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Mastiff puppies and dogs in Mechanicsburg, Pennsylvania

Looking for a Mastiff puppy or dog in Mechanicsburg, Pennsylvania? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you in Mechanicsburg, Pennsylvania

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These Mastiffs are available for adoption close to Mechanicsburg, Pennsylvania.
Photo of Fernie *Courtesy Post*

Fernie *Courtesy Post*

Mastiff

Female, Young
Harrisburg, PA
Size
(when grown) -
Details
Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
You can fill out an adoption application online on our official website. Fill out an Adoption Application Fern is now available please read her PetFinder post  https://www.petfinder.com/dog/fernie-d98ba9c5-c010-4bc0-b0e0-0e56e047e84b/pa/warrington/brookline-labrador-rescue-pa06/details/Click here to watch a video of Fernie *Courtesy Post*.Visit this organization's web site to see any additional information available about this pet. Application Fees, Adoption Donations and Rescue Policy: Please know that 100% of our fees and donations pay for the costs of rescuing dogs. These include but are not limited to pull fees from shelters, veterinary examinations, vaccinations, medications and care, microchips, neuter/spay surgeries, heartworm treatments, behavior evaluations, and foster care, as needed. Important notes before applying. Approved adopters must have their primary residence in one of the following states: Delaware, Maryland, Michigan, New Jersey, Ohio, Pennsylvania, West Virginia, Virginia, and parts of North Carolina and Kentucky. You must be at least 21 years of age to apply and legally sign our contract for adoption. Applications must be completed by the homeowner.  We do not adopt giant breed dogs to renters. If you are renting, and you are applying to adopt a dog that is not a giant breed, permission to adopt an animal must be obtained from the landlord or property owner. We do not adopt giant breed dogs to homes with children under 6 years of age. Homes with children should have a fenced yard. Applications will be denied if anyone residing in the household has a record indicating drug/alcohol abuse, theft, or violence. Pets currently in the applicant's home must have a history of appropriate veterinary care. Homes with intact dogs will not be approved for adoption.  Proof of any of the following exceptions is required: The intact dog is a working member of a law enforcement, or search and rescue/recovery team. The intact dog is registered under the auspices of the American Kennel Club and is actively being shown. A veterinarian has determined the sterilization procedure would harm the intact dog.  We believe in Force Free Training Methods and do not approve of methods or devices using pain or force to control the dog, or to deter undesirable behavior.  Homes with highly varnished steps must have carpeting, securely fixed stair treads, or a non-skid surface. **We encourage you to remediate potential safety issues while your application is under review, prior to the home visit. &#226&#128&#139Any inside steps to which the dog(s) have access, must have carpeting, securely fixed stair treads, or a non-skid surface. Homes with highly varnished floors must have non-slip area rugs or mats wherever your animal walks or rests frequently.  **Puppy Adoption Policy** To ensure proper house training and socialization, puppies will only be adopted to homes where an adult will not be away more than an hour per day, per month of age of the puppy, up to 6 months. Certain large-breed dogs should not be sterilized prior to 12 - 18 months of age.  If you adopt an intact puppy, you will sign an adoption contract agreeing to have the dog sterilized at your expense at the time your veterinarian recommends. Proof of sterilization must be provided to Mastiffs To Mutts Rescue as soon as the procedure is completed.  If the puppy is not sterilized as required, Mastiffs To Mutts Rescue reserves the right to claim legal ownership of the dog.  For additional information please review our FAQs or contact mastiffstomutts@gmail.com **Mastiffs To Mutts Rescue reserves the right to approve or deny any adoption that occurs through this organization without disclosure.  We reserve the right to make exceptions for special circumstances. **PA Kennel License: 05845   March 7, 2026, 8:16 pm
Photo of Rufio

