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Great Dane puppies and dogs in San Diego, California

Looking for a Great Dane puppy or dog in San Diego, California? Adopt a Pet can help you find an adorable Great Dane near you.

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Adopt a Great Dane near you Great Dane in cities near San Diego, California Other pups in San Diego, California Search for a Great Dane puppy or dog near you Browse Great Dane puppies and dogs in nearby cities Browse related breeds in San Diego, California Great Dane shelters and rescues in San Diego, California Learn more about adopting a Great Dane puppy or dog

Adopt a Great Dane near you in San Diego, California

These Great Danes are available in San Diego, California.
We'll also keep you updated on Loki's adoption status with email updates.
Photo of Loki

Loki

Great Dane

Male, Young
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived: This pet was brought in by our Humane Law Enforcement team. Why this pet is the one for you:Meet Loki, one of our gentle giants. Loki is sweet-natured and polite, and loves to make human friends wherever he goes. He is as playful as he is affectionate, and will show off his best zoomies for you. If you are looking for a new companion like Loki, come adopt him at our San Diego campus today! At SDHS:This pet has been vaccinated, microchipped and spayed neutered. This pet is now ready for their new home! Primary Color: Black Weight: 106 Age: 1yrs 4mths 1wks

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We'll also keep you updated on Da Right's adoption status with email updates.
Photo of Da Right

Da Right

Great Dane American Bulldog

Male, Adult
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived: This pet was brought in by our Humane Law Enforcement. Why Da Right might be the Right one for you: Da Right has not had it easy and it is going to take a special person to make things Right for Da Right. Da Right wants to know that he is doing the right thing. He wants to be told when he is a good boy. He is social with people (not other dogs) and very food motivated so training should come easy and naturally with Da Right. We can help you with positive reinforcement training techniques that will build Da Rights confidence and encourage good behaviors. He wants (needs) to be the only dog in the home and best if he is the only pet. He wants to be the focus of attention, care and play. He will want lots of playtime. He will be best in a quiet home with low traffic. He will benefit from a clear routine and enrichment schedule that he can depend on. Do you want to take on a needy dog who has not had a great start in life and give him the love and care he deserves and wants? He is ready for a new life. He will try his hardest to make you proud of him. At SDHS:Da Right has been vaccinated, microchipped and spayed neutered. Da Right is now ready for his new home! Primary Color: White Secondary Color: Black Weight: 90 Age: 4yrs 1mths 2wks

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We'll also keep you updated on Lewy's adoption status with email updates.
Photo of Lewy

Lewy

Great Dane

Male, Adult
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived:This pet was brought in by a community member on October 5, 2025. Why this pet is the one for you:Meet Lewy! While we are still getting to know this pooch, we cannot deny one thing: they're ready for their next chapter in life! A consistent routine and fun, enriching activities will help them get used to their home and feel like part of the family! If you'd like to learn more about this pup come visit us at the San Diego Campus today!At SDHS:This pet has been vaccinated, microchipped and spayed neutered. This pet is now ready for their new home! Primary Color: Black Secondary Color: White Weight: 129 Age: 3yrs 5mths 0wks

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We'll also keep you updated on Nova's adoption status with email updates.
Photo of Nova

Nova

Great Dane

Female, Senior
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived: Nova was brought in by their previous owner. Why Nova might be the one for you:Meet Nova, a friendly and affectionate pup in search of a loving new home! Nova has been doing great in a foster home, and settled into her new routine in just a few days. She is friendly with guests and if you offer her pets, she loves to weave between your legs for full body scratches. Nova is also very food motivated and is pretty content with just one long walk each day. Nova does get excited when she sees other dogs on walks, so she'll benefit from ongoing positive reinforcement training to help manage her reactions. If you're looking for a laidback and loving companion, Nova is ready to enjoy her golden years with you. Inquire about adopting this sweet gal today! At SDHS:This pet has been vaccinated, microchipped and spayed/neutered. This pet is now ready for their new home! Primary Color: Tan Secondary Color: Black Weight: 89.5 Age: 10yrs 5mths 0wks

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We'll also keep you updated on Ruby's adoption status with email updates.
Photo of Ruby

Ruby

Great Dane

Female, Adult
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived:This pet was brought in by a community member on November 3, 2025. Why this pet is the one for you:Meet Ruby! While we are still getting to know this pooch, we cannot deny one thing: she is a sweet girl! A consistent routine and fun, enriching activities will help her get used to her home and feel like part of the family! If you'd like to learn more about this pup come visit us at the San Diego Campus today!At SDHS:This pet has been vaccinated, microchipped and spayed neutered. This pet is now ready for their new home! Primary Color: Black Secondary Color: Black Weight: 64 Age: 2yrs 1mths 0wks

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We'll also keep you updated on Da Left's adoption status with email updates.
Photo of Da Left

Da Left

Great Dane American Bulldog

Male, Adult
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived: Da Left was brought in by our Humane Law Enforcement. Why Da Left might be the right dog for you: Da Left with his one white ear and one black ear is a special dog and will want a special person to show him what life is like as someone's good dog in a warm and caring home. Da Left has not had a lot of positive reinforcement in his life and he wants to be told when he is a good boy. He is social with people (not other dogs) and very food motivated so training should come easy and naturally with Da Left. We can help you with positive reinforcement training techniques that will build Da Left's confidence and encourage good behaviors. He wants (needs) to be the only dog in the home and best if he is the only pet. He wants to be the focus of attention, care and play. He will want lots of playtime. He will be best in a quiet home with low traffic. He will benefit from a clear routine and enrichment schedule that he can depend on. Do you want to take on a needy dog who has not had a great start in life and give him the love and care he deserves and wants? He is ready for a new life. He will try his hardest to make you proud of him. At SDHS:Da Left has been vaccinated, microchipped and spayed neutered. Da Left is now ready for his new home! Primary Color: White Secondary Color: Black Weight: 89.5 Age: 4yrs 1mths 2wks

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Or, how about these Great Danes in cities near San Diego, California

These Great Danes are available for adoption close to San Diego, California.
We'll also keep you updated on Loki's adoption status with email updates.
Photo of Loki

Loki

Great Dane

Male, Young
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived: This pet was brought in by our Humane Law Enforcement team. Why this pet is the one for you:Meet Loki, one of our gentle giants. Loki is sweet-natured and polite, and loves to make human friends wherever he goes. He is as playful as he is affectionate, and will show off his best zoomies for you. If you are looking for a new companion like Loki, come adopt him at our San Diego campus today! At SDHS:This pet has been vaccinated, microchipped and spayed neutered. This pet is now ready for their new home! Primary Color: Black Weight: 106 Age: 1yrs 4mths 1wks

Learn More

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We'll also keep you updated on Da Right's adoption status with email updates.
Photo of Da Right

Da Right

Great Dane American Bulldog

Male, Adult
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived: This pet was brought in by our Humane Law Enforcement. Why Da Right might be the Right one for you: Da Right has not had it easy and it is going to take a special person to make things Right for Da Right. Da Right wants to know that he is doing the right thing. He wants to be told when he is a good boy. He is social with people (not other dogs) and very food motivated so training should come easy and naturally with Da Right. We can help you with positive reinforcement training techniques that will build Da Rights confidence and encourage good behaviors. He wants (needs) to be the only dog in the home and best if he is the only pet. He wants to be the focus of attention, care and play. He will want lots of playtime. He will be best in a quiet home with low traffic. He will benefit from a clear routine and enrichment schedule that he can depend on. Do you want to take on a needy dog who has not had a great start in life and give him the love and care he deserves and wants? He is ready for a new life. He will try his hardest to make you proud of him. At SDHS:Da Right has been vaccinated, microchipped and spayed neutered. Da Right is now ready for his new home! Primary Color: White Secondary Color: Black Weight: 90 Age: 4yrs 1mths 2wks

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We'll also keep you updated on Nova's adoption status with email updates.
Photo of Nova

Nova

Great Dane

Female, Senior
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived: Nova was brought in by their previous owner. Why Nova might be the one for you:Meet Nova, a friendly and affectionate pup in search of a loving new home! Nova has been doing great in a foster home, and settled into her new routine in just a few days. She is friendly with guests and if you offer her pets, she loves to weave between your legs for full body scratches. Nova is also very food motivated and is pretty content with just one long walk each day. Nova does get excited when she sees other dogs on walks, so she'll benefit from ongoing positive reinforcement training to help manage her reactions. If you're looking for a laidback and loving companion, Nova is ready to enjoy her golden years with you. Inquire about adopting this sweet gal today! At SDHS:This pet has been vaccinated, microchipped and spayed/neutered. This pet is now ready for their new home! Primary Color: Tan Secondary Color: Black Weight: 89.5 Age: 10yrs 5mths 0wks

Learn More

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We'll also keep you updated on Lewy's adoption status with email updates.
Photo of Lewy

Lewy

Great Dane

Male, Adult
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived:This pet was brought in by a community member on October 5, 2025. Why this pet is the one for you:Meet Lewy! While we are still getting to know this pooch, we cannot deny one thing: they're ready for their next chapter in life! A consistent routine and fun, enriching activities will help them get used to their home and feel like part of the family! If you'd like to learn more about this pup come visit us at the San Diego Campus today!At SDHS:This pet has been vaccinated, microchipped and spayed neutered. This pet is now ready for their new home! Primary Color: Black Secondary Color: White Weight: 129 Age: 3yrs 5mths 0wks

Learn More

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We'll also keep you updated on Ruby's adoption status with email updates.
Photo of Ruby

Ruby

Great Dane

Female, Adult
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived:This pet was brought in by a community member on November 3, 2025. Why this pet is the one for you:Meet Ruby! While we are still getting to know this pooch, we cannot deny one thing: she is a sweet girl! A consistent routine and fun, enriching activities will help her get used to her home and feel like part of the family! If you'd like to learn more about this pup come visit us at the San Diego Campus today!At SDHS:This pet has been vaccinated, microchipped and spayed neutered. This pet is now ready for their new home! Primary Color: Black Secondary Color: Black Weight: 64 Age: 2yrs 1mths 0wks

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We'll also keep you updated on Da Left's adoption status with email updates.
Photo of Da Left

Da Left

Great Dane American Bulldog

Male, Adult
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived: Da Left was brought in by our Humane Law Enforcement. Why Da Left might be the right dog for you: Da Left with his one white ear and one black ear is a special dog and will want a special person to show him what life is like as someone's good dog in a warm and caring home. Da Left has not had a lot of positive reinforcement in his life and he wants to be told when he is a good boy. He is social with people (not other dogs) and very food motivated so training should come easy and naturally with Da Left. We can help you with positive reinforcement training techniques that will build Da Left's confidence and encourage good behaviors. He wants (needs) to be the only dog in the home and best if he is the only pet. He wants to be the focus of attention, care and play. He will want lots of playtime. He will be best in a quiet home with low traffic. He will benefit from a clear routine and enrichment schedule that he can depend on. Do you want to take on a needy dog who has not had a great start in life and give him the love and care he deserves and wants? He is ready for a new life. He will try his hardest to make you proud of him. At SDHS:Da Left has been vaccinated, microchipped and spayed neutered. Da Left is now ready for his new home! Primary Color: White Secondary Color: Black Weight: 89.5 Age: 4yrs 1mths 2wks

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These pups are in San Diego, California too!

Below are our newest added Great Danes available for adoption in San Diego, California. To see more adoptable Great Danes in San Diego, California, use the search tool below to enter specific criteria!
We'll also keep you updated on Hippo's adoption status with email updates.
Special Needs
Photo of Hippo

Hippo

Bullmastiff

Male, Adult
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Needs special attention, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Age: 6 years old Gender: Male Breed: Bull Mastiff mix Weight: 84 lbs Personality: Very sweet and cuddly! He is very pleasant to walk if there are no other dogs in the area. He is learning to be more confident and less reactive. Education: Good with bathroom and leash training and is working on leash reactivity Favorite Activities: Tug of war, long night walks, hanging out in the kitchen Looking for: An active family who will love him and play with him! Some patient training will help him be the best boy ever! He will do best as an only dog right now. Hippo likes routine so someone who can create some structure for him would be ideal to help with his anxiety! A family with kids would be good, too - he has been great with kids of all ages, even with toddlers! A home with a backyard in a quiet neighborhood would be great! Special needs: Current medication to help with separation anxiety Prozac (fluoxetine) (~$5.00). Monthly cost depending on where purchased and market value. Adoption Fee: $ 250 ##1733826##

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We'll also keep you updated on Titus's adoption status with email updates.
Photo of Titus

Titus

Anatolian Shepherd

Male
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered,
Story
Titus Your Next Adventure Buddy! Titus is an 18-month-old, 83-lb bundle of love and energy! This handsome boy is curious, intelligent, and full of life. He’s housebroken, neutered, and up to date on all vaccines — ready to start his next chapter! Titus has been well-socialized and loves to play with other dogs. Whether it’s walks, hikes, or any outdoor fun, he’s always up for it! He’d thrive in a home with a backyard and maybe another playful pup to keep him company. He’s also a sweetheart with people — Titus loves attention from children and adults alike and happily soaks up every pet and scratch he can get. He hasn’t been around cats yet, but he’s such a good-natured, fun-loving, and beautiful dog who just wants to be part of a loving home. Interested in meeting Titus? Please contact Rita at (619) 672-0806 or email rfarris60@gmail.com to learn more.October 11, 2025, 9:18 pm

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We'll also keep you updated on Bethoveen's adoption status with email updates.
Photo of Bethoveen

Bethoveen

Anatolian Shepherd Mountain Cur

Male, 2 yrs 7 mos
San Diego, CA
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats, Spayed or Neutered, Shots are up-to-date,
Story
Meet Beethoven. This young boy is an almost 2 year old puppy, affectionate, effusive, and sometimes a little goofy, but he is a dog that has a lot of love to give, he has been spoiled and loved from the moment he was found, and he is looking for a home where he will be given the same love. He plays with cats and dogs and gets along well with children and adults. At first he may be a little shy, but he adapts very quickly. He loves walks, treats and chew toys. He knows basic commands and is very easy to be training, he is food-motivated. He will be happy to see you before a workday and play a little with you. He licks like a turtle to give you affection and will hug you with his front legs. The $350.00 adoption fee covers the following: Transport to San Diego, CA. Spay/Neuter. All vaccines up to date. Deworming (puppies 2 sets). Flea medication up to date. Tick control up to date. Microchip. Microchip registration to new owner paid for. Collar. Temporary leash. The adoption fee does not include transportation to North of San Diego

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Search for a Great Dane puppy or dog

Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in San Diego, California.

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Great Dane puppies and dogs in nearby cities

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Related breeds in San Diego, California

Anatolian Shepherds in San Diego, California Bullmastiffs in San Diego, California Irish Wolfhounds in San Diego, California

Great Dane shelters & rescues in San Diego, California

There are animal shelters and rescues that focus specifically on finding great homes for Great Dane puppies in San Diego, California. Browse these Great Dane rescues and shelters below.

Here are a few organizations closest to you:

Shelter

3.6 miles

San Diego Humane Society - San Diego Campus

5500 Gaines Street, San Diego, CA 92110

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

6.1 miles

Amazing Strays Rescue

San Diego, CA 92115

Pet Types: cats, dogs

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Rescue

9.5 miles

Animal Advocates of the US - San Diego Chapter

El Cajon, CA 92122

Pet Types: cats, dogs, rabbits

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Rescue

16 miles

Friends of Humane Services in Tijuana

641 E. San Ysidro Blvd. #B3-431, San Ysidro, CA 92173

Pet Types: cats, dogs

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Rescue

20.1 miles

Wet Noses Rescue

San Diego, CA 92067

Pet Types: cats, dogs

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Rescue

30.9 miles

Amazing Dogs

Carlsbad, CA 92011

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Great Dane puppy or dog?

We've got all the info you need on adopting and caring for a Great Dane puppy. Check out the links below for everything you ever wanted to know about Great Dane puppies and adults.

Great Dane basics

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Where do Great Danes come from? How many types of Great Danes are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Great Dane.

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