Great Dane Adoption in Frederick, MD: Great Dane Puppies for Sale in Frederick, MD

Adopt a Great Dane near you in Frederick, Maryland

These Great Danes are available in Frederick, Maryland.

Skye *adoption pending*

Great Dane Mixed Breed (Large)

Female, 3 yrs

Frederick, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, Spayed or Neutered,

Story

Current Location: Rockville, MD Hello! My name is Skye! I'm coming to OPH on 1/9/2026. Please check back soon for updates on my personality, and to see adorable new photos. I’m looking for my forever family! Is that with you? If so please click “apply for adoption” or submit an application through the Adopt tab. Let’s get our family started!

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Christopher

Great Dane Mixed Breed (Large)

Male, 3 mos

Frederick, MD

Size

(when grown) Small 25 lbs (11 kg) or less

Details

Story

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Broadway

Great Dane Border Collie

Male, 10 mos

Frederick, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Spayed or Neutered, Shots are up-to-date,

Story

Broadway- Great Dane/Border Collie X male puppy, ~ 9 mo (Nov. 2025) Contact rescuebc@hotmail.com for an application. Broadway was rescued from a high kill rural shelter in a mountain area. He had been found as a stay in their small community. This beautiful big male is a player, doing great in the new foster home, with lots of new dog friends of all ages. He will enjoy an active lifestyle and needs a new family/owner who understands his breeding and energy level. Broadway's adoption fee is $350 to help cover the medical costs of getting ready for adoption. For our application, please email rescuebc@hotmail.com Include your location and a phone number for future communication.

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Or, how about these Great Danes in cities near Frederick, Maryland

These Great Danes are available for adoption close to Frederick, Maryland.

Skye *adoption pending*

Great Dane Mixed Breed (Large)

Female, 3 yrs

Frederick, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, Spayed or Neutered,

Story

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Christopher

Great Dane Mixed Breed (Large)

Male, 3 mos

Frederick, MD

Size

(when grown) Small 25 lbs (11 kg) or less

Details

Story

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Broadway

Great Dane Border Collie

Male, 10 mos

Frederick, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Spayed or Neutered, Shots are up-to-date,

Story

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Dolly

Great Dane Labrador Retriever

Female, Adult

Westminster, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

You can fill out an adoption application online on our official website.All of the animals posted on our site have been temperament tested. While not all are in the immediate area, once we have processed and approved your application, we will move the dog to our adoptive area for you to meet, greet and hopefully adopt. Sometimes we will have more than one application on a dog. That does not mean it automatically goes to another family but you should be aware of the fact that until you are approved and set up for the meet/greet.. the dog could get adopted by another applicant.Dolly has large Great Dane genes grafted onto a somewhat smaller body. Not that anyone would ever call her small, but you would say she's a manageable size, which is perfect. If you love the Dane look, but aren't sure you could handle a full size model, we have Dolly waiting for you. She is currently only 60 lbs., but that is a bit deceiving, as she is very underweight. We would like to see at least 15 lbs. more on her ribs and we are working on it. She is now getting top quality groceries, something she has never had before. Still a young dog, at only about 2 years old, she is in the process of learning about how to deal with the world around her and she is learning fast. Her foster has some comments to help you understand this 'dog-in-progress. 'She’s nervous around new people and things. She does warm up after a bit. Her initial reaction to people that she doesn’t know is to low growl. She is trying to tell everyone to give her a moment to process the new information. I don’t recommend a house with cats or small animals. She’ tries to chase down all the birds, and squirrels when we’re outside. I’m fairly confident her life prior to rescue wasn’t a good one. It's heartbreaking seeing a good dog trying to cope with a world she was never shown. UPDATE:I have had her for a month now, and she is learning! I took her to the vet today, and while she was nervous, she did not growl. So there has been improvement on that aspect. She wasn’t super outgoing and wanting everyone’s attention, so definitely stand by the slower to warm up to strangers. I highly suspect she’s been abused. She is highly intelligent and learns new things really fast. She really has the potential to be an excellent dog, and wants to be loved and please her person. MORE UPDATE: Since being here at my house over a month now I have some new insights into her. She is not dog friendly with all dogs. She's OK with my male dog, but not so happy with my female. I've been working on getting her to ignore people on walks and she's doing better. She doesn't like it if strangers get to close when we are out. In the yard. she's definitely going to need at least a 6 foot fence to keep her safely secured. I will say, she is house trained and does let you know when she needs to go out. She also does very well in her kennel. She is very smart, and can learn things pretty quickly. She has all her shots and is ready and waiting for the person or family who like bigger dogs, but aren't ready for an actual Goliath. Dolly is a good girl! She is hoping you will want to help her be a good dog and come for her soon. If you are interested in Dolly, please fill out an application at: https://reachoutrescue.rescuegroups.org/forms/form?formid=4588 Or contact: rorrcanine@gmail.com *** Click here to sponsor this dog! ***Visit this organization's web site to see any additional information available about this pet.December 26, 2025, 11:42 am

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SCOOBY

Great Dane

Male, 7 yrs 5 mos

Hagerstown, MD

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Not good with dogs, Not good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

LOCAL TN ADOPTION ONLY.Video here: https://www.facebook.com/share/v/1ZKqnaG9dD/Mr Scooby His life has been one of text book tragedy in my opinionWe’ve done our best to make his life comfortable in rescue but it is a life inside an intake facility.Five years of teaching him that it isn’t cool the crawl all over a human and try to kiss their face with an open mouth and over sized hugs.His love was so much that it was almost like an aggressive love me situation.Now i have concluded he is and has been reformed.He’s a happy gentleman with that calm Dane state of mind It makes me sad knowing he’s been in rescue for five years He is so loving and so eager to just have a chance at a normal life.If you are looking at a Dane for adoption you already should know how kind and gentle they are.LOCAL ADOPTION ONLY IN TN.The Adoption Fee Includes Age-Appropriate Vaccinations (DA2PPV, Bordetella, Rabies), Deworming, Spay/Neuter, Microchip, Flea, Tick and Heartworm Treatment and Prevention, and Sheltering. Adult Dogs are Heartworm Tested and Treated as Needed.Scooby's adoption fee (picked up locally in Crossville, Tennessee) is $225. He is not available for out of state adoption.Thank You for Your Interest in Adopting a Canine Companion from Foccas-tn.org!To Apply Please Copy and Paste to Your Browser:https://service.sheltermanager.com/asmservice?account=hb2428&method=online_form_html&formid=41LOCATED IN CROSSVILLE, CUMBERLAND COUNTY, TN. WE CAN TRANSPORT OUT OF STATE, Visit out website for a full list of adoptable pets… https://foccas-tn.org/

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MEME

Great Dane Dutch Shepherd

Female, 7 mos

HAGERSTOWN, MD

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with kids, Good with dogs, Good with cats, Spayed or Neutered,

Story

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These pups are in Frederick, Maryland too!

Below are our newest added Great Danes available for adoption in Frederick, Maryland. To see more adoptable Great Danes in Frederick, Maryland, use the search tool below to enter specific criteria!

Blackberry

Anatolian Shepherd

Male, 4 mos

Frederick, MD

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with dogs, Spayed or Neutered,

Story

Current Location: Frederick, MD Hello! My name is Blackberry! I'm coming to OPH on 1/9. Please check back soon for updates on my personality, and to see adorable new photos. I'm searching for... * someone who won't leave me home alone for more than 4 hrs, at least not until I am older. The older I am the more I can stay home alone. I just don't want you to get mad at me if I have accidents or chew things I'm not supposed to when you leave me for too long. I'm a puppy, so I get bored quick and when I'm bored I could get in trouble. * I am looking for my forever home, not my for right now home. So as I get bigger I need someone to teach me how to be the best dog I can be. I am young and still learning. You may want to teach me some new tricks like sit, stay, etc. Professional training will help me bond with you. That sounds like fun! * I saved the most important for last. I am hoping my new mom or dad will snuggle with me, play with me and love me forever and ever! I'm making my way north in search of my new family. Is that with you? If so apply today because this cuteness won’t be around for long!

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Great Dane puppies and dogs in Frederick, Maryland

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Below are our newest added Great Danes available for adoption in Frederick, Maryland. To see more adoptable Great Danes in Frederick, Maryland, use the search tool below to enter specific criteria!

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Great Dane puppies and dogs in Frederick, Maryland

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Adopt a Great Dane near you in Frederick, Maryland

These Great Danes are available in Frederick, Maryland.

Or, how about these Great Danes in cities near Frederick, Maryland

These Great Danes are available for adoption close to Frederick, Maryland.

These pups are in Frederick, Maryland too!

Below are our newest added Great Danes available for adoption in Frederick, Maryland. To see more adoptable Great Danes in Frederick, Maryland, use the search tool below to enter specific criteria!

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in nearby cities

Related breeds in Frederick, Maryland

Great Dane shelters & rescues in Frederick, Maryland

Looking for a specific shelter or rescue?

Want to learn more about adopting a Great Dane puppy or dog?

Great Dane basics

Great Dane basics