Mastiff Adoption in Minnesota: Mastiff Puppies for Sale in Minnesota

Adopt a Mastiff near you in Minnesota

Below are our newest added Mastiffs available for adoption in Minnesota. To see more adoptable Mastiffs in Minnesota, use the search tool below to enter specific criteria!

Hazel

Mastiff/American Pit Bull Terrier

Female, 2 yrs

Park Rapids, MN

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

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Helen

Mastiff

Female, 6 yrs 5 mos

Rochester, MN

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

6-18-26: Great Update on Helen, from one of our staff members!! New pictures included from her home visit…. Our awesome Kari took Helen for a day trip away from the shelter, here is what she had to say:Helen is such a sweet and fun girl. She did great in the car and loved walks and just being outside in the fresh air. She would walk well on a leash when there were no distractions, but would pull pretty hard when she saw squirrels/bunnies or other dogs. She was more active than I thought she would be, wanting to stay outside sniffing around. Helen is a gentle giant, she was down and depressed for the longest time upon arrival and has been here for over two months and is starting to come into her own and show her true colors.04/10/26: Check out Helen!This chunky girl came to PCHS when she wandered onto a property where she did not belong just outside of Spring Valley. The property owners held onto her for a few days while having her scanned for a microchip and looking for her owners. They were unable to find out who she belonged to, so she came to us. We then kept her through her stray hold and we also could not locate her owners. So now, sweet Helen is looking for a new home to call her own. Helen is estimated to be some sort of mastiff mix and is thought to be around 6 years old. She is a bit on the `thick` side, and the vet recommended she loose 10-12 pounds. She currently weighs 109 pounds but a more ideal weight for her would be just under 100. She is a quiet girl who is looking for a home where she can lounge with her people, bask in the morning sun, and go for leisurely walks. She did not get along with the finders female dog. She may do okay with a submissive male dog, but we would want to do a meet and greet to be sure. It is unknown how she would be with cats or kids. If you think she could be a good match for yo, apply online today!Adoption fee is $350 + $30 microchip fee + tax

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Annalisa

Mastiff/American Staffordshire Terrier

Female, Puppy

Minneapolis, MN

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs,

Story

You can fill out an adoption application online on our official website.Annalisa and her siblings, Boone Booze and Emberlee, found themselves in a high kill shelter in West Texas. They are good with other dogs and people, and cats are unknown. (Weight listed was taken 8/06) All dogs and puppies require supervision and training to be successful.She will be arriving in MN at the end of October if she has a foster or foster to adopt home to come here to. First priority will go to someone who lives in the twin cities metro in order to bring to a vetting appointment. Please put in your application on our website mattysheartandsoulanimalrescue.rescuegroups.org. Visit this organization's web site to see any additional information available about this pet.September 17, 2026, 9:25 pm

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Emberlee

Mastiff/American Staffordshire Terrier

Female, Puppy

Minneapolis, MN

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs,

Story

You can fill out an adoption application online on our official website.Emberlee and her siblings, AnnaLisa and Boone Booze, found themselves in a high kill shelter in West Texas. They are good with other dogs and people, and cats are unknown. Weight listed was taken 8/06) All dogs and puppies require supervision and training to be successful. She will be arriving in MN at the end of October if she has a foster or foster to adopt home to come here to. First priority will go to someone who lives in the twin cities metro in order to bring to a vetting appointment. Please put in your application on our website mattysheartandsoulanimalrescue.rescuegroups.org. Visit this organization's web site to see any additional information available about this pet.September 17, 2026, 9:25 pm

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Boone Booze

Mastiff/American Staffordshire Terrier

Male, Puppy

Minneapolis, MN

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs,

Story

You can fill out an adoption application online on our official website.Boone Booze and his siblings, AnnaLisa and Emberlee, found themselves in a high kill shelter in West Texas. They are good with other dogs and people, and cats are unknown. Weight was taken 8/06. All dogs and puppies require supervision and training to be successful.He will be arriving in MN at the end of October if he has a foster or foster to adopt home to come here to. First priority will go to someone who lives in the twin cities metro in order to bring to a vetting appointment. Please put in your application on our website mattysheartandsoulanimalrescue.rescuegroups.org. Visit this organization's web site to see any additional information available about this pet.September 17, 2026, 9:25 pm

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Diego JuM

Mastiff/Mixed Breed (Large)

Male, 2 yrs 1 mo

Richfield, MN

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs,

Story

I'm Diego, a striking 2-year-old chocolate and blond brindle Mastiff mix, and I've got the heart of an adventurer! 🐕 At 63 pounds of pure energy and loyalty, I'm already neutered and crate trained—ready to be your partner in crime. I thrive with active owners who can match my enthusiasm, and I'm fantastic with other dogs, so playdates are always a go! If you're looking for a friendly, energetic companion who'll stick by your side through thick and thin, come meet me today. 💪❤️ Local adoption fee is $300 (in TX) Out of state adoption fee is $550 (includes transport to your area)

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Mastiff puppies and dogs in Minnesota

Jump to:

Adopt a Mastiff near you in Minnesota

Below are our newest added Mastiffs available for adoption in Minnesota. To see more adoptable Mastiffs in Minnesota, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Minnesota cities

Mastiff shelters & rescues in Minnesota

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics