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Mastiff puppies and dogs in Denver, Colorado

Looking for a Mastiff puppy or dog in Denver, Colorado? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near Denver, Colorado Other pups in Denver, Colorado Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in Denver, Colorado Mastiff shelters and rescues in Denver, Colorado Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Denver, Colorado

These Mastiffs are available in Denver, Colorado.
Special Needs
No photo available for Sabrina

Sabrina

Mastiff American Bulldog

Female, 7 yrs 10 mos
Boulder, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Needs special attention, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Sabrina, a gentle 6-year-old Mastiff mix who’s in need of a special forever home. Sabrina is living with mast cell tumors (MCT) due to cancer and is currently on medication to keep her as comfortable as possible. She requires a loving home that is prepared to offer her hospice care and a peaceful environment. Sabrina can be shy with new people and may give a warning growl or snap if approached when she’s not ready. However, once she builds trust, she becomes deeply affectionate and very attached to her people. She gets along well with mellow dogs and will thrive in a calm household where she can feel safe and loved. If you have a compassionate heart and are ready to provide a supportive and caring home for a special dog like Sabrina, you’ll find a loyal and loving companion in her.

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Photo of Monique

Monique

Mastiff

Female, 5 mos
Littleton, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, Spayed or Neutered, Shots are up-to-date,
Story
Meet Monique!   Looking for a puppy who turns heads everywhere she goes? Meet Monique! At just 4½ months old, this gorgeous Mastiff girl is all oversized paws, goofy charm, and endless love. She’s incredibly sweet, whip-smart, and has the kind of personality that makes everyone she meets fall in love. Whether she’s playing, learning something new, or soaking up attention, Monique does everything with enthusiasm.   She’s going to be a BIG girl, so she’s looking for a family ready for giant-breed snuggles, loyal companionship, and a lifetime of adventures. If you’ve been dreaming of a gentle giant with a heart as big as her future, Monique is ready to make your house a home. ##2776213##

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Photo of Zen

Zen

Neapolitan Mastiff Mastiff

Male, 7 yrs 10 mos
Boulder, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with dogs, Needs experienced adopter, Spayed or Neutered, Shots are up-to-date,
Story
Zen is a 6-year-old male Neo Mastiff mix who’s as big-hearted as he is big in stature. Rescued from a shelter after his previous owners surrendered him for being “too big,” Zen is now on the hunt for his forever home where he can truly shine. Zen is a sweet, playful giant with a lot of energy for his breed. He’s very intelligent and learns quickly, making him a joy to train. However, Zen prefers to be the only dog in the home; he can get jealous and aggressive with other dogs, wanting all the attention for himself. When he's your one and only, he’s incredibly loving and will shower you with affection. Though he’s not reactive to other dogs on leash, Zen does best in a home without canine companions. He appreciates careful introductions to new people, especially those who approach unexpectedly. Zen’s ideal owner will be someone experienced with his breed and capable of continuing his training and socialization. If you’re ready to welcome a devoted and energetic companion into your life, Zen could be the perfect fit. He’s looking for a loving home where he can be the center of attention and enjoy all the love he has to give!

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Photo of Monte aka Moose

Monte aka Moose

Boxer Mastiff

Male, 1 yr
Boulder, CO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with dogs, Shots are up-to-date,
Story
Moose is a 1-year-old Pitbull mix with a heart as big as his smile. This sweet boy is the perfect combination of playful, loving, and eager to be your best friend. He absolutely loves people and has shown that he enjoys spending time with other dogs too! Moose has a gentle, affectionate personality and is always ready to share his love with those around him. Whether he’s going for a walk, playing with his furry friends, or simply relaxing by your side, Moose is happiest when he’s with his people. This handsome boy is looking for a forever home where he can continue to be loved, spoiled, and treated like the special dog he is. If you’re looking for a loyal companion with a sweet personality, Moose may be the perfect addition to your family!

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Or, how about these Mastiffs in cities near Denver, Colorado

These Mastiffs are available for adoption close to Denver, Colorado.
Special Needs
No photo available for Sabrina

Sabrina

Mastiff American Bulldog

Female, 7 yrs 10 mos
Boulder, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Needs special attention, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Sabrina, a gentle 6-year-old Mastiff mix who’s in need of a special forever home. Sabrina is living with mast cell tumors (MCT) due to cancer and is currently on medication to keep her as comfortable as possible. She requires a loving home that is prepared to offer her hospice care and a peaceful environment. Sabrina can be shy with new people and may give a warning growl or snap if approached when she’s not ready. However, once she builds trust, she becomes deeply affectionate and very attached to her people. She gets along well with mellow dogs and will thrive in a calm household where she can feel safe and loved. If you have a compassionate heart and are ready to provide a supportive and caring home for a special dog like Sabrina, you’ll find a loyal and loving companion in her.

Learn More

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Photo of Monique

Monique

Mastiff

Female, 5 mos
Littleton, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, Spayed or Neutered, Shots are up-to-date,
Story
Meet Monique!   Looking for a puppy who turns heads everywhere she goes? Meet Monique! At just 4½ months old, this gorgeous Mastiff girl is all oversized paws, goofy charm, and endless love. She’s incredibly sweet, whip-smart, and has the kind of personality that makes everyone she meets fall in love. Whether she’s playing, learning something new, or soaking up attention, Monique does everything with enthusiasm.   She’s going to be a BIG girl, so she’s looking for a family ready for giant-breed snuggles, loyal companionship, and a lifetime of adventures. If you’ve been dreaming of a gentle giant with a heart as big as her future, Monique is ready to make your house a home. ##2776213##

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Photo of Freya

Freya

Mastiff

Female, 4 yrs 2 mos
Aurora, CO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Spayed or Neutered, Shots are up-to-date,
Story
Hi, I'm Freya! I'm a sweet mama and came with my 9 puppies. I'm a very good girl. I'm said to have had a few litters in the past and I'm ready to put motherhood behind me and have a little time for myself. Won't you spend it with me? If you're interested in adopting me, please fill out an application at www.polkcountyhumanesociety.org/adopt. You can also reserve an appointment to meet me. Some pets are in foster homes or may already have visits scheduled, so appointments help ensure I’ll be available. Polk County Humane Society is located in Bolivar, Missouri, and we welcome adopters from any state. We have access to a transport to Aurora, CO. Other out of state adopters either travel to Missouri or arrange & pay for air transport. Virtual meet and greets are available on the appointment request. ##2755149##

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Photo of Tenille

Tenille

Mastiff

Female, 5 yrs 1 mo
Aurora, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
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Story
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Photo of Nala

Nala

Mastiff Husky

Female, Adult
Erie, CO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Shots are up-to-date,
Story
We have had Nala since she was 8weeks old! She is now 5 will be 6 December 22nd! She is a cuddle bug for sure and loves to play! shes very smart and learns quickly. She is kennel trained, house trained and knows basic commands. She loves her paw held. She will literally be your best friend. She needs an active loving family. I have developed an allergy to her fur and while i have been able to manage it pretty well our work situation is also changing within the next few weeks and i dont want her home alone or kenneled for the majority of the day. She deserves better than that. She is up to date on shots and goes to her annual well checks. Shes also been to doggy boarding and does great. Shes great with other dogs big or small and loves kids. she loves anyone that loves her honestly.She is not spayed but probably should be.She will come with all of her things to her new home.

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Photo of Zen

Zen

Neapolitan Mastiff Mastiff

Male, 7 yrs 10 mos
Boulder, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with dogs, Needs experienced adopter, Spayed or Neutered, Shots are up-to-date,
Story
Zen is a 6-year-old male Neo Mastiff mix who’s as big-hearted as he is big in stature. Rescued from a shelter after his previous owners surrendered him for being “too big,” Zen is now on the hunt for his forever home where he can truly shine. Zen is a sweet, playful giant with a lot of energy for his breed. He’s very intelligent and learns quickly, making him a joy to train. However, Zen prefers to be the only dog in the home; he can get jealous and aggressive with other dogs, wanting all the attention for himself. When he's your one and only, he’s incredibly loving and will shower you with affection. Though he’s not reactive to other dogs on leash, Zen does best in a home without canine companions. He appreciates careful introductions to new people, especially those who approach unexpectedly. Zen’s ideal owner will be someone experienced with his breed and capable of continuing his training and socialization. If you’re ready to welcome a devoted and energetic companion into your life, Zen could be the perfect fit. He’s looking for a loving home where he can be the center of attention and enjoy all the love he has to give!

