Great Dane Adoption in Frederick, MD: Great Dane Puppies for Sale in Frederick, MD

Adopt a Great Dane near you in Frederick, Maryland

These Great Danes are available in Frederick, Maryland.

Skye

Great Dane Mixed Breed (Large)

Female, 3 yrs

Frederick, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, Spayed or Neutered,

Story

Current Location: Rockville, MD Hello! My name is Skye! I'm coming to OPH on 1/9/2026. Please check back soon for updates on my personality, and to see adorable new photos. I’m looking for my forever family! Is that with you? If so please click “apply for adoption” or submit an application through the Adopt tab. Let’s get our family started!

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Christopher *Adoption Pending*

Great Dane Mixed Breed (Large)

Male, 4 mos

Frederick, MD

Size

(when grown) Small 25 lbs (11 kg) or less

Details

Story

Current Location: Seven Valleys, PA Meet Christopher: A Gentle Giant Looking for Love Christopher is a lovable Great Dane mix with stunning coloring and the most endearing floppy forward ears that give him serious personality. This big, clumsy goofball is equal parts snuggle bug and Velcro pup who wants nothing more than to be glued to his favorite person's side. If you're looking for a couch companion who will lounge with you for hours, Christopher is your guy. Despite his impressive size, Christopher is a total sweetheart with a gentle soul. He gets along beautifully with other dogs and cats, showing zero aggression toward anyone. He's smart and food motivated, already knows "sit," and is eager to learn more. Christopher does have some areas where he needs patient guidance. He's currently working on crate training and house training, so his ideal adopter will be committed to continuing this progress with consistency and positive reinforcement. This big boy has so much love to give and just needs someone willing to meet him where he is and help him grow. If you have the space in your home and heart for a devoted companion who will follow you everywhere and reward your patience with endless affection, Christopher might be your perfect match.

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Broadway

Great Dane Border Collie

Male, 11 mos

Frederick, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Spayed or Neutered, Shots are up-to-date,

Story

Broadway- Great Dane/Border Collie X male puppy, ~ 9 mo (Nov. 2025) Contact rescuebc@hotmail.com for an application. Broadway was rescued from a high kill rural shelter in a mountain area. He had been found as a stay in their small community. This beautiful big male is a player, doing great in the new foster home, with lots of new dog friends of all ages. He will enjoy an active lifestyle and needs a new family/owner who understands his breeding and energy level. Broadway's adoption fee is $350 to help cover the medical costs of getting ready for adoption. For our application, please email rescuebc@hotmail.com Include your location and a phone number for future communication.

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Or, how about these Great Danes in cities near Frederick, Maryland

These Great Danes are available for adoption close to Frederick, Maryland.

Skye

Great Dane Mixed Breed (Large)

Female, 3 yrs

Frederick, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, Spayed or Neutered,

Story

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Christopher *Adoption Pending*

Great Dane Mixed Breed (Large)

Male, 4 mos

Frederick, MD

Size

(when grown) Small 25 lbs (11 kg) or less

Details

Story

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Broadway

Great Dane Border Collie

Male, 11 mos

Frederick, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Spayed or Neutered, Shots are up-to-date,

Story

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Dolly

Great Dane Labrador Retriever

Female, Adult

Westminster, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

You can fill out an adoption application online on our official website.All of the animals posted on our site have been temperament tested. While not all are in the immediate area, once we have processed and approved your application, we will move the dog to our adoptive area for you to meet, greet and hopefully adopt. Sometimes we will have more than one application on a dog. That does not mean it automatically goes to another family but you should be aware of the fact that until you are approved and set up for the meet/greet.. the dog could get adopted by another applicant.Dolly has large Great Dane genes grafted onto a somewhat smaller body. Not that anyone would ever call her small, but you would say she's a manageable size, which is perfect. If you love the Dane look, but aren't sure you could handle a full size model, we have Dolly waiting for you. She is currently only 60 lbs., but that is a bit deceiving, as she is very underweight. We would like to see at least 15 lbs. more on her ribs and we are working on it. She is now getting top quality groceries, something she has never had before. Still a young dog, at only about 2 years old, she is in the process of learning about how to deal with the world around her and she is learning fast. Her foster has some comments to help you understand this 'dog-in-progress. 'She’s nervous around new people and things. She does warm up after a bit. Her initial reaction to people that she doesn’t know is to low growl. She is trying to tell everyone to give her a moment to process the new information. I don’t recommend a house with cats or small animals. She’ tries to chase down all the birds, and squirrels when we’re outside. I’m fairly confident her life prior to rescue wasn’t a good one. It's heartbreaking seeing a good dog trying to cope with a world she was never shown. UPDATE:I have had her for a month now, and she is learning! I took her to the vet today, and while she was nervous, she did not growl. So there has been improvement on that aspect. She wasn’t super outgoing and wanting everyone’s attention, so definitely stand by the slower to warm up to strangers. I highly suspect she’s been abused. She is highly intelligent and learns new things really fast. She really has the potential to be an excellent dog, and wants to be loved and please her person. MORE UPDATE: Since being here at my house over a month now I have some new insights into her. She is not dog friendly with all dogs. She's OK with my male dog, but not so happy with my female. I've been working on getting her to ignore people on walks and she's doing better. She doesn't like it if strangers get to close when we are out. In the yard. she's definitely going to need at least a 6 foot fence to keep her safely secured. I will say, she is house trained and does let you know when she needs to go out. She also does very well in her kennel. She is very smart, and can learn things pretty quickly. She has all her shots and is ready and waiting for the person or family who like bigger dogs, but aren't ready for an actual Goliath. Dolly is a good girl! She is hoping you will want to help her be a good dog and come for her soon. If you are interested in Dolly, please fill out an application at: https://reachoutrescue.rescuegroups.org/forms/form?formid=4588 Or contact: rorrcanine@gmail.com *** Click here to sponsor this dog! ***Visit this organization's web site to see any additional information available about this pet.December 26, 2025, 11:42 am

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SCOOBY

Great Dane

Male, 7 yrs 5 mos

Hagerstown, MD

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Not good with dogs, Not good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

LOCAL TN ADOPTION ONLY.Video here: https://www.facebook.com/share/v/1ZKqnaG9dD/Mr Scooby His life has been one of text book tragedy in my opinionWe’ve done our best to make his life comfortable in rescue but it is a life inside an intake facility.Five years of teaching him that it isn’t cool the crawl all over a human and try to kiss their face with an open mouth and over sized hugs.His love was so much that it was almost like an aggressive love me situation.Now i have concluded he is and has been reformed.He’s a happy gentleman with that calm Dane state of mind It makes me sad knowing he’s been in rescue for five years He is so loving and so eager to just have a chance at a normal life.If you are looking at a Dane for adoption you already should know how kind and gentle they are.LOCAL ADOPTION ONLY IN TN.The Adoption Fee Includes Age-Appropriate Vaccinations (DA2PPV, Bordetella, Rabies), Deworming, Spay/Neuter, Microchip, Flea, Tick and Heartworm Treatment and Prevention, and Sheltering. Adult Dogs are Heartworm Tested and Treated as Needed.Scooby's adoption fee (picked up locally in Crossville, Tennessee) is $225. He is not available for out of state adoption.Thank You for Your Interest in Adopting a Canine Companion from Foccas-tn.org!To Apply Please Copy and Paste to Your Browser:https://service.sheltermanager.com/asmservice?account=hb2428&method=online_form_html&formid=41LOCATED IN CROSSVILLE, CUMBERLAND COUNTY, TN. WE CAN TRANSPORT OUT OF STATE, Visit out website for a full list of adoptable pets… https://foccas-tn.org/

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MEME

Great Dane Dutch Shepherd

Female, 7 mos

HAGERSTOWN, MD

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with kids, Good with dogs, Good with cats, Spayed or Neutered,

Story

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These pups are in Frederick, Maryland too!

