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Mastiff puppies and dogs in Mesa, Arizona

Looking for a Mastiff puppy or dog in Mesa, Arizona? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you in Mesa, Arizona

These Mastiffs are available in Mesa, Arizona.
Photo of MARABELLE

MARABELLE

Mastiff

Female, 3 yrs 6 mos
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
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Photo of Janice

Janice

English Mastiff

Female, Young
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
Janice is a female Mastiff mix pup who recently joined the Big Hearts for Big Breeds crew. She's got the kind of sweet face that instantly melts hearts! Janice is another sibling from the beloved “Friends” foster pups, and she’s already showing what a special girl she is. Playful and curious, Janice is settling right into her new foster home and learning the ropes alongside other large dogs. She enjoys playtime, companionship, and is gaining confidence every day as she adapts to her new surroundings. With her loving nature and easygoing personality, Janice is ready to grow into a wonderful companion for a family who will continue guiding her, loving her, and cheering her on as she blossoms.

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Photo of Maple

Maple

English Mastiff

Female, Young
Mesa, AZ
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
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Photo of Everest

Everest

English Mastiff Great Dane

Male, Adult
Mesa, AZ
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, House-trained,
Story
Everest is a two-year-old Great Dane/Mastiff mix who has already made a big impression at Big Hearts for Big Breeds. With his big blocky head and soft, expressive face, this sweet boy absolutely melts into a puddle the moment he’s getting affection. Everest is a gentle, submissive soul who leans into love and enjoys being close to his people. While we’re still getting to know him, he is already showing that he does well with other dogs and has a calm, easygoing nature that makes him a joy to be around. As Everest settles into rescue, we’re excited to continue learning more about him and watching his personality unfold. What’s already clear is that he’s a kind-hearted, affectionate dog who is ready for a home where he can feel safe, loved, and part of the family. If you’re looking for a big, soft-hearted companion who just wants to love and be loved, Everest may be your perfect match.

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Photo of PANCAKE

PANCAKE

American Pit Bull Terrier Mastiff

Female, 1 yr 8 mos
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
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Story
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Or, how about these Mastiffs in cities near Mesa, Arizona

These Mastiffs are available for adoption close to Mesa, Arizona.
Photo of MARABELLE

MARABELLE

Mastiff

Female, 3 yrs 6 mos
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
-

Learn More

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Photo of Janice

Janice

English Mastiff

Female, Young
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
Janice is a female Mastiff mix pup who recently joined the Big Hearts for Big Breeds crew. She's got the kind of sweet face that instantly melts hearts! Janice is another sibling from the beloved “Friends” foster pups, and she’s already showing what a special girl she is. Playful and curious, Janice is settling right into her new foster home and learning the ropes alongside other large dogs. She enjoys playtime, companionship, and is gaining confidence every day as she adapts to her new surroundings. With her loving nature and easygoing personality, Janice is ready to grow into a wonderful companion for a family who will continue guiding her, loving her, and cheering her on as she blossoms.

Learn More

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Photo of Maple

Maple

English Mastiff

Female, Young
Mesa, AZ
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
-

Learn More

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Photo of Everest

Everest

English Mastiff Great Dane

Male, Adult
Mesa, AZ
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, House-trained,
Story
Everest is a two-year-old Great Dane/Mastiff mix who has already made a big impression at Big Hearts for Big Breeds. With his big blocky head and soft, expressive face, this sweet boy absolutely melts into a puddle the moment he’s getting affection. Everest is a gentle, submissive soul who leans into love and enjoys being close to his people. While we’re still getting to know him, he is already showing that he does well with other dogs and has a calm, easygoing nature that makes him a joy to be around. As Everest settles into rescue, we’re excited to continue learning more about him and watching his personality unfold. What’s already clear is that he’s a kind-hearted, affectionate dog who is ready for a home where he can feel safe, loved, and part of the family. If you’re looking for a big, soft-hearted companion who just wants to love and be loved, Everest may be your perfect match.

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Photo of Bruno

Bruno

Mastiff

Male, 2 yrs 1 mo
Gilbert, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Bruno 🐾 Bruno is a handsome ~2-year-old brindle boy with a gentle soul and a heart that just needs a little time to shine. At first, he can be a bit shy and timid, but once he warms up, you’ll see his sweet and loyal personality come through. He does well with most other dogs and would likely enjoy a home with a calm, friendly companion to help build his confidence. Bruno would thrive in a patient, loving home where he can take things at his own pace and feel safe. He’s the kind of dog that forms a deep bond with his people—quiet, observant, and incredibly loving once he trusts you. With a little reassurance and consistency, Bruno is going to blossom into an amazing companion. If you’re looking for a loyal best friend and are willing to give him the time he deserves, Bruno might just be your perfect match ❤️ Please email ADOPT@VALLEYDOGS.ORG for an adoption application. Thank you!

