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Great Dane puppies and dogs in San Diego, California

Looking for a Great Dane puppy or dog in San Diego, California? Adopt a Pet can help you find an adorable Great Dane near you.

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Adopt a Great Dane near you in San Diego, California

These Great Danes are available in San Diego, California.
We'll also keep you updated on Nova's adoption status with email updates.
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Nova

Great Dane

Female, Senior
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
How this pet arrived: Nova was brought in by their previous owner. Why Nova might be the one for you:Meet Nova, a friendly and affectionate pup in search of a loving new home! Nova has been doing great in a foster home, and settled into her new routine in just a few days. She is friendly with guests and if you offer her pets, she loves to weave between your legs for full body scratches. Nova is also very food motivated and is pretty content with just one long walk each day. Nova does get excited when she sees other dogs on walks, so she'll benefit from ongoing positive reinforcement training to help manage her reactions. If you're looking for a laidback and loving companion, Nova is ready to enjoy her golden years with you. Inquire about adopting this sweet gal today! At SDHS:This pet has been vaccinated, microchipped and spayed/neutered. This pet is now ready for their new home! Primary Color: Tan Secondary Color: Black Weight: 98.5 Age: 10yrs 9mths 2wks

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We'll also keep you updated on Roscoe's adoption status with email updates.
Photo of Roscoe

Roscoe

Great Dane

Male, Young
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, Spayed or Neutered, Shots are up-to-date,
Story
ATTENTION:  All of our dogs are in private foster homes.  We do NOT have a kennel with multiple dogs.  If you find a dog you want to meet in person, please go to www.secondchancedogrescue.org and complete an application.    We will make every attempt to process all applications within 3 business days of receipt. Meet Roscoe! Roscoe is a 1½-year-old, 85-pound Great Dane mix with a big heart to match his size. He may be a little shy for the first few minutes when meeting new people, but once he warms up, he quickly becomes your loyal best friend. Roscoe is a young, playful guy who would love a canine buddy to run and play with. Like many big, enthusiastic pups, he’s still working on his manners and would benefit from continued guidance and training as he grows into his best self. Roscoe’s story started with heartbreak—he was abandoned when his family moved away and left him in the backyard. He ended up on the euthanasia list before finding safety with us, and now he’s ready for a fresh start with a family who will love him forever. Roscoe has been neutered, microchipped, and is up to date on all vaccines. He also appears to be house trained. With his sweet nature and playful spirit, Roscoe is ready to bring a lot of love (and a little Dane-sized goofiness) into his forever home. His adoption fee is $300. All Second Chance Dog Rescue dogs are spayed/neutered, are up to date on vaccines and have microchips prior to adoption.   Adoption fees vary depending on age of dog. Fees help Second Chance Dog Rescue cover spay/neuter costs,   vaccinations, medical treatments, food and supplies. Please go to  www.secondchancedogrescue.org  and complete an application today!    All dogs live in private foster homes until they are adopted.  April 18, 2026, 6:19 pm

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We'll also keep you updated on Odin's adoption status with email updates.
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Odin

Great Dane

Male, Puppy
El Cajon, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Oden is a wonderful and growing Great Dane puppy. He spent the first five months of his life on a 5 to 6 foot chain. So when he arrived at the shelter, he did not have a lot of manners. But he is sweet as all get out. He is loving, playful, and just wonderful!

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We'll also keep you updated on Odin's adoption status with email updates.
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Odin

Great Dane

Male, 3 yrs 3 mos
El Cajon, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Oden is a wonderful and growing Great Dane puppy. He spent the first five months of his life on a 5 to 6 foot chain. So when he arrived at the shelter, he did not have a lot of manners. But he is sweet as all get out. He is loving, playful, and just wonderful! **** Please read adoption information carefully!!!**** Odin is a stunningly handsome little boy -male, 7 months -supposedly pure-bread, -Neutered -Current Weight : 90 lbs, will grow -Crate trained -Potty trained Odin is a big, funny bundle of joy, energy, and affection. He is just a big goofball! Odin is still a puppy, and will continue to grow. He is on the bigger side, but has an abundance of affection and cuteness! Odin is a well-adjusted puppy who has been hand raised. He has never shown any signs of aggression of any kind, including food aggression, although he can occasionally be a little rambunctious. He really thinks that he is a little dog…. ? Odin wants to be a lapdog; he can’t quite figure out why he doesn’t fit in my lap, but he settles for putting his head in my lap, since the rest of him doesn’t fit 😜 Odin is used to playing and sleeping with the other dogs on the property. He is well socialized, both with humans and dogs. While I have never seen him interact with a cat, I have no reason to anticipate a problem. ************************************ ADOPTION INFORMATION ************************************ I only adopt LOCALLY; San Diego and immediate vicinity. No long distance. Certainly no out of state. I cannot respond to questions as to whether the animal is available. Please DO NOT contact me asking if the animal is available. If the dog is listed as adoptable, it is available. A home check and a background check are MANDATORY to be considered. If you are unable or unwilling to consent to these requirements, please do not apply. An adoption interview Is REQUIRED. One of our volunteers must meet and observe the dog interact with every member of the household, including pets. Preference will be given to individuals who follow the instructions AND provide complete information for adoption purposes. 1) Please go to our website ( http://aaofus.org/adoption-application.html ) 2) submit it online. Must include dog’s name and “forward to Kim” under pet’s name 3) then forward the confirmation email to me directly at animalsandkim@gmail.com That’s it: easy Peezy! You must Submit an application or at least provide written answers to the following questions in an email in order for me to respond: Must include information on EVERY person in household Number of people in household and their ages ______________________________ ____________________________________________________________ occupations ________________________________________________________________________________________ Type of residential dwelling? __________________ Rent or own? Address: __________________ __________________ __________________ Phone number: __________________ Text available? does anyone in the family suffer from allergies? ___________________ I currently own _____ dogs and _____ cats _____ other animals (please specify) their breed(s) and age(s) are as follows: ____________________________________________________________ are you willing to housebreak this pet? ________________ how will you exercise your pet ______________________ how long will your pet be left alone during the day or night _______________ where will your pet sleep ___________________________________________ do you have a door that will enable your pet to go in and out of the house freely while he is being house trained? do you have a swimming pool ?________________________________ dogs frequently dig, chew and bark - are you willing to work with the dog to stop this behavior? under what circumstance would you not be able to keep your dog? Pets can live 12 to 15 years. Would anyone be willing to help with your pet if you could no longer take care of him/her?

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We'll also keep you updated on Apollo's adoption status with email updates.
Photo of Apollo

Apollo

Great Dane Vizsla

Male, 1 yr 11 mos
San Ysidro, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, Spayed or Neutered, Shots are up-to-date,
Story
Apollo is approximately 1.5 years, around 85 pounds, neutered, fully vaccinated Great Dane/Visla mix breed. He is crate trained and good with potty & leash training~ soon he will be a pro of all three!! He is affectionate, but can be a bit nervous when first met with unexpected changes. Apollo gets along well with most dogs (but we suggest he be paired with a female companion), adults and older children alike. Given his adaptability, he should be able to learn your family’s routine rather quickly and become part of the gang in no time!!! Apollo was discovered in the Tecate neighborhoods. When found He was skinny and suffered from ehrlichiosis and anaplasmosis. Fortunately, he is now healthy & flourishing under the loving care of a foster. (June 2025) Apollo has a lot of love to give and longs for a family who can provide him patience, affection and attention he craves. He deserves a warm and loving home where he can feel cherished as a member of the family!!!

