Great Dane Adoption in Missouri: Great Dane Puppies for Sale in Missouri

Adopt a Great Dane near you in Missouri

Below are our newest added Great Danes available for adoption in Missouri. To see more adoptable Great Danes in Missouri, use the search tool below to enter specific criteria!

DROOLBERT

Great Dane

Male, 4 yrs

Maryland Heights, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Story

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Duke

Great Dane

Male

Warrenton, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Meet Duke, a delightful canine companion residing at our local shelter. Duke's personality is a winning combination of sweetness and smarts, paired with a goofy charm that endears him to everyone he meets. His gentle nature makes him an excellent friend for children and adults alike, and his loyalty knows no bounds. Duke is also quite clever, mastering tricks and commands with ease. Adopting Duke means bringing home a forever friend who will fill your days with joy and laughter. He's ready to be part of a loving family!March 19, 2026, 11:01 am

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Gunner JB

Great Dane/Poodle (Miniature)

Male, 1 mo

St Louis, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs,

Story

Meet the "Gentle Giant" Doodles! Are you looking for a best friend who is equal parts majestic and mischievous? Our litter of "Danedoodles" (Great Dane x Some Poodle & couple other breeds) are officially ready to find their forever familes!These pups have hit the genetic jackpot: they’ve inherited the calm, "velcro-dog" heart of the Great Dane and the clever, playful wit of the Poodle. Despite their growing size, these pups firmly believe they are lap dogs. If there’s a spot next to you, they’ll find it. Thanks to their Poodle roots, they are quick learners! They’re already working on their "sit" and "stay," though they might try to negotiate for an extra treat. Most of the litter sports those soft, wavy coats that mean less time vacuuming and more time playing. Goofy Personalities-From "zoomies" to tilting their heads at every word you say, their curiosity is endless and their wagging tails are lethal weapons of joy. Temperament - Patient, goofy, and incredibly affectionate Energy Level - Playful bursts followed by epic 3-hour naps Future Size – Based on their DNA (50% Great Dane), these pups are likely to grow big enough to reach the counter—so you might want to hide the cookies! That said, some may take after Mom, a medium-to-large Poodle mix weighing around 60 lbs, meaning you may only need to keep an eye on your end tables instead. If you're looking for smart, loving and velcro puppies, then adopt one of us! Local adoption fee is $250(in TX) Out of state adoption fee is $550 (includes transport to your area)

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