Mastiff Adoption in Wayne, MI: Mastiff Puppies for Sale in Wayne, MI

Adopt a Mastiff near you in Wayne, Michigan

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Wayne, Michigan

These Mastiffs are available for adoption close to Wayne, Michigan.

Bones

Mastiff

Female, 4 yrs

Taylor, MI

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with dogs, Good with cats, House-trained, Shots are up-to-date,

Story

Bones is a big girl with an even bigger heart. Weighing in at around 130 pounds, she may not realize her size—once she trusts you, she’ll happily climb into your lap or wrap you up in a big hug, showering you with sweet chin kisses.She can be shy at first and takes a little time to warm up, but once she does, her affectionate and loyal nature truly shines. Bones is housebroken and well-mannered in the home. She does well around cats, often choosing to ignore them, but she would do best as the only dog so she can soak up all the love and attention she deserves.Loud noises and thunderstorms can be scary for her, so she’ll need a patient, understanding home where she feels safe and secure.Bones is being rehomed through no fault of her own after the passing of her owner. She’s ready to find a loving family who will give her the comfort, stability, and affection she cravesFOCCAS is a foster based, non-profit rescue in Crossville, TN. The adoption fee Includes Age-Appropriate Vaccinations (DA2PPV, Bordetella, Rabies), Deworming, Spay/Neuter, Microchip, Flea/Tick/Heartworm Prevention, and Sheltering. Adult Dogs are Heartworm Tested and Treated as Needed. FOCCAS does not DNA test or guarantee breed. If transport is needed, there are additional fees to cover department of agriculture requirements and transport, the additional fee adds $300 to the adoption fee (any location out of Tennessee, East Coast, Great Lakes or New England regions)Thank You for Your Interest in Adopting a Canine Companion from Foccas-tn.org!To Apply Please Copy and Paste to your browser:https://service.sheltermanager.com/asmservice?account=hb2428&method=online_form_html&formid=41LOCATED IN CROSSVILLE, CUMBERLAND COUNTY, TN. WE CAN TRANSPORT OUT OF STATE, Visit out website for a full list of adoptable pets… https://foccas-tn.org/

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Bubs

Mastiff

Male, Puppy

Belleville, MI

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

You can fill out an adoption application online on our official website.Meet Bubs Born on January 21, 2026, Bubs is an adorable mastiff mix puppy with a whole lot of growing (and cuddling) ahead of him. With his cute black mask and big, clumsy paws, he may have some Cane Corso or Bullmastiff in the mix—but right now, he’s all puppy energy and sweetness. Bubs is incredibly affectionate and loves being close to his people. He’s the kind of pup who will happily follow you around, flop over for belly rubs, and then bounce right back up for playtime. Curious and gentle, he’s still figuring out the world one sniff (and probably one chew) at a time. Like any young pup, he’s learning his manners and building confidence every day. With a little guidance and a lot of love, Bubs is going to grow into a wonderful, loyal companion. For now, he’s just a big baby with a soft heart and an even softer spot for cuddles.Visit this organization's web site to see any additional information available about this pet.April 28, 2026, 8:18 pm

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Hetti

Mastiff Boxer

Female, Adult

Livonia, MI

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

You can fill out an adoption application online on our official website.If interested in any of our animals for adoption, or to foster an animal, please fill out the respective application here to get the process started. Visit our FAQ webpage for commonly asked questions about our adoption/foster process. Meet the magnificent Miss Hetti. She is a playful, energy abundant Mastiff, and likely, boxer mix. She loves tummy rubs, fetch, and Benebone chew toys. Hetti thrives on multiple walks per day however can over heat quickly in higher temps. She is very strong and still learning manners with passing animals so an experienced handler and dog owner is a must. She loves greeting people but due to her size and still puppy behaviors, a house with kids over 12 is preferred. For Hetti to live her best life she should be a solo canine with a large fenced yard and an active owner willing to give her the exercise and attention she needs. Visit this organization's web site to see any additional information available about this pet.Last Day Dog Rescue now microchips all animals before adoption. Microchips are implanted between the animals shoulder blades and are a permanent form of identification. If the animal is ever lost and slips his/her collar/tags the microchip allows the finder to know who to contact if scanned for a microchip. Animals MUST still have a collar with tags on at all times. Per our contract, we take all our animals back if for any reason you can't keep your adopted animal. Please understand the statements about this animal are based upon the foster home's evaluation of the animal. The animal might behave differently (negatively or positively) in your home. While the animal might be good with the current foster’s dogs, cats, children, etc., it may not be with your animal(s) or children. The animal may be housebroken or litter trained in the home of the foster but may relapse in your home. The animal is represented to the public as it performs in the foster home and any statements made regarding the animal are conditional to that foster home setting. Please understand that statements made regarding this animal are simply overviews and are not guaranteed. The Petfinder.com system requires that we choose a predominant breed or breed mix for our animals. Visual breed identification in animals is unreliable so for most of the animals we are only guessing at predominant breed or breed mix. We get to know each animal as an individual and will do our best to describe each of our animals based on personality, not by breed label. Thank you for looking through our list of animals needing forever homes and choosing rescue first. We appreciate you stopping by. March 7, 2026, 8:41 am

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Maisy

Mastiff

Female, 5 yrs 11 mos

Belleville, MI

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with dogs, Spayed or Neutered, Shots are up-to-date,

