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Mastiff puppies and dogs in Santee, California

Looking for a Mastiff puppy or dog in Santee, California? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near Santee, California Other pups in Santee, California Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in Santee, California Mastiff shelters and rescues in Santee, California Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Santee, California

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Santee, California

These Mastiffs are available for adoption close to Santee, California.
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Octavia

English Mastiff

Female, 7 yrs 2 mos
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Octavia also called Tavi. Octavia is a big girl with an even bigger heart. Since being rescued from the shelter, she’s proven herself to be the perfect houseguest—gentle, loving, and so grateful for a second chance. Affectionately known as Tavi, she’s ready to leave her past behind and find a forever home where she can truly shine. She just needs someone to give her that chance… and we know she’ll give a lifetime of love in return. Due to Tavi's neglect, she had a severe eye infection when we rescued her from the shelter on the euth list.  Unfortunately, we were unable to save her eye but that doesn't stop her one bit! ##2688495##

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Photo of Awesome Sauce

Awesome Sauce

Mastiff

Male, Adult
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Spayed or Neutered,
Story
How Awesome Sauce arrived:Awesome Sauce was brought in by our Humane Law Enforcement team on April 19, 2026. Why Awesome Sauce is the one for you:Meet Awesome Sauce, a big, lovable goofball who lives up to his name with a personality that is equal parts heart and hype. From the moment you meet him, he brings a whole lot of flavor to the table with his wiggly body, soft eyes and signature tail that whips with excitement when he sees his people. He bonds quickly and thrives on attention, always ready to soak up pets or stick close by your side. He walks well for the most part and enjoys sniffing and exploring, though he can get a bit amped up during transitions, such as leaving or returning to his kennel. When he's excited, he may jump or get a little mouthy, but he is already showing improvement and responds well to redirection and clear guidance. He does have a few medical considerations to keep in mind, including sun-related skin growths on his belly, an inward-rolling eyelid and a small growth on his chin that will need observation over time. This big boy will do best with an adopter who can help him continue working on his manners and give him outlets for his energy, along with plenty of companionship. If you're looking for a dog with a big personality, a bigger heart and just the right amount of zest, Awesome Sauce is ready to spice up your life. Please bring a leash & collar when adopting. At SDHS:Awesome Sauce has been vaccinated, microchipped and neutered.Excitable Dog: This pet requires a virtual behavior consult, please watch THIS video to learn more about them. Primary Color: Blue Weight: 99 Age: 6yrs 2mths 0wks

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Photo of Bonbon

Bonbon

Mastiff Catahoula Leopard Dog

Female, Adult
San Diego, CA
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Spayed or Neutered,
Story
How this pet arrived:This pet was brought in by our Humane Law Enforcement team on June 15, 2026. Why this pet is the one for you: Say hello to Bonbon! We are still learning about Bonbon's unique personality, but we would be happy to introduce you to her to see if she is a good fit for your family. Bonbon is a friendly, affectionate pup who greets everyone she meets with a wagging tail and heartwarming smile. Bonbon is a laid-back, easygoing pup who's perfectly content to join you for a leisurely stroll or cuddle up for a long nap. If you'd like to meet this loving pup, speak with our team today! At SDHS:This pet has been vaccinated, microchipped and spayed. This pet is now ready for adoption! Primary Color: Brindle Secondary Color: Black Weight: 64 Age: 4yrs 0mths 1wks

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Photo of Bonehead

Bonehead

Mastiff Catahoula Leopard Dog

Male, Adult
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived:This pet was brought in by our Humane Law Enforcement team on June 15, 2026. Why this pet is the one for you: Say hello to Bonehead! We are still learning about Bonehead's unique personality, but we would be happy to introduce you to him to see if he is a good fit for your family. Bonehead is a smart, curious canine who is excited to learn new tricks, explore new environments and get plenty of sniffs in on walks. He would love to find a family that can give him all of the activity and affection he needs. If you'd like to meet this handsome pup, speak with our team today! At SDHS:This pet has been vaccinated, microchipped and neutered. This pet is now ready for adoption! Primary Color: Brindle Secondary Color: Black Weight: 61 Age: 4yrs 0mths 1wks

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Photo of Scarlett

Scarlett

Mastiff Great Dane

Female, Young
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
This is Scarlett.She is an "American Molossus", but the form doesn't have that as an option. Her mom is full American Molossus, her dad is half American Molossus, half Great Dane. So she's a little more slender than her breed usually gets, but she's still a big girl (220+ lbs).All my life I've wanted a big dog, truly big. And my wife surprised me for father's day 2 years ago with a puppy. And she grew fast. She is currently a little north of 200 lbs. She is spayed and microchipped and current on her shots. She is loving and playful and protective. She does drool a lot, but we got used to having a handful of "dog towels" around the house to just wipe up after her. And she's trained to come to me so I can clean her face after she drinks water.But unfortunately, I am in the military and live in military housing, and now we have to move, and won't be able to bring her.Please understand that this is not easy, I do not want to give her up, but she's a good girl and deserves a good home.

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Photo of Pumpkin

Pumpkin

Mastiff

Female, Young
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Spayed or Neutered, Shots are up-to-date,
Story
Pumpkin is 2 years old and weighs 106 lbs. She’s active and playful, friendly with people, and very social with dogs of all sizes. Pumpkin was first given to a friend of BAS because her original owner was going to surrender her to the local pound. She was then relinquished to due to lack of space for this large girl. If you would like to meet this dog you can read about our adoption process and submit an application on our website at: http://www.bajaanimalsanctuary.org/dogs.htm  June 24, 2026, 12:23 am

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Santee, California.

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Mastiff puppies and dogs in nearby cities

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Related breeds in Santee, California

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Mastiff shelters & rescues in Santee, California

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Santee, California. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Rescue

10.2 miles

Rescue Fenix

San Diego, CA 92192

Pet Types: cats, dogs

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Shelter

10.5 miles

San Diego Humane Society - San Diego Campus

5500 Gaines Street, San Diego, CA 92110

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

18.8 miles

Baja Animal Sanctuary

P.O. Box 439060, PMB 626, San Diego, CA 92143

Pet Types: cats, dogs

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Shelter

21.1 miles

San Diego Humane Society - Escondido Campus

3500 Burnet Drive, Escondido, CA 92027

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

23.4 miles

Saving Shelter Pets of CA

San Marcos, CA 92069

Pet Types: dogs

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Rescue

27.2 miles

Amazing Dogs

Carlsbad, CA 92011

Pet Types: dogs

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Rescue

48.5 miles

Angel Dog Alliance, NFP (CA)

Temecula, CA 92591

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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