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Mastiff puppies and dogs in Santee, California

Looking for a Mastiff puppy or dog in Santee, California? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near Santee, California Other pups in Santee, California Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in Santee, California Mastiff shelters and rescues in Santee, California Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Santee, California

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Santee, California

These Mastiffs are available for adoption close to Santee, California.
Photo of Octavia

Octavia

English Mastiff

Female, 7 yrs 5 mos
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Octavia also called Tavi. Octavia is a big girl with an even bigger heart. Since being rescued from the shelter, she’s proven herself to be the perfect houseguest—gentle, loving, and so grateful for a second chance. Affectionately known as Tavi, she’s ready to leave her past behind and find a forever home where she can truly shine. She just needs someone to give her that chance… and we know she’ll give a lifetime of love in return. Due to Tavi's neglect, she had a severe eye infection when we rescued her from the shelter on the euth list.  Unfortunately, we were unable to save her eye but that doesn't stop her one bit! ##2688495##

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Photo of Louise

Louise

Mastiff

Female, Puppy
San Diego, CA
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats, Shots are up-to-date,
Story
You can fill out an adoption application online on our official website.It's The Pits is still getting to know me! Check back soon for more information about my personality :) If interested in adopting a puppy, you must be local to San Diego County, Murrieta or Temecula, and have a private yard or large patio area that is securely fenced with a minimum height of 5 feet, as puppies are not fully vaccinated.   Please consider sponsoring Louise  with either a one-time or monthly tax-deductible donation. Your donation will help It's The Pits with day-to-day care, including food, vaccinations, flea treatment, treats and toys. Click on the Sponsor This Pet link above to make your donation today. Thank you!Visit this organization's web site to see any additional information available about this pet.Complete an Adoption Application!September 20, 2026, 5:49 pm

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Photo of Thelma

Thelma

Mastiff

Female, Puppy
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, Shots are up-to-date,
Story
You can fill out an adoption application online on our official website.It's The Pits is still getting to know me! Check back soon for more information about my personality :) If interested in adopting a puppy, you must be local to San Diego County, Murrieta or Temecula, and have a private yard or large patio area that is securely fenced with a minimum height of 5 feet, as puppies are not fully vaccinated.   Please consider sponsoring Thelma  with either a one-time or monthly tax-deductible donation. Your donation will help It's The Pits with day-to-day care, including food, vaccinations, flea treatment, treats and toys. Click on the Sponsor This Pet link above to make your donation today. Thank you!Visit this organization's web site to see any additional information available about this pet.Complete an Adoption Application!September 20, 2026, 5:49 pm

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Photo of Phoebe

Phoebe

Mastiff Pit Bull Terrier

Female, Adult
San Diego, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Not good with dogs, Not good with cats, Spayed or Neutered, Shots are up-to-date,
Story
ATTENTION:  All of our dogs are in private foster homes.  We do NOT have a kennel with multiple dogs.  If you find a dog you want to meet in person, please go to www.secondchancedogrescue.org and complete an application.    We will make every attempt to process all applications within 3 business days of receipt. Meet Phoebe! Your one and only best girl!  This sweet lady is looking for a home where she can soak up all of the love and attention she deserves. She is affectionate, loyal, and ready to be someone's very best friend. Preferably without having to share her spotlight with another dog.  She would thrive as the only dog in the home, where she can relax, feel secure, and enjoy her people all to herself. She would do well with older, respectful kids who understand how to give a pup her space when she needs it.  If you're looking for a loving companion to be your sidekick, cuddle buddy, and devoted 4 legged family member, this beautiful girl may be exactly who you're looking for.  Phoebe is spayed, microchipped and up to date on all vaccinations. Her adoption fee is $300.  All Second Chance Dog Rescue dogs are spayed/neutered, are up to date on vaccines and have microchips prior to adoption.   Adoption fees vary depending on age of dog. Fees help Second Chance Dog Rescue cover spay/neuter costs,   vaccinations, medical treatments, food and supplies. Please go to  www.secondchancedogrescue.org  and complete an application today!    All dogs live in private foster homes until they are adopted.  September 21, 2026, 1:35 am

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Photo of Princess

Princess

Mastiff

Female, 10 yrs 8 mos
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Princess Princess is a 10-year-old, 103-pound Pitbull whose life story will break your heart — and then completely inspire you. She was living on the streets, used for multiple litters, and found covered in massive tumors with a severe skin infection. Despite everything she endured, her spirit never broke. Since coming into rescue, her tumors have been surgically removed, she has been spayed, microchipped, vaccinated, placed on flea control, and her skin has beautifully healed. And through it all… she has remained the sweetest soul on the planet. Princess is incredibly gentle and loving. She is wonderful with puppies, cats, big dogs, and little dogs. For a 103-pound girl, she has the softest heart and the calmest presence. She simply wants comfort, safety, and someone to love her the way she has always deserved. After a lifetime of hardship, Princess is finally ready for her happily ever after. If you would like to meet this extraordinary girl, please fill out an application at: www.secondleashonlife.org Princess has survived everything. Now she just needs someone to choose her.   ##2665693##

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Special Needs
Photo of Howie

Howie

Mastiff

Male, Adult
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Needs special attention, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Howie is a lovely 4-year old Mastiff with a large heart and lots of love to give! He's very playful (with his favorite being tug of war), loves to run around, go on leisurely walks, and most of all relax at home with his family. If you're looking for a cuddle buddy, your search has ended as Howie loves to cuddle up whether it be next to his person or even just at their feet. His love isn't limited to people only as Howie also gets along with other pets at home. Howie thrives in homes where he's kept company with someone else or another furry companion. After having the pleasure of being Howie's family, we've experimented with many food brands and have found the ScienceHill prescribed Gastrointestinal Biome Dog Food works best for his stomach. Furthermore, Howie is prone to anxiety and is currently on Fluoxetine.

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Santee, California.

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Mastiff puppies and dogs in nearby cities

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Related breeds in Santee, California

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Mastiff shelters & rescues in Santee, California

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Santee, California. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Rescue

10.2 miles

Rescue Fenix

San Diego, CA 92192

Pet Types: cats, dogs

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Rescue

10.9 miles

It's The Pits

PO Box 720008, San Diego, CA 92172

Pet Types: dogs

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Rescue

11.8 miles

Second Chance Dog Rescue

4284 Cass Street, San Diego, CA 92109

Pet Types: dogs

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Rescue

13.6 miles

Second Leash on Life

San Diego, CA 92130

Pet Types: dogs

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Shelter

15.5 miles

Chula Vista Animal Care Facility (public)

130 Beyer Way, Chula Vista, CA 91911

Pet Types: cats, birds, dogs, rabbits, reptiles, small animals

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Rescue

23.4 miles

Saving Shelter Pets of CA

San Marcos, CA 92069

Pet Types: dogs

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Rescue

48.5 miles

Angel Dog Alliance, NFP (CA)

Temecula, CA 92591

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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