Adopt
Rehome
Menu Hamburger Icon

Mastiff puppies and dogs in San Diego, California

Looking for a Mastiff puppy or dog in San Diego, California? Adopt a Pet can help you find an adorable Mastiff near you.

Picture of Mastiff

Learn More:

Adopt a Mastiff near you Mastiff in cities near San Diego, California Other pups in San Diego, California Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in San Diego, California Mastiff shelters and rescues in San Diego, California Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in San Diego, California

These Mastiffs are available in San Diego, California.
We'll also keep you updated on Sunflower's adoption status with email updates.
Photo of Sunflower

Sunflower

Mastiff Boxer

Female, Adult
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived: This pet was brought in by a community member on December 23, 2025. Why this pet is the one for you:Despite her shyness, Sunflower is full of affection to give. Once warming up she becomes a big cuddly companion, seeking nothing more than a cozy lap and lots of love. Her playful side emerges while chasing toys and during games in the yard. Past the timid surface Sunflower's sweet nature makes her a delightful friend for those seeking a loyal and loving pet. At SDHS:This pet has been vaccinated, microchipped and spayed. This pet is now ready for their new home! Primary Color: Black Weight: 74 Age: 3yrs 1mths 3wks

Learn More

Small right facing arrow
We'll also keep you updated on Jughead's adoption status with email updates.
Photo of Jughead

Jughead

Mastiff American Staffordshire Terrier

Male, 2 yrs 11 mos
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered,
Story
Meet Jughead! DOB: March 2023Weight: 70lbsDisposition: Jughead is a friendly and curious boy who loves nothing more than exploring the outdoors. He's a natural on the trails and is working on his leash manners so he can be the best hiking partner possible. When he's not adventuring, he's busy with his toys, treating them with a surprising amount of care before he finally lets loose and has a blast. He loves his people and is looking for someone who can help him work on building his focus and attention span.History: Rescued from a shelter in LA County by TBL in March 2025Best Home: A family (or single person) looking for a loyal companion to join you on your adventures and a sweet boy to cuddle up with at the end of the day.Amazing Qualities: Jughead is curious and confident! He's ready to explore the world.If you're interested in meeting this dog, please visit our website to fill out an adoption application: www.thebarkinglot.net/adoptOur dogs are located in San Diego County, CA. We will happily consider out of town applications and can conduct virtual play dates with interested adopters. We have monthly transport to various locations in the Pacific Northwest, individual arrangements would need to be made for other locations across the US and Canada.To initiate the adoption process for this dog, please complete our online application by clicking below. Your adoption coordinator will respod to you via email once they receive your application: www.thebarkinglot.net/adopt

Learn More

Small right facing arrow
We'll also keep you updated on Gus's adoption status with email updates.
Photo of Gus

Gus

English Mastiff

Male, 6 yrs 10 mos
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Gus Gus is an 8-year-old black Mastiff with a heart as big as his paws. Found as a stray in Ontario alongside his friend—possibly his daughter—Tavi, Gus has shown nothing but gentle, loving energy. While they would love to find a home together, they can be adopted separately if needed. Weighing in at approximately 115 lbs, Gus is a true gentle giant. He’s the sweetest big boy who lives for chew sticks, affection, and cozy snuggles. Gus would be perfectly happy spending his days as a couch potato, soaking up love and giving it right back. He is housetrained and has wonderful manners, making him an easy, loving companion for a calm home looking for a loyal best friend. ##2648733##

Learn More

Small right facing arrow

Or, how about these Mastiffs in cities near San Diego, California

These Mastiffs are available for adoption close to San Diego, California.
We'll also keep you updated on Sunflower's adoption status with email updates.
Photo of Sunflower

Sunflower

Mastiff Boxer

Female, Adult
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived: This pet was brought in by a community member on December 23, 2025. Why this pet is the one for you:Despite her shyness, Sunflower is full of affection to give. Once warming up she becomes a big cuddly companion, seeking nothing more than a cozy lap and lots of love. Her playful side emerges while chasing toys and during games in the yard. Past the timid surface Sunflower's sweet nature makes her a delightful friend for those seeking a loyal and loving pet. At SDHS:This pet has been vaccinated, microchipped and spayed. This pet is now ready for their new home! Primary Color: Black Weight: 74 Age: 3yrs 1mths 3wks

Learn More

Small right facing arrow
We'll also keep you updated on Jughead's adoption status with email updates.
Photo of Jughead

