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Mastiff puppies and dogs in Denver, Colorado

Looking for a Mastiff puppy or dog in Denver, Colorado? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near Denver, Colorado Other pups in Denver, Colorado Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in Denver, Colorado Mastiff shelters and rescues in Denver, Colorado Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Denver, Colorado

These Mastiffs are available in Denver, Colorado.
We'll also keep you updated on Sabrina's adoption status with email updates.
Special Needs
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Sabrina

Mastiff American Bulldog

Female, 7 yrs 3 mos
Boulder, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Needs special attention, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Sabrina, a gentle 6-year-old Mastiff mix who’s in need of a special forever home. Sabrina is living with mast cell tumors (MCT) due to cancer and is currently on medication to keep her as comfortable as possible. She requires a loving home that is prepared to offer her hospice care and a peaceful environment. Sabrina can be shy with new people and may give a warning growl or snap if approached when she’s not ready. However, once she builds trust, she becomes deeply affectionate and very attached to her people. She gets along well with mellow dogs and will thrive in a calm household where she can feel safe and loved. If you have a compassionate heart and are ready to provide a supportive and caring home for a special dog like Sabrina, you’ll find a loyal and loving companion in her.

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We'll also keep you updated on Effie's adoption status with email updates.
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Effie

Mastiff

Female, Young
Denver, CO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Effie, 1 year and 2 month old Mastiff mix who has a healthy appreciation for both naps and play time! She is a bit timid at first, but warms up very quickly. Effie is still young, so she is fairly quick to train and to learn new things. Effie is an amazing, kind dog - She is good with cats, dogs, and kids. After adopting Effie from the Humane Society, we discovered our senior cat was having an allergic reaction to her that worsened his pre-existing medical condition. For the sake of our cat’s health, we have made the difficult decision to find a new home for Effie. Effie thrives in a home with someone who can snuggle, play, and spend quality time with her.

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We'll also keep you updated on Stimpy's adoption status with email updates.
Photo of Stimpy

Stimpy

Mastiff Catahoula Leopard Dog

Female 6 mos
Littleton, CO
Size
(when grown) -
Details
Spayed or Neutered, Shots are up-to-date,
Story
Apply online at www.lolasrescue.com/available-animals please note if you utilize an Iphone there are two scroll bars on the side of the screen to scroll down through available animals.   You can email Info@lolasrescue.com anytime with questions pertaining to animals in our care.  ##2593147##

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We'll also keep you updated on ZEUS's adoption status with email updates.
Photo of ZEUS

ZEUS

Mastiff

Male, Senior
Denver, CO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
Zeus is seeking a foster home until 11/30. Last day to find foster is 11/7.Owner reports: Friendly,always follows owner around, loves cuddles, nervous around other animals as he was attacked by a dog. Is nervous around strangers, seem to do better with women as opposed to men. House trained.No resource housing.Diet and feeding: Used to eating 2-3 cans of wet food a day, and goes out about 2 times a day. He has also been eating dry kibble in shelter just fine.Toys & Enrichment: Does not seem to care for toys too much, does like shreddable enrichment with treats inside.Sleeping arrangements: On a blaket or towel on the floor, paces if not given one.Commands: Sit (sientate), Paw (mano), lay down (acuestate) - family speaks spanish.Dogs: Is nervous at first, but does well with an appropriate dog. Cats: He is afraid of cats.Kids: Allows pets but keeps his distance. Alone time: Does well, not destructibe and no accidents.Crate-trained. Not destructive, No escape. December 8, 2025, 5:22 pm

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Or, how about these Mastiffs in cities near Denver, Colorado

These Mastiffs are available for adoption close to Denver, Colorado.
We'll also keep you updated on Sabrina's adoption status with email updates.
Special Needs
Photo of Sabrina

Sabrina

Mastiff American Bulldog

Female, 7 yrs 3 mos
Boulder, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Needs special attention, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Sabrina, a gentle 6-year-old Mastiff mix who’s in need of a special forever home. Sabrina is living with mast cell tumors (MCT) due to cancer and is currently on medication to keep her as comfortable as possible. She requires a loving home that is prepared to offer her hospice care and a peaceful environment. Sabrina can be shy with new people and may give a warning growl or snap if approached when she’s not ready. However, once she builds trust, she becomes deeply affectionate and very attached to her people. She gets along well with mellow dogs and will thrive in a calm household where she can feel safe and loved. If you have a compassionate heart and are ready to provide a supportive and caring home for a special dog like Sabrina, you’ll find a loyal and loving companion in her.

