Mastiff Adoption in Pennsylvania: Mastiff Puppies for Sale in Pennsylvania

Adopt a Mastiff near you in Pennsylvania

Below are our newest added Mastiffs available for adoption in Pennsylvania. To see more adoptable Mastiffs in Pennsylvania, use the search tool below to enter specific criteria!

Atkin

Mastiff/Cane Corso

Female 4 yrs 2 mos

Manchester, PA

Size

(when grown) -

Details

Story

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Lucy

Mastiff/Labrador Retriever

Female, Adult

Lansdale, PA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Hi, my name is Lucy and I am a 5-year-old Mastiff mix. Please visit our website www.homeatlastdogrescue.com for more information, our complete listing of available dogs, and to submit an application. PA kennel license #5310 100 W Main St Lansdale, PA 19446

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Johnny *Urgent

Mastiff/Great Dane

Male, Adult

Harrisburg, PA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs,

Story

PLEASE NOTE! Unless stated otherwise, our dogs and puppies are located in Arkansas, and transported to the north/northeast once adopted. We do occasionally have dogs/puppies placed in foster homes in the north/northeast. In the cases where the pet is somewhere other than Arkansas, it will be noted beside the name of the pet.Urgent need for foster or adopter!! Johnny (renamed to Ozzy) has become urgent. Not because he is dangerous in any way, but because he's inconvenient. He makes a mess in a crate, and barks when left outside, and now neighbors have called the police because he was barking while his adopter went out to dinner. Clearly, he has some separation anxiety and it breaks my heart that he is going to have to make yet another change. He needs a patient adopter. He was NOT like that while he was in Arkansas. He was very well adjusted. I feel that he is not getting nearly enough exercise. I believe that is a big part of the problem. And I think the other part is that he needs more time to adjust. Johnny did great with other non aggressive dogs at doggy daycare while here in Arkansas. He has not been with other dogs since going to his home in January. Johnny adores all people. He did great with kids here, but was never around any really small kids. We have no reason to believe he would not do well with them, but he might accidentally knock them down, because he himself is just a giant baby and doesn't know his size. Johnny is just over 100 lbs, is about 2 years old, and is located in New York. To foster: You can find my form 'AASR Foster Application' at: https://form.jotform.com/213335552163046 To adopt: You can find my form 'ADOPT A STRAY RESCUE' at: https://form.jotform.com/212690945239059 Message us or email apps.aasr@gmail.com with any questions.Visit this organization's web site to see any additional information available about this pet.Our typical adoption fee for puppies younger than 6 months old is $400, and for older puppies and adults, the usual fee is $350. This includes microchip, spay/neuter, up to date on age appropriate vaccinations, dewormings, flea/tick treatment, and heartworm test (if over 6 months old) as well as heartworm treatment if they test positive. There is a transport fee of $150 per dog, depending on the transporter. We use Pack Leaders Rescue Dog Transport most often, but also use Hearts Transport as well on occasion. Please visit our Facebook page too! https://www.facebook.com/adoptastrayrescueorg For more info regarding adopting, email apps.aasr@gmail.com Thank you for considering one of our rescue babies!April 12, 2026, 8:02 am

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Ralph BW

Mastiff/Mixed Breed (Large)

Male, 1 yr 2 mos

Pittsburgh, PA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

Ralph the Derp! Ralph is a huge friendly, enthusiastic, uncoordinated 4-legged energetic goofball! He was rescued from “death row” at a high kill shelter, as a skinny stray with a treatable skin condition. His fur has almost completely grown in & he is now at a healthy weight. This overgrown mastiff/Cane Corso mix pup has no comprehension of his size, leaning into humans for affection or trying to ooze onto laps for cuddles. He is being trained not to jump and not to paw for attention/affection/play because he currently has 85# of mass behind those “congenial” moves. Ralph plays well with dogs of all sizes, but would do best with med-to-larger dogs due to his size & poorly curbed gusto. He hordes toys, taking them all to his chosen dog bed of the day. He likes to carry a special toy “baby” in his mouth when going out in the yard. He does need to be fed in his crate & will guard his empty food bowl from other dogs, unless he is distracted with a toy & led outdoors after meals. He is great on a leash, makes awesome grunty sounds when cuddled, enjoys baths. Ralph will make a great addition to an active family with older children. He is eager to please, food and affection oriented (although a bit stubborn at times), making him an ideal candidate for success with continuation of his training. Please consider adopting the gorgeous big derp into your home. Attributes: In training to avoid jumping/pawing Active family He is neutered, microchipped, had recent cherry eye repair and up to date on all vaccines and preventions. Local adoption fee is $200(in TX) Out of state adoption fee is $450 (includes transport to your area)

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Xena

Mastiff

Female, Young

Marietta, PA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, House-trained,

Story

Xena is a wonderful, gentle dog with a sweet and loving personality. She is amazing with children and enjoys being around people. At 4 years old, she has a calm nature, she likes short walks and is perfectly happy spending most of her day relaxing and napping. Xena loves attention, especially being pet, and is a big fan of snuggling up with her humans. She would make a loyal and affectionate companion in a loving home.

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Howie

Mastiff/Mixed Breed (Medium)

Male, 9 mos

Manchester, PA

Size

(when grown) -

Details

Story

Meet Howie 🐾 Howie is a Cane Corso mix with a gentle soul who’s still learning that the world can be a safe and loving place. He came to us at around 8 months old alongside four of his littermates, and it’s clear he didn’t get much early socialization. Because of this, Howie is extremely timid and can be unsure in new situations or around unfamiliar people. Despite his shyness, there’s a sweet, sensitive dog just waiting to blossom. Howie will need a patient and understanding adopter who’s willing to move at his pace and help him build confidence through positive experiences. With time, consistency, and kindness, he has so much potential to grow into a loyal and devoted companion. Howie is currently awaiting his neuter surgery, and our hope is to have a home lined up so he can smoothly transition into his new life once he’s ready. He is located in the Pittsburgh area and is looking for a calm, supportive environment where he can truly come out of his shell. If you have the heart and patience to help a shy dog find his footing, Howie could be the one for you. 💛

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Mastiff puppies and dogs in Pennsylvania

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Below are our newest added Mastiffs available for adoption in Pennsylvania. To see more adoptable Mastiffs in Pennsylvania, use the search tool below to enter specific criteria!

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Mastiff puppies and dogs in Pennsylvania

Jump to:

Adopt a Mastiff near you in Pennsylvania

Below are our newest added Mastiffs available for adoption in Pennsylvania. To see more adoptable Mastiffs in Pennsylvania, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Pennsylvania cities

Mastiff shelters & rescues in Pennsylvania

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics