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Mastiff puppies and dogs in Denver, Colorado

Looking for a Mastiff puppy or dog in Denver, Colorado? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you in Denver, Colorado

These Mastiffs are available in Denver, Colorado.
Special Needs
No photo available for Sabrina

Sabrina

Mastiff American Bulldog

Female, 7 yrs 8 mos
Boulder, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Needs special attention, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Sabrina, a gentle 6-year-old Mastiff mix who’s in need of a special forever home. Sabrina is living with mast cell tumors (MCT) due to cancer and is currently on medication to keep her as comfortable as possible. She requires a loving home that is prepared to offer her hospice care and a peaceful environment. Sabrina can be shy with new people and may give a warning growl or snap if approached when she’s not ready. However, once she builds trust, she becomes deeply affectionate and very attached to her people. She gets along well with mellow dogs and will thrive in a calm household where she can feel safe and loved. If you have a compassionate heart and are ready to provide a supportive and caring home for a special dog like Sabrina, you’ll find a loyal and loving companion in her.

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Photo of Huckleberry

Huckleberry

Mastiff

Male, 1 yr 1 mo
Denver, CO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
I’m Huckleberry, a 1 year old male Mastiff mix. I am rather cute, if I do say so myself. Like many young dogs, I can be a little mouthy so may be a bit much for super-young kids, but I would do great with older kids and love attention. I enjoyed the tranquil atmosphere at Movie Night with my Foster family-tbh I slept through most of it! ********PLEASE READ BELOW PRIOR TO EMAILING IN**********If you are interested in adopting this dog or any other from our rescue, please go to https://www.hobocare.org/adopt to review our home requirements and fill out an application. Please do not email and ask for more information on how to adopt, all the information is already available online. The information you see here is all that is currently available about this dog. No boxers are adopted without a completed application and home check. Thank you! ##2619848##

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Photo of Zen

Zen

Neapolitan Mastiff Mastiff

Male, 7 yrs 9 mos
Boulder, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with dogs, Needs experienced adopter, Spayed or Neutered, Shots are up-to-date,
Story
Zen is a 6-year-old male Neo Mastiff mix who’s as big-hearted as he is big in stature. Rescued from a shelter after his previous owners surrendered him for being “too big,” Zen is now on the hunt for his forever home where he can truly shine. Zen is a sweet, playful giant with a lot of energy for his breed. He’s very intelligent and learns quickly, making him a joy to train. However, Zen prefers to be the only dog in the home; he can get jealous and aggressive with other dogs, wanting all the attention for himself. When he's your one and only, he’s incredibly loving and will shower you with affection. Though he’s not reactive to other dogs on leash, Zen does best in a home without canine companions. He appreciates careful introductions to new people, especially those who approach unexpectedly. Zen’s ideal owner will be someone experienced with his breed and capable of continuing his training and socialization. If you’re ready to welcome a devoted and energetic companion into your life, Zen could be the perfect fit. He’s looking for a loving home where he can be the center of attention and enjoy all the love he has to give!

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Photo of Mishka

Mishka

Great Dane Mastiff

Female, 4 mos
Denver, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, Shots are up-to-date,
Story
Mishka is a gentle giant who loves snoozing to classical music and will be a serious cuddle buddy once she hits her full size (100+ lbs, though she's convinced she's a lap dog). She's treat-motivated and a quick learner, already potty trained and great with the doggie door. Off-leash, she's the life of the party and plays beautifully with other dogs. She's also good with kids. She does have a stubborn streak. On leash walks, she'll occasionally plant her paws and decide she's done, and she can get a bit awkward with unfamiliar dogs while leashed. She'd benefit from some intentional socialization and training. Mishka is growing quickly and her big feet make her a little clumsy, especially when she's excited to hop in the car. If you want a sweet, goofy, occasionally bossy companion, Mishka might be your girl. She's fostered in Colorado Springs, CO and would love to meet you! Submit a no obligation adoption application today to discuss a meeting. ##2748308##

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Photo of Bella

Bella

Great Dane Mastiff

Female, Young
Thornton, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Bella is an amazing dog, very friendly, sweet, and well trained. She loves walks and playing with toys. She loves the groomer and is very easy going. My husband has been diagnosed with cancer and we cannot take care of her the way she needs. We are looking for a good home with lots of love and a yard for her to enjoy!

