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Great Dane puppies and dogs in La Mesa, California

Looking for a Great Dane puppy or dog in La Mesa, California? Adopt a Pet can help you find an adorable Great Dane near you.

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Adopt a Great Dane near you Great Dane in cities near La Mesa, California Other pups in La Mesa, California Search for a Great Dane puppy or dog near you Browse Great Dane puppies and dogs in nearby cities Browse related breeds in La Mesa, California Great Dane shelters and rescues in La Mesa, California Learn more about adopting a Great Dane puppy or dog

Adopt a Great Dane near you in La Mesa, California

We don't see any Great Danes available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Great Danes in cities near La Mesa, California

These Great Danes are available for adoption close to La Mesa, California.
We'll also keep you updated on Astro's adoption status with email updates.
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Astro

Great Dane

Male, Adult
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
You can fill out an adoption application online on our official website.Check Me out ! Meet Astro!  This sweet boy was turned in to the shelter by his family as they lived in military housing and were about to welcome a baby. Unfortunately, the 29 Palms shelter has limited resources and little space for a dog of Astro's size. ASR stepped in and found a foster for Astro that had land and space for him to romp around on. Astro is a true gentle giant. He is friendly with people, dogs, and cats. He walks well on a leash and is working on taking commands and directions. He is treat-motivated and loves his ball. He is smart and rides well in the car. At around 3 years old, this sweet boy weighs a whomping 120 lbs. Astro has all the fantastic attributes of a Great Dane. Could Astro be the mini horse you've been looking for?    If interested in adopting Astro, click HERE!   Astro's adoption fee is $495, which covers his up-to-date vaccines, microchip, and neuter.  Visit this organization's web site to see any additional information available about this pet.October 14, 2025, 10:03 pm

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We'll also keep you updated on Astro's adoption status with email updates.
Photo of Astro

Astro

Great Dane

Male, 3 yrs 4 mos
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, Spayed or Neutered,
Story
Meet Astro! This sweet boy was turned in to the shelter by his family as they lived in military housing and were about to welcome a baby. Unfortunately, the 29 Palms shelter has limited resources and little space for a dog of Astro's size. ASR stepped in and found a foster for Astro that had land and space for him to romp around on. Astro is a true gentle giant. He is friendly with people, dogs, and cats. He walks well on a leash and is working on taking commands and directions. He is treat-motivated and loves his ball. He is smart and rides well in the car. At around 3 years old, this sweet boy weighs a whomping 120 lbs. Astro has all the fantastic attributes of a Great Dane. Could Astro be the mini horse you've been looking for? If interested in meeting Astro, please apply on our website.

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We'll also keep you updated on Loki's adoption status with email updates.
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Loki

Great Dane

Male, Young
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived: This pet was brought in by their previous owner on December 16, 2025. Why this pet is the one for you:Meet Loki! He is proof that big dogs have even bigger hearts. This gentle giant is sweet, affectionate, and truly a great boy who loves people and enjoys spending time with his humans.Loki still learning how to manage all that power in his growing body. He can be reactive around other dogs, so he'll do best with an adopter who can provide guidance, structure, and confident handling to help him succeed.With continued training and a little patience, Loki has all the potential to be an amazing companion. If you're looking for a loyal, loving, oversized best friend and have room in your heart (and on your couch), Loki might be your perfect match. At SDHS:Loki has been vaccinated, microchipped and neutered. Loki is now ready for his new home! Primary Color: Black Weight: 112 Age: 1yrs 5mths 2wks

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We'll also keep you updated on Nova's adoption status with email updates.
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Nova

Great Dane

Female, Senior
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived: Nova was brought in by their previous owner. Why Nova might be the one for you:Meet Nova, a friendly and affectionate pup in search of a loving new home! Nova has been doing great in a foster home, and settled into her new routine in just a few days. She is friendly with guests and if you offer her pets, she loves to weave between your legs for full body scratches. Nova is also very food motivated and is pretty content with just one long walk each day. Nova does get excited when she sees other dogs on walks, so she'll benefit from ongoing positive reinforcement training to help manage her reactions. If you're looking for a laidback and loving companion, Nova is ready to enjoy her golden years with you. Inquire about adopting this sweet gal today! At SDHS:This pet has been vaccinated, microchipped and spayed/neutered. This pet is now ready for their new home! Primary Color: Tan Secondary Color: Black Weight: 91.5 Age: 10yrs 6mths 0wks

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We'll also keep you updated on BALGRUUF's adoption status with email updates.
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BALGRUUF

Great Dane

Male, 1 yr 4 mos
Chula Vista, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Spayed or Neutered,
Story
-

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We'll also keep you updated on Odin's adoption status with email updates.
Photo of Odin

Odin

Great Dane

Male, Puppy
El Cajon, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Oden is a wonderful and growing Great Dane puppy. He spent the first five months of his life on a 5 to 6 foot chain. So when he arrived at the shelter, he did not have a lot of manners. But he is sweet as all get out. He is loving, playful, and just wonderful!

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Search for a Great Dane puppy or dog

Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in La Mesa, California.

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Great Dane puppies and dogs in nearby cities

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Great Dane shelters & rescues in La Mesa, California

There are animal shelters and rescues that focus specifically on finding great homes for Great Dane puppies in La Mesa, California. Browse these Great Dane rescues and shelters below.

Here are a few organizations closest to you:

Rescue

2.9 miles

Amazing Strays Rescue

San Diego, CA 92115

Pet Types: cats, dogs

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Shelter

10.5 miles

San Diego Humane Society - San Diego Campus

5500 Gaines Street, San Diego, CA 92110

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Shelter

11.2 miles

Chula Vista Animal Care Facility (public)

130 Beyer Way, Chula Vista, CA 91911

Pet Types: cats, birds, dogs, rabbits, reptiles, small animals

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Rescue

12.6 miles

Animal Advocates of the US - San Diego Chapter

El Cajon, CA 92122

Pet Types: cats, dogs, rabbits

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Rescue

14.7 miles

Friends of Humane Services in Tijuana

641 E. San Ysidro Blvd. #B3-431, San Ysidro, CA 92173

Pet Types: cats, dogs

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Rescue

20 miles

Wet Noses Rescue

San Diego, CA 92067

Pet Types: cats, dogs

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Shelter

25.6 miles

San Diego Humane Society - Escondido Campus

3500 Burnet Drive, Escondido, CA 92027

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

31.4 miles

Amazing Dogs

Carlsbad, CA 92011

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Great Dane puppy or dog?

We've got all the info you need on adopting and caring for a Great Dane puppy. Check out the links below for everything you ever wanted to know about Great Dane puppies and adults.

Great Dane basics

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Where do Great Danes come from? How many types of Great Danes are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Great Dane.

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