Mastiff Adoption in Colorado: Mastiff Puppies for Sale in Colorado

Adopt a Mastiff near you in Colorado

Below are our newest added Mastiffs available for adoption in Colorado. To see more adoptable Mastiffs in Colorado, use the search tool below to enter specific criteria!

Zeus

Mastiff

Male, Adult

Fort Collins, CO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, House-trained,

Story

Hi, I’m Zeus, a 6-year-old Mastiff–Rottweiler mix weighing in at a totally manageable 103 lbs (even though I firmly believe I’m lap-sized). If you’re looking for world-class cuddles, look no further. I was surrendered to my foster by my family because my parents were getting divorced. Neither could find space for me in their new homes. It's been a hard transition but I'm finally coming out of my shell. I’m sweet, soft-hearted, and full of love, living up to the title of gentle giant. I adore dogs, do great with kids, and I’m totally cool with cats—no chasing, just peaceful coexistence. I’m fully potty trained, walk beautifully on a leash (no pulling here!), and I know my basics commands like sit and drop it. I am a good boy and proud of it. Even though I am 6 at heart, I’m still a big puppy. My determination to catch my own tail and joyful energy is guaranteed to make you laugh even on your worst day. Toys? Oh, I love them… but fair warning: if it squeaks, I will surgically remove the squeaker with my teeth. A few things I’m working on: I can be shy and bark when people show up unannounced, men especially, but I’m working hard on my confidence. Public outings are helping a lot, and I’m improving every day. I don’t love being alone and would do best with someone who has time for me—or even better, another medium to large dog to keep me company. I’m a bit of a counter surfer and an occasional trash inspector. A locked trash can solves that problem completely. But my foster has yet to find a place high enough on her shelves to keep me from having a second breakfast. I'm clever but not destructive. If you’re looking for a loyal shadow, a cuddle buddy, and a companion who will love you endlessly, I might just be your guy.March 10, 2026, 3:01 pm

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Cedar

Mastiff

Male, 3 mos

Sedalia, CO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs,

Story

Cedar was rescued from a shelter in New Mexico. Meet and greets are by appointment only. An approved application is required to schedule a meeting. Check out our events page for upcoming open adoption events! We have no additional back story or update for this dog at this time. When we do, it will be updated here. This is all the information we have currently. Approved Applicants may make the adoption fee payment by clicking donate above. Partial adoption fees will not hold a dog. If upon meeting the dog of your choosing at your scheduled pickup time you find that you aren't a good match, your deposit will be fully refunded. Adoption fees include vaccines up until time of adoption, microchip, spay/neuter and 1st 30 days of free pet insurance. We are not affiliated with MetLife pet insurance. (you have to sign up for the insurance or it will not go into effect). Adoption fees help cover the medical care of the animals while he or she waits for a new home, as well as food and transportation costs. These fees help to provide care for the other animals in the shelter or rescue group who may have medical bills that are much higher than any possible adoption fee. The money also acts as a donation to help support the organization as a whole, allowing the group to continue its efforts to rescue and rehome pets. The dogs in our care are fostered in Colorado, Texas, and New Mexico. While all dogs are picked up during our scheduled times, sometimes transport dates change due to unforeseen circumstances. More questions? Read our FAQs here: https://4p4l.org/faqs/ Breed labels are a "best guess" by a shelter veterinarian and cannot be guaranteed. ##2678173##

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Snookie

Mastiff/Mixed Breed (Large)

Female, 2 yrs 2 mos

Cedaredge, CO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

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Shira

Mastiff

Female, Young

Greeley, CO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs,

Story

Shira, Mastiff mix, 2 yrs. 89 lbs. Shira is a great dog and seems very calm. She is good with dogs. Shira was surrendered due to owner moving and can’t have a dog. Courtesy listing. Call Cindy 970-353-1385

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Shamrock

Mastiff

Male, 3 mos

Cortez, CO

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Story

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Nelson (JA26-144)

Mastiff

Male, 9 yrs 1 mo

Peyton, CO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

~Nelson's adoption fee has been waived thanks to a generous donation.~ Nelson is a 9-year-old, 96 lb mastiff with a sweet and affectionate personality. He loves being part of the action but, due to his age, sometimes struggles to keep up. Nelson is highly food motivated and once he sets his mind on something, he is determined—whether it’s a treat, a toy, or a game. He adores his toys and walks well on a leash, though he has some mobility issues due to Spondylosis and will need a home willing to cater to his needs and manage his pain as needed for the rest of his life. Nelson also loves to relax in bed or soak up the sunshine. He gets along with dogs of all sizes, but very high-energy pups can be a bit much for him. He would thrive in a home with calm, gentle canine companions who will play with him at his own pace. If you’re looking for a loyal, loving, and gentle giant who enjoys toys, treats, relaxation, and companionship, Nelson could be the perfect addition to your family. A meet and greet at the shelter is required to ensure a great fit with both people and pets. ------ Before being rescued, many of our dogs had limited socialization, so they may need some time to adjust to life as a family pet. Older kids are often a great fit for our dogs, and homes with younger children will be considered based on each dog’s individual needs. Skills like house training and leash walking may take a little extra patience and practice. However, with understanding and a gentle hand, most of these dogs adapt quite quickly. Being a part of their rehabilitation is a truly rewarding experience. To learn more about mill dogs and start the adoption process, visit our website!

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Below are our newest added Mastiffs available for adoption in Colorado. To see more adoptable Mastiffs in Colorado, use the search tool below to enter specific criteria!

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Mastiff puppies and dogs in Colorado

Jump to:

Adopt a Mastiff near you in Colorado

Below are our newest added Mastiffs available for adoption in Colorado. To see more adoptable Mastiffs in Colorado, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Colorado cities

Mastiff shelters & rescues in Colorado

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics