Adopt
Rehome
Menu Hamburger Icon

Mastiff puppies and dogs in La Mesa, California

Looking for a Mastiff puppy or dog in La Mesa, California? Adopt a Pet can help you find an adorable Mastiff near you.

Picture of Mastiff

Learn More:

Adopt a Mastiff near you Mastiff in cities near La Mesa, California Other pups in La Mesa, California Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in La Mesa, California Mastiff shelters and rescues in La Mesa, California Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in La Mesa, California

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near La Mesa, California

These Mastiffs are available for adoption close to La Mesa, California.
We'll also keep you updated on PJ's adoption status with email updates.
Photo of PJ

PJ

Mastiff

Male, Young
San Diego, CA
Size
(when grown) -
Details
Not good with kids, Not good with dogs, Not good with cats, Spayed or Neutered,
Story
How this pet arrived:PJ was brought in by a Humane Law Officer. Why this pet is the one for you:Meet PJ, a sweet and playful pup looking for a loving and patient new home! PJ may be a bit shy at first, but don't let that fool you - this gentle giant has a heart of gold just waiting to shine. He appreciates slow introductions and will reward your kindness with sweet, tender affection. Once he feels comfortable, he will solicit pets and stretch out on his side to lounge in the sun. PJ will thrive with adopters who allow him to adjust at his pace and can continue his positive reinforcement training. He loves treats, making training sessions a breeze! If you're ready to give PJ the love and patience he deserves, and help this shy boy blossom, come speak to an adoption counselor today! At SDHS:This pet has been vaccinated, microchipped and spayed/neutered. This pet is now ready for adoption! Primary Color: Brindle Weight: 109 Age: 1yrs 10mths 1wks

Learn More

Small right facing arrow
We'll also keep you updated on Ponyboy's adoption status with email updates.
Photo of Ponyboy

Ponyboy

Mastiff

Male, Adult
San Diego, CA
Size
(when grown) -
Details
Not good with kids, Not good with dogs, Not good with cats, Spayed or Neutered,
Story
How this pet arrived: This pet was brought in by a community member. Why this pet is the one for you:Meet Ponyboy, a sweet and lovable dog with a heart as big as his size! This gentle giant is the definition of a laid-back companion who thrives on love and affection. Despite his imposing stature, Ponyboy is as soft-hearted as they come. He loves nothing more than lounging around, basking in attention, and enjoying the occasional treat-he's definitely a treat connoisseur! Ponyboy has a calm and patient demeanor, making him an excellent companion for families or individuals looking for a relaxed, easygoing pet. He's incredibly sweet and affectionate, forming strong bonds with those who show him kindness. Whether it's a leisurely walk or a snuggle session on the couch, Ponyboy is content to just be by your side, showing his devotion with his big, soulful eyes. If you're looking for a laid-back, loving giant to share your home with, Ponyboy is your guy! His love for treats and gentle nature will bring endless joy to your life. Come meet this lovable boy-he's ready to find his new home, and he can't wait to shower you with all the love you can handle. At SDHS:This pet has been vaccinated, microchipped and spayed/neutered. This pet is now ready for their new home! Primary Color: Black Weight: 139 Age: 6yrs 1mths 1wks

Learn More

Small right facing arrow
We'll also keep you updated on Vampira's adoption status with email updates.
Photo of Vampira

Vampira

Mastiff

Female, Adult
San Diego, CA
Size
(when grown) -
Details
Not good with kids, Good with dogs, Not good with cats, Spayed or Neutered,
Story
How this pet arrived: This pet was brought in by our Humane Law Enforcement team. Why this pet is the one for you:Meet Vampira, a gentle soul residing in our shelter. Despite her unique name, she's nothing but kindness personified. With a shy and reserved demeanor, she might take a little while to warm up to new people. But once she does, her gentle nature shines through. She's unsure if she's house trained, but with patience and love, she's ready to learn. She can be a bit nervous, but her sweet temperament is sure to win you over. She's the perfect companion for someone who understands that trust takes time to build. Adopt Vampira, because every dog deserves a loving home where they can thrive! At SDHS:This pet has been vaccinated, microchipped and spayed/neutered. This pet is now ready for their new home! Primary Color: Tan Weight: 83 Age: 5yrs 1mths 1wks

Learn More

Small right facing arrow
We'll also keep you updated on Jughead's adoption status with email updates.
Photo of Jughead

Jughead

Mastiff American Staffordshire Terrier

Male, 2 yrs 2 mos
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Not good with kids, Not good with dogs, Not good with cats, Spayed or Neutered,
Story
Meet Jughead! DOB: March 2023Weight: 70lbsDisposition: Friendly, Engaged, HappyHistory: Rescued from a shelter in LA County by TBL in March 2025Best Home: Amazing Qualities: If you're interested in meeting this dog, please visit our website to fill out an adoption application: www.thebarkinglot.net/adoptOur dogs are located in San Diego County, CA. We will happily consider out of town applications and can conduct virtual play dates with interested adopters. We have monthly transport to various locations in the Pacific Northwest, individual arrangements would need to be made for other locations across the US and Canada.To initiate the adoption process for this dog, please complete our online application by clicking below. Your adoption coordinator will respod to you via email once they receive your application: www.thebarkinglot.net/adopt

Learn More

Small right facing arrow
We'll also keep you updated on Hannah's adoption status with email updates.
Photo of Hannah

Hannah

Mastiff American Pit Bull Terrier

Female, Adult
Riverside, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Not good with dogs, Not good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
COURTESY POST Hannah’s journey hasn’t been an easy one. She found herself scared and just days away from giving birth at one of California’s toughest high-kill shelters, where she and her 10 puppies were placed on the euthanasia list. But Real Good Rescue and two amazing rescue partners came together to save this brave mama. Despite losing seven of her puppies during this tough transition, Hannah’s spirit never wavered. She proved to be the most loving and dedicated mother, nurturing her babies with unwavering attention, care and play. Thanks to her, all three surviving puppies were quickly adopted into loving homes. And like most mama dogs, Hannah was overlooked. Now, it’s Hannah’s turn to find the forever home she so deeply deserves. At 75lbs and approximately 4 years old, Hannah is the perfect mix of active and chill. She’s a social butterfly who’s lived harmoniously with small dogs and even a 5-year-old child. However, her dream home would be calm, peaceful, and all about her—no other pets, just allowing Hannah to soak up all the love. Outdoors, she enjoys staying active and exploring, but indoors she’s the ultimate couch potato, ready for cuddles and naps. If you or someone you know is ready to give this incredible girl the life and love she’s been waiting for, email adopt@realgood.dog

Learn More

Small right facing arrow
We'll also keep you updated on Spartan's adoption status with email updates.
Photo of Spartan

Spartan

Mastiff American Pit Bull Terrier

Male, Adult
Oceanside, CA
Size
(when grown) -
Details
Not good with kids, Not good with dogs, Not good with cats, Spayed or Neutered,
Story
How this pet arrived: Spartan was brought in by Humane Law Enforcement on March 16, 2025. Why this pet is the one for you:Meet Spartan, the mighty toy warrior with a personality as big as his blocky head! This fun-loving goofball is ready to march into your life and conquer your heart with his charm and playful spirit. Whether he's tossing toys around like a true gladiator or entertaining himself with a solo play session, Spartan knows how to keep life exciting. He's a strong boy (true to his name!) who could use a refresher on leash manners - sometimes he forgets his size. With a little positive reinforcement, Spartan will be more than ready to earn his place in your hall of fame. He does get a bit overzealous when it comes to barriers and needs some help working through that, but he's eager to learn and grow into the best version of himself. Spartan does have some skin issues that may be allergy-related, so his future family should be ready to support him with a little TLC. Due to his size and exuberance, he's best suited for a home with kids over 10. If you're looking for a loyal companion with legendary levels of love, Spartan is ready to be your heroic sidekick! Come in and ask about meeting him today! At SDHS:Spartan has been vaccinated, microchipped and spayed/neutered. Spartan is now ready for his new home! Primary Color: White Secondary Color: Brown Weight: 81.6 Age: 3yrs 4mths 3wks

Learn More

Small right facing arrow

Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in La Mesa, California.

    an arrow icon
  • Ashburn, VA
  • Ashburn, VA

Sorry, we can’t find that location! Please try again.

    Age
    an arrow icon

Mastiff puppies and dogs in nearby cities

Mastiff Puppies near me Mastiff in Carlsbad, CA Mastiff in Chula Vista, CA Mastiff in Coronado, CA Mastiff in El Cajon, CA Mastiff in Encinitas, CA Mastiff in Escondido, CA Mastiff in Imperial Beach, CA Mastiff in Lemon Grove, CA Mastiff in National City, CA Mastiff in Oceanside, CA Mastiff in Poway, CA Mastiff in San Diego, CA Mastiff in San Marcos, CA Mastiff in Santee, CA Mastiff in Solana Beach, CA Mastiff in Vista, CA

Related breeds in La Mesa, California

Bullmastiffs in La Mesa, California Neapolitan Mastiffs in La Mesa, California Saint Bernards in La Mesa, California

Mastiff shelters & rescues in La Mesa, California

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in La Mesa, California. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

10.5 miles

San Diego Humane Society - San Diego Campus

5500 Gaines Street, San Diego, CA 92110

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

More an arrow icon

Rescue

11.2 miles

The Barking Lot

San Diego, CA 92117

Pet Types: dogs

More an arrow icon

Shelter

33 miles

San Diego Humane Society - Oceanside Campus (Dogs)

2905 San Luis Rey Road, Oceanside, CA 92058

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

More an arrow icon

Rescue

33 miles

Underdog Heroes

Riverside, CA 92058

Pet Types: dogs

More an arrow icon

Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

magnifying glass with cat and dog

Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

clipboard with list

Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

Learn More an arrow icon