Story

Meet Maisy! Maisy is a 5-year-old Mastiff mix with a heart as big as her paws! She came to us as a stray from Sumpter, severely underweight and clearly having been through a lot. But oh, how far she's come! With time, love, and plenty of good meals, Maisy has transformed into a healthy, happy pup who's ready for her forever home. Despite her tough start, Maisy's outlook on life is nothing short of amazing. She's always wiggly with excitement to see people and has never met a stranger-she's as friendly and affectionate as they come. Her favorite things? Stuffy toys (even if they only last a few minutes), snacks (she's very food motivated), and simply hanging out with her humans. Maisy is still learning the ropes of home life, including potty training and basic manners, but her eagerness to please and strong bond with her people make her a great student. She's mellow by nature and prefers relaxed exploration in the yard over high-energy activities. While she hasn't quite figured out how to "play" just yet, we can tell she's curious and interested-and with time, she might just become a pro! She's currently unsure around other dogs but has done fine in calm playgroups, mostly keeping to herself. If you already have a dog at home, we're still happy to consider a meet-and-greet to see how they might get along. As for cats-we're not sure yet. Maisy would do best in a moderately active home, possibly with older kids and maybe a laid-back dog sibling. Most importantly, she needs a patient and loving family who can help her continue her journey from survivor to spoiled companion. If you're looking for a sweet, soulful, easygoing girl to share your heart and home with-Maisy might just be your perfect match. ---------------------------------------------------------------------------------------------------------------------------------- If you would like to meet Maisy, please submit an application for her on our website https://www.friendsofmichigan.org/adoptable-dogs. She is spayed, up to date on all age appropriate vaccines, microchipped, and on monthly flea & tick prevention. Maisy is currently heartworm positive, and has begun her treatment as of 5/8/25. FMAR covers the full cost of heartworm treatment and works with Home Care Veterinary Services for the treatment. You're still encouraged to apply to adopt Maisy! We'll work closely with you to ensure her treatment continues smoothly and she gets everything she needs to thrive in her new home. Her treatment after adoption would continue through HCVS until successfully completed. Her adoption fee is $250, which helps cover the cost of the medical care she has received. **Please note that the breed listed for each of our dogs is a rough estimate unless DNA results are provided in their Bio. All strays have rough estimates of their age based on the condition of their teeth. Each dog is different, so each adoption is different. Our adoption process might require multiple visits to the shelter before our dogs can go home. Or they may be ready on the first visit. It really depends on the individual dog and the potential adopters. Once we receive your application, the Dog Staff will contact you to discuss meeting our dogs.

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Murphy

Mastiff

Male, Puppy

Northville, MI

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

House-trained, Shots are up-to-date,

Story

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Tassels

Mastiff American Staffordshire Terrier

Female, Young

Detroit, MI

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Meet Tassels: A Gentle Giant with a Heart of Gold Introducing Tassels, also lovingly called Mumma by her fosters, a majestic 1.5-year-old Mastiff/Mountain Cur mix whose journey to happiness is truly inspiring. Rescued from a life of uncertainty while extremely pregnant and terrified, Tassels has shown incredible resilience. She was elusive for over a year, only seen on a Ring camera in the Detroit neighborhood she roamed, until we finally secured her safety. Since then, she has blossomed in foster care, watching her babies find their forever homes. Now, it's her turn! Why Tassels is Special: Loving and Affectionate: Tassels expresses her love by placing her massive head in your lap or under your hand for scratches. Her affectionate nature makes her a wonderful companion. Well-Trained and Mannered: She knows basic commands, is potty trained, crate trained, and walks beautifully on a leash. Playful and Joyful: Despite her size, Tassels is playful and enjoys the simple pleasures of cuddling, playing with toys, and lounging in the grass on sunny days. Her zoomies are a sight to behold and bring laughter and joy to everyone around her. Curious and Easygoing: Over the months, Tassels has overcome her initial shyness and now approaches life with curiosity and ease. She’s come to enjoy her interactions with people and her foster sibling. Tassels’ Ideal Home: Tassels would thrive in a home without cats or small dogs. She can live with another dog, but a proper, slow introduction is necessary to ensure a harmonious relationship. Her ideal family will be one that can provide stability, plenty of space for her to stretch her legs, and lots of love. She responds wonderfully to food, affection, and praise, making her a delightful and grateful companion. Is Tassels the Missing Piece in Your Family? If you’re looking for a loyal, loving, and serene companion to add warmth and joy to your home, consider welcoming Tassels into your life. She promises to fill your days with affection and happiness. Ready to adopt Tassels? Apply today! Visit our website to fill out an adoption application and learn more about how you can bring Tassels home! Adoption is $275, which includes spay/neuter at our vet, vaccines, dewormer, microchip, and clean bill of health. Although we work to potty train all of our dogs, we cannot guarantee full house training before adoption. Regression is a normal part of transitioning to a new home and we want our adopters to be prepared for that! APPLY on our WEBSITE: rebeldogsdetroit.com/applytoadopt

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Mastiff puppies and dogs in Wayne, Michigan

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Adopt a Mastiff near you in Wayne, Michigan

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Wayne, Michigan

These Mastiffs are available for adoption close to Wayne, Michigan.

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in Wayne, Michigan

Mastiff shelters & rescues in Wayne, Michigan

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics