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Mastiff puppies and dogs in Santee, California

Looking for a Mastiff puppy or dog in Santee, California? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near Santee, California Other pups in Santee, California Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in Santee, California Mastiff shelters and rescues in Santee, California Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Santee, California

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Santee, California

These Mastiffs are available for adoption close to Santee, California.
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Octavia

English Mastiff

Female, 7 yrs 1 mo
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Octavia also called Tavi. Octavia is a big girl with an even bigger heart. Since being rescued from the shelter, she’s proven herself to be the perfect houseguest—gentle, loving, and so grateful for a second chance. Affectionately known as Tavi, she’s ready to leave her past behind and find a forever home where she can truly shine. She just needs someone to give her that chance… and we know she’ll give a lifetime of love in return. Due to Tavi's neglect, she had a severe eye infection when we rescued her from the shelter on the euth list.  Unfortunately, we were unable to save her eye but that doesn't stop her one bit! ##2688495##

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Awesome Sauce

Mastiff

Male, Adult
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Spayed or Neutered,
Story
How Awesome Sauce arrived:Awesome Sauce was brought in by our Humane Law Enforcement team on April 19, 2026. Why Awesome Sauce is the one for you:Meet Awesome Sauce, a big, lovable goofball who lives up to his name with a personality that is equal parts heart and hype. From the moment you meet him, he brings a whole lot of flavor to the table with his wiggly body, soft eyes and signature tail that whips with excitement when he sees his people. He bonds quickly and thrives on attention, always ready to soak up pets or stick close by your side. He walks well for the most part and enjoys sniffing and exploring, though he can get a bit amped up during transitions, such as leaving or returning to his kennel. When he's excited, he may jump or get a little mouthy, but he is already showing improvement and responds well to redirection and clear guidance. He does have a few medical considerations to keep in mind, including sun-related skin growths on his belly, an inward-rolling eyelid and a small growth on his chin that will need observation over time. This big boy will do best with an adopter who can help him continue working on his manners and give him outlets for his energy, along with plenty of companionship. If you're looking for a dog with a big personality, a bigger heart and just the right amount of zest, Awesome Sauce is ready to spice up your life. Please bring a leash & collar when adopting. At SDHS:Awesome Sauce has been vaccinated, microchipped and neutered.Excitable Dog: This pet requires a virtual behavior consult, please watch THIS video to learn more about them. Primary Color: Blue Weight: 99 Age: 6yrs 1mths 3wks

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Bubba

Mastiff

Male, Senior
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Spayed or Neutered,
Story
How this pet arrived:This pet was brought in by their previous owner on May 12, 2026. Why this pet is the one for you: Say hello to Bubba! We are still learning about Bubba's unique personality, but we would be happy to introduce you to him to see if he is a good fit for your family. Bubba is a delightful dog with a heart full of joy. Bubba's days are spent eagerly awaiting playtime and cuddles from anyone who walks by. His gentle nature makes him a favorite among children, and he's always up for a cozy snuggle after a playful day. Bubba has a unique love for baths, making grooming sessions a breeze. His affectionate demeanor and zest for life make him the perfect companion for any family looking to add a bundle of love to their home. Bubba loves to be the star of the show and soak up all the love and attention, so he is requesting to be the only dog in new home. If you'd like to meet this loving pup, speak with our team today! At SDHS:This pet has been vaccinated, microchipped and spayed/neutered. This pet is now ready for adoption! Primary Color: Brown Brindle Weight: 90 Age: 8yrs 0mths 2wks

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Photo of Pumpkin

Pumpkin

Mastiff

Female, Young
San Diego, CA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Spayed or Neutered, Shots are up-to-date,
Story
Pumpkin is 2 years old and weighs 106 lbs. She’s active and playful, friendly with people, and very social with dogs of all sizes. Pumpkin was first given to a friend of BAS because her original owner was going to surrender her to the local pound. She was then relinquished to due to lack of space for this large girl. If you would like to meet this dog you can read about our adoption process and submit an application on our website at: http://www.bajaanimalsanctuary.org/dogs.htm  June 7, 2026, 9:46 pm

