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Mastiff puppies and dogs in Pennsylvania

Looking for a Mastiff puppy or dog in Pennsylvania? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you in Pennsylvania

Below are our newest added Mastiffs available for adoption in Pennsylvania. To see more adoptable Mastiffs in Pennsylvania, use the search tool below to enter specific criteria!
We'll also keep you updated on Venus's adoption status with email updates.
Photo of Venus

Venus

Mastiff

Female, 3 yrs
Erie, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, Good with cats,
Story
Hi there, I’m Venus — a 126-pound bundle of love wrapped in soft fur and sleepy eyes. At 3 years old, I’ve already mastered the fine art of lounging. If there’s a comfy bed or a sunny spot on the floor, you’ll find me there, snoring softly and dreaming of belly rubs. I’m what you might call a professional napper, but don’t worry, I’ve still got plenty of tail wags and affection to go around. I’m a super chill girl who gets along wonderfully with other dogs and even cats. I have a calm, gentle nature that makes me easy to love and even easier to be around. I’ve been putting on some healthy weight recently (gained about 10 pounds — go me!) and could probably stand to gain a few more. I’m not in any rush though... slow and steady wins the snuggle race. What I’m looking for is a home that appreciates the beauty of a relaxed lifestyle. I don’t need high-energy adventures, just a soft place to land, some treats, and a person or family who loves big, sweet dogs with even bigger hearts. So if you’ve got a cozy spot and an open heart, I’d love to meet you. Let’s lounge our way through life together. With love and lazy tail wags, Venus Venus' adoption fee is $275. You can learn more about Venus and other dogs at Happy Bark by visiting www.happybark.org PA Kennel License 17445
We'll also keep you updated on Triss's adoption status with email updates.
Photo of Triss

Triss

Mastiff/Mixed Breed (Large)

Female, 3 mos
Uniontown, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
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We'll also keep you updated on Freya's adoption status with email updates.
Photo of Freya

Freya

Mastiff

Female, 6 yrs
York, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
Freya is a sweet, gentle girl who just needed a little time to warm up, but once she did, her goofy, loving personality began to shine. Surrendered through no fault of her own, she’s now ready to start fresh with a family who will adore her. Freya is currently being treated for some skin issues and is healing wonderfully. She loves being with people and we know her personality will only continue to blossom in a home of her own.
We'll also keep you updated on Zoey's adoption status with email updates.
Photo of Zoey