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Or, how about these Great Danes in cities near San Diego, California

These Great Danes are available for adoption close to San Diego, California.
We'll also keep you updated on Nova's adoption status with email updates.
Photo of Nova

Nova

Great Dane

Female, Senior
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
How this pet arrived: Nova was brought in by their previous owner. Why Nova might be the one for you:Meet Nova, a friendly and affectionate pup in search of a loving new home! Nova has been doing great in a foster home, and settled into her new routine in just a few days. She is friendly with guests and if you offer her pets, she loves to weave between your legs for full body scratches. Nova is also very food motivated and is pretty content with just one long walk each day. Nova does get excited when she sees other dogs on walks, so she'll benefit from ongoing positive reinforcement training to help manage her reactions. If you're looking for a laidback and loving companion, Nova is ready to enjoy her golden years with you. Inquire about adopting this sweet gal today! At SDHS:This pet has been vaccinated, microchipped and spayed/neutered. This pet is now ready for their new home! Primary Color: Tan Secondary Color: Black Weight: 98.5 Age: 10yrs 9mths 2wks

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We'll also keep you updated on Roscoe's adoption status with email updates.
Photo of Roscoe

Roscoe

Great Dane

Male, Young
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, Spayed or Neutered, Shots are up-to-date,
Story
ATTENTION:  All of our dogs are in private foster homes.  We do NOT have a kennel with multiple dogs.  If you find a dog you want to meet in person, please go to www.secondchancedogrescue.org and complete an application.    We will make every attempt to process all applications within 3 business days of receipt. Meet Roscoe! Roscoe is a 1½-year-old, 85-pound Great Dane mix with a big heart to match his size. He may be a little shy for the first few minutes when meeting new people, but once he warms up, he quickly becomes your loyal best friend. Roscoe is a young, playful guy who would love a canine buddy to run and play with. Like many big, enthusiastic pups, he’s still working on his manners and would benefit from continued guidance and training as he grows into his best self. Roscoe’s story started with heartbreak—he was abandoned when his family moved away and left him in the backyard. He ended up on the euthanasia list before finding safety with us, and now he’s ready for a fresh start with a family who will love him forever. Roscoe has been neutered, microchipped, and is up to date on all vaccines. He also appears to be house trained. With his sweet nature and playful spirit, Roscoe is ready to bring a lot of love (and a little Dane-sized goofiness) into his forever home. His adoption fee is $300. All Second Chance Dog Rescue dogs are spayed/neutered, are up to date on vaccines and have microchips prior to adoption.   Adoption fees vary depending on age of dog. Fees help Second Chance Dog Rescue cover spay/neuter costs,   vaccinations, medical treatments, food and supplies. Please go to  www.secondchancedogrescue.org  and complete an application today!    All dogs live in private foster homes until they are adopted.  April 18, 2026, 6:19 pm

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We'll also keep you updated on Shadow's adoption status with email updates.
No photo available for Shadow

Shadow

Great Dane

Female, 2 yrs 6 mos
Bonita, CA
Size
(when grown) -
Details
-
Story
-

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We'll also keep you updated on Odin's adoption status with email updates.
Photo of Odin

Odin

Great Dane

Male, Puppy
El Cajon, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Oden is a wonderful and growing Great Dane puppy. He spent the first five months of his life on a 5 to 6 foot chain. So when he arrived at the shelter, he did not have a lot of manners. But he is sweet as all get out. He is loving, playful, and just wonderful!

Learn More

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We'll also keep you updated on Odin's adoption status with email updates.
Photo of Odin

Odin

Great Dane

Male, 3 yrs 3 mos
El Cajon, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Oden is a wonderful and growing Great Dane puppy. He spent the first five months of his life on a 5 to 6 foot chain. So when he arrived at the shelter, he did not have a lot of manners. But he is sweet as all get out. He is loving, playful, and just wonderful! **** Please read adoption information carefully!!!**** Odin is a stunningly handsome little boy -male, 7 months -supposedly pure-bread, -Neutered -Current Weight : 90 lbs, will grow -Crate trained -Potty trained Odin is a big, funny bundle of joy, energy, and affection. He is just a big goofball! Odin is still a puppy, and will continue to grow. He is on the bigger side, but has an abundance of affection and cuteness! Odin is a well-adjusted puppy who has been hand raised. He has never shown any signs of aggression of any kind, including food aggression, although he can occasionally be a little rambunctious. He really thinks that he is a little dog…. ? Odin wants to be a lapdog; he can’t quite figure out why he doesn’t fit in my lap, but he settles for putting his head in my lap, since the rest of him doesn’t fit 😜 Odin is used to playing and sleeping with the other dogs on the property. He is well socialized, both with humans and dogs. While I have never seen him interact with a cat, I have no reason to anticipate a problem. ************************************ ADOPTION INFORMATION ************************************ I only adopt LOCALLY; San Diego and immediate vicinity. No long distance. Certainly no out of state. I cannot respond to questions as to whether the animal is available. Please DO NOT contact me asking if the animal is available. If the dog is listed as adoptable, it is available. A home check and a background check are MANDATORY to be considered. If you are unable or unwilling to consent to these requirements, please do not apply. An adoption interview Is REQUIRED. One of our volunteers must meet and observe the dog interact with every member of the household, including pets. Preference will be given to individuals who follow the instructions AND provide complete information for adoption purposes. 1) Please go to our website ( http://aaofus.org/adoption-application.html ) 2) submit it online. Must include dog’s name and “forward to Kim” under pet’s name 3) then forward the confirmation email to me directly at animalsandkim@gmail.com That’s it: easy Peezy! You must Submit an application or at least provide written answers to the following questions in an email in order for me to respond: Must include information on EVERY person in household Number of people in household and their ages ______________________________ ____________________________________________________________ occupations ________________________________________________________________________________________ Type of residential dwelling? __________________ Rent or own? Address: __________________ __________________ __________________ Phone number: __________________ Text available? does anyone in the family suffer from allergies? ___________________ I currently own _____ dogs and _____ cats _____ other animals (please specify) their breed(s) and age(s) are as follows: ____________________________________________________________ are you willing to housebreak this pet? ________________ how will you exercise your pet ______________________ how long will your pet be left alone during the day or night _______________ where will your pet sleep ___________________________________________ do you have a door that will enable your pet to go in and out of the house freely while he is being house trained? do you have a swimming pool ?________________________________ dogs frequently dig, chew and bark - are you willing to work with the dog to stop this behavior? under what circumstance would you not be able to keep your dog? Pets can live 12 to 15 years. Would anyone be willing to help with your pet if you could no longer take care of him/her?

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We'll also keep you updated on Lucky's adoption status with email updates.
Photo of Lucky

Lucky

Great Dane

Female, 4 yrs 2 mos
La Mesa, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Lucky is a 4-year-old stunning Great Dane who is incredibly sweet, gentle, and loving. After being abandoned by her original family, she was taken in by a very generous foster who has given her the safety and care she needed to start fresh. She is wonderful with other dogs and enjoys their company, whether it’s calmly coexisting or sharing space for play and companionship. Like many Danes, she’s a big girl with an even bigger heart — leaning in for affection, soaking up attention, and just wanting to be near her people. Lucky truly deserves a forever family who understands the commitment of owning a giant breed and can give her the time, stability, and love she’s always deserved. She’s ready to leave her past behind and step into a future filled with comfort, kindness, and belonging. If you’re ready to open your heart and home to this gentle giant, Lucky is ready to meet you. Lucky will come with on leash training. She is dog-friendly, we believe she is kid friendly as well.

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These pups are in San Diego, California too!

Below are our newest added Great Danes available for adoption in San Diego, California. To see more adoptable Great Danes in San Diego, California, use the search tool below to enter specific criteria!
We'll also keep you updated on Hippo's adoption status with email updates.
Special Needs
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Hippo

Bullmastiff

Male, Adult
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Needs special attention, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Age: 6 years old Gender: Male Breed: Bull Mastiff mix Weight: 84 lbs Personality: Very sweet and cuddly! He is very pleasant to walk if there are no other dogs in the area. He is learning to be more confident and less reactive. Education: Good with bathroom and leash training and is working on leash reactivity Favorite Activities: Tug of war, long night walks, hanging out in the kitchen Looking for: An active family who will love him and play with him! Some patient training will help him be the best boy ever! He will do best as an only dog right now. Hippo likes routine so someone who can create some structure for him would be ideal to help with his anxiety! A family with kids would be good, too - he has been great with kids of all ages, even with toddlers! A home with a backyard in a quiet neighborhood would be great! Special needs: Current medication to help with separation anxiety Prozac (fluoxetine) (~$5.00). Monthly cost depending on where purchased and market value. Adoption Fee: $ 250 ##1733826##

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We'll also keep you updated on Titus's adoption status with email updates.
Photo of Titus

Titus

Anatolian Shepherd

Male
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered,
Story
Titus Your Next Adventure Buddy! Titus is an 18-month-old, 83-lb bundle of love and energy! This handsome boy is curious, intelligent, and full of life. He’s housebroken, neutered, and up to date on all vaccines — ready to start his next chapter! Titus has been well-socialized and loves to play with other dogs. Whether it’s walks, hikes, or any outdoor fun, he’s always up for it! He’d thrive in a home with a backyard and maybe another playful pup to keep him company. He’s also a sweetheart with people — Titus loves attention from children and adults alike and happily soaks up every pet and scratch he can get. He hasn’t been around cats yet, but he’s such a good-natured, fun-loving, and beautiful dog who just wants to be part of a loving home. Interested in meeting Titus? Please contact Rita at (619) 672-0806 or email rfarris60@gmail.com to learn more.March 8, 2026, 8:45 pm

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We'll also keep you updated on Toby's adoption status with email updates.
Photo of Toby

Toby

Anatolian Shepherd Labrador Retriever

Male, 1 yr 11 mos
San Diego, CA
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats, Spayed or Neutered,
Story
Meet Toby! This sweet boy was rescued from the streets of Mexico after likely being hit by a car and damaging his two front legs. He's a friendly, gentle boy who is dog, kid, and cat-friendly. He prefers cat companions who are dog-friendly. Toby rides in the car well. He is estimated to be around 1.5 years old and weighs about 60 lbs. Our guess is he is a lab/shepherd blend. Toby has recovered and walks well; he is working on his leash skills and crate skills and is house-trained. He loves playing with his toys and romping around with other dogs. Toby is a bright and gentle boy who deserves the warmth of a loving family. Could that be you?

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Search for a Great Dane puppy or dog

Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in San Diego, California.

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Great Dane puppies and dogs in nearby cities

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Related breeds in San Diego, California

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Great Dane shelters & rescues in San Diego, California

There are animal shelters and rescues that focus specifically on finding great homes for Great Dane puppies in San Diego, California. Browse these Great Dane rescues and shelters below.

Here are a few organizations closest to you:

Shelter

3.6 miles

San Diego Humane Society - San Diego Campus

5500 Gaines Street, San Diego, CA 92110

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

6.4 miles

Second Chance Dog Rescue

4284 Cass Street, San Diego, CA 92109

Pet Types: dogs

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Rescue

9 miles

PAWS4thought Animal Rescue

PO Box 1893, Bonita, CA 91908

Pet Types: cats, dogs, rabbits

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Rescue

9.5 miles

Lavender Run Rescue

La Mesa, CA 91942

Pet Types: dogs

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Rescue

9.5 miles

Animal Advocates of the US - San Diego Chapter

El Cajon, CA 92122

Pet Types: cats, dogs, rabbits

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Rescue

16 miles

Friends of Humane Services in Tijuana

641 E. San Ysidro Blvd. #B3-431, San Ysidro, CA 92173

Pet Types: cats, dogs

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Rescue

20.1 miles

Wet Noses Rescue

San Diego, CA 92067

Pet Types: cats, dogs

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Rescue

27.2 miles

Furry Friends Rescue

Ramona, CA 92065

Pet Types: cats, dogs, farm animals

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Rescue

30.9 miles

Amazing Dogs

Carlsbad, CA 92011

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Great Dane puppy or dog?

We've got all the info you need on adopting and caring for a Great Dane puppy. Check out the links below for everything you ever wanted to know about Great Dane puppies and adults.

Great Dane basics

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Where do Great Danes come from? How many types of Great Danes are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Great Dane.

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