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These pups are in Denver, Colorado too!

Below are our newest added Mastiffs available for adoption in Denver, Colorado. To see more adoptable Mastiffs in Denver, Colorado, use the search tool below to enter specific criteria!
Photo of Zen

Zen

Neapolitan Mastiff Mastiff

Male, 7 yrs 10 mos
Boulder, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Not good with dogs, Needs experienced adopter, Spayed or Neutered, Shots are up-to-date,
Story
Zen is a 6-year-old male Neo Mastiff mix who’s as big-hearted as he is big in stature. Rescued from a shelter after his previous owners surrendered him for being “too big,” Zen is now on the hunt for his forever home where he can truly shine. Zen is a sweet, playful giant with a lot of energy for his breed. He’s very intelligent and learns quickly, making him a joy to train. However, Zen prefers to be the only dog in the home; he can get jealous and aggressive with other dogs, wanting all the attention for himself. When he's your one and only, he’s incredibly loving and will shower you with affection. Though he’s not reactive to other dogs on leash, Zen does best in a home without canine companions. He appreciates careful introductions to new people, especially those who approach unexpectedly. Zen’s ideal owner will be someone experienced with his breed and capable of continuing his training and socialization. If you’re ready to welcome a devoted and energetic companion into your life, Zen could be the perfect fit. He’s looking for a loving home where he can be the center of attention and enjoy all the love he has to give!

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Photo of Mortimer

Mortimer

St. Bernard Shepherd (Unknown Type)

Male, 5 yrs 10 mos
Denver, CO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Hi there!  Mortimer here! The nice rescue people have asked me to tell you about myself, so here goes .... I am a world class squirrel defense expert. I have been told that i shouldn't lead wth that, but I think it's the most important, so there we go. I am also an expert at eating snacks :) aaaaaaand now they say they are taking over writing this .... Morti is around 5 years old and survived prostate cancer in 2021! The required surgery has made him a bit sensitive about his rear end when it comes to other dogs sniffing it, so he can be a bit dog selective. He does better with female dogs that respect his boundaries. He was not kidding about the squirrel defense expert bit - he has an ongoing feud with the neighborhood squirrels at his foster house. Morti can't live with cats (or any small animals really) as his prey drive is just too high. He would thrive in a home with a fenced yard and a family that can continue his structured daily walks. If you have a garden, he will "help" you in it. His foster mom solved this by giving him his own garden bed to till. Morti is house and crate trained, and does fine in the crate while his foster family is away from the house.

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Bonded Pair
Photo of Gus

Gus

St. Bernard

Male, 8 yrs 2 mos
Denver, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Bonded pair Gus & Maggie come to after Maggie tore her CCL and their previous owner was unable to provide the level of care that she needed. Maggie is almost completely recovered from her TPLO surgery and these two are ready for their happy ever after! Gus can be protective of Maggie, so we recommend a home with no other dogs in it, but they get along just fine with their foster kitty brother! A home with few stairs and a fenced yard would be best for these two. Favorite activities include sunbathing, snowbathing, napping, watching squirrels, and getting belly rubs - in other words, the good life! Adoption application: https://cosaintrescue.org/adopt/

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Denver, Colorado.

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Mastiff puppies and dogs in nearby cities

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Related breeds in Denver, Colorado

Bullmastiffs in Denver, Colorado Neapolitan Mastiffs in Denver, Colorado Saint Bernards in Denver, Colorado

Mastiff shelters & rescues in Denver, Colorado

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Denver, Colorado. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Rescue

6 miles

Ace of Hearts Dog Rescue - CO Transport Stop

711 Walnut St, Boulder, CO 80203

Pet Types: dogs

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Rescue

7.6 miles

L.O.L.A.'S Rescue

6005 S. Taft Way, Littleton, CO 80127

Pet Types: dogs

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Shelter

15.9 miles

Polk County Humane Society (in Missouri) - Colorado Transport

3511 N Salida Court, Aurora, CO 80011

Pet Types: cats, dogs

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Rescue

15.9 miles

Big Dogs Huge Paws, Inc

PO Box 460699, Aurora, CO 80046

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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