Rufio

Mastiff

Male, 6 yrs 11 mos
Harrisburg, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
Rufio is a gentle soul. He is a little shy and more on the quiet side. He does good with other dogs, even small ones.I just can’t say enough sweet things about this pup. He is good in a car and is learning the leash. It takes a little while for him to trust new people, but once he does, his goofy and sweet personality shines!Rufio is medium energy and would do great with any family with a little patience. Rufio is not completely potty trained. He still marks in the house but is working on that.Located in Houston, Tx. Transport to most states available for an additional fee of $300.
Photo of PUMPKIN

PUMPKIN

Mastiff

Female, Young
CARISLE, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
PUMPKIN IS IN HER FOSTER HOME IN MEMPHIS, TN, AND WILL BE TRANSPORTED TO PA ONCE ADOPTED!    Pumpkin is a big, beautiful Mastiff mix who is about one year old and weighs around 115 pounds. She’s a loving, playful girl who enjoys treats and spending time outside. Pumpkin can be a little shy at first, so her adopters will need to be patient and give her time to feel comfortable. Once she warms up, she’s incredibly sweet and affectionate. She is crate trained and housebroken, and she walks well on a leash. Pumpkin enjoys walks around the neighborhood and trips to the park. After a day of fun, she’s happiest snuggling on the couch with her people. Despite her big size, Pumpkin is calm, quiet, and gentle — the perfect companion for someone looking for a loyal and loving friend. She is fully vetted. Vetting includes spay/neuter, microchip, rabies and all dog vaccinations. Her adoption fee of $600 includes the transport to PA. We use a licensed and registered USDA transport company that will bring Pumpkin up north to her new family. You can apply to adopt her today!     If you have any questions, please email us at: newbeginnings_animalrescue@yahoo.com   You can apply to adopt Pumpkin here: www.newbeginningsanimalrescue.net   THANK YOU FOR CONSIDERING ADOPTING A RESCUED PET! Visit this organization's web site to see any additional information available about this pet.June 9, 2026, 6:38 pm
Photo of Eli

Eli

Mastiff

Male, 2 yrs
Manchester, PA
Size
(when grown) -
Details
Good with dogs,
Story
-
Photo of Howie

Howie

Mastiff Mixed Breed (Medium)

Male, 10 mos
Manchester, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
Meet Howie 🐾 Howie is a Cane Corso mix with a gentle soul who’s still learning that the world can be a safe and loving place. He came to us at around 8 months old alongside four of his littermates, and it’s clear he didn’t get much early socialization. Because of this, Howie is extremely timid and can be unsure in new situations or around unfamiliar people. Despite his shyness, there’s a sweet, sensitive dog just waiting to blossom. Howie will need a patient and understanding adopter who’s willing to move at his pace and help him build confidence through positive experiences. With time, consistency, and kindness, he has so much potential to grow into a loyal and devoted companion. Howie is currently awaiting his neuter surgery, and our hope is to have a home lined up so he can smoothly transition into his new life once he’s ready. He is located in the Pittsburgh area and is looking for a calm, supportive environment where he can truly come out of his shell. If you have the heart and patience to help a shy dog find his footing, Howie could be the one for you. 💛
Photo of Shrimp Taco

Shrimp Taco

Mastiff

Male, 3 yrs 1 mo
Manchester, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, Spayed or Neutered,
Story
-

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Mastiff shelters & rescues in Mechanicsburg, Pennsylvania

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Mechanicsburg, Pennsylvania. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Rescue

12.1 miles

Mastiffs To Mutts - Central PA

Harrisburg, PA 17109

Pet Types: dogs

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Shelter

13.3 miles

Waiting Under the Willow Foundation - PA Transport

Harrisburg, PA 17112

Pet Types: dogs

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Rescue

16.4 miles

New Beginnings Animal Rescue - Carisle, PA Transport

CARISLE, PA 17013

Pet Types: cats, dogs

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Rescue

17.3 miles

Koch's Corsos & Rescues

Manchester, PA 17345

Pet Types: dogs

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Shelter

25.3 miles

York County SPCA

3159 Susquehanna Trail North, York, PA 17406

Pet Types: cats, birds, dogs, rabbits, reptiles, small animals

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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