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Mastiff puppies and dogs in La Mesa, California

Looking for a Mastiff puppy or dog in La Mesa, California? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near La Mesa, California Other pups in La Mesa, California Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in La Mesa, California Mastiff shelters and rescues in La Mesa, California Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in La Mesa, California

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!
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Or, how about these Mastiffs in cities near La Mesa, California

These Mastiffs are available for adoption close to La Mesa, California.
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1011017

Mastiff

Male, Young
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
How this pet arrived:This pet was brought in by a community member October 30, 2026. Why this pet is the one for you: Say hello to Pawl Rudd! We are still learning about Pawl Rudd's unique personality, but we would be happy to introduce you to him to see if he is a good fit for your family. If you'd like to meet this sweet pup, speak with our team today! At SDHS:This pet has been vaccinated, microchipped and spayed/neutered. This pet is now ready for adoption! Primary Color: Black Secondary Color: White Weight: 52.6 Age: 0yrs 10mths 1wks

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NALA

Mastiff

Female, 4 yrs 2 mos
Chula Vista, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
Hi, Nala here! I am the biggest gentle giant you will ever meet. I love meeting new people and other four legged friends. I do great around kids and public spaces! I am a very chill and sweet girl who loves belly rubs and cuddles. I am house broken, walk well on a leash and prefer to just lay around soaking up the sun if I can. If you`d like to meet me please submit an adoption application or email: ymota@chulavistaca.gov

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Octavia

English Mastiff

Female, 7 yrs 6 mos
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Octavia also called Tavi. Octavia is a big girl with an even bigger heart. Since being rescued from the shelter, she’s proven herself to be the perfect houseguest—gentle, loving, and so grateful for a second chance. Affectionately known as Tavi, she’s ready to leave her past behind and find a forever home where she can truly shine. She just needs someone to give her that chance… and we know she’ll give a lifetime of love in return. Due to Tavi's neglect, she had a severe eye infection when we rescued her from the shelter on the euth list.  Unfortunately, we were unable to save her eye but that doesn't stop her one bit! ##2688495##

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Phoebe

Mastiff Pit Bull Terrier

Female, Adult
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Not good with dogs, Not good with cats, Spayed or Neutered, Shots are up-to-date,
Story
ATTENTION:  All of our dogs are in private foster homes.  We do NOT have a kennel with multiple dogs.  If you find a dog you want to meet in person, please go to www.secondchancedogrescue.org and complete an application.    We will make every attempt to process all applications within 3 business days of receipt. Meet Phoebe! Your one and only best girl!  This sweet lady is looking for a home where she can soak up all of the love and attention she deserves. She is affectionate, loyal, and ready to be someone's very best friend. Preferably without having to share her spotlight with another dog.  She would thrive as the only dog in the home, where she can relax, feel secure, and enjoy her people all to herself. She would do well with older, respectful kids who understand how to give a pup her space when she needs it.  If you're looking for a loving companion to be your sidekick, cuddle buddy, and devoted 4 legged family member, this beautiful girl may be exactly who you're looking for.  Phoebe is spayed, microchipped and up to date on all vaccinations. Her adoption fee is $300.  All Second Chance Dog Rescue dogs are spayed/neutered, are up to date on vaccines and have microchips prior to adoption.   Adoption fees vary depending on age of dog. Fees help Second Chance Dog Rescue cover spay/neuter costs,   vaccinations, medical treatments, food and supplies. Please go to  www.secondchancedogrescue.org  and complete an application today!    All dogs live in private foster homes until they are adopted.  November 8, 2026, 3:03 pm

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Scarlett

Mastiff Great Dane

Female, Young
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with dogs, Good with cats, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
This is Scarlett.She is an "American Molossus", but the form doesn't have that as an option. Her mom is full American Molossus, her dad is half American Molossus, half Great Dane. So she's a little more slender than her breed usually gets, but she's still a big girl (220+ lbs).All my life I've wanted a big dog, truly big. And my wife surprised me for father's day 2 years ago with a puppy. And she grew fast. She is currently a little north of 220 lbs. She is spayed and microchipped and current on her shots. She is loving and playful and protective. She does drool a lot, but we got used to having a handful of "dog towels" around the house to just wipe up after her. And she's trained to come to me so I can clean her face after she drinks water.But unfortunately, I am in the military and live in military housing, and now we have to move, and won't be able to bring her.Please understand that this is not easy, I do not want to give her up, but she's a good girl and deserves a good home.

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Princess

Mastiff

Female, 10 yrs 9 mos
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Princess Princess is a 10-year-old, 103-pound Pitbull whose life story will break your heart — and then completely inspire you. She was living on the streets, used for multiple litters, and found covered in massive tumors with a severe skin infection. Despite everything she endured, her spirit never broke. Since coming into rescue, her tumors have been surgically removed, she has been spayed, microchipped, vaccinated, placed on flea control, and her skin has beautifully healed. And through it all… she has remained the sweetest soul on the planet. Princess is incredibly gentle and loving. She is wonderful with puppies, cats, big dogs, and little dogs. For a 103-pound girl, she has the softest heart and the calmest presence. She simply wants comfort, safety, and someone to love her the way she has always deserved. After a lifetime of hardship, Princess is finally ready for her happily ever after. If you would like to meet this extraordinary girl, please fill out an application at: www.secondleashonlife.org Princess has survived everything. Now she just needs someone to choose her.   ##2665693##

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in La Mesa, California.

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Mastiff puppies and dogs in nearby cities

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Related breeds in La Mesa, California

Bullmastiffs in La Mesa, California Neapolitan Mastiffs in La Mesa, California Saint Bernards in La Mesa, California

Mastiff shelters & rescues in La Mesa, California

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in La Mesa, California. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

10.5 miles

San Diego Humane Society - San Diego Campus

5500 Gaines Street, San Diego, CA 92110

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Shelter

11.2 miles

Chula Vista Animal Care Facility (public)

130 Beyer Way, Chula Vista, CA 91911

Pet Types: cats, birds, dogs, rabbits, reptiles, small animals

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Rescue

12.7 miles

Rescue Fenix

San Diego, CA 92192

Pet Types: cats, dogs

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Rescue

12.7 miles

Second Chance Dog Rescue

4284 Cass Street, San Diego, CA 92109

Pet Types: dogs

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Rescue

17.4 miles

Second Leash on Life

San Diego, CA 92130

Pet Types: dogs

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Rescue

27.9 miles

Saving Shelter Pets of CA

San Marcos, CA 92069

Pet Types: dogs

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Rescue

33 miles

Underdog Heroes

Riverside, CA 92058

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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