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Mastiff puppies and dogs in Santee, California

Looking for a Mastiff puppy or dog in Santee, California? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near Santee, California Other pups in Santee, California Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in Santee, California Mastiff shelters and rescues in Santee, California Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Santee, California

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Santee, California

These Mastiffs are available for adoption close to Santee, California.
We'll also keep you updated on Big Randy's adoption status with email updates.
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Big Randy

Mastiff

Male, Young
El Cajon, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Spayed or Neutered,
Story
How this pet arrived: This pet was brought in by a community member. Why this pet is the one for you:Big Randy is a shy but sweet pup who's still learning to feel safe and confident in new situations. He may need a little time to warm up, but once he does, he shows a gentle and loving side that makes him truly special. Big Randy would do best as the only dog in the home, where he can soak up all the attention and build a strong bond with his people. At SDHS:This pet has been vaccinated, microchipped and spayed neutered. This pet is now ready for their new home! Primary Color: Black Weight: 109 Age: 1yrs 6mths 2wks

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We'll also keep you updated on Octavia's adoption status with email updates.
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Octavia

English Mastiff

Female, 6 yrs 11 mos
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Octavia also called Tavi. Octavia is a big girl with an even bigger heart. Since being rescued from the shelter, she’s proven herself to be the perfect houseguest—gentle, loving, and so grateful for a second chance. Affectionately known as Tavi, she’s ready to leave her past behind and find a forever home where she can truly shine. She just needs someone to give her that chance… and we know she’ll give a lifetime of love in return. Due to Tavi's neglect, she had a severe eye infection when we rescued her from the shelter on the euth list.  Unfortunately, we were unable to save her eye but that doesn't stop her one bit! ##2688495##

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We'll also keep you updated on Bistro's adoption status with email updates.
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Bistro

Mastiff

Male
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived:This pet was brought in by our Humane Law Enforcement team on March 19, 2026. Why this pet is the one for you: Say hello to beautiful brindled Bistro! We are still learning about Bistro's unique personality, but from what we know so far, he's a gem - a big love who has been through adversity and come out the other side still gentle and unbroken. As soon as he arrived at the shelter, Bistro was treated by our veterinary team who extracted cactus thorns from his muzzle, and he's healing well! Prior to his arrival, he was briefly looked after by a Good Samaritan who reported that Bistro played well with their young child. Playful yet mellow, loyal and kind, Bistro's friendly and sweet nature endears him to everyone he gets to know. Adopting Bistro means bringing home a canine best friend who's ready to adopt a human family of his own! If you'd like to meet this courageous and devoted pup, speak with our team today! At SDHS:This pet has been vaccinated, microchipped and spayed/neutered. This pet is now ready for adoption! Primary Color: Brindle Weight: 63

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We'll also keep you updated on Sunflower's adoption status with email updates.
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Sunflower

Mastiff Boxer

Female, Adult
San Diego, CA
Size
(when grown) -
Details
Spayed or Neutered,
Story
How this pet arrived: This pet was brought in by a community member on December 23, 2025. Why this pet is the one for you:Meet Sunflower! Despite her initial shyness, Sunflower is full of affection to share. Once she warms up, she becomes a big cuddly companion, seeking nothing more than a cozy lap and lots of love. Her playful side emerges in the yard with toys and interactive games. With a patient and gentle adopter, Sunflower is ready to bloom into a delightful companion. If you're looking for a loyal and loving cuddle bug, Sunflower could be your perfect match! At SDHS:This pet has been vaccinated, microchipped and spayed. This pet is now ready for their new home! Primary Color: Black Weight: 74 Age: 3yrs 3mths 2wks

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We'll also keep you updated on soony's adoption status with email updates.
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soony

Mastiff Cane Corso

Female, Puppy
San Diego, CA
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats, Needs experienced adopter, Shots are up-to-date,
Story
Soony is a beautiful puppy born on October 1st, 2026, and she’s ready to find her forever home! She has been raised in a loving household since birth, alongside both of her parents (which I own), so she has a great temperament and comes from a well-cared-for environment. She has such a fun and lovable personality—Soony is goofy, playful, and full of energy, but also very sweet and affectionate. She loves going on walks, playing, and being around people. She’s been well-socialized from an early age and is comfortable around other dogs, cats, and small children, making her a great fit for a family home. Soony is already showing great habits for her age: 🐶 Crate trained 🐶 Knows how to sit 🐶 Patiently waits during feeding time 🐶 Used to a daily routine She’s a smart puppy who is eager to learn and will make a loyal, loving companion. I’m looking for a responsible and caring home that will give her the time, attention, and love she deserves. Rehoming fee applies. Please message me

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We'll also keep you updated on Priscillo's adoption status with email updates.
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Priscillo

Mastiff

Male, Adult
Escondido, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
How this pet arrived: This pet was brought in by a community member on 2/12/26. Why this pet is the one for you:Priscillo is a sweet and sensitive dog who is still learning that the world can be a safe and kind place. He can be fearful when it comes to handling and new situations, so he needs a little extra time and understanding as he gets comfortable. While he may seem shy at first, Priscillo has a soft and loving personality that begins to shine once he feels secure.Meeting new people and exploring unfamiliar environments can be overwhelming for Priscillo. Because of this, he does best when introductions are slow and calm. With patience, gentle encouragement, and consistency, he gradually warms up and begins to show his affectionate and loyal nature. At SDHS:This pet has been vaccinated, microchipped and spayed neutered. This pet is now ready for their new home! Primary Color: Black Brindle Weight: 74 Age: 2yrs 1mths 3wks

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Santee, California.

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Mastiff puppies and dogs in nearby cities

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Related breeds in Santee, California

Bullmastiffs in Santee, California Neapolitan Mastiffs in Santee, California Saint Bernards in Santee, California

Mastiff shelters & rescues in Santee, California

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Santee, California. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

5.1 miles

San Diego Humane Society - El Cajon Campus

1373 N. Marshall Ave., El Cajon, CA 92020

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

10.2 miles

Rescue Fenix

San Diego, CA 92192

Pet Types: cats, dogs

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Shelter

10.5 miles

San Diego Humane Society - San Diego Campus

5500 Gaines Street, San Diego, CA 92110

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Shelter

21.1 miles

San Diego Humane Society - Escondido Campus

3500 Burnet Drive, Escondido, CA 92027

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

48.5 miles

Angel Dog Alliance, NFP (CA)

Temecula, CA 92591

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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