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Mastiff puppies and dogs in Mesa, Arizona

Looking for a Mastiff puppy or dog in Mesa, Arizona? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near Mesa, Arizona Other pups in Mesa, Arizona Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in Mesa, Arizona Mastiff shelters and rescues in Mesa, Arizona Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Mesa, Arizona

These Mastiffs are available in Mesa, Arizona.
Photo of SWIRL

SWIRL

Mastiff

Male, 4 yrs 3 mos
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
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NITRO

Mastiff

Male, 2 yrs 6 mos
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
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Photo of LU LU

LU LU

Mastiff

Female, 4 yrs 5 mos
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
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Photo of Janice

Janice

English Mastiff

Female, Young
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
Janice is a female Mastiff mix pup who recently joined the Big Hearts for Big Breeds crew. She's got the kind of sweet face that instantly melts hearts! Janice is another sibling from the beloved “Friends” foster pups, and she’s already showing what a special girl she is. Playful and curious, Janice is settling right into her new foster home and learning the ropes alongside other large dogs. She enjoys playtime, companionship, and is gaining confidence every day as she adapts to her new surroundings. With her loving nature and easygoing personality, Janice is ready to grow into a wonderful companion for a family who will continue guiding her, loving her, and cheering her on as she blossoms.

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Photo of Maple

Maple

English Mastiff

Female, Young
Mesa, AZ
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
Maple is a one-year-old Mastiff mix who may be petite in size, but she’s overflowing with personality, playfulness, and charm. Now in the care of Big Hearts for Big Breeds, this sweet young girl is ready to find a forever family to grow up with. Maple is the sibling of some familiar Big Hearts faces—the beloved “Friends” crew, Rachel, Monica, Phoebe, and Janice—but she’s just beginning her own rescue journey. Like her siblings, she is shy and timid at first, but she truly has a loving heart and is eager to make lasting connections with the people around her. Still very much a puppy, Maple loves to play and brings a fun, energetic spirit wherever she goes. She does well with other dogs and was around cats when she was younger, giving her a solid foundation as she continues to learn and mature. With continued guidance, socialization, and plenty of positive experiences, she’s sure to blossom into an incredible companion. Maple is looking for a family that will embrace her youthful enthusiasm, celebrate her milestones, and give her all the love she deserves. If you’re searching for a playful, affectionate best friend with a bright future ahead, Maple might just be the perfect addition to your home.

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Special Needs
Photo of Dahlia

Dahlia

English Mastiff Great Dane

Female, Senior
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, Needs special attention, House-trained, Spayed or Neutered,
Story
Dahlia is a eight-year-old Mastiff mix with the softest heart and the gentlest soul. When her time was running out at the county shelter, Big Hearts for Big Breeds stepped in to give her the second chance she so deeply deserves. Despite everything she’s been through, Dahlia remains incredibly sweet and trusting. She leans into love, soaking up gentle pets and quiet companionship. She is a calm, tender presence — the kind of dog who simply wants to rest her head beside you and feel safe. Dahlia is considered special needs. She is almost blind and will be undergoing eye removal surgery to keep her comfortable and pain-free. Even with limited vision, she navigates the world with quiet bravery, relying on kindness, routine, and the reassurance of her people. Her resilience is nothing short of inspiring. This beautiful girl doesn’t need much — a soft place to land, a patient home willing to help her adjust, and hearts big enough to see past her medical needs and into her incredible spirit. If you believe that every dog deserves safety, dignity, and love — especially the ones who need a little extra — Dahlia is waiting for you.

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Or, how about these Mastiffs in cities near Mesa, Arizona

These Mastiffs are available for adoption close to Mesa, Arizona.
Photo of SWIRL

SWIRL

Mastiff

Male, 4 yrs 3 mos
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
-

Learn More

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Photo of NITRO

NITRO

Mastiff

Male, 2 yrs 6 mos
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
-

Learn More

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Photo of LU LU

LU LU

Mastiff

Female, 4 yrs 5 mos
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
-

Learn More

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Photo of Janice

Janice

English Mastiff

Female, Young
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
Janice is a female Mastiff mix pup who recently joined the Big Hearts for Big Breeds crew. She's got the kind of sweet face that instantly melts hearts! Janice is another sibling from the beloved “Friends” foster pups, and she’s already showing what a special girl she is. Playful and curious, Janice is settling right into her new foster home and learning the ropes alongside other large dogs. She enjoys playtime, companionship, and is gaining confidence every day as she adapts to her new surroundings. With her loving nature and easygoing personality, Janice is ready to grow into a wonderful companion for a family who will continue guiding her, loving her, and cheering her on as she blossoms.

Learn More

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Photo of Maple

Maple

English Mastiff

Female, Young
Mesa, AZ
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
Maple is a one-year-old Mastiff mix who may be petite in size, but she’s overflowing with personality, playfulness, and charm. Now in the care of Big Hearts for Big Breeds, this sweet young girl is ready to find a forever family to grow up with. Maple is the sibling of some familiar Big Hearts faces—the beloved “Friends” crew, Rachel, Monica, Phoebe, and Janice—but she’s just beginning her own rescue journey. Like her siblings, she is shy and timid at first, but she truly has a loving heart and is eager to make lasting connections with the people around her. Still very much a puppy, Maple loves to play and brings a fun, energetic spirit wherever she goes. She does well with other dogs and was around cats when she was younger, giving her a solid foundation as she continues to learn and mature. With continued guidance, socialization, and plenty of positive experiences, she’s sure to blossom into an incredible companion. Maple is looking for a family that will embrace her youthful enthusiasm, celebrate her milestones, and give her all the love she deserves. If you’re searching for a playful, affectionate best friend with a bright future ahead, Maple might just be the perfect addition to your home.

Learn More

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Special Needs
Photo of Dahlia

Dahlia

English Mastiff Great Dane

Female, Senior
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, Needs special attention, House-trained, Spayed or Neutered,
Story
Dahlia is a eight-year-old Mastiff mix with the softest heart and the gentlest soul. When her time was running out at the county shelter, Big Hearts for Big Breeds stepped in to give her the second chance she so deeply deserves. Despite everything she’s been through, Dahlia remains incredibly sweet and trusting. She leans into love, soaking up gentle pets and quiet companionship. She is a calm, tender presence — the kind of dog who simply wants to rest her head beside you and feel safe. Dahlia is considered special needs. She is almost blind and will be undergoing eye removal surgery to keep her comfortable and pain-free. Even with limited vision, she navigates the world with quiet bravery, relying on kindness, routine, and the reassurance of her people. Her resilience is nothing short of inspiring. This beautiful girl doesn’t need much — a soft place to land, a patient home willing to help her adjust, and hearts big enough to see past her medical needs and into her incredible spirit. If you believe that every dog deserves safety, dignity, and love — especially the ones who need a little extra — Dahlia is waiting for you.

Learn More

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These pups are in Mesa, Arizona too!

Below are our newest added Mastiffs available for adoption in Mesa, Arizona. To see more adoptable Mastiffs in Mesa, Arizona, use the search tool below to enter specific criteria!
Photo of Ocean

Ocean

Bullmastiff

Female, Adult
Mesa, AZ
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, Needs experienced adopter, House-trained, Spayed or Neutered,
Story
Ocean is a beautiful four-year-old brindle Bullmastiff mix with a big heart and a loyal spirit. Now in the care of Big Hearts for Big Breeds, this lovely girl is looking for a forever home that understands her protective nature and will appreciate all the love she has to give. Ocean is wonderful with both big and little dogs and enjoys having canine companions around. Her compatibility with cats is currently unknown. She doesn't need a kennel and has done well without one, making her a great fit for a home where she can simply be part of the family. Ocean can be protective of her home when strangers arrive, so she will do best with an experienced large-breed adopter who understands the importance of structure, confidence, and thoughtful introductions. She would also be happiest with older children, ages 14 and up. Once Ocean knows you're her person, you'll have a devoted companion who is ready to be by your side. She's looking for a family who will respect her protective instincts, give her clear guidance, and allow her the time she needs to feel comfortable with new people. If you're an experienced large-breed home looking for a loyal, beautiful Bullmastiff mix with a heart of gold, Ocean may be your girl. Big Hearts for Big Breeds can't wait to help her find the forever home where she can feel safe, loved, and truly belong.

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Photo of Odin

Odin

Bullmastiff

Male, Adult
Mesa, AZ
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered,
Story
Odin is a three-year-old Bullmastiff with a mellow personality and a big heart. Now in the care of Big Hearts for Big Breeds, this handsome boy is ready to find a forever home where he can settle in, relax, and be the loyal companion he was meant to be. Odin is wonderful with kids and has a laid-back nature that makes him a pleasure to have around. When it comes to canine companions, Odin is looking for a specific match—he does well with small dogs and female dogs, but is not a match for male dogs. This mellow guy is house trained and ready to enjoy the comforts of home. He's happiest when life is relaxed and he can simply hang out with his people and be part of the family. Odin is not yet neutered, but that will be taken care of while he is in the care of Big Hearts for Big Breeds. If you're looking for a big, mellow Bullmastiff with a sweet personality and a love for family life, Odin could be the perfect addition to your home.

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Mesa, Arizona.

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Mastiff puppies and dogs in nearby cities

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Related breeds in Mesa, Arizona

Bullmastiffs in Mesa, Arizona Neapolitan Mastiffs in Mesa, Arizona Saint Bernards in Mesa, Arizona

Mastiff shelters & rescues in Mesa, Arizona

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Mesa, Arizona. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

2.8 miles

Maricopa County Animal Care & Control East Valley Animal Shelter

1920 S Lewis, Mesa, AZ 85210

Pet Types: dogs

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Rescue

3.6 miles

Big Hearts for Big Breeds

Mesa, AZ 85202

Pet Types: dogs

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Rescue

8.1 miles

Valley Dogs

P.O. Box 364, Gilbert, AZ 85299

Pet Types: dogs

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Rescue

12.8 miles

Underdog Rescue of Arizona

P.O. Box 13392, Chandler, AZ 85248

Pet Types: cats, dogs

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Shelter

16.4 miles

Maricopa County Animal Care & Control West Animal Shelter

2500 S. 27th Avenue, Phoenix, AZ 85009

Pet Types: dogs

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Shelter

18.4 miles

Central Arizona Animal Rescue

San Tan Valley, AZ 85142

Pet Types: cats, dogs, rabbits, reptiles

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Rescue

24.4 miles

Regal Dane Rescue

4410 W UNION HILLS DR STE 7-187, GLENDALE, AZ 85308

Pet Types: dogs

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Rescue

26.7 miles

Handover Rover

Scottsdale, AZ 85262

Pet Types: cats, dogs

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Rescue

31.4 miles

AZ Mastiff Rescue- English Mastiff and Other Mastiff and Giant breeds

Goodyear, AZ 85338

Pet Types: dogs

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Shelter

38.2 miles

Pinal County Animal Care and Control

1150 S. Eleven Mile Corner Rd, Casa Grande, AZ 85194

Pet Types: cats, dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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