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Photo of Tank

Tank

Mastiff

Male, 5 yrs
Gilbert, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Hank! This impressive and devoted Boerboel — a striking, 5-year-old neutered male with a heart as big as his presence. Confident, intelligent, and deeply loyal, he embodies the true spirit of a guardian breed and flourishes in a home that understands and appreciates his protective nature. He would do best in an adult-only home (no kids), as he plays rough and doesn’t always realize his own strength. This boy loves to explore and would be happiest on a property with space, where he can spend most of his time outdoors doing what he loves—patrolling, roaming, and taking in his surroundings. While he enjoys his independence, he also appreciates human interaction on his terms. He may take a little time to warm up, but once he trusts you, he’s a solid, loyal companion. Ideal Home: Adult-only household Experienced, confident dog owner Property or large yard preferred Someone who understands guardian breeds He’s a great dog in the right setting—strong, smart, and full of character. With the right person, he’ll be an incredibly rewarding companion. Please email ADOPT@VALLEYDOGS.ORG for an adoption application.

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These pups are in Mesa, Arizona too!

Below are our newest added Mastiffs available for adoption in Mesa, Arizona. To see more adoptable Mastiffs in Mesa, Arizona, use the search tool below to enter specific criteria!
Photo of Clover

Clover

St. Bernard

Male, Young
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, House-trained, Spayed or Neutered,
Story
Clover is an estimated 1–2-year-old mixed-breed sweetheart who came to Big Hearts for Big Breeds just in time for a fresh start. Originally listed as a St. Bernard mix, we may never know exactly what breeds make up this adorable boy — but at around 50 pounds, he’s the perfect blend of size, softness, and charm. Clover is currently settling into a loving, patient foster home where he’s beginning to discover what safety and comfort truly feel like. As he decompresses, he’s slowly building confidence and showing glimpses of his gentle, lovable personality. This sweet boy is still finding his footing, but with time, kindness, and encouragement, Clover is sure to continue blossoming. He’s looking for a home that will give him the space and support he needs to grow into the happy, secure dog he’s meant to be. At Big Hearts for Big Breeds, we believe Clover’s best days are ahead of him — and we can’t wait to see him thrive.

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Photo of Patagonia (Patty)

Patagonia (Patty)

Neapolitan Mastiff

Female, Adult
Mesa, AZ
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
Patagonia, lovingly known as Patty, is a stunning Neapolitan Mastiff with a heart every bit as big as her signature wrinkles. Now in the care of Big Hearts for Big Breeds, this gentle girl is looking for a forever home where she can relax, love, and be adored right back. Patty is the definition of a gentle giant. She’s wonderful with kids, does well with cats, and gets along nicely with male dogs or submissive female dogs. She enjoys car rides, walks well on a leash, and is happiest when she’s lounging nearby — especially if there’s a sunny pool deck involved. Patty does have Valley Fever, which is being successfully managed with medication, and she is currently healthy and doing well. She is house trained and does not require a crate, as she behaves beautifully in the home. With her easygoing nature and loving personality, Patty is the kind of companion who will quietly become the heart of the home. If you’re looking for a calm, affectionate, and loyal best friend, Patagonia may be your perfect match.

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Mesa, Arizona.

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Mastiff puppies and dogs in nearby cities

Mastiff Puppies near me Mastiff in Apache Junction, AZ Mastiff in Avondale, AZ Mastiff in Cave Creek, AZ Mastiff in Chandler, AZ Mastiff in El Mirage, AZ Mastiff in Fountain Hills, AZ Mastiff in Gilbert, AZ Mastiff in Glendale, AZ Mastiff in Goodyear, AZ Mastiff in Guadalupe, AZ Mastiff in Litchfield Park, AZ Mastiff in Maricopa, AZ Mastiff in Paradise Valley, AZ Mastiff in Peoria, AZ Mastiff in Phoenix, AZ Mastiff in Queen Creek, AZ Mastiff in Scottsdale, AZ Mastiff in Surprise, AZ Mastiff in Tempe, AZ Mastiff in Tolleson, AZ

Related breeds in Mesa, Arizona

Bullmastiffs in Mesa, Arizona Neapolitan Mastiffs in Mesa, Arizona Saint Bernards in Mesa, Arizona

Mastiff shelters & rescues in Mesa, Arizona

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Mesa, Arizona. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

2.8 miles

Maricopa County Animal Care & Control East Valley Animal Shelter

1920 S Lewis, Mesa, AZ 85210

Pet Types: dogs

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Rescue

3.6 miles

Big Hearts for Big Breeds

Mesa, AZ 85202

Pet Types: dogs

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Rescue

8.1 miles

Valley Dogs

P.O. Box 364, Gilbert, AZ 85299

Pet Types: dogs

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Rescue

12.8 miles

Underdog Rescue of Arizona

P.O. Box 13392, Chandler, AZ 85248

Pet Types: cats, dogs

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Rescue

14.5 miles

Desert Dog Project

Scottsdale, AZ 85254

Pet Types: dogs

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Shelter

16.4 miles

Maricopa County Animal Care & Control West Animal Shelter

2500 S. 27th Avenue, Phoenix, AZ 85009

Pet Types: dogs

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Rescue

24.4 miles

Regal Dane Rescue

4410 W UNION HILLS DR STE 7-187, GLENDALE, AZ 85308

Pet Types: dogs

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Rescue

26.7 miles

Handover Rover

Scottsdale, AZ 85262

Pet Types: cats, dogs

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Rescue

31.4 miles

AZ Mastiff Rescue- English Mastiff and Other Mastiff and Giant breeds

Goodyear, AZ 85338

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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