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Mastiff puppies and dogs in San Diego, California

Looking for a Mastiff puppy or dog in San Diego, California? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near San Diego, California Other pups in San Diego, California Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in San Diego, California Mastiff shelters and rescues in San Diego, California Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in San Diego, California

These Mastiffs are available in San Diego, California.
We'll also keep you updated on Jones's adoption status with email updates.
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Jones

Mastiff

Male, Young
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived:This pet was brought in by a community member on September 9, 2025. Why this pet is the one for you:Meet Jones! Jones is a total lovebug who's ready and waiting to find his new loving home. He adores people and will display his excited wiggles when he greets you. He can be a bit shy with new faces and places, but once he builds confidence, he'll share his playful and energetic side. He's very smart and treat motivated, and has already mastered "sit," "paw" and "down." Jones has been known to have big feelings around other dogs, and may do best as your one and only canine companion. Although he may not be a candidate for dog parks or other off-leash venues, there are lots of other activities you can do together to strengthen your bond! If you're interested in opening your heart and home to this sweet pup, come speak to an adoption counselor today!At SDHS:This pet has been vaccinated, microchipped and neutered. This pet is now ready for their new home!Dog Reactive Dog:  This pet requires a virtual behavior consult, please watch THIS video to learn more about them. Primary Color: Brown Secondary Color: Black Weight: 62.5 Age: 1yrs 2mths 4wks

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We'll also keep you updated on Jughead's adoption status with email updates.
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Jughead

Mastiff American Staffordshire Terrier

Male, 2 yrs 9 mos
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
Meet Jughead! DOB: March 2023Weight: 70lbsDisposition: Jughead is a friendly and curious boy who loves nothing more than exploring the outdoors. He's a natural on the trails and is working on his leash manners so he can be the best hiking partner possible. When he's not adventuring, he's busy with his toys, treating them with a surprising amount of care before he finally lets loose and has a blast. He loves his people and is looking for someone who can help him work on building his focus and attention span.History: Rescued from a shelter in LA County by TBL in March 2025Best Home: A family (or single person) looking for a loyal companion to join you on your adventures and a sweet boy to cuddle up with at the end of the day.Amazing Qualities: Jughead is curious and confident! He's ready to explore the world.If you're interested in meeting this dog, please visit our website to fill out an adoption application: www.thebarkinglot.net/adoptOur dogs are located in San Diego County, CA. We will happily consider out of town applications and can conduct virtual play dates with interested adopters. We have monthly transport to various locations in the Pacific Northwest, individual arrangements would need to be made for other locations across the US and Canada.To initiate the adoption process for this dog, please complete our online application by clicking below. Your adoption coordinator will respod to you via email once they receive your application: www.thebarkinglot.net/adopt

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Or, how about these Mastiffs in cities near San Diego, California

These Mastiffs are available for adoption close to San Diego, California.
We'll also keep you updated on Jones's adoption status with email updates.
Photo of Jones

Jones

Mastiff

Male, Young
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived:This pet was brought in by a community member on September 9, 2025. Why this pet is the one for you:Meet Jones! Jones is a total lovebug who's ready and waiting to find his new loving home. He adores people and will display his excited wiggles when he greets you. He can be a bit shy with new faces and places, but once he builds confidence, he'll share his playful and energetic side. He's very smart and treat motivated, and has already mastered "sit," "paw" and "down." Jones has been known to have big feelings around other dogs, and may do best as your one and only canine companion. Although he may not be a candidate for dog parks or other off-leash venues, there are lots of other activities you can do together to strengthen your bond! If you're interested in opening your heart and home to this sweet pup, come speak to an adoption counselor today!At SDHS:This pet has been vaccinated, microchipped and neutered. This pet is now ready for their new home!Dog Reactive Dog:  This pet requires a virtual behavior consult, please watch THIS video to learn more about them. Primary Color: Brown Secondary Color: Black Weight: 62.5 Age: 1yrs 2mths 4wks

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We'll also keep you updated on Jughead's adoption status with email updates.
Photo of Jughead

Jughead

Mastiff American Staffordshire Terrier

Male, 2 yrs 9 mos
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
Meet Jughead! DOB: March 2023Weight: 70lbsDisposition: Jughead is a friendly and curious boy who loves nothing more than exploring the outdoors. He's a natural on the trails and is working on his leash manners so he can be the best hiking partner possible. When he's not adventuring, he's busy with his toys, treating them with a surprising amount of care before he finally lets loose and has a blast. He loves his people and is looking for someone who can help him work on building his focus and attention span.History: Rescued from a shelter in LA County by TBL in March 2025Best Home: A family (or single person) looking for a loyal companion to join you on your adventures and a sweet boy to cuddle up with at the end of the day.Amazing Qualities: Jughead is curious and confident! He's ready to explore the world.If you're interested in meeting this dog, please visit our website to fill out an adoption application: www.thebarkinglot.net/adoptOur dogs are located in San Diego County, CA. We will happily consider out of town applications and can conduct virtual play dates with interested adopters. We have monthly transport to various locations in the Pacific Northwest, individual arrangements would need to be made for other locations across the US and Canada.To initiate the adoption process for this dog, please complete our online application by clicking below. Your adoption coordinator will respod to you via email once they receive your application: www.thebarkinglot.net/adopt

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We'll also keep you updated on TACO BELLA's adoption status with email updates.
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TACO BELLA

Mastiff

Female, 8 yrs 1 mo
Chula Vista, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
Hi there! I’m Taco Bella! Big in size, lots of love, and maybe just a little extra around the middle (but that’s because food is amazing). I live for mealtime, snacks, treats, crumbs, and anything that might possibly be edible. I’m loyal through and through! Wherever my people go, I go. I like to keep them close, just in case they need a snuggle or a nudge of reassurance. I love curling up at their feet, leaning against them, or sprawling across the couch if they’ll let me.But don’t let my size fool you... I’ve got plenty of play in me! Give me a squeaky toy, a ball, or a tug rope, and I’m ready for action. I’ll chase, chew, roll, and zoom around with all the enthusiasm of a pup. Playtime and snack time might just be my favorite times of day… though cuddles come pretty close.I’m a big-hearted, big-bodied girl with an even bigger appetite for love!

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We'll also keep you updated on Cjay's adoption status with email updates.
Photo of Cjay

Cjay

Mastiff

Male, Senior
Carlsbad, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Goof, derp, lover of life. Cjay is loving, loyal, funny – a tongue flopping, trotting next to you kind of bestie. He’s a great hybrid dog who loves to enjoy the great outdoors and go on walks, play ball and bike ride.  But he also is a chill couch potato who likes to cozy in and watch TV.  Everyone who meets Cjay falls in love with him – he’s one of those dogs who doesn’t lack for personality haha and keeps you laughing. Cjay has been fostered by an awesome trainer so whoever adopts him will get a dog who has been through an in depth board and train program already. Cjay’s the right dog for an experienced family who are strong leaders with kind hearts to stay consistent with his training to continue to set him up for success. Approved adopters will receive training sessions so you know what Cjay knows to make the transition smooth :). Cjay’s favorite thing to do is play ball WHILE rolling in the grass at the same time 🤯 ❤️ He's available for adoption anywhere in SoCal.

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We'll also keep you updated on URGENT! SHELTER IS FULL's adoption status with email updates.
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URGENT! SHELTER IS FULL

Mastiff

Female, 7 yrs
San Marcos, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, Spayed or Neutered, Shots are up-to-date,
Story
URGENT - Shelter needs to clear kennels. Please save this dog's life! WE ARE COURTESY POSTING THIS DOG FOR THE MORENO VALLEY ANIMAL SHELTER TO HELP THEM FIND A HOME. The shelter is severely overcrowded and desperately needs help. Dogs are being turned in higher numbers than the shelter can accommodate, therefore many are losing their lives due to lack of cage space. We are helping get the word out of their immediate need. Please save this deserving pooch and clear a kennel for another dog in need today! This beautiful dog is located in the Moreno Valley shelter. Please feel free to reach out to us with questions. Thank you! SUGAR BABY #A541069 I am a spayed, female, blue and fawn Mastiff mix. The shelter thinks I am about 7 years old. I weigh approximately 110.00 lbs. VIDEOS: https://myalbum.com/album/tURmGddwp3mxo6/ STAFF NOTES: * Very sweet girl * Will lay down and roll over for belly rubs every chance she gets * Loves attention, pets and scratches. * Easy to leash and walk once out of the kennel * No aggression seen when walking by the other dogs. * She wants cuddles, belly rubs and being told what a good girl she is... because she is a great girl! Moreno Valley Animal Shelter 14041 Elsworth Street, Moreno Valley, CA 92553 951-413-3790 Adoption hours: Tuesday - Friday 10 am - 5 pm Saturday 10:30 am - 3:30 pm Closed Sunday-Monday & HolidaysURGENT! SHELTER IS FULLURGENT! SHELTER IS FULL

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These pups are in San Diego, California too!

Below are our newest added Mastiffs available for adoption in San Diego, California. To see more adoptable Mastiffs in San Diego, California, use the search tool below to enter specific criteria!
We'll also keep you updated on Hippo's adoption status with email updates.
Special Needs
Photo of Hippo

Hippo

Bullmastiff

Male, Adult
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Needs special attention, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Age: 6 years old Gender: Male Breed: Bull Mastiff mix Weight: 84 lbs Personality: Very sweet and cuddly! He is very pleasant to walk if there are no other dogs in the area. He is learning to be more confident and less reactive. Education: Good with bathroom and leash training and is working on leash reactivity Favorite Activities: Tug of war, long night walks, hanging out in the kitchen Looking for: An active family who will love him and play with him! Some patient training will help him be the best boy ever! He will do best as an only dog right now. Hippo likes routine so someone who can create some structure for him would be ideal to help with his anxiety! A family with kids would be good, too - he has been great with kids of all ages, even with toddlers! A home with a backyard in a quiet neighborhood would be great! Special needs: Current medication to help with separation anxiety Prozac (fluoxetine) (~$5.00). Monthly cost depending on where purchased and market value. Adoption Fee: $ 250 ##1733826##

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We'll also keep you updated on Leo's adoption status with email updates.
Photo of Leo

Leo

Neapolitan Mastiff

Male, Adult
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Not good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Leo is a gorgeous neapolitan mastiff.  His ideal home would be a home with someone who knows the breed and can set boundaries for him to thrive. He has the potential to do well with other dogs as long as the other dogs have good temperament. He was fostered with kids who were 12 years of age and he did good with them. Come meet sweet Leo if you are looking for a gorgeous large boy. Leo's adoption comes with training. June 2, 2025, 11:00 pm

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in San Diego, California.

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Mastiff puppies and dogs in nearby cities

Mastiff Puppies near me Mastiff in Carlsbad, CA Mastiff in Chula Vista, CA Mastiff in Coronado, CA Mastiff in El Cajon, CA Mastiff in Encinitas, CA Mastiff in Escondido, CA Mastiff in Imperial Beach, CA Mastiff in La Mesa, CA Mastiff in Lemon Grove, CA Mastiff in National City, CA Mastiff in Oceanside, CA Mastiff in Poway, CA Mastiff in San Marcos, CA Mastiff in Santee, CA Mastiff in Solana Beach, CA Mastiff in Vista, CA

Related breeds in San Diego, California

Bullmastiffs in San Diego, California Neapolitan Mastiffs in San Diego, California Saint Bernards in San Diego, California

Mastiff shelters & rescues in San Diego, California

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in San Diego, California. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

3.6 miles

San Diego Humane Society - San Diego Campus

5500 Gaines Street, San Diego, CA 92110

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

7.4 miles

The Barking Lot

San Diego, CA 92117

Pet Types: dogs

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Shelter

10.4 miles

Chula Vista Animal Care Facility (public)

130 Beyer Way, Chula Vista, CA 91911

Pet Types: cats, birds, dogs, rabbits, reptiles, small animals

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Rescue

29.5 miles

Saving Shelter Pets of CA

San Marcos, CA 92069

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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