Below are our newest added Great Danes available for adoption in Frederick, Maryland. To see more adoptable Great Danes in Frederick, Maryland, use the search tool below to enter specific criteria!

Mellow

Anatolian Shepherd Mixed Breed (Medium)

Female, 11 mos

Frederick, MD

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

Current Location: Pasadena, MD Hello! My name is Mellow I'm coming to OPH on 01/23. Please check back soon for updates on my personality, and to see adorable new photos. I’m looking for my forever family! Is that with you? If so please click “apply for adoption” or submit an application through the Adopt tab. Let’s get our family started!

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Blackberry

Anatolian Shepherd

Male, 4 mos

Frederick, MD

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with dogs, Spayed or Neutered,

Story

Current Location: Frederick, MD Meet Blackberry: A Loveable Companion Who Just Wants to Be Part of the Pack This curious, silly, utterly loveable boy has one simple wish: to be where his people are. Blackberry is the kind of puppy who will steal your heart with his affectionate nature and his deep desire to be included in every moment of family life. He adores being around adults, children, and other dogs, soaking up all the love and companionship he can get. Blackberry is food motivated and treat enthusiastic (he loves his Hills Science food, mini milk bone biscuits, cheese, and kongs stuffed with peanut butter), which makes training a joy. He's already shown he's a smart cookie who needs and enjoys mental stimulation like working kongs and treat dispenser puzzle balls. He's making progress on potty training with fewer accidents each day, and while he still has his baby teeth and can get nippy and mouthy as puppies do, he's learning what's appropriate to chew on with proper supervision. His energy comes in delightful bursts throughout the day, followed by content naps on his puppy bed near his people. At night, he loves to sleep with company, settling in peacefully when he's not alone. He enjoys different types of toys, from benebones for chewing to plush toys for playing, and he's curious about the yard, though he's still figuring out this whole leash walking thing and can be a bit scared and confused by it. Here's what Blackberry needs you to know: he really does not like to be alone. He will let you know with whines, howls, and his best protests that he wants to be part of the action. He's even shown his determination by breaking out of his crate because being separated from his family just isn't his style. Blackberry would thrive in a home with someone who works from home or is around during the day, ideally with children and other dogs who can be his constant companions. He needs a family who understands that his clinginess isn't a flaw but simply proof of how much love he has to give. If you're looking for a sweet, silly shadow who will follow you everywhere and fill your home with puppy joy, Blackberry is your boy.

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Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in Frederick, Maryland.

Great Dane puppies and dogs in Frederick, Maryland

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Adopt a Great Dane near you in Frederick, Maryland

These Great Danes are available in Frederick, Maryland.

Or, how about these Great Danes in cities near Frederick, Maryland

These Great Danes are available for adoption close to Frederick, Maryland.

These pups are in Frederick, Maryland too!

Below are our newest added Great Danes available for adoption in Frederick, Maryland. To see more adoptable Great Danes in Frederick, Maryland, use the search tool below to enter specific criteria!

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Great Dane puppies and dogs in nearby cities

Related breeds in Frederick, Maryland

Great Dane shelters & rescues in Frederick, Maryland

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Great Dane basics

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Frederick

Great Dane puppies and dogs in Frederick, Maryland

Learn More:

Adopt a Great Dane near you in Frederick, Maryland

These Great Danes are available in Frederick, Maryland.

Or, how about these Great Danes in cities near Frederick, Maryland

These Great Danes are available for adoption close to Frederick, Maryland.

These pups are in Frederick, Maryland too!

Below are our newest added Great Danes available for adoption in Frederick, Maryland. To see more adoptable Great Danes in Frederick, Maryland, use the search tool below to enter specific criteria!

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in nearby cities

Related breeds in Frederick, Maryland

Great Dane shelters & rescues in Frederick, Maryland

Looking for a specific shelter or rescue?

Want to learn more about adopting a Great Dane puppy or dog?

Great Dane basics

Great Dane basics