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Mastiff puppies and dogs in Centennial, Colorado

Looking for a Mastiff puppy or dog in Centennial, Colorado? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near Centennial, Colorado Other pups in Centennial, Colorado Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in Centennial, Colorado Mastiff shelters and rescues in Centennial, Colorado Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Centennial, Colorado

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Centennial, Colorado

These Mastiffs are available for adoption close to Centennial, Colorado.
We'll also keep you updated on HUDSON's adoption status with email updates.
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HUDSON

Mastiff

Male, Adult
Denver, CO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Spayed or Neutered,
Story
February 22, 2026, 5:17 pm

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We'll also keep you updated on NANI's adoption status with email updates.
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NANI

Mastiff

Female, Young
Denver, CO
Size
(when grown) -
Details
Spayed or Neutered,
Story
What a gorgeous sweetheart! Nani is so great! She's very sweet, gentle, friendly, fun and playful, and she has a calm, thoughtful personality. She's all about pets, cuddles, tummy rubs, and leisurely, luxurious walks with lots of sniffing on Nani-time! She just really enjoys being outdoors -- taking in all the sights, smells, and sounds, and stopping to smell the roses. Nani also loves treats and recently dried lamb and tripe was a hit. But most of all, she loves you and being your loving companion. Nani is housetrained and while she may be shy when meeting some men for the first time, she opens her heart when she knows you're a trusted friend. Only because of her size, kids age 10+ and no cats are best in a home with no shared walls. Nani is really an incredible, special girl, come fall in love!February 21, 2026, 9:39 pm

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We'll also keep you updated on Tenille's adoption status with email updates.
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Tenille

Mastiff

Female, 4 yrs 7 mos
Aurora, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
-
Story
-

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We'll also keep you updated on Sabrina's adoption status with email updates.
Special Needs
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Sabrina

Mastiff American Bulldog

Female, 7 yrs 4 mos
Boulder, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Needs special attention, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Sabrina, a gentle 6-year-old Mastiff mix who’s in need of a special forever home. Sabrina is living with mast cell tumors (MCT) due to cancer and is currently on medication to keep her as comfortable as possible. She requires a loving home that is prepared to offer her hospice care and a peaceful environment. Sabrina can be shy with new people and may give a warning growl or snap if approached when she’s not ready. However, once she builds trust, she becomes deeply affectionate and very attached to her people. She gets along well with mellow dogs and will thrive in a calm household where she can feel safe and loved. If you have a compassionate heart and are ready to provide a supportive and caring home for a special dog like Sabrina, you’ll find a loyal and loving companion in her.

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We'll also keep you updated on SCOOBY-DOO's adoption status with email updates.
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SCOOBY-DOO

Mastiff Husky

Male, Young
Federal Heights, CO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Not good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Hello my Name is Scooby-Doo I'm 2 Yrs Old I'm a Great and Very Loving Dog, However I'm a litte Hard Headed And Sometimes Times Stubborn. I'm Very Playfully, I Frequently Go to the Westminster Open Space Dog Park near Stanley Lake, I run and play with all the other Dogs making Friends and having a Wonderful time, Never Showing any Aggression towards the other Dogs or the other people there, I'm Well Tempted. My Eyes are Ghost Blue, I get that From My Husky Father and My Mother is Mastiff. I'm looking For Great new Home with tons of Love, And a Big Back yard to run And Play, All my Vaccination Are Current Threw The Spur Clinic, I Am Also Fixed and House Trained. PLEASE Consider Being My New Family and Home , Thank you

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We'll also keep you updated on Bella's adoption status with email updates.
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Bella

Mastiff

Female, Adult
Colorado Springs, CO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Rehoming the sweetest English Mastiff. We have had her since she was 8 weeks old, but will be traveling in the near future, unfortunately. Some "musts"- must have a back yard for her. She is not an outdoors dog, so an "average" size doggy door that she can come in and out of is also a must. Trained in all basic commands, potty trained, loves people, has never been aggressive towards people or other dogs, does not "food guard". Shes has been around children of all ages and is very gentle. She is a GREAT guard dog, will bark if something is amiss. She is lazy, making her an easy keeper. Must have love from family. In good health, has only ever had an ear infection. She is a gentle giant and will be very devoted to you. Rehoming fee of $50 to the right person. Note- you will want to have her groomed every 3 months or so. If you have a higher vehicle (SUV) you will need to be able to lift her back-side into it, must be able to lift 50 pounds of said back-side.

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Centennial, Colorado.

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Mastiff puppies and dogs in nearby cities

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Related breeds in Centennial, Colorado

Bullmastiffs in Centennial, Colorado Neapolitan Mastiffs in Centennial, Colorado Saint Bernards in Centennial, Colorado

Mastiff shelters & rescues in Centennial, Colorado

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Centennial, Colorado. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

6.7 miles

Humane Colorado

2080 S Quebec St, Denver, CO 80231

Pet Types: cats, dogs, horses, rabbits, small animals

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Rescue

8.9 miles

Big Dogs Huge Paws, Inc

PO Box 460699, Aurora, CO 80046

Pet Types: dogs

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Rescue

9.3 miles

Ace of Hearts Dog Rescue - CO Transport Stop

711 Walnut St, Boulder, CO 80203

Pet Types: dogs

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Rescue

44.4 miles

Mile High Canine Rescue, Inc.

Mead, CO 80542

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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