Jughead

Mastiff American Staffordshire Terrier

Male, 2 yrs 11 mos
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered,
Story
Meet Jughead! DOB: March 2023Weight: 70lbsDisposition: Jughead is a friendly and curious boy who loves nothing more than exploring the outdoors. He's a natural on the trails and is working on his leash manners so he can be the best hiking partner possible. When he's not adventuring, he's busy with his toys, treating them with a surprising amount of care before he finally lets loose and has a blast. He loves his people and is looking for someone who can help him work on building his focus and attention span.History: Rescued from a shelter in LA County by TBL in March 2025Best Home: A family (or single person) looking for a loyal companion to join you on your adventures and a sweet boy to cuddle up with at the end of the day.Amazing Qualities: Jughead is curious and confident! He's ready to explore the world.If you're interested in meeting this dog, please visit our website to fill out an adoption application: www.thebarkinglot.net/adoptOur dogs are located in San Diego County, CA. We will happily consider out of town applications and can conduct virtual play dates with interested adopters. We have monthly transport to various locations in the Pacific Northwest, individual arrangements would need to be made for other locations across the US and Canada.To initiate the adoption process for this dog, please complete our online application by clicking below. Your adoption coordinator will respod to you via email once they receive your application: www.thebarkinglot.net/adopt

Learn More

Small right facing arrow
We'll also keep you updated on Gus's adoption status with email updates.
Photo of Gus

Gus

English Mastiff

Male, 6 yrs 10 mos
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Gus Gus is an 8-year-old black Mastiff with a heart as big as his paws. Found as a stray in Ontario alongside his friend—possibly his daughter—Tavi, Gus has shown nothing but gentle, loving energy. While they would love to find a home together, they can be adopted separately if needed. Weighing in at approximately 115 lbs, Gus is a true gentle giant. He’s the sweetest big boy who lives for chew sticks, affection, and cozy snuggles. Gus would be perfectly happy spending his days as a couch potato, soaking up love and giving it right back. He is housetrained and has wonderful manners, making him an easy, loving companion for a calm home looking for a loyal best friend. ##2648733##

Learn More

Small right facing arrow
We'll also keep you updated on CHUNK's adoption status with email updates.
Photo of CHUNK

CHUNK

Mastiff

Male, 2 yrs 2 mos
Chula Vista, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Spayed or Neutered,
Story
Hi, I’m Chunk. I’m a mastiff with a big body, a big brain, and an even bigger heart. I’m very social and incredibly sweet. I love attention and being around people. If you’re looking for a dog who wants to interact, learn, and be part of your world, that’s me. I’m also very smart and already know my basics: sit, shake, and down. I pick things up quickly and enjoy using my brain. I’ll be honest, though... I’m strong. Like, very strong. Because of that, I do best with experienced handlers who can guide me confidently and keep me learning. With the right person, I’m an amazing partner who’s eager to please and happy to work. I love my people deeply, and I’m more than ready to leave the shelter behind and start my next chapter. I’ve got so much love (and muscle) to give. I just need someone to give me the chance.

Learn More

Small right facing arrow
We'll also keep you updated on Stella's adoption status with email updates.
Photo of Stella

Stella

Mastiff

Female, 1 mo
Chula Vista, CA
Size
(when grown) -
Details
Not good with kids, Not good with dogs, Not good with cats,
Story
Meet the delightful Stella! 🌟 This sweetheart is a gentle giant, still a playful puppy at heart and less than a year old! Just like Scooby Doo, she has a big, warm heart but also a hint of shyness—think of her as a lovable scaredy-cat! 🐾 If you come at her too quickly, you might see her back up and bark, but fear not! This lovely lady is making strides every day to gain her confidence. Stella is all about socializing and learning—as she embraces the world around her, she’s also getting better at leash walking and responding to commands. With a little firm guidance, she’s a quick learner thanks to her intelligence and a major love for treats! 🍖 Now, it’s important to note that Stella is still a big puppy who needs daily adventures—she dreams of long, joyous walks where she can soak up the sun 🌞 and explore her surroundings. But don’t worry; she’s also a champion napper who is content to rest in her crate for hours after a thrilling outing! 💤 Given her size and playful nature, it would be wise for Stella to find a home without small children to avoid any accidental oopsies. Just so you know—Stella has a soft spot for men over women, which makes her unique and intriguing. 🦸‍♂️ This charming canine is dog-friendly and loves to frolic and play with her furry pals! While she hasn’t met any cats yet, she certainly has a zest for chasing squirrels, birds, and butterflies. 🐦🦋 When startled or nervous, she does tend to bark, but it’s just her way of saying, "I’m learning to trust!" If you're a patient soul who can help this lovely lady shine, she's ready to shower her forever home with all the love she has to give. If you think you can provide a safe and supportive environment for Stella, then you're in for a special journey together! 🥰 Please remember, potential adopters must apply through the Buddy App to embrace this sweet giant into their hearts and homes! Apply for the pet here: https://tinyurl.com/3ce7e893

Learn More

Small right facing arrow

These pups are in San Diego, California too!

Below are our newest added Mastiffs available for adoption in San Diego, California. To see more adoptable Mastiffs in San Diego, California, use the search tool below to enter specific criteria!
We'll also keep you updated on Hippo's adoption status with email updates.
Special Needs
Photo of Hippo

Hippo

Bullmastiff

Male, Adult
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Needs special attention, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Age: 6 years old Gender: Male Breed: Bull Mastiff mix Weight: 84 lbs Personality: Very sweet and cuddly! He is very pleasant to walk if there are no other dogs in the area. He is learning to be more confident and less reactive. Education: Good with bathroom and leash training and is working on leash reactivity Favorite Activities: Tug of war, long night walks, hanging out in the kitchen Looking for: An active family who will love him and play with him! Some patient training will help him be the best boy ever! He will do best as an only dog right now. Hippo likes routine so someone who can create some structure for him would be ideal to help with his anxiety! A family with kids would be good, too - he has been great with kids of all ages, even with toddlers! A home with a backyard in a quiet neighborhood would be great! Special needs: Current medication to help with separation anxiety Prozac (fluoxetine) (~$5.00). Monthly cost depending on where purchased and market value. Adoption Fee: $ 250 ##1733826##

Learn More

Small right facing arrow
We'll also keep you updated on Leo's adoption status with email updates.
Photo of Leo

Leo

Neapolitan Mastiff

Male, Adult
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Not good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Leo is a gorgeous neapolitan mastiff.  His ideal home would be a home with someone who knows the breed and can set boundaries for him to thrive. He has the potential to do well with other dogs as long as the other dogs have good temperament. He was fostered with kids who were 12 years of age and he did good with them. Come meet sweet Leo if you are looking for a gorgeous large boy. Leo's adoption comes with training. June 2, 2025, 11:00 pm

Learn More

Small right facing arrow
We'll also keep you updated on Strawberry's adoption status with email updates.
Photo of Strawberry

Strawberry

St. Bernard Labrador Retriever

Female, Young
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Spayed or Neutered,
Story
You can fill out an adoption application online on our official website.Forever Home Wanted: Meet Strawberry! Strawberry is a St. Bernard/Labrador Retriever mix who came to us through no fault of her own. She and her brother, Chunk-O (also available for adoption), were the last two remaining pups from an accidental litter of eight, and we stepped in to make sure they get the happy endings they deserve. Strawberry is brand new to our rescue, but so far she’s been nothing but a sweetheart. She loves pets and affection, has a gentle-giant demeanor, appears to be crate trained, and is both dog and people friendly. She’s the kind of girl who would be perfectly content soaking up love and being part of a family. As we continue to get to know Strawberry, we’ll share more about her personality—but one thing is already clear: she’s ready for a family to call her own. If you’re interested in meeting Strawberry, please fill out an application at  www.labradorsandfriends.org Strawberry is located in Southern California.   Visit this organization's web site to see any additional information available about this pet.February 12, 2026, 6:29 pm

Learn More

Small right facing arrow

Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in San Diego, California.

    an arrow icon
location arrow icon Current location
  • New York, NY
  • Los Angeles, CA
  • Houston, TX
  • Dallas, TX
  • Brooklyn, NY

Sorry, we can’t find that location! Please try again.

    Age
    an arrow icon

Mastiff puppies and dogs in nearby cities

Mastiff Puppies near me Mastiff in Carlsbad, CA Mastiff in Chula Vista, CA Mastiff in Coronado, CA Mastiff in El Cajon, CA Mastiff in Encinitas, CA Mastiff in Escondido, CA Mastiff in Imperial Beach, CA Mastiff in La Mesa, CA Mastiff in Lemon Grove, CA Mastiff in National City, CA Mastiff in Oceanside, CA Mastiff in Poway, CA Mastiff in San Marcos, CA Mastiff in Santee, CA Mastiff in Solana Beach, CA Mastiff in Vista, CA

Related breeds in San Diego, California

Bullmastiffs in San Diego, California Neapolitan Mastiffs in San Diego, California Saint Bernards in San Diego, California

Mastiff shelters & rescues in San Diego, California

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in San Diego, California. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

3.6 miles

San Diego Humane Society - San Diego Campus

5500 Gaines Street, San Diego, CA 92110

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

More an arrow icon

Rescue

7.4 miles

The Barking Lot

San Diego, CA 92117

Pet Types: dogs

More an arrow icon

Rescue

9.5 miles

Rescue Fenix

San Diego, CA 92192

Pet Types: cats, dogs

More an arrow icon

Shelter

10.4 miles

Chula Vista Animal Care Facility (public)

130 Beyer Way, Chula Vista, CA 91911

Pet Types: cats, birds, dogs, rabbits, reptiles, small animals

More an arrow icon

Rescue

13 miles

Passion for Pitties

P.O. Box 212574, Chula Vista, CA 91921

Pet Types: dogs

More an arrow icon

Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

magnifying glass with cat and dog

Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

clipboard with list

Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

Learn More an arrow icon