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We'll also keep you updated on Effie's adoption status with email updates.
Photo of Effie

Effie

Mastiff

Female, Young
Denver, CO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Effie, 1 year and 2 month old Mastiff mix who has a healthy appreciation for both naps and play time! She is a bit timid at first, but warms up very quickly. Effie is still young, so she is fairly quick to train and to learn new things. Effie is an amazing, kind dog - She is good with cats, dogs, and kids. After adopting Effie from the Humane Society, we discovered our senior cat was having an allergic reaction to her that worsened his pre-existing medical condition. For the sake of our cat’s health, we have made the difficult decision to find a new home for Effie. Effie thrives in a home with someone who can snuggle, play, and spend quality time with her.

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We'll also keep you updated on Stimpy's adoption status with email updates.
Photo of Stimpy

Stimpy

Mastiff Catahoula Leopard Dog

Female 6 mos
Littleton, CO
Size
(when grown) -
Details
Spayed or Neutered, Shots are up-to-date,
Story
Apply online at www.lolasrescue.com/available-animals please note if you utilize an Iphone there are two scroll bars on the side of the screen to scroll down through available animals.   You can email Info@lolasrescue.com anytime with questions pertaining to animals in our care.  ##2593147##

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We'll also keep you updated on Maggie's adoption status with email updates.
Photo of Maggie

Maggie

Mastiff American Bulldog

Female, Adult
Golden, CO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
If you've been searching for a dog who will make you smile every single day, say hello to Maggie! This bright-eyed, tail-wagging sweetheart is the perfect mix of playful energy and loving companionship.Maggie is an active, joyful, and endlessly curious pup who's always ready for fun. Whether it's a game of fetch, playing with other dogs, or exploring a new trail, she's happiest when she's moving and sharing life's adventures with her favorite humans. Primary Color: White Secondary Color: Black Weight: 71.6 Age: 4yrs 2mths 3wks

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We'll also keep you updated on ZEUS's adoption status with email updates.
Photo of ZEUS

ZEUS

Mastiff

Male, Senior
Denver, CO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
Zeus is seeking a foster home until 11/30. Last day to find foster is 11/7.Owner reports: Friendly,always follows owner around, loves cuddles, nervous around other animals as he was attacked by a dog. Is nervous around strangers, seem to do better with women as opposed to men. House trained.No resource housing.Diet and feeding: Used to eating 2-3 cans of wet food a day, and goes out about 2 times a day. He has also been eating dry kibble in shelter just fine.Toys & Enrichment: Does not seem to care for toys too much, does like shreddable enrichment with treats inside.Sleeping arrangements: On a blaket or towel on the floor, paces if not given one.Commands: Sit (sientate), Paw (mano), lay down (acuestate) - family speaks spanish.Dogs: Is nervous at first, but does well with an appropriate dog. Cats: He is afraid of cats.Kids: Allows pets but keeps his distance. Alone time: Does well, not destructibe and no accidents.Crate-trained. Not destructive, No escape. December 8, 2025, 5:22 pm

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We'll also keep you updated on Tenille's adoption status with email updates.
Photo of Tenille

Tenille

Mastiff

Female, 4 yrs 5 mos
Aurora, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
-
Story
-

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These pups are in Denver, Colorado too!

Below are our newest added Mastiffs available for adoption in Denver, Colorado. To see more adoptable Mastiffs in Denver, Colorado, use the search tool below to enter specific criteria!
We'll also keep you updated on Zen's adoption status with email updates.
Photo of Zen

Zen

Neapolitan Mastiff Mastiff

Male, 7 yrs 2 mos
Boulder, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with dogs, Needs experienced adopter, Spayed or Neutered, Shots are up-to-date,
Story
Zen is a 6-year-old male Neo Mastiff mix who’s as big-hearted as he is big in stature. Rescued from a shelter after his previous owners surrendered him for being “too big,” Zen is now on the hunt for his forever home where he can truly shine. Zen is a sweet, playful giant with a lot of energy for his breed. He’s very intelligent and learns quickly, making him a joy to train. However, Zen prefers to be the only dog in the home; he can get jealous and aggressive with other dogs, wanting all the attention for himself. When he's your one and only, he’s incredibly loving and will shower you with affection. Though he’s not reactive to other dogs on leash, Zen does best in a home without canine companions. He appreciates careful introductions to new people, especially those who approach unexpectedly. Zen’s ideal owner will be someone experienced with his breed and capable of continuing his training and socialization. If you’re ready to welcome a devoted and energetic companion into your life, Zen could be the perfect fit. He’s looking for a loving home where he can be the center of attention and enjoy all the love he has to give!

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We'll also keep you updated on Hank's adoption status with email updates.
Photo of Hank

Hank

St. Bernard Labrador Retriever

Male, Adult
Denver, CO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Hank is a lovable, easygoing 5-year-old pup who has been part of our family for four wonderful years. He’s fantastic with kids, playful with other dogs, and happiest when he’s cuddling or relaxing by your side. Originally from Tennessee, he’s currently staying with a trusted friend in Denver while he waits for his forever home. Hank is an amazing companion, but the home we thought we found for him was not a great choice because he didn’t mesh well with their cats. Where we looking to rehoming him due to our young child’s dog allergies and our limited time. He deserves a family who can give him all the love and attention he gives so freely.

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We'll also keep you updated on Babs's adoption status with email updates.
Photo of Babs

Babs

St. Bernard

Female, 3 yrs 6 mos
Denver, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs,
Story
Babs is an absolute sweetheart at 18 months young. She came in after her owner decided her energy no longer matched his own. She is a pretty active girl that needs someone to continue to work on training with her. Her current foster mama says she is very sweet little tornado 🌪 💜. She weighs in around 110 lbs and still needs to be spayed and have her gastropexy before she is ready to be adopted out. However, she is available to meet. She does have some resource guarding we are working through when it comes to food, and she is still learning how to be polite on a leash.

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Denver, Colorado.

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Mastiff puppies and dogs in nearby cities

Mastiff Puppies near me Mastiff in Arvada, CO Mastiff in Aurora, CO Mastiff in Boulder, CO Mastiff in Brighton, CO Mastiff in Broomfield, CO Mastiff in Castle Rock, CO Mastiff in Centennial, CO Mastiff in Cherry Hills Village, CO Mastiff in Commerce City, CO Mastiff in Edgewater, CO Mastiff in Englewood, CO Mastiff in Erie, CO Mastiff in Federal Heights, CO Mastiff in Firestone, CO Mastiff in Fort Lupton, CO Mastiff in Frederick, CO Mastiff in Golden, CO Mastiff in Greenwood Village, CO Mastiff in Lafayette, CO Mastiff in Lakewood, CO Mastiff in Littleton, CO Mastiff in Lone Tree, CO Mastiff in Longmont, CO Mastiff in Louisville, CO Mastiff in Northglenn, CO Mastiff in Parker, CO Mastiff in Sheridan, CO Mastiff in Superior, CO Mastiff in Thornton, CO Mastiff in Westminster, CO Mastiff in Wheat Ridge, CO

Related breeds in Denver, Colorado

Bullmastiffs in Denver, Colorado Neapolitan Mastiffs in Denver, Colorado Saint Bernards in Denver, Colorado

Mastiff shelters & rescues in Denver, Colorado

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Denver, Colorado. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Rescue

6 miles

Ace of Hearts Dog Rescue - CO Transport Stop

711 Walnut St, Boulder, CO 80203

Pet Types: dogs

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Rescue

7.6 miles

L.O.L.A.'S Rescue

6005 S. Taft Way, Littleton, CO 80127

Pet Types: dogs

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Shelter

7.8 miles

Foothills Animal Shelter

580 McIntyre St., Golden, CO 80401

Pet Types: cats, birds, dogs, rabbits, reptiles, small animals

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Shelter

10.6 miles

Humane Colorado

2080 S Quebec St, Denver, CO 80231

Pet Types: cats, dogs, horses, rabbits, small animals

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Rescue

15.9 miles

Big Dogs Huge Paws, Inc

PO Box 460699, Aurora, CO 80046

Pet Types: dogs

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Shelter

25.1 miles

Humane Society of Boulder Valley

2323 55th Street, Boulder, CO 80301

Pet Types: cats, dogs, small animals

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Shelter

49.2 miles

Grand County Animal Shelter

3475 CR 57, Granby, CO 80446

Pet Types: cats, birds, dogs, rabbits, reptiles, small animals

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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