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Mastiff puppies and dogs in Mesa, Arizona

Looking for a Mastiff puppy or dog in Mesa, Arizona? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you in Mesa, Arizona

These Mastiffs are available in Mesa, Arizona.
Photo of MISS BERTHA

MISS BERTHA

Mastiff

Female, 3 yrs
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
-

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Photo of MARABELLE

MARABELLE

Mastiff

Female, 3 yrs 7 mos
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
-

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Photo of WRANGLER

WRANGLER

Mastiff

Male, 2 yrs
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
-

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Photo of Fern

Fern

English Mastiff Irish Wolfhound

Female, Adult
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained,
Story
Fern is a five-year-old Irish Wolfhound, Great Dane, and Mastiff mix with the sweetest sugary face and a personality to match. This one-of-a-kind girl is the kind of dog who makes everyone she meets smile, effortlessly winning hearts with her gentle nature and loving spirit. Now in the care of Big Hearts for Big Breeds, Fern has shown herself to be an absolute treasure. She is wonderful with other dogs, great with cats, and loves kids, making her the kind of companion who fits beautifully into a variety of family dynamics. Whether she's making new friends or simply enjoying quiet time with her people, Fern brings warmth and joy wherever she goes. With her unique blend of giant breeds comes an equally giant heart. She’s affectionate without being demanding, sweet without trying, and has the kind of calm presence that makes every day a little brighter. Her soulful eyes and sugar-dusted face tell the story of a dog who is simply happy to be loved and to love in return. If you've been searching for a loyal best friend who gets along with everyone and has enough love to fill an entire home, Fern may be exactly the companion you've been waiting for. Big Hearts for Big Breeds can't wait to see this special girl find the forever family she so richly deserves.

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Photo of Janice

Janice

English Mastiff

Female, Young
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
Janice is a female Mastiff mix pup who recently joined the Big Hearts for Big Breeds crew. She's got the kind of sweet face that instantly melts hearts! Janice is another sibling from the beloved “Friends” foster pups, and she’s already showing what a special girl she is. Playful and curious, Janice is settling right into her new foster home and learning the ropes alongside other large dogs. She enjoys playtime, companionship, and is gaining confidence every day as she adapts to her new surroundings. With her loving nature and easygoing personality, Janice is ready to grow into a wonderful companion for a family who will continue guiding her, loving her, and cheering her on as she blossoms.

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Photo of Maple

Maple

English Mastiff

Female, Young
Mesa, AZ
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
Maple is a one-year-old Mastiff mix who may be petite in size, but she’s overflowing with personality, playfulness, and charm. Now in the care of Big Hearts for Big Breeds, this sweet young girl is ready to find a forever family to grow up with. Maple is the sibling of some familiar Big Hearts faces—the beloved “Friends” crew, Rachel, Monica, Phoebe, and Janice—but she’s just beginning her own rescue journey. Like her siblings, she is shy and timid at first, but she truly has a loving heart and is eager to make lasting connections with the people around her. Still very much a puppy, Maple loves to play and brings a fun, energetic spirit wherever she goes. She does well with other dogs and was around cats when she was younger, giving her a solid foundation as she continues to learn and mature. With continued guidance, socialization, and plenty of positive experiences, she’s sure to blossom into an incredible companion. Maple is looking for a family that will embrace her youthful enthusiasm, celebrate her milestones, and give her all the love she deserves. If you’re searching for a playful, affectionate best friend with a bright future ahead, Maple might just be the perfect addition to your home.

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Or, how about these Mastiffs in cities near Mesa, Arizona

These Mastiffs are available for adoption close to Mesa, Arizona.
Photo of MISS BERTHA

MISS BERTHA

Mastiff

Female, 3 yrs
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
-

Learn More

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Photo of MARABELLE

MARABELLE

Mastiff

Female, 3 yrs 7 mos
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
-

Learn More

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Photo of WRANGLER

WRANGLER

Mastiff

Male, 2 yrs
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
-

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Photo of Fern

Fern

English Mastiff Irish Wolfhound

Female, Adult
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained,
Story
Fern is a five-year-old Irish Wolfhound, Great Dane, and Mastiff mix with the sweetest sugary face and a personality to match. This one-of-a-kind girl is the kind of dog who makes everyone she meets smile, effortlessly winning hearts with her gentle nature and loving spirit. Now in the care of Big Hearts for Big Breeds, Fern has shown herself to be an absolute treasure. She is wonderful with other dogs, great with cats, and loves kids, making her the kind of companion who fits beautifully into a variety of family dynamics. Whether she's making new friends or simply enjoying quiet time with her people, Fern brings warmth and joy wherever she goes. With her unique blend of giant breeds comes an equally giant heart. She’s affectionate without being demanding, sweet without trying, and has the kind of calm presence that makes every day a little brighter. Her soulful eyes and sugar-dusted face tell the story of a dog who is simply happy to be loved and to love in return. If you've been searching for a loyal best friend who gets along with everyone and has enough love to fill an entire home, Fern may be exactly the companion you've been waiting for. Big Hearts for Big Breeds can't wait to see this special girl find the forever family she so richly deserves.

Learn More

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Photo of Janice

Janice

English Mastiff

Female, Young
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
Janice is a female Mastiff mix pup who recently joined the Big Hearts for Big Breeds crew. She's got the kind of sweet face that instantly melts hearts! Janice is another sibling from the beloved “Friends” foster pups, and she’s already showing what a special girl she is. Playful and curious, Janice is settling right into her new foster home and learning the ropes alongside other large dogs. She enjoys playtime, companionship, and is gaining confidence every day as she adapts to her new surroundings. With her loving nature and easygoing personality, Janice is ready to grow into a wonderful companion for a family who will continue guiding her, loving her, and cheering her on as she blossoms.

Learn More

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Photo of Maple

Maple

English Mastiff

Female, Young
Mesa, AZ
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
Maple is a one-year-old Mastiff mix who may be petite in size, but she’s overflowing with personality, playfulness, and charm. Now in the care of Big Hearts for Big Breeds, this sweet young girl is ready to find a forever family to grow up with. Maple is the sibling of some familiar Big Hearts faces—the beloved “Friends” crew, Rachel, Monica, Phoebe, and Janice—but she’s just beginning her own rescue journey. Like her siblings, she is shy and timid at first, but she truly has a loving heart and is eager to make lasting connections with the people around her. Still very much a puppy, Maple loves to play and brings a fun, energetic spirit wherever she goes. She does well with other dogs and was around cats when she was younger, giving her a solid foundation as she continues to learn and mature. With continued guidance, socialization, and plenty of positive experiences, she’s sure to blossom into an incredible companion. Maple is looking for a family that will embrace her youthful enthusiasm, celebrate her milestones, and give her all the love she deserves. If you’re searching for a playful, affectionate best friend with a bright future ahead, Maple might just be the perfect addition to your home.

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These pups are in Mesa, Arizona too!

Below are our newest added Mastiffs available for adoption in Mesa, Arizona. To see more adoptable Mastiffs in Mesa, Arizona, use the search tool below to enter specific criteria!
Photo of Clover

Clover

St. Bernard

Male, Young
Mesa, AZ
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, House-trained, Spayed or Neutered,
Story
Clover is an estimated 1–2-year-old mixed-breed sweetheart who came to Big Hearts for Big Breeds just in time for a fresh start. Originally listed as a St. Bernard mix, we may never know exactly what breeds make up this adorable boy — but at around 50 pounds, he’s the perfect blend of size, softness, and charm. Clover is currently settling into a loving, patient foster home where he’s beginning to discover what safety and comfort truly feel like. As he decompresses, he’s slowly building confidence and showing glimpses of his gentle, lovable personality. This sweet boy is still finding his footing, but with time, kindness, and encouragement, Clover is sure to continue blossoming. He’s looking for a home that will give him the space and support he needs to grow into the happy, secure dog he’s meant to be. At Big Hearts for Big Breeds, we believe Clover’s best days are ahead of him — and we can’t wait to see him thrive.