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Photo of Astrid

Astrid

Mastiff American Pit Bull Terrier

Female, Young
Escondido, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
How this pet arrived:Astrid was brought in by their previous owner on June 3, 2026. Why this pet is the one for you: Astrid is a sweet and friendly dog looking for a loving home. According to her owner, she is a social companion who loves to play with other dogs and has previously done well living with both cats and children. Astrid also knows basic commands like "sit" and "stay," which highlights her bright personality. Since she can sometimes show some arousal and impulsivity when she's excited, she would benefit from a family that can offer her a structured routine and healthy outlets for her enthusiasm. Astrid flourishes in an environment that provides plenty of companionship, interactive play, and the steady guidance she needs to be her best self. She is ready to become a loyal and fun-loving member of her new family. At SDHS:Astrid has been vaccinated, microchipped and spayed. Astrid is now ready for adoption! Primary Color: Brindle Secondary Color: White Weight: 73.2 Age: 1yrs 0mths 0wks

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Photo of Rowdy

Rowdy

Mastiff Mixed Breed (Large)

Male, Young
Carlsbad, CA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Exciting News: This adorable pup can be at an adoption event NEAR YOU! First check our website to make sure the pup is still available for adoption: https://amazingdogsrescue.org/ap-dogs Or call or text 888.508.8943 (Monday to Sunday, 8 AM to 8 PM). Our medical team does everything they can to ensure the health of our dogs before they are placed up for adoption, which includes (but is not limited to): - Vaccinations against Parvovirus, Distemper, Adenovirus and Parainfluenza (all dogs have at least 2 of these vaccines (value $60+), puppies at least 3 (value $90+)) - Vaccination against Bordetella and Leptospirosis (value $40+) - Vaccination against Rabies (dogs 5+ months; value $20+) - Test (Idexx Snap 4Dx) for Heartworm, Lyme's disease, Anaplasmosis and Ehrlichiosis (for adult dogs; value $60+) - Recent full panel blood test (value $150+) for all adult dogs - Micro-chip with life long free registration (value $50+) - Deworming (roundworms, hookworms, whipworms and tapeworms; value $20+) - Treatment with Bravecto against fleas and ticks (value $50+) Of course, ALL our dogs are spayed or neutered before going to their new home. These surgeries cost anywhere from $150 to $500+). We even cut their nails for you ... We organize adoption events throughout the states of CA, NV and AZ. Check our website for more information. Here you can check if the pup is still looking for a home: https://amazingdogsrescue.org/ap-dogs Call or text 888.508.8943 (Monday to Sunday, 8 AM to 8 PM) if you have any questions. Check our social media to see the happy pictures of thousands of rescues who found a new loving home through us: https://www.facebook.com/AmazingDogsRescue https://www.instagram.com/AmazingDogsRescue

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Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Santee, California.

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Mastiff puppies and dogs in nearby cities

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Related breeds in Santee, California

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Mastiff shelters & rescues in Santee, California

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Santee, California. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Rescue

10.2 miles

Rescue Fenix

San Diego, CA 92192

Pet Types: cats, dogs

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Shelter

10.5 miles

San Diego Humane Society - San Diego Campus

5500 Gaines Street, San Diego, CA 92110

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

18.8 miles

Baja Animal Sanctuary

P.O. Box 439060, PMB 626, San Diego, CA 92143

Pet Types: cats, dogs

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Shelter

21.1 miles

San Diego Humane Society - Escondido Campus

3500 Burnet Drive, Escondido, CA 92027

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

27.2 miles

Amazing Dogs

Carlsbad, CA 92011

Pet Types: dogs

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Rescue

48.5 miles

Angel Dog Alliance, NFP (CA)

Temecula, CA 92591

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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