Mastiff Adoption in San Francisco, CA: Mastiff Puppies for Sale in San Francisco, CA

Adopt a Mastiff near you in San Francisco, California

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near San Francisco, California

These Mastiffs are available for adoption close to San Francisco, California.

COFFEY

Mastiff

Male, 2 yrs

Martinez, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Learn More

Nami

Mastiff Rhodesian Ridgeback

Female, Adult

Vallejo, CA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Spayed or Neutered,

Story

NOTE:Submit the adoption interest application directly at our HSNB website:https://www.hsnb.org/dog-adoption-applicationWe may not receive anything submitted through PetFinder or Adopt-A-Pet! If you do not receive confirmation from us, email adoptions@hsnb.org . -----Meet Nami, a beautiful Mastiff/Rhodesian Ridgeback mix with a heart of gold. When she first arrived at our shelter, Nami was a bit shy, taking her time to observe her new surroundings and the people around her. Once she got the hang of things, her true, affectionate personality became very apparent.Now, Nami has truly blossomed into a wonderful companion who clearly adores people. She enjoys a relaxed pace on her leash walks, taking everything in with a quiet demeanor, and is even open to making new dog friends. More than anything, Nami longs for a place where she can feel safe, secure, and cherished. She dreams of a loving home where she can offer endless affection and receive it in return. Nami's adoption fee is $350.https://youtube.com/shorts/tCoPkwAgl2M Primary Color: Brown Secondary Color: Brindle Weight: 82.5 Age: 2yrs 8mths 3wks

Learn More

Max

Mastiff

Male, Young

Concord, CA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Needs experienced adopter, Shots are up-to-date,

Story

Duke and Max were abandoned in their kennels. Max is a sweet boy still learning the walk of life. he does not get along with Duke because both are not fixed. Hoping to find him a good loving safe home

Learn More

She-Ra

Mastiff

Female, 5 yrs

Dublin, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Shots are up-to-date,

Story

She-Ra is a female Mastiff. She is approximately five years old, and currently weighs 93 pounds. She was brought to our shelter on 11/17/25 after being found in unincorporated Livermore. She hasn't been reclaimed by her previous person, so she's now looking for a new home! She has been vaccinated, and will be spayed and micro-chipped before going to her new home. Her adoption fee is $35, plus licensing (if applicable), plus the cost of her spay surgery.

Learn More

Romeo

Mastiff

Male, 6 yrs 7 mos

Palo Alto, CA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Not good with dogs, Not good with cats, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Romeo is very sweet 6 year old boy but the vets think he may be younger. He would love to be a family dog and definitely wants to find his forever home, but can be protective of his people and his space. That being said once he knows you are part of the family he listens very well and knows many commands, sit, stay, down, shake, wait. He is slow to warm up to new people but once he has been introduced to you he is a gentle giant and big couch potato that loves to cuddle. He also really enjoys going for a ride in the car. It is not recommended to have young kids due to his size. He is good on the leash and knows many commands but needs someone that is not afraid of his size and can properly handle him. Experienced adopter with larger breeds is a must. No other dogs or animals in the household and not a good candidate for crates.

Learn More

She-Ra - ECAS

Mastiff Mixed Breed (Medium)

Female 5 yrs

Pleasanton, CA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

She-Ra was brought to our shelter on 11/17/25 after being found in unincorporated Livermore. She hasn't been reclaimed by her previous person, so she's now looking for a new home! Her adoption fee is $35, plus licensing (if applicable), plus the cost of her spay surgery. She-Ra’s Shelter ID# is 88279. She is an approximately 5-year-old, black, Mastiff mix. She currently weighs around 93 lbs. She has already been vaccinated and will be spayed and microchipped before going to her new home. She-Ra is located in kennel C-2. ** Age shown is an estimate only ** THIS IS A COURTESY POSTING If you are interested, please call the East County Animal Shelter at 925-803-7040 to see if this dog is still available.

Learn More

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in San Francisco, California.

Mastiff puppies and dogs in San Francisco, California

Learn More:

Adopt a Mastiff near you in San Francisco, California

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near San Francisco, California

These Mastiffs are available for adoption close to San Francisco, California.

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in San Francisco, California

Mastiff shelters & rescues in San Francisco, California

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics

Home

Adopt a Dog

Adopt a Mastiff

California

San Francisco

Mastiff puppies and dogs in San Francisco, California

Learn More:

Adopt a Mastiff near you in San Francisco, California

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near San Francisco, California

These Mastiffs are available for adoption close to San Francisco, California.

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in San Francisco, California

Mastiff shelters & rescues in San Francisco, California

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics