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Great Dane puppies and dogs in Frederick, Maryland

Looking for a Great Dane puppy or dog in Frederick, Maryland? Adopt a Pet can help you find an adorable Great Dane near you.

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Adopt a Great Dane near you in Frederick, Maryland

These Great Danes are available in Frederick, Maryland.
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Shadow

Husky Great Dane

Female, Young
Frederick, MD
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Not good with dogs, Not good with cats, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
We have had Shadow since she was a baby that was found on the side of the road. She gets along with bigger dogs but plays rough. She doesn’t play well with small dogs as she doesn’t realize her size. Will not tolerate cats. She was born around 9/18/2024. Shadow would benefit having plenty of yard and someone to play with a lot of the day. She is crate trained and would come with a crate and all of her belongings. She also likes to chew on everything. She also loves kids but can get a little rough with the younger they are but shows no aggression.

Or, how about these Great Danes in cities near Frederick, Maryland

These Great Danes are available for adoption close to Frederick, Maryland.
Photo of Dolly

Dolly

Great Dane Labrador Retriever

Female, Adult
Westminster, MD
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Not good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
You can fill out an adoption application online on our official website.All of the animals posted on our site have been temperament tested. While not all are in the immediate area, once we have processed and approved your application, we will move the dog to our adoptive area for you to meet, greet and hopefully adopt. Sometimes we will have more than one application on a dog. That does not mean it automatically goes to another family but you should be aware of the fact that until you are approved and set up for the meet/greet.. the dog could get adopted by another applicant.Dolly has large Great Dane genes grafted onto a somewhat smaller body. Not that anyone would ever call her small, but you would say she's a manageable size, which is perfect. If you love the Dane look, but aren't sure you could handle a full size model, we have Dolly waiting for you. She is currently only 60 lbs., but that is a bit deceiving, as she is very underweight. We would like to see at least 15 lbs. more on her ribs and we are working on it. She is now getting top quality groceries, something she has never had before. Still a young dog,  she is in the process of learning about how to deal with the world around her and she is learning fast. Her foster has some comments to help you understand this 'dog-in-progress. 'She’s nervous around new people and things. She does warm up after a bit. Her initial reaction to people that she doesn’t know is to low growl. She is trying to tell everyone to give her a moment to process the new information. I don’t recommend a house with cats or small animals. She’ tries to chase down all the birds,  and squirrels when we’re outside. I’m fairly confident her life prior to rescue wasn’t a good one. It's heartbreaking seeing a good dog trying to cope with a world she was never shown. UPDATE:I have had her for a month now, and she is learning! I took her to the vet today, and while she was nervous, she did not growl. So there has been improvement on that aspect. She wasn’t super outgoing and wanting everyone’s attention, so definitely stand by the slower to warm up to strangers. I highly suspect she’s been abused. She is highly intelligent and learns new things really fast.  She really has the potential to be an excellent dog, and wants to be loved and please her person. MORE UPDATE: Since being here at my house over a month now I have some new insights into her. She is not dog friendly with all dogs.  She's OK with my male dog, but not so happy with my female.  I've been working on getting her to ignore people on walks and she's doing better. She doesn't like it if strangers get too close when we are out.  In the yard. she's definitely going to need at least a 6 foot fence to keep her safely secured.  I will say, she is house trained and does let you know when she needs to go out. She also does very well in her kennel. She is very smart, and can learn things pretty quickly. She has all her shots and is ready and waiting for the person or family who like bigger dogs, but aren't ready for an actual Goliath. Dolly is a good girl! She is hoping you will want to help her be a good dog and come for her soon.   If you are interested in Dolly, please fill out an application at: https://reachoutrescue.rescuegroups.org/forms/form?formid=4588    Or contact: rorrcanine@gmail.com   *** Click here to sponsor this dog! ***Visit this organization's web site to see any additional information available about this pet.October 7, 2026, 1:01 pm
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ROO

