Great Dane Adoption in Missouri: Great Dane Puppies for Sale in Missouri

Adopt a Great Dane near you in Missouri

Below are our newest added Great Danes available for adoption in Missouri. To see more adoptable Great Danes in Missouri, use the search tool below to enter specific criteria!

Ozzy

Great Dane

Female, Young

Savannah, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, House-trained,

Story

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Persephone

Great Dane

Female, 5 mos

Kansas City, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

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Ghost

Great Dane

Male, 1 yr

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats, House-trained,

Story

Meet Ghost 👻 Ghost is a loving, playful, and downright charming pup who brings a sweet mix of goofiness and affection everywhere he goes. His foster mom says he has this adorable habit of “cat-rubbing” on your legs—he’ll gently lean or wiggle against you just like a cat asking for love. It’s impossible not to smile when he does it. This boy is still very much a puppy at heart. He loves to play, plop himself right onto your feet, and even sit on his dog friends’ faces mid-playtime (they don’t seem to mind—he’s just being Ghost!). He soaks up attention, enjoys being close, and always finds a way to sneak in a cuddle. Ghost is amazing with other dogs and great with kids. He’s also been around horses and ducks and does wonderfully with them too! His gentle spirit really shines around all kinds of animals. He can be a little skittish with loud noises, but his reaction is just to duck his head and trot to his kennel for a sense of safety. With reassurance and consistency, he’ll continue growing more confident. Ghost is sweet, funny, social, and full of love—everything you could want in a companion. He’s ready to bring joy, laughter, and loyalty to a forever family of his very own. https://new.shelterluv.com/matchme/adopt/NASD/Dog

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Roxanne

Great Dane

Female, 4 yrs

Branson, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

25-D-149

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Costa

Great Dane

Male, 6 yrs

St. Louis, MO

Size

(when grown) -

Details

Story

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Lacey

Great Dane/Labrador Retriever

Female, 3 yrs 6 mos

Lebanon, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Lacey Mae is a 3½-year-old Lab x Great Dane mix with a heart as big as her paws. She originally came to us as a stray and quickly stole everyone’s hearts with her gentle, loving nature. Sadly, she was recently returned—but we’re confident her true forever family is still out there. Her previous home didn’t share much information, only noting that she’d been living mostly outdoors with a wireless fence and had started chasing the cats. That said, here at the shelter, she hasn’t batted an eye at our office cat! We suspect it’s more a case of boredom and lack of stimulation than anything else—Lacey is a bright girl who thrives on companionship, interaction, and having a purpose. This big sweetheart is calm, affectionate, and happiest when she’s close to her people. She leans in for cuddles, follows you from room to room, and gives the kind of soft, soulful looks that make your heart melt. Despite her size, she’s gentle and well-mannered, with a nurturing, almost motherly way about her. Lacey Mae would love a home that can give her what she’s been missing—time, attention, and engagement. Whether that’s daily walks, playtime, or just being included in family life, she’ll give back every ounce of love she receives (and then some!). If you’re ready to welcome a truly special girl into your home—one who will adore you unconditionally and make every day brighter—Lacey Mae is waiting to meet you. 💖 Could this big-hearted girl be your perfect match? Come meet Lacey Mae today!

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Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in Missouri.

Great Dane puppies and dogs in Missouri

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Adopt a Great Dane near you in Missouri

Below are our newest added Great Danes available for adoption in Missouri. To see more adoptable Great Danes in Missouri, use the search tool below to enter specific criteria!

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Great Dane puppies and dogs in Missouri cities

Great Dane shelters & rescues in Missouri

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Great Dane puppies and dogs in Missouri

Jump to:

Adopt a Great Dane near you in Missouri

Below are our newest added Great Danes available for adoption in Missouri. To see more adoptable Great Danes in Missouri, use the search tool below to enter specific criteria!

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in Missouri cities

Great Dane shelters & rescues in Missouri

Looking for a specific shelter or rescue?

Want to learn more about adopting a Great Dane puppy or dog ?

Great Dane information

Great Dane basics