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Photo of Dirt

Dirt

St. Bernard

Male, Young
Mesa, AZ
Size
(when grown) -
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered,
Story
Dirt is a 12–18-month-old Saint Bernard who is still growing into both his giant paws and his confidence. Now safe with Big Hearts for Big Breeds, this handsome young boy is looking for a patient family that will help him continue learning that the world is a safe place. Like many young Saint Bernards, Dirt has a gentle heart and a thoughtful nature. He does well with children and has shown himself to be non-reactive around other dogs. His compatibility with cats is currently unknown as we continue to learn more about him. Dirt can be shy and nervous around men when first meeting them, but with patience and kindness, he warms up and begins to show his sweet personality. True to his Saint Bernard roots, he also has a protective nature and appreciates slow, respectful introductions to new people entering the home. Once he understands that everyone is a friend, he settles in nicely. As a young giant-breed dog, Dirt will benefit from continued socialization, structure, and positive experiences that help build his confidence. With the right guidance, he has all the makings of a loyal, loving companion who will be deeply devoted to his family. If you're looking for a young Saint Bernard with a heart of gold and are willing to give him the time he needs to blossom, Dirt may be the perfect addition to your family.

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Photo of Patagonia (Patty)

Patagonia (Patty)

Neapolitan Mastiff

Female, Adult
Mesa, AZ
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
Patagonia, lovingly known as Patty, is a stunning Neapolitan Mastiff with a heart every bit as big as her signature wrinkles. Now in the care of Big Hearts for Big Breeds, this gentle girl is looking for a forever home where she can relax, love, and be adored right back. Patty is the definition of a gentle giant. She’s wonderful with kids, does well with cats, and gets along nicely with male dogs or submissive female dogs. She enjoys car rides, walks well on a leash, and is happiest when she’s lounging nearby — especially if there’s a sunny pool deck involved. Patty does have Valley Fever, which is being successfully managed with medication, and she is currently healthy and doing well. She is house trained and does not require a crate, as she behaves beautifully in the home. With her easygoing nature and loving personality, Patty is the kind of companion who will quietly become the heart of the home. If you’re looking for a calm, affectionate, and loyal best friend, Patagonia may be your perfect match.

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Mesa, Arizona.

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Mastiff puppies and dogs in nearby cities

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Related breeds in Mesa, Arizona

Bullmastiffs in Mesa, Arizona Neapolitan Mastiffs in Mesa, Arizona Saint Bernards in Mesa, Arizona

Mastiff shelters & rescues in Mesa, Arizona

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Mesa, Arizona. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

2.8 miles

Maricopa County Animal Care & Control East Valley Animal Shelter

1920 S Lewis, Mesa, AZ 85210

Pet Types: dogs

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Rescue

3.6 miles

Big Hearts for Big Breeds

Mesa, AZ 85202

Pet Types: dogs

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Rescue

8.1 miles

Valley Dogs

P.O. Box 364, Gilbert, AZ 85299

Pet Types: dogs

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Rescue

12.8 miles

Underdog Rescue of Arizona

P.O. Box 13392, Chandler, AZ 85248

Pet Types: cats, dogs

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Rescue

14.5 miles

Desert Dog Project

Scottsdale, AZ 85254

Pet Types: dogs

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Shelter

16.4 miles

Maricopa County Animal Care & Control West Animal Shelter

2500 S. 27th Avenue, Phoenix, AZ 85009

Pet Types: dogs

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Rescue

24.4 miles

Regal Dane Rescue

4410 W UNION HILLS DR STE 7-187, GLENDALE, AZ 85308

Pet Types: dogs

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Rescue

26.7 miles

Handover Rover

Scottsdale, AZ 85262

Pet Types: cats, dogs

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Rescue

31.4 miles

AZ Mastiff Rescue- English Mastiff and Other Mastiff and Giant breeds

Goodyear, AZ 85338

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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