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Or, how about these Mastiffs in cities near Denver, Colorado

These Mastiffs are available for adoption close to Denver, Colorado.
Special Needs
No photo available for Sabrina

Sabrina

Mastiff American Bulldog

Female, 7 yrs 8 mos
Boulder, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Needs special attention, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Sabrina, a gentle 6-year-old Mastiff mix who’s in need of a special forever home. Sabrina is living with mast cell tumors (MCT) due to cancer and is currently on medication to keep her as comfortable as possible. She requires a loving home that is prepared to offer her hospice care and a peaceful environment. Sabrina can be shy with new people and may give a warning growl or snap if approached when she’s not ready. However, once she builds trust, she becomes deeply affectionate and very attached to her people. She gets along well with mellow dogs and will thrive in a calm household where she can feel safe and loved. If you have a compassionate heart and are ready to provide a supportive and caring home for a special dog like Sabrina, you’ll find a loyal and loving companion in her.

Learn More

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Photo of Huckleberry

Huckleberry

Mastiff

Male, 1 yr 1 mo
Denver, CO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
I’m Huckleberry, a 1 year old male Mastiff mix. I am rather cute, if I do say so myself. Like many young dogs, I can be a little mouthy so may be a bit much for super-young kids, but I would do great with older kids and love attention. I enjoyed the tranquil atmosphere at Movie Night with my Foster family-tbh I slept through most of it! ********PLEASE READ BELOW PRIOR TO EMAILING IN**********If you are interested in adopting this dog or any other from our rescue, please go to https://www.hobocare.org/adopt to review our home requirements and fill out an application. Please do not email and ask for more information on how to adopt, all the information is already available online. The information you see here is all that is currently available about this dog. No boxers are adopted without a completed application and home check. Thank you! ##2619848##

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Photo of Pluto

Pluto

Mastiff Rottweiler

Male, Adult
Littleton, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Spayed or Neutered,
Story
Hi there, my name is Pluto! I am a big handsome guy with a fun demeanor. I am social, intelligent, and active. I am looking for a home where I will be treated just like a member of the family. I am going to need exercise, training, socialization, and affection. In return, I promise to bring you years of love, laughter, and loyalty. My adoption fee includes my neuter, a microchip, vaccines, and a fourteen day limited health guarantee through Redstone Animal Hospital! Come and visit me today! Primary Color: Red Secondary Color: White Weight: 90 Age: 3yrs 0mths 4wks

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Photo of Freya

Freya

Mastiff

Female, 4 yrs
Aurora, CO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Spayed or Neutered, Shots are up-to-date,
Story
Hi, I'm Freya! I'm a sweet mama and came with my 9 puppies. I'm a very good girl. I'm said to have had a few litters in the past and I'm ready to put motherhood behind me and have a little time for myself. Won't you spend it with me? If you're interested in adopting me, please fill out an application at www.polkcountyhumanesociety.org/adopt. You can also reserve an appointment to meet me. Some pets are in foster homes or may already have visits scheduled, so appointments help ensure I’ll be available. Polk County Humane Society is located in Bolivar, Missouri, and we welcome adopters from any state. We have access to a transport to Aurora, CO. Other out of state adopters either travel to Missouri or arrange & pay for air transport. Virtual meet and greets are available on the appointment request. ##2755149##

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Photo of Creek

Creek

Mastiff Great Pyrenees

Male, 1 mo
Aurora, CO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, Spayed or Neutered, Shots are up-to-date,
Story
Meet this splashingly adorable puddle of puppies! Introducing Cove, Sea, Brook, Ocean, Reef, Harbor, Bayou, Lake & Creek! They are ready to send waves of love, fun, and playfulness right into your homes. Born to their mama Freya, these pups are going to make excellent dogs. They are a great mix of Great Pyrenees, Mastiff and who knows what- so they are sure to be big pups. NOTE: They will be available to meet at our PetSmart Adoption Events in Springfield and Rolla, MO on Saturday, June 27. Come meet them and take one home! If you're interested in adopting me, please fill out an application at www.polkcountyhumanesociety.org/adopt. You can also reserve an appointment to meet me. Some pets are in foster homes or may already have visits scheduled, so appointments help ensure I’ll be available. Polk County Humane Society is located in Bolivar, Missouri, and we welcome adopters from any state. We have access to a transport to Aurora, CO. Other out of state adopters either travel to Missouri or arrange & pay for air transport. Virtual meet and greets are available on the appointment request. ##2755261##

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Photo of Brook

Brook

Mastiff Great Pyrenees

Female, 1 mo
Aurora, CO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, Spayed or Neutered, Shots are up-to-date,
Story
Meet this splashingly adorable puddle of puppies! Introducing Cove, Sea, Brook, Ocean, Reef, Harbor, Bayou, Lake & Creek! They are ready to send waves of love, fun, and playfulness right into your homes. Born to their mama Freya, these pups are going to make excellent dogs. They are a great mix of Great Pyrenees, Mastiff and who knows what- so they are sure to be big pups. NOTE: They will be available to meet at our PetSmart Adoption Events in Springfield and Rolla, MO on Saturday, June 27. Come meet them and take one home! If you're interested in adopting me, please fill out an application at www.polkcountyhumanesociety.org/adopt. You can also reserve an appointment to meet me. Some pets are in foster homes or may already have visits scheduled, so appointments help ensure I’ll be available. Polk County Humane Society is located in Bolivar, Missouri, and we welcome adopters from any state. We have access to a transport to Aurora, CO. Other out of state adopters either travel to Missouri or arrange & pay for air transport. Virtual meet and greets are available on the appointment request. ##2755255##

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These pups are in Denver, Colorado too!

Below are our newest added Mastiffs available for adoption in Denver, Colorado. To see more adoptable Mastiffs in Denver, Colorado, use the search tool below to enter specific criteria!
Photo of Zen

Zen

Neapolitan Mastiff Mastiff

Male, 7 yrs 9 mos
Boulder, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with dogs, Needs experienced adopter, Spayed or Neutered, Shots are up-to-date,
Story
Zen is a 6-year-old male Neo Mastiff mix who’s as big-hearted as he is big in stature. Rescued from a shelter after his previous owners surrendered him for being “too big,” Zen is now on the hunt for his forever home where he can truly shine. Zen is a sweet, playful giant with a lot of energy for his breed. He’s very intelligent and learns quickly, making him a joy to train. However, Zen prefers to be the only dog in the home; he can get jealous and aggressive with other dogs, wanting all the attention for himself. When he's your one and only, he’s incredibly loving and will shower you with affection. Though he’s not reactive to other dogs on leash, Zen does best in a home without canine companions. He appreciates careful introductions to new people, especially those who approach unexpectedly. Zen’s ideal owner will be someone experienced with his breed and capable of continuing his training and socialization. If you’re ready to welcome a devoted and energetic companion into your life, Zen could be the perfect fit. He’s looking for a loving home where he can be the center of attention and enjoy all the love he has to give!

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Photo of Nina

Nina

St. Bernard

Female, 3 yrs
Denver, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Say hello to Nina! She came into rescue through no fault of her own when her family experienced medical issues and could no longer care for her. Nina has lived successfully with both children and other dogs and enjoys being part of a family. She is house-trained, crate-trained, and settles in nicely to home life. One of her favorite things is spending time with her people—whether that means lounging nearby or snuggling up for some affection. Like many dogs, Nina can be a little protective of especially high-value treats. She needs to eat separate so she can feel secure and doesn't feel like she needs to protect her dinner. The good news is that she communicates her boundaries appropriately and responds well when those signals are respected. Her adopters should be mindful of this behavior and continue to set her up for success through positive management and training. Nina is looking for a family who will appreciate her sweet nature, giant-breed charm, and love of companionship. If you're searching for a loyal best friend who enjoys cuddles as much as she enjoys being part of the family, Nina may be the perfect match. Apply to adopt on our website! https://cosaintrescue.org/adopt/

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Bonded Pair
Photo of Maggie

Maggie

St. Bernard

Female, 8 yrs
Denver, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Bonded pair Gus & Maggie come to after Maggie tore her CCL and their previous owner was unable to provide the level of care that she needed. Maggie is almost completely recovered from her TPLO surgery and these two are ready for their happy ever after! Gus can be protective of Maggie, so we recommend a home with no other dogs in it, but they get along just fine with their foster kitty brother! A home with few stairs and a fenced yard would be best for these two. Favorite activities include sunbathing, snowbathing, napping, watching squirrels, and getting belly rubs - in other words, the good life! Adoption application: https://cosaintrescue.org/adopt/

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Denver, Colorado.

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Mastiff puppies and dogs in nearby cities

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Related breeds in Denver, Colorado

Bullmastiffs in Denver, Colorado Neapolitan Mastiffs in Denver, Colorado Saint Bernards in Denver, Colorado

Mastiff shelters & rescues in Denver, Colorado

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Denver, Colorado. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Rescue

6 miles

Ace of Hearts Dog Rescue - CO Transport Stop

711 Walnut St, Boulder, CO 80203

Pet Types: dogs

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Rescue

6.7 miles

Ho-Bo Care Boxer Rescue

Denver, CO 80209

Pet Types: dogs

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Shelter

7.7 miles

Humane Society of the South Platte Valley

2129 W Chenango Ave, Littleton, CO 80120

Pet Types: cats, birds, dogs, rabbits, small animals

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Shelter

15.9 miles

Polk County Humane Society (in Missouri) - Colorado Transport

3511 N Salida Court, Aurora, CO 80011

Pet Types: cats, dogs

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Rescue

15.9 miles

Big Dogs Huge Paws, Inc

PO Box 460699, Aurora, CO 80046

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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