Mastiff Adoption in Colorado: Mastiff Puppies for Sale in Colorado

Adopt a Mastiff near you in Colorado

Below are our newest added Mastiffs available for adoption in Colorado. To see more adoptable Mastiffs in Colorado, use the search tool below to enter specific criteria!

RAY

Mastiff

Male, Senior

Denver, CO

Size

(when grown) -

Details

Story

Who loves belly rubs and a robust walk and will sit for treats and likes to hand out kisses? It's Ray! Ray is more than okay, he's wonderful, and he is eager to spend plenty of time with you and go out for walks--he can be enthusiastic and strong when he walks, so be prepared! He'd also love for you to bring in any dogs to meet him and is looking forward to meeting you soon!December 22, 2025, 7:47 pm

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Luna

Mastiff/Rottweiler

Female, Adult

Golden, CO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Story

Luna is a big dog who loves the snow! She will enjoy a gentle transition where she can take life one step at a time and not be expected to be a social butterfly right off the bat. If considered for a multi-dog household, we will require a meet at the shelter prior to departure, and at this time, she will only be rehomed to a family without children or with kids at least 10 years of age. Primary Color: Fawn Weight: 92.4 Age: 5yrs 0mths 3wks

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Abby

Mastiff/Labrador Retriever

Female, 8 mos

loglane village, CO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, House-trained,

Story

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Effie

Mastiff

Female, Young

Denver, CO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats, House-trained,

Story

Meet Effie, 1 year and 2 month old Mastiff mix who has a healthy appreciation for both naps and play time! She is a bit timid at first, but warms up very quickly. Effie is still young, so she is fairly quick to train and to learn new things. Effie is an amazing, kind dog - She is good with cats, dogs, and kids. After adopting Effie from the Humane Society, we discovered our senior cat was having an allergic reaction to her that worsened his pre-existing medical condition. For the sake of our cat’s health, we have made the difficult decision to find a new home for Effie. Effie thrives in a home with someone who can snuggle, play, and spend quality time with her.

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Stimpy

Mastiff/Catahoula Leopard Dog

Female 6 mos

Littleton, CO

Size

(when grown) -

Details

Good with kids, Good with dogs,

Story

Meet Stimpy, the perfect family dog Stimpy is a 6-month-old Mastiff/Catahoula Leopard Dog mix with the softest heart and sweetest soul. He’s truly not a fearful pup — while he was a bit hesitant about leaving the house or getting into the car at first, he now walks right out and hops in with no problem. He’s been enjoying off-leash trails, meeting other dogs and people, and he’s friendly with everyone. He loves social time and is clearly comfortable exploring new environments. At home, his playful personality really shines — including his signature move: a full-send “Superman jump” off the couch that never fails to make his people laugh (even if we never quite catch it on camera!). Stimpy is gentle and especially tender with kids, melting into cuddles the moment he feels safe. Overall, he’s a sweet, loving, and friendly pup who is still learning appropriate play manners. He’s hopeful, curious, and ready to bring joy, laughter, and cuddles to his forever family If you’re looking for a loving, gentle, big-dog puppy with a heart of gold, Stimpy is your guy. Apply online at www.lolasrescue.com/available-animals please note if you utilize an Iphone there are two scroll bars on the side of the screen to scroll down through available animals. You can email Info@lolasrescue.com anytime with questions pertaining to animals in our care. ##2593147##

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Maggie

Mastiff/American Bulldog

Female, Adult

Golden, CO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

If you've been searching for a dog who will make you smile every single day, say hello to Maggie! This bright-eyed, tail-wagging sweetheart is the perfect mix of playful energy and loving companionship.Maggie is an active, joyful, and endlessly curious pup who's always ready for fun. Whether it's a game of fetch, playing with other dogs, or exploring a new trail, she's happiest when she's moving and sharing life's adventures with her favorite humans. Primary Color: White Secondary Color: Black Weight: 71.6 Age: 4yrs 3mths 1wks

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Mastiff puppies and dogs in Colorado

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Below are our newest added Mastiffs available for adoption in Colorado. To see more adoptable Mastiffs in Colorado, use the search tool below to enter specific criteria!

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Mastiff puppies and dogs in Colorado

Jump to:

Adopt a Mastiff near you in Colorado

Below are our newest added Mastiffs available for adoption in Colorado. To see more adoptable Mastiffs in Colorado, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Colorado cities

Mastiff shelters & rescues in Colorado

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics