Mastiff Adoption in Colorado: Mastiff Puppies for Sale in Colorado

Adopt a Mastiff near you in Colorado

Below are our newest added Mastiffs available for adoption in Colorado. To see more adoptable Mastiffs in Colorado, use the search tool below to enter specific criteria!

ZEUS

Mastiff

Male, 10 mos

Loveland, CO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Hello! My name is Zeus and I am a sweet energetic pup looking for a home. I will still need some help with leash and potty training but I know basic commands like sit and stop. I can be rambunctious when meeting other dogs so I will need to meet any dogs in the home at the shelter to ensure we are a good fit! I would love to meet you!

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Harley

Mastiff

Male, 2 yrs

Fort Collins, CO

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Story

Big heart, strong stride, and sweetness all the way through — this handsome boy is ready to find his place in the world. He’s a gentle soul who loves other dogs and greets people with warmth and happy energy. The kind of companion who leans in for affection and looks at you like you’re the best part of his day. On leash, his excitement sometimes takes the wheel, and he pulls hard — not out of stubbornness, just pure eagerness to explore everything life has to offer. With a little guidance and consistency, this very good boy is sure to blossom into a wonderful walking partner. If you’re looking for a loyal friend with a big heart, dog-friendly charm, and love to give in abundance, he’s ready to step forward and walk right into your life. 🐾

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Kenai

Mastiff

Male, 4 yrs 7 mos

Boulder, CO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Story

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Duke

Mastiff

Male, 1 yr

Pueblo, CO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

🐾 Meet Mamaduke “Duke” 🐾 Duke’s story is one of resilience, love, and second chances. 💔➡️❤️ At just 6 weeks old, Duke and his two siblings were found tied to a pole—in 10-degree weather—while their mama was tied to another, unable to reach them to feed or comfort them. Despite such a heartbreaking and cruel start to life, Duke has grown into a strong, loving, and loyal boy who is ready to find his forever home. Now 1 year old, Duke is a Mastiff mix with a big heart to match his size. He loves going for walks and enjoys being active, but he also has a gentle, affectionate side that shines once he feels safe. Duke does have a minor eye condition where his eyes may occasionally roll back. He can see, but his peripheral vision is limited, so he sometimes needs a little extra patience and understanding while navigating new environments. Because of this, Duke would do best with someone who is calm, kind, and willing to give him the time he needs to build trust. 🐕 Dog-Friendly: Yes, with slow introductions 💪 Strong Walker: Will benefit from continued leash training ❤️ Personality: Loyal, loving, resilient Duke was adopted as a young puppy, but sadly his owner recently passed away, and he has found himself back with us through no fault of his own. This sweet boy has already experienced loss twice in his short life—he deserves a home that will be forever. ✨ Ideal Home: Patient and understanding adopter Someone comfortable with a large, strong dog A calm environment where he can feel secure Duke isn’t just looking for a home… he’s looking for his person. Someone who will see past his imperfections and recognize the incredible, loving companion he truly is. 💛 If you’re looking for a loyal best friend with a powerful story and an even bigger heart, Duke is your guy.

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Fang

Mastiff/Shepherd (Unknown Type)

Male, Adult

Parker, CO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with cats, House-trained,

Story

Meet Fang, a Mastiff mix with a heart of gold and the most intuitive soul you’ll ever encounter. Fang is the ultimate "gentle giant" who has reached his glory days and is looking for a couch to call his own. Fang is incredibly smart and acts as a loyal alert dog for the home. He is trained off and on lease and is naturally defensive of women. While he sounds intimidating to a stranger, he’s actually a total "scaredy-cat" who just wants to feel safe and loved. He surprisingly loves cats and enjoys a good game of tug-of-war. As he’s gotten older, his back legs get tired a bit faster, so he prefers short, leisurely strolls over long hikes. He’s a professional lounger who will happily nap on the sofa all day. He has been lovingly spoiled! His favorites include chicken and any kind of cheese. We’ve recently welcomed a new baby into our family, and we’ve realized we can no longer give Fang the focused attention and environment he deserves.

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Zeus

Mastiff/Rottweiler

Male, Young

Golden, CO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Story

Meet Zeus! This big, playful boy might need a little time to warm up, but once he does, his goofy personality really shines. Zeus is a total ham who loves to show off his silly side and keep his people smiling. He's looking for a patient home that will give him the chance to settle in and feel comfortable. Once he opens up, he's all about fun, attention, and making you laugh. Zeus will only be rehomed to a family without children or with kids at least 10 years of age, and if considered for a multi-animal home, family must be skilled in managing food resources to mitigate guarding behavior between household dogs. Primary Color: Red Brown Secondary Color: White Weight: 96.125 Age: 1yrs 3mths 2wks

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Mastiff puppies and dogs in Colorado

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Below are our newest added Mastiffs available for adoption in Colorado. To see more adoptable Mastiffs in Colorado, use the search tool below to enter specific criteria!

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Mastiff puppies and dogs in Colorado

Jump to:

Adopt a Mastiff near you in Colorado

Below are our newest added Mastiffs available for adoption in Colorado. To see more adoptable Mastiffs in Colorado, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Colorado cities

Mastiff shelters & rescues in Colorado

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics