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Mastiff puppies and dogs in San Diego, California

Looking for a Mastiff puppy or dog in San Diego, California? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near San Diego, California Other pups in San Diego, California Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in San Diego, California Mastiff shelters and rescues in San Diego, California Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in San Diego, California

These Mastiffs are available in San Diego, California.
We'll also keep you updated on Zeuko's adoption status with email updates.
Photo of Zeuko

Zeuko

Mastiff

Male, Young
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived:Zeuko was brought in by a Good Samaritan on January 11th, 2026. At SDHS:Bruno has been vaccinated, microchipped and neutered and is ready for his new home! Why this pet is the one for you:Meet Zeuko! Zeuko is a big-hearted, super snuggly boy who wants nothing more than to be right by your side. He's affectionate, loving, and thrives on close human connection. Zeuko already knows several commands like sit, wait, drop it, and leave it, and he's eager to keep learning.This energetic guy is always alert to the world around him and loves staying busy. Long walks, interactive play, fetch, and tug-of-war are some of his favorites. Because he's strong and can get very excited, he'll need a confident handler who can continue working on leash manners and jumping. He can be mouthy when overstimulated, but redirection and structure go a long way.Zeuko would do best in an active home that understands big, enthusiastic dogs and is ready to help him channel his energy.If you'd like to learn more about Zeuko come visit him at the San Diego Campus today! Don't forget to bring a leash and collar. Primary Color: Black Brindle Weight: 68 Age: 1yrs 11mths 2wks

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We'll also keep you updated on Jones's adoption status with email updates.
Photo of Jones

Jones

Mastiff

Male, Young
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived:This pet was brought in by a community member on September 9, 2025. Why this pet is the one for you:Meet Jones! Jones is a total lovebug who's ready and waiting to find his new loving home. He adores people and will display his excited wiggles when he greets you. He can be a bit shy with new faces and places, but once he builds confidence, he'll share his playful and energetic side. He's very smart and treat motivated, and has already mastered "sit," "paw" and "down." Jones has been known to have big feelings around other dogs, and may do best as your one and only canine companion. Although he may not be a candidate for dog parks or other off-leash venues, there are lots of other activities you can do together to strengthen your bond! If you're interested in opening your heart and home to this sweet pup, come speak to an adoption counselor today!At SDHS:This pet has been vaccinated, microchipped and neutered. This pet is now ready for their new home!Dog Reactive Dog:  This pet requires a virtual behavior consult, please watch THIS video to learn more about them. Primary Color: Brown Secondary Color: Black Weight: 62.5 Age: 1yrs 4mths 2wks

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We'll also keep you updated on Rudolph's adoption status with email updates.
Photo of Rudolph

Rudolph

Mastiff

Male, Adult
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived: This pet was brought in by a community member. Why this pet is the one for you:He can be a bit anxious, which is common in shelter environments, but once he's out with his handlers, his true personality shines. He's a good boy on leash and enjoys getting out for walks, making him an easy companion to take along. Our staff and volunteers absolutely adore him and speak highly of his kind nature. He may have some skin issues that will need a little care, but with love and consistency, he has so much potential to thrive. He may feel more comfortable with women, so a calm, patient home would be ideal for him to continue building confidence. This handsome guy is just looking for someone to see past the stress of the shelter and give him the chance he deserves. If you're looking for a loyal, sweet companion, he could be the perfect match. Adopt Rudolph at the San Diego Campus today! Primary Color: Brindle Weight: 103 Age: 4yrs 1mths 1wks

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We'll also keep you updated on Wick's adoption status with email updates.
Photo of Wick

Wick

Mastiff

Male, 1 yr 2 mos
Coronado, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with dogs, Not good with cats, Spayed or Neutered, Shots are up-to-date,
Story
Meet Wick, a lovable 1-year-old Mastiff with a big heart and an even bigger personality! This gentle giant is still growing into his paws and has all the youthful curiosity and sweetness you could hope for. Wick absolutely adores people—he greets everyone with pure joy and enthusiasm, his whole body wiggling with happiness. He also completely believes he’s a lap dog (despite… well, his very large reality!). Wick loves to lean in close, soak up affection, and be as near to his humans as possible. His loving nature makes him a total favorite. Because he gets so excited to say hello, he's working on greeting people politely—and he’s making great progress with gentle guidance. Wick thrives when he knows what’s expected of him and gets lots of praise and love along the way. Wick would shine as the main star of his future home—he’s the kind of dog who really blossoms when he gets to be the center of attention and affection. If you’re looking for a loyal, goofy, affectionate companion who will fill your home with warmth, laughter, and endless love, Wick is ready to be your gentle best friend for life! About Me: Estimated DOB 10/25/2024, 1 year old Male, Mastiff, 97 lbs Neutered, Vaccinated, up to date on flea and heart worm prevention Adoption Fee: $150 Adoption Application – https://new.shelterluv.com/matchme/adopt/PCOR/Dog

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We'll also keep you updated on Jughead's adoption status with email updates.
Photo of Jughead

Jughead

Mastiff American Staffordshire Terrier

Male, 2 yrs 10 mos
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
Meet Jughead! DOB: March 2023Weight: 70lbsDisposition: Jughead is a friendly and curious boy who loves nothing more than exploring the outdoors. He's a natural on the trails and is working on his leash manners so he can be the best hiking partner possible. When he's not adventuring, he's busy with his toys, treating them with a surprising amount of care before he finally lets loose and has a blast. He loves his people and is looking for someone who can help him work on building his focus and attention span.History: Rescued from a shelter in LA County by TBL in March 2025Best Home: A family (or single person) looking for a loyal companion to join you on your adventures and a sweet boy to cuddle up with at the end of the day.Amazing Qualities: Jughead is curious and confident! He's ready to explore the world.If you're interested in meeting this dog, please visit our website to fill out an adoption application: www.thebarkinglot.net/adoptOur dogs are located in San Diego County, CA. We will happily consider out of town applications and can conduct virtual play dates with interested adopters. We have monthly transport to various locations in the Pacific Northwest, individual arrangements would need to be made for other locations across the US and Canada.To initiate the adoption process for this dog, please complete our online application by clicking below. Your adoption coordinator will respod to you via email once they receive your application: www.thebarkinglot.net/adopt

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Or, how about these Mastiffs in cities near San Diego, California

These Mastiffs are available for adoption close to San Diego, California.
We'll also keep you updated on Zeuko's adoption status with email updates.
Photo of Zeuko

Zeuko

Mastiff

Male, Young
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived:Zeuko was brought in by a Good Samaritan on January 11th, 2026. At SDHS:Bruno has been vaccinated, microchipped and neutered and is ready for his new home! Why this pet is the one for you:Meet Zeuko! Zeuko is a big-hearted, super snuggly boy who wants nothing more than to be right by your side. He's affectionate, loving, and thrives on close human connection. Zeuko already knows several commands like sit, wait, drop it, and leave it, and he's eager to keep learning.This energetic guy is always alert to the world around him and loves staying busy. Long walks, interactive play, fetch, and tug-of-war are some of his favorites. Because he's strong and can get very excited, he'll need a confident handler who can continue working on leash manners and jumping. He can be mouthy when overstimulated, but redirection and structure go a long way.Zeuko would do best in an active home that understands big, enthusiastic dogs and is ready to help him channel his energy.If you'd like to learn more about Zeuko come visit him at the San Diego Campus today! Don't forget to bring a leash and collar. Primary Color: Black Brindle Weight: 68 Age: 1yrs 11mths 2wks

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We'll also keep you updated on Jones's adoption status with email updates.
Photo of Jones

Jones

Mastiff

Male, Young
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived:This pet was brought in by a community member on September 9, 2025. Why this pet is the one for you:Meet Jones! Jones is a total lovebug who's ready and waiting to find his new loving home. He adores people and will display his excited wiggles when he greets you. He can be a bit shy with new faces and places, but once he builds confidence, he'll share his playful and energetic side. He's very smart and treat motivated, and has already mastered "sit," "paw" and "down." Jones has been known to have big feelings around other dogs, and may do best as your one and only canine companion. Although he may not be a candidate for dog parks or other off-leash venues, there are lots of other activities you can do together to strengthen your bond! If you're interested in opening your heart and home to this sweet pup, come speak to an adoption counselor today!At SDHS:This pet has been vaccinated, microchipped and neutered. This pet is now ready for their new home!Dog Reactive Dog:  This pet requires a virtual behavior consult, please watch THIS video to learn more about them. Primary Color: Brown Secondary Color: Black Weight: 62.5 Age: 1yrs 4mths 2wks

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We'll also keep you updated on Rudolph's adoption status with email updates.
Photo of Rudolph

Rudolph

Mastiff

Male, Adult
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived: This pet was brought in by a community member. Why this pet is the one for you:He can be a bit anxious, which is common in shelter environments, but once he's out with his handlers, his true personality shines. He's a good boy on leash and enjoys getting out for walks, making him an easy companion to take along. Our staff and volunteers absolutely adore him and speak highly of his kind nature. He may have some skin issues that will need a little care, but with love and consistency, he has so much potential to thrive. He may feel more comfortable with women, so a calm, patient home would be ideal for him to continue building confidence. This handsome guy is just looking for someone to see past the stress of the shelter and give him the chance he deserves. If you're looking for a loyal, sweet companion, he could be the perfect match. Adopt Rudolph at the San Diego Campus today! Primary Color: Brindle Weight: 103 Age: 4yrs 1mths 1wks

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We'll also keep you updated on Wick's adoption status with email updates.
Photo of Wick

Wick

Mastiff

Male, 1 yr 2 mos
Coronado, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with dogs, Not good with cats, Spayed or Neutered, Shots are up-to-date,
Story
Meet Wick, a lovable 1-year-old Mastiff with a big heart and an even bigger personality! This gentle giant is still growing into his paws and has all the youthful curiosity and sweetness you could hope for. Wick absolutely adores people—he greets everyone with pure joy and enthusiasm, his whole body wiggling with happiness. He also completely believes he’s a lap dog (despite… well, his very large reality!). Wick loves to lean in close, soak up affection, and be as near to his humans as possible. His loving nature makes him a total favorite. Because he gets so excited to say hello, he's working on greeting people politely—and he’s making great progress with gentle guidance. Wick thrives when he knows what’s expected of him and gets lots of praise and love along the way. Wick would shine as the main star of his future home—he’s the kind of dog who really blossoms when he gets to be the center of attention and affection. If you’re looking for a loyal, goofy, affectionate companion who will fill your home with warmth, laughter, and endless love, Wick is ready to be your gentle best friend for life! About Me: Estimated DOB 10/25/2024, 1 year old Male, Mastiff, 97 lbs Neutered, Vaccinated, up to date on flea and heart worm prevention Adoption Fee: $150 Adoption Application – https://new.shelterluv.com/matchme/adopt/PCOR/Dog

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We'll also keep you updated on Jughead's adoption status with email updates.
Photo of Jughead

Jughead

Mastiff American Staffordshire Terrier

Male, 2 yrs 10 mos
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
Meet Jughead! DOB: March 2023Weight: 70lbsDisposition: Jughead is a friendly and curious boy who loves nothing more than exploring the outdoors. He's a natural on the trails and is working on his leash manners so he can be the best hiking partner possible. When he's not adventuring, he's busy with his toys, treating them with a surprising amount of care before he finally lets loose and has a blast. He loves his people and is looking for someone who can help him work on building his focus and attention span.History: Rescued from a shelter in LA County by TBL in March 2025Best Home: A family (or single person) looking for a loyal companion to join you on your adventures and a sweet boy to cuddle up with at the end of the day.Amazing Qualities: Jughead is curious and confident! He's ready to explore the world.If you're interested in meeting this dog, please visit our website to fill out an adoption application: www.thebarkinglot.net/adoptOur dogs are located in San Diego County, CA. We will happily consider out of town applications and can conduct virtual play dates with interested adopters. We have monthly transport to various locations in the Pacific Northwest, individual arrangements would need to be made for other locations across the US and Canada.To initiate the adoption process for this dog, please complete our online application by clicking below. Your adoption coordinator will respod to you via email once they receive your application: www.thebarkinglot.net/adopt

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We'll also keep you updated on CHUNK's adoption status with email updates.
Photo of CHUNK

CHUNK

Mastiff

Male, 2 yrs 1 mo
Chula Vista, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Spayed or Neutered,
Story
-

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These pups are in San Diego, California too!

Below are our newest added Mastiffs available for adoption in San Diego, California. To see more adoptable Mastiffs in San Diego, California, use the search tool below to enter specific criteria!
We'll also keep you updated on Hippo's adoption status with email updates.
Special Needs
Photo of Hippo

Hippo

Bullmastiff

Male, Adult
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Needs special attention, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Age: 6 years old Gender: Male Breed: Bull Mastiff mix Weight: 84 lbs Personality: Very sweet and cuddly! He is very pleasant to walk if there are no other dogs in the area. He is learning to be more confident and less reactive. Education: Good with bathroom and leash training and is working on leash reactivity Favorite Activities: Tug of war, long night walks, hanging out in the kitchen Looking for: An active family who will love him and play with him! Some patient training will help him be the best boy ever! He will do best as an only dog right now. Hippo likes routine so someone who can create some structure for him would be ideal to help with his anxiety! A family with kids would be good, too - he has been great with kids of all ages, even with toddlers! A home with a backyard in a quiet neighborhood would be great! Special needs: Current medication to help with separation anxiety Prozac (fluoxetine) (~$5.00). Monthly cost depending on where purchased and market value. Adoption Fee: $ 250 ##1733826##

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We'll also keep you updated on Leo's adoption status with email updates.
Photo of Leo

Leo

Neapolitan Mastiff

Male, Adult
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Not good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Leo is a gorgeous neapolitan mastiff.  His ideal home would be a home with someone who knows the breed and can set boundaries for him to thrive. He has the potential to do well with other dogs as long as the other dogs have good temperament. He was fostered with kids who were 12 years of age and he did good with them. Come meet sweet Leo if you are looking for a gorgeous large boy. Leo's adoption comes with training. June 2, 2025, 11:00 pm

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in San Diego, California.

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Mastiff puppies and dogs in nearby cities

Mastiff Puppies near me Mastiff in Carlsbad, CA Mastiff in Chula Vista, CA Mastiff in Coronado, CA Mastiff in El Cajon, CA Mastiff in Encinitas, CA Mastiff in Escondido, CA Mastiff in Imperial Beach, CA Mastiff in La Mesa, CA Mastiff in Lemon Grove, CA Mastiff in National City, CA Mastiff in Oceanside, CA Mastiff in Poway, CA Mastiff in San Marcos, CA Mastiff in Santee, CA Mastiff in Solana Beach, CA Mastiff in Vista, CA

Related breeds in San Diego, California

Bullmastiffs in San Diego, California Neapolitan Mastiffs in San Diego, California Saint Bernards in San Diego, California

Mastiff shelters & rescues in San Diego, California

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in San Diego, California. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

3.6 miles

San Diego Humane Society - San Diego Campus

5500 Gaines Street, San Diego, CA 92110

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Shelter

4.4 miles

PAWS of Coronado

1395 First Street, Coronado, CA 92118

Pet Types: cats, birds, dogs, rabbits, reptiles, small animals

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Rescue

7.4 miles

The Barking Lot

San Diego, CA 92117

Pet Types: dogs

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Shelter

10.4 miles

Chula Vista Animal Care Facility (public)

130 Beyer Way, Chula Vista, CA 91911

Pet Types: cats, birds, dogs, rabbits, reptiles, small animals

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Rescue

13 miles

Passion for Pitties

P.O. Box 212574, Chula Vista, CA 91921

Pet Types: dogs

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Rescue

29.5 miles

Saving Shelter Pets of CA

San Marcos, CA 92069

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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