisburg Mastiff in Havelock Mastiff in Henderson Mastiff in Hendersonville Mastiff in Hickory Mastiff in High Point Mastiff in Hillsborough Mastiff in Holly Springs Mastiff in Hope Mills Mastiff in Huntersville Mastiff in Indian Trail Mastiff in Jacksonville Mastiff in Kannapolis Mastiff in Kernersville Mastiff in Kill Devil Hills Mastiff in King Mastiff in Kings Mountain Mastiff in Kinston Mastiff in Knightdale Mastiff in Laurinburg Mastiff in Leland Mastiff in Lenoir Mastiff in Lewisville Mastiff in Lexington Mastiff in Lincolnton Mastiff in Lumberton Mastiff in Maggie Valley Mastiff in Marion Mastiff in Matthews Mastiff in Mebane Mastiff in Mills River Mastiff in Mint Hill Mastiff in Mocksville Mastiff in Monroe Mastiff in Mooresville Mastiff in Morehead City Mastiff in Morganton Mastiff in Morrisville Mastiff in Mount Airy Mastiff in Mount Holly Mastiff in Mount Olive Mastiff in Nashville Mastiff in New Bern Mastiff in Newport Mastiff in Newton Mastiff in Oak Island Mastiff in Oak Ridge Mastiff in Oxford Mastiff in Pinehurst Mastiff in Pineville Mastiff in Pleasant Garden Mastiff in Raleigh Mastiff in Reidsville Mastiff in Roanoke Rapids Mastiff in Rockingham Mastiff in Rocky Mount Mastiff in Roxboro Mastiff in Salisbury Mastiff in Sanford Mastiff in Sawmills Mastiff in Selma Mastiff in Shelby Mastiff in Siler City Mastiff in Smithfield Mastiff in Southern Pines Mastiff in Spring Lake Mastiff in Stallings Mastiff in Statesville Mastiff in Summerfield Mastiff in Tarboro Mastiff in Thomasville Mastiff in Trinity Mastiff in Unionville Mastiff in Valdese Mastiff in Wadesboro Mastiff in Wake Forest Mastiff in Walkertown Mastiff in Washington Mastiff in Waynesville Mastiff in Weddington Mastiff in Wendell Mastiff in Whiteville Mastiff in Williamston Mastiff in Wilmington Mastiff in Wilson Mastiff in Winston Salem Mastiff in Winterville Mastiff in Woodfin Mastiff in Zebulon

Mastiff shelters & rescues in North Carolina

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in North Carolina. Browse these Mastiff rescues and shelters below.

Here are a few organizations

Rescue

Carolina Animal Network

Wendell , NC 27591

Pet Types: cats, dogs

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Shelter

Pitt County Animal Services

4550 County Home Road, Greenville , NC 27858

Pet Types: cats, dogs

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Shelter

Wake County Animal Center

820 Beacon Lake Drive, Raleigh , NC 27610

Pet Types: cats, birds, dogs, rabbits, small animals

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Shelter

Orange County Animal Services

1601 Eubanks Road, Chapel Hill , NC 27516

Pet Types: cats, dogs, rabbits, small animals

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Shelter

Onslow County Animal Services (OCAS)

244 Georgetown Road, Jacksonville , NC 28540

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Shelter

Pender County Animal Shelter

3280 New Savannah Rd, 3280 New Savannah Rd, Burgaw , NC 28425

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, small animals

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Shelter

Carteret County Humane Society & Animal Shelter

853 Hibbs Rd, Newport , NC 28570

Pet Types: cats, birds, dogs, farm animals, rabbits, small animals

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If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog ?

We've got all the info you need on adopting and caring for a Mastiff puppy . Check out the links below for everything you ever wanted to know about Mastiff puppies and adults .

Mastiff information

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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