Great Dane

Female, Adult
Hagerstown, MD
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered, Shots are up-to-date,
Story
  Roo is a 2–3 year old Blue Merle Great Dane adult who weighs 85 pounds and was found abandoned by a well-known lake in Tennessee.  Someone rescued her from this terrible fate of no food or clean water and no place to be as she was wandering around the lake area very skinny and starved.  She was so grateful when someone took her home.  She then had different people foster her only for a few days at a time until this wonderful family saw her plight and need and said.....let us take her and foster her with a good rescue group.  Now this big girl named Roo has some stability in her life and has earned the nickname “Velcro dog.”  Of course this lost and abandoned girl who was deserted by a lake and then bounced a few times, wants to be right by your side and soak up every ounce of love and attention you’re willing to give her.  She will learn one day that noone is ever going to abandon her again.  This athletic girl has plenty of energy, loves to play with a happy spirit and and is an impressive olympic class jumper. She will thrive best in an active home.  Food definitely motivates her and this makes it super easy to train her and get her undivided attention. Roo is house-trained, crate-trained, cat-friendly, and absolutely loves to snuggle in the bed with her humans.    Roo bonds quickly and becomes very protective of her people so we will have tips on how to temper that zealous enthusiasm to claim you. She needs a family where she can be the queen of the castle and receive endless love and attention in return. If you’re looking for a loyal companion who will stick by you through everything, Roo is your girl!       Please write to Critter Cavalry Rescue at ccrtennessee@gmail.com if you are interested.  She is currently fostered in Tennessee and can be adopted locally and also can transport to a loving family that is northeast of Tennessee.  We transport almost weekly on the weekends.       PLEASE NOTE:  Our dogs are transported from Tennessee to meeting places in the states where we have posted.  Further information about us is given on our Adopt-A-Pet site.  The adoption fees vary and will be provided as well as noted on the application you receive.  Contact us at 615-661-5333 or ccrnewengland@gmail.comOctober 6, 2026, 6:55 pm
Bonded Pair
Photo of Cleopatra

Cleopatra

Great Dane English Mastiff

Female, 1 yr 8 mos
Hagerstown, MD
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, Shots are up-to-date,
Story
Sweet and affectionate girl who thrives with her brother Wreckx or solo. Up to date with vaccines and preventatives. Crate trained.
Photo of Journey

Journey

Great Dane Catahoula Leopard Dog

Female, 1 yr 5 mos
Hagerstown, MD
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, House-trained, Spayed or Neutered,
Story
Meet Journey 🐾 Journey is a beautiful, affectionate girl with a fun loving personality and a heart full of loyalty. She’s the perfect mix of playful and loving, always ready for an adventure but just as happy soaking up attention from her people. She’s friendly, outgoing, and gets along wonderfully with other dogs. Journey also absolutely adores children and would make an amazing family companion. Whether it’s a walk, a car ride, or just hanging out at home, Journey is happiest when she’s included. She’s athletic, curious, and loves to explore, making her a great match for an active home. Journey is crate trained, house trained, rides well in the car, and walks nicely on a leash. She’s got a solid foundation and is ready to settle right into her forever home. With her sweet nature and easygoing personality, she’s the kind of dog who fits in just about anywhere. If you’re looking for a loyal companion who’s equal parts fun and affection, Journey is ready to start her next chapter with you. Journey’s adoption fee is $300 which includes spay, age appropriate vaccines, parasite prevention, and microchip. Apply to adopt at www.fullcirclerescueandsanctuary.com
Photo of Duke

Duke

Great Dane

Male, 1 yr 1 mo
Silver Spring, MD
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, Spayed or Neutered, Shots are up-to-date,
Story
Hi, I’m Duke. While my brother Cash is busy diving headfirst into muddy puddles, I tend to be the contemplative, regal member of our duo. At 80 pounds, I'm lean, athletic, and built for a proper sprint, but I balance that with quiet stoicism. You’ll often spot me stalking through tall grass like a sleek jungle cat or entertaining myself by playing solo fetch with rubber balls and stray walnuts! Still, don't let the noble posture fool you—I will happily melt into a goofy puddle the second belly scratches are offered. I take pride in listening well, but my gentleness with little ones is my favorite trait. I adore toddlers, delicately taking treats from tiny open palms and soaking up all their love. I'm also calm and respectful around cats—even the suspicious ones! I'm neutered, microchipped, fully vaccinated. While Cash and I would be thrilled to share a big fenced yard together, I'm also more than ready to shine on my own. If an intelligent, soulful companion sounds like your match, I'm waiting! ##2853222##
Photo of Cash

Cash

Great Dane

Male, 1 yr 1 mo
Silver Spring, MD
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, Spayed or Neutered, Shots are up-to-date,
Story
Big clumsy paws, legs that go on forever, and a heart twice my size—call me Cash! I’m a 1-year-old, 74-pound Great Dane mix with a ton of charm and zero spatial awareness. If you have a creek, pond, or kiddie pool nearby, consider me gone. I’ll spend hours wading up to my knees, chasing frogs, and blowing big, wet snort-bubbles through my nose! Back inside, I’m a designated couch potato, though I still have typical puppy chewing habits. Keep sturdy chew bones within reach and your sneakers will stay in one piece! My nose usually leads the way (which means my ears "conveniently" ignore my name outside), but I am remarkably gentle around little kids and love soaking up their cuddles. I make an unbeatable wrestling tag-team with my brother Duke and love having dog buddies to romp with, so a home with a secure fence where I can gallop would be a dream. I’m already neutered, microchipped, fully vaccinated. Got a soft sofa with room for a gentle giant? Let's do this! ##2853217##

These pups are in Frederick, Maryland too!

Below are our newest added Great Danes available for adoption in Frederick, Maryland. To see more adoptable Great Danes in Frederick, Maryland, use the search tool below to enter specific criteria!
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Jackson

Bullmastiff Boxer

Male, 2 yrs 5 mos
Frederick, MD
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, Spayed or Neutered,
Story
Currently fostered in: Brooklyn Park, MD 💙Meet Jackson!💙 Some dogs are content with minimal human interaction. Some dogs enjoy their personal space. Jackson? He has never heard of either of those things. This big, goofy teddy bear adores people, has personality for days, and has one of the sweetest hearts you'll ever meet! At 2.5 years old and about 70 pounds, Jackson firmly believes he is the perfect size to be your personal shadow, weighted blanket, emotional support buddy, and full-time best friend. He takes the title 'sidekick' very seriously. Privacy? Never met her. Getting up to grab a snack? He's coming with you (and wants one too) Going to run errands? He's by his leash ready to go! Need to use the bathroom? Well... Jackson believes that's a team activity too. This all means one thing: Once Jackson bonds with you- you've got the most loyal best friend for life. 💙ENERGY AND PERSONALITY💙 Jackson is everything people love about big dogs— equal parts sweetheart and goofball! He will make you laugh with his oversized puppy antics and his determination to convince you that he is lap-dog sized. He adores meeting new people, listens well, and has a happy-go-lucky outlook on life that makes everyone fall in love with him. Jackson also loves toys, bones, car rides, naps in his humans bed, and is 100% convinced that every snack in your hand was probably meant for him. (Honestly...he makes a really compelling argument.) Jackson has a medium/balanced energy level and is happy to lounge around OR go on an adventure. He doesn't care where you're going- he's just so grateful he gets to go with you! 💙SOCIAL LIFE💙 Jackson is known to quickly wins hearts whereever he goes. He gets along very well with other dogs, though his play style is best described as "VERY enthusiastic." He'd love a larger canine friend who enjoys roughhousing as much as he does or one who doesn't mind his goofy antics. He'd also be perfectly happy soaking up all of your attention as an only dog. 💙IDEAL HOME ENVIRONMENT💙 Like many rescue dogs, Jackson is still learning that being alone isn't so scary and that his humans will always be back for him. He would do best in a home where someone is home often, or where they can make arrangements for him to spend the day with someone while they are at work (i.e: doggie daycare, hanging out with a family member/friend/sitter, etc.) After spending so much of his life without a family of his own, Jackson's hoping for a home that understands he's still healing from his rough start, will be patient as he continues to build confidence, and won't mind having a devoted sidekick who thinks life is better together. Jackson has brought so much joy to his foster home, so we know he will bring a ton of joy to your home too! At the end of the day, Jackson is just a big sweet softie that has waited far too long for a furever family that shows him endless love and safety. Jackson has spent long enough wondering when it will finally be his turn. If you're looking for a dog who will love you with his whole entire heart every single day for the rest of his life... Jackson has been waiting his whole life for you. 💙INCLUDED VETERINARY CARE💙 Jackson is up to date on vaccinations, neutered, microchipped, and receiving heartworm, flea, and tick preventatives along with routine parasite treatments and yearly routine heartworm/lyme testing.
Photo of Maggie

Maggie

Anatolian Shepherd Mixed Breed (Medium)

Female, 3 yrs 4 mos
Frederick, MD
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, House-trained, Spayed or Neutered,
Story
Location: Parkville, MD Maggie is an incredibly smart, lively girl who is always ready for her next adventure. She loves people and thrives on human companionship. While she may take a few minutes to warm up to someone new, once she does, she’s all about snuggles, pets, and plenty of sweet kisses. This girl is eager to learn, making her a great candidate for continued training. She is already crate trained, potty trained, and walks well on a leash, giving her a strong foundation for success in her forever home. She is great with other dogs after a short introduction! Maggie loves to run, play, and stay active. Whether she’s zooming around the yard, exploring on walks, or engaging her brain with training and enrichment activities, she’s happiest when she has an outlet for her energy and intelligence. On the other hand, she also loves to lay at your feet and relax while you watch a movie with the family! Maggie could excel as a working dog, farm dog, or active companion for someone looking for a partner in adventure. After a few weeks, she could even settle into a typical 9-5 routine. She loves her crate and is extremely quiet, too, making her the ideal candidate for any type of abode! If you’re looking for a smart, fun, and loving dog to share life’s adventures with, Maggie may be the perfect match!

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Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in Frederick, Maryland.

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Great Dane shelters & rescues in Frederick, Maryland

There are animal shelters and rescues that focus specifically on finding great homes for Great Dane puppies in Frederick, Maryland. Browse these Great Dane rescues and shelters below.

Here are a few organizations closest to you:

Rescue

22.5 miles

Critter Cavalry Rescue - MD

Hagerstown, MD 21746

Pet Types: dogs

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Rescue

22.6 miles

Reach Out Rescue & Resources

P. O. Box 542, Westminster, MD 21158

Pet Types: cats, dogs

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Rescue

25.4 miles

RRARS

Hagerstown, MD 21740

Pet Types: dogs

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Rescue

25.4 miles

Full Circle Rescue & Sanctuary - Maryland Transport Stop

Hagerstown, MD 21740

Pet Types: cats, dogs

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Rescue

27.5 miles

A Home of Their Own Animal Rescue

Silver Spring, MD 20906

Pet Types: cats, dogs

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Rescue

31.8 miles

Traveling Tails Dog Rescue - Round Hill, VA

Round Hill, VA 20141

Pet Types: dogs

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Rescue

33.6 miles

Mid-Atlantic Great Dane Rescue, West Virginia Chapter (6)

N/A, Martinsburg, WV 25404

Pet Types: dogs

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Rescue

37 miles

Canines and Kitties Rescue

Chantilly, VA 20152

Pet Types: cats, dogs

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Rescue

37.5 miles

A Forever Home Rescue Foundation

PO Box 222801, Chantilly, VA 20153

Pet Types: dogs

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Rescue

38.1 miles

Critter Cavalry Rescue - DC

Washington, DC 20009

Pet Types: dogs

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Want to learn more about adopting a Great Dane puppy or dog?

We've got all the info you need on adopting and caring for a Great Dane puppy. Check out the links below for everything you ever wanted to know about Great Dane puppies and adults.

Great Dane basics

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Where do Great Danes come from? How many types of Great Danes are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Great Dane.

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