Zoey

Mastiff

Female, Adult
Harrisburg, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained,
Story
You can fill out an adoption application online on our official website. Fill out an Adoption Application Zoey (fka Ruckus) came back to MTM after being adopted several years ago and her adopter recently passed away.    She is doing great in her foster home living with a toddler, 2 young kids and dogs of all sizes.   Zoey did take a bit to adjust. She is shy at first meeting, but once she settles in, she seeks attention and thrives off of routine. So if interested in meeting her, please understand, she does not show well, but given some time and patience, she will come around and show great affection.    She has begun to engage the other dogs in play and loves to spend time outside in the yard. She does well being left alone with the other dogs, with no concern of messes or destructive behavior.     She does pull on the leash and will need some help with that, but that too needs to be made part of her routine. Zoey is a low to medium energy dog and is content to just hang out. She will pick a favorite bed and that becomes her spot.    Zoey does well riding in the car, was well behaved at the vets office and doesn't mind a nail trim as long as shes being scratched at the same time.   She is potty trained and will go to the door or even come wake you if she needs to go out.    Zoey has been fully updated on vaccines and received a dental. She is ready for a new family! Visit this organization's web site to see any additional information available about this pet. Application Fees, Adoption Donations and Rescue Policy: Please know that 100% of our fees and donations pay for the costs of rescuing dogs. These include but are not limited to pull fees from shelters, veterinary examinations, vaccinations, medications and care, microchips, neuter/spay surgeries, heartworm treatments, behavior evaluations, and foster care, as needed. Important notes before applying. Approved adopters must have their primary residence in one of the following states: Delaware, Maryland, Michigan, New Jersey, Ohio, Pennsylvania, West Virginia, Virginia, and parts of North Carolina and Kentucky. You must be at least 21 years of age to apply and legally sign our contract for adoption. Applications must be completed by the homeowner.  We do not adopt giant breed dogs to renters. If you are renting, and you are applying to adopt a dog that is not a giant breed, permission to adopt an animal must be obtained from the landlord or property owner. We do not adopt giant breed dogs to homes with children under 6 years of age. Homes with children should have a fenced yard. Applications will be denied if anyone residing in the household has a record indicating drug/alcohol abuse, theft, or violence. Pets currently in the applicant's home must have a history of appropriate veterinary care. Homes with intact dogs will not be approved for adoption.  Proof of any of the following exceptions is required: The intact dog is a working member of a law enforcement, or search and rescue/recovery team. The intact dog is registered under the auspices of the American Kennel Club and is actively being shown. A veterinarian has determined the sterilization procedure would harm the intact dog.  We believe in Force Free Training Methods and do not approve of methods or devices using pain or force to control the dog, or to deter undesirable behavior.  Homes with highly varnished steps must have carpeting, securely fixed stair treads, or a non-skid surface. **We encourage you to remediate potential safety issues while your application is under review, prior to the home visit. &#226&#128&#139Any inside steps to which the dog(s) have access, must have carpeting, securely fixed stair treads, or a non-skid surface. Homes with highly varnished floors must have non-slip area rugs or mats wherever your animal walks or rests frequently.  **Puppy Adoption Policy** To ensure proper house training and socialization, puppies will only be adopted to homes where an adult will not be away more than an hour per day, per month of age of the puppy, up to 6 months. Certain large-breed dogs should not be sterilized prior to 12 - 18 months of age.  If you adopt an intact puppy, you will sign an adoption contract agreeing to have the dog sterilized at your expense at the time your veterinarian recommends. Proof of sterilization must be provided to Mastiffs To Mutts Rescue as soon as the procedure is completed.  If the puppy is not sterilized as required, Mastiffs To Mutts Rescue reserves the right to claim legal ownership of the dog.  For additional information please review our FAQs or contact mastiffstomutts@gmail.com **Mastiffs To Mutts Rescue reserves the right to approve or deny any adoption that occurs through this organization without disclosure.  We reserve the right to make exceptions for special circumstances. **PA Kennel License: 05845   December 5, 2025, 6:54 pm
We'll also keep you updated on Zoey's adoption status with email updates.
Photo of Zoey

Zoey

Mastiff

Female, Adult
McDonald, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained,
Story
You can fill out an adoption application online on our official website. Fill out an Adoption Application Zoey (fka Ruckus) came back to MTM after being adopted several years ago and her adopter recently passed away.    She is doing great in her foster home living with a toddler, 2 young kids and dogs of all sizes.   Zoey did take a bit to adjust. She is shy at first meeting, but once she settles in, she seeks attention and thrives off of routine. So if interested in meeting her, please understand, she does not show well, but given some time and patience, she will come around and show great affection.    She has begun to engage the other dogs in play and loves to spend time outside in the yard. She does well being left alone with the other dogs, with no concern of messes or destructive behavior.     She does pull on the leash and will need some help with that, but that too needs to be made part of her routine. Zoey is a low to medium energy dog and is content to just hang out. She will pick a favorite bed and that becomes her spot.    Zoey does well riding in the car, was well behaved at the vets office and doesn't mind a nail trim as long as shes being scratched at the same time.   She is potty trained and will go to the door or even come wake you if she needs to go out.    Zoey has been fully updated on vaccines and received a dental. She is ready for a new family! Visit this organization's web site to see any additional information available about this pet. Application Fees, Adoption Donations and Rescue Policy: Please know that 100% of our fees and donations pay for the costs of rescuing dogs. These include but are not limited to pull fees from shelters, veterinary examinations, vaccinations, medications and care, microchips, neuter/spay surgeries, heartworm treatments, behavior evaluations, and foster care, as needed. Important notes before applying. Approved adopters must have their primary residence in one of the following states: Delaware, Maryland, Michigan, New Jersey, Ohio, Pennsylvania, West Virginia, Virginia, and parts of North Carolina and Kentucky. You must be at least 21 years of age to apply and legally sign our contract for adoption. Applications must be completed by the homeowner.  We do not adopt giant breed dogs to renters. If you are renting, and you are applying to adopt a dog that is not a giant breed, permission to adopt an animal must be obtained from the landlord or property owner. We do not adopt giant breed dogs to homes with children under 6 years of age. Homes with children should have a fenced yard. Applications will be denied if anyone residing in the household has a record indicating drug/alcohol abuse, theft, or violence. Pets currently in the applicant's home must have a history of appropriate veterinary care. Homes with intact dogs will not be approved for adoption.  Proof of any of the following exceptions is required: The intact dog is a working member of a law enforcement, or search and rescue/recovery team. The intact dog is registered under the auspices of the American Kennel Club and is actively being shown. A veterinarian has determined the sterilization procedure would harm the intact dog.  We believe in Force Free Training Methods and do not approve of methods or devices using pain or force to control the dog, or to deter undesirable behavior.  Homes with highly varnished steps must have carpeting, securely fixed stair treads, or a non-skid surface. **We encourage you to remediate potential safety issues while your application is under review, prior to the home visit. &#226&#128&#139Any inside steps to which the dog(s) have access, must have carpeting, securely fixed stair treads, or a non-skid surface. Homes with highly varnished floors must have non-slip area rugs or mats wherever your animal walks or rests frequently.  **Puppy Adoption Policy** To ensure proper house training and socialization, puppies will only be adopted to homes where an adult will not be away more than an hour per day, per month of age of the puppy, up to 6 months. Certain large-breed dogs should not be sterilized prior to 12 - 18 months of age.  If you adopt an intact puppy, you will sign an adoption contract agreeing to have the dog sterilized at your expense at the time your veterinarian recommends. Proof of sterilization must be provided to Mastiffs To Mutts Rescue as soon as the procedure is completed.  If the puppy is not sterilized as required, Mastiffs To Mutts Rescue reserves the right to claim legal ownership of the dog.  For additional information please review our FAQs or contact mastiffstomutts@gmail.com **Mastiffs To Mutts Rescue reserves the right to approve or deny any adoption that occurs through this organization without disclosure.  We reserve the right to make exceptions for special circumstances. **PA Kennel License: 05845   December 5, 2025, 6:54 pm
We'll also keep you updated on Zoey's adoption status with email updates.
Photo of Zoey

Zoey

Mastiff

Female, Adult
Exton, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained,
Story
You can fill out an adoption application online on our official website. Fill out an Adoption Application Zoey (fka Ruckus) came back to MTM after being adopted several years ago and her adopter recently passed away.    She is doing great in her foster home living with a toddler, 2 young kids and dogs of all sizes.   Zoey did take a bit to adjust. She is shy at first meeting, but once she settles in, she seeks attention and thrives off of routine. So if interested in meeting her, please understand, she does not show well, but given some time and patience, she will come around and show great affection.    She has begun to engage the other dogs in play and loves to spend time outside in the yard. She does well being left alone with the other dogs, with no concern of messes or destructive behavior.     She does pull on the leash and will need some help with that, but that too needs to be made part of her routine. Zoey is a low to medium energy dog and is content to just hang out. She will pick a favorite bed and that becomes her spot.    Zoey does well riding in the car, was well behaved at the vets office and doesn't mind a nail trim as long as shes being scratched at the same time.   She is potty trained and will go to the door or even come wake you if she needs to go out.    Zoey has been fully updated on vaccines and received a dental. She is ready for a new family! Visit this organization's web site to see any additional information available about this pet. Application Fees, Adoption Donations and Rescue Policy: Please know that 100% of our fees and donations pay for the costs of rescuing dogs. These include but are not limited to pull fees from shelters, veterinary examinations, vaccinations, medications and care, microchips, neuter/spay surgeries, heartworm treatments, behavior evaluations, and foster care, as needed. Important notes before applying. Approved adopters must have their primary residence in one of the following states: Delaware, Maryland, Michigan, New Jersey, Ohio, Pennsylvania, West Virginia, Virginia, and parts of North Carolina and Kentucky. You must be at least 21 years of age to apply and legally sign our contract for adoption. Applications must be completed by the homeowner.  We do not adopt giant breed dogs to renters. If you are renting, and you are applying to adopt a dog that is not a giant breed, permission to adopt an animal must be obtained from the landlord or property owner. We do not adopt giant breed dogs to homes with children under 6 years of age. Homes with children should have a fenced yard. Applications will be denied if anyone residing in the household has a record indicating drug/alcohol abuse, theft, or violence. Pets currently in the applicant's home must have a history of appropriate veterinary care. Homes with intact dogs will not be approved for adoption.  Proof of any of the following exceptions is required: The intact dog is a working member of a law enforcement, or search and rescue/recovery team. The intact dog is registered under the auspices of the American Kennel Club and is actively being shown. A veterinarian has determined the sterilization procedure would harm the intact dog.  We believe in Force Free Training Methods and do not approve of methods or devices using pain or force to control the dog, or to deter undesirable behavior.  Homes with highly varnished steps must have carpeting, securely fixed stair treads, or a non-skid surface. **We encourage you to remediate potential safety issues while your application is under review, prior to the home visit. &#226&#128&#139Any inside steps to which the dog(s) have access, must have carpeting, securely fixed stair treads, or a non-skid surface. Homes with highly varnished floors must have non-slip area rugs or mats wherever your animal walks or rests frequently.  **Puppy Adoption Policy** To ensure proper house training and socialization, puppies will only be adopted to homes where an adult will not be away more than an hour per day, per month of age of the puppy, up to 6 months. Certain large-breed dogs should not be sterilized prior to 12 - 18 months of age.  If you adopt an intact puppy, you will sign an adoption contract agreeing to have the dog sterilized at your expense at the time your veterinarian recommends. Proof of sterilization must be provided to Mastiffs To Mutts Rescue as soon as the procedure is completed.  If the puppy is not sterilized as required, Mastiffs To Mutts Rescue reserves the right to claim legal ownership of the dog.  For additional information please review our FAQs or contact mastiffstomutts@gmail.com **Mastiffs To Mutts Rescue reserves the right to approve or deny any adoption that occurs through this organization without disclosure.  We reserve the right to make exceptions for special circumstances. **PA Kennel License: 05845   December 5, 2025, 6:54 pm

Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Pennsylvania.

Mastiff puppies and dogs in Pennsylvania cities

Mastiff Puppies near me Mastiff in Aliquippa Mastiff in Allentown Mastiff in Altoona Mastiff in Ambler Mastiff in Ambridge Mastiff in Archbald Mastiff in Arnold Mastiff in Avalon Mastiff in Bangor Mastiff in Beaver Mastiff in Beaver Falls Mastiff in Bellefonte Mastiff in Bellevue Mastiff in Berwick Mastiff in Bethel Park Mastiff in Bethlehem Mastiff in Birdsboro Mastiff in Blakely Mastiff in Bloomsburg Mastiff in Braddock Mastiff in Bradford Mastiff in Brentwood Mastiff in Bridgeport Mastiff in Bridgeville Mastiff in Bristol Mastiff in Brookhaven Mastiff in Butler Mastiff in California Mastiff in Camp Hill Mastiff in Canonsburg Mastiff in Carbondale Mastiff in Carlisle Mastiff in Carnegie Mastiff in Castle Shannon Mastiff in Catasauqua Mastiff in Chambersburg Mastiff in Charleroi Mastiff in Chester Mastiff in Clairton Mastiff in Clarion Mastiff in Clarks Summit Mastiff in Clearfield Mastiff in Clifton Heights Mastiff in Coatesville Mastiff in Collegeville Mastiff in Collingdale Mastiff in Columbia Mastiff in Connellsville Mastiff in Conshohocken Mastiff in Coraopolis Mastiff in Corry Mastiff in Crafton Mastiff in Danville Mastiff in Darby Mastiff in Dickson City Mastiff in Donora Mastiff in Downingtown Mastiff in Doylestown Mastiff in Dubois Mastiff in Dunmore Mastiff in Duquesne Mastiff in Duryea Mastiff in Easton Mastiff in East Petersburg Mastiff in East Stroudsburg Mastiff in Edinboro Mastiff in Edwardsville Mastiff in Elizabethtown Mastiff in Ellwood City Mastiff in Emmaus Mastiff in Ephrata Mastiff in Erie Mastiff in Exeter Mastiff in Farrell Mastiff in Folcroft Mastiff in Fountain Hill Mastiff in Franklin Mastiff in Gettysburg Mastiff in Glassport Mastiff in Glenolden Mastiff in Greensburg Mastiff in Greenville Mastiff in Grove City Mastiff in Hanover Mastiff in Harrisburg Mastiff in Hatboro Mastiff in Hazleton Mastiff in Hellertown Mastiff in Hermitage Mastiff in Hollidaysburg Mastiff in Honesdale Mastiff in Hummelstown Mastiff in Huntingdon Mastiff in Indiana Mastiff in Jeannette Mastiff in Jefferson Hills Mastiff in Jenkintown Mastiff in Jersey Shore Mastiff in Jessup Mastiff in Jim Thorpe Mastiff in Johnstown Mastiff in Kennett Square Mastiff in Kingston Mastiff in Kittanning Mastiff in Kutztown Mastiff in Lancaster Mastiff in Lansdale Mastiff in Lansdowne Mastiff in Larksville Mastiff in Latrobe Mastiff in Lebanon Mastiff in Lehighton Mastiff in Lewisburg Mastiff in Lewistown Mastiff in Lititz Mastiff in Lock Haven Mastiff in Lower Burrell Mastiff in Mahanoy City Mastiff in Manheim Mastiff in McKeesport Mastiff in Mc Kees Rocks Mastiff in Meadville Mastiff in Mechanicsburg Mastiff in Media Mastiff in Middletown Mastiff in Millersville Mastiff in Milton Mastiff in Monaca Mastiff in Monessen Mastiff in Monongahela Mastiff in Monroeville Mastiff in Montoursville Mastiff in Moosic Mastiff in Morrisville Mastiff in Mount Carmel Mastiff in Mount Joy Mastiff in Mount Pleasant Mastiff in Munhall Mastiff in Murrysville Mastiff in Nanticoke Mastiff in Nazareth Mastiff in New Brighton Mastiff in New Castle Mastiff in New Cumberland Mastiff in New Holland Mastiff in New Kensington Mastiff in Norristown Mastiff in Northampton Mastiff in Norwood Mastiff in Oakmont Mastiff in Oil City Mastiff in Old Forge Mastiff in Olyphant Mastiff in Oxford Mastiff in Palmerton Mastiff in Palmyra Mastiff in Perkasie Mastiff in Philadelphia Mastiff in Phoenixville Mastiff in Pittsburgh Mastiff in Pittston Mastiff in Pleasant Hills Mastiff in Plum Mastiff in Plymouth Mastiff in Pottstown Mastiff in Pottsville Mastiff in Prospect Park Mastiff in Punxsutawney Mastiff in Quakertown Mastiff in Reading Mastiff in Red Lion Mastiff in Ridley Park Mastiff in Royersford Mastiff in Saint Marys Mastiff in Sayre Mastiff in Schuylkill Haven Mastiff in Scottdale Mastiff in Scranton Mastiff in Selinsgrove Mastiff in Sellersville Mastiff in Shamokin Mastiff in Sharon Mastiff in Sharon Hill Mastiff in Shenandoah Mastiff in Shillington Mastiff in Shippensburg Mastiff in Slatington Mastiff in Somerset Mastiff in Souderton Mastiff in South Williamsport Mastiff in State College Mastiff in Steelton Mastiff in Stroudsburg Mastiff in Sunbury Mastiff in Swarthmore Mastiff in Swissvale Mastiff in Swoyersville Mastiff in Tamaqua Mastiff in Tarentum Mastiff in Taylor Mastiff in Telford Mastiff in Titusville Mastiff in Turtle Creek Mastiff in Tyrone Mastiff in Uniontown Mastiff in Vandergrift Mastiff in Warren Mastiff in Washington Mastiff in Waynesboro Mastiff in West Chester Mastiff in West Mifflin Mastiff in West Pittston Mastiff in West View Mastiff in Whitehall Mastiff in White Oak Mastiff in Wilkes Barre Mastiff in Wilkinsburg Mastiff in Williamsport Mastiff in Wyomissing Mastiff in Yeadon Mastiff in York

Mastiff shelters & rescues in Pennsylvania

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Pennsylvania. Browse these Mastiff rescues and shelters below.

Here are a few organizations

Rescue

Pitter Pat Junction, York PA transport

York transport , PA 17403

Pet Types: dogs

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Shelter

York County SPCA

3159 Susquehanna Trail North, York , PA 17406

Pet Types: cats, birds, dogs, rabbits, reptiles, small animals

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Shelter

Antietam Humane Society Inc

8513 Lyons Road, Waynesboro , PA 17268

Pet Types: cats, birds, dogs, farm animals, rabbits, reptiles, small animals

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Rescue

Mastiffs To Mutts - Central PA

Harrisburg , PA 17109

Pet Types: dogs

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Shelter

Brandywine Valley SPCA - Lancaster

2195 Lincoln Hwy E, Lancaster , PA 17602

Pet Types: dogs

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Rescue

Angies Stray Foundation

Oxford , PA 19363

Pet Types: cats, dogs

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Shelter

Huntingdon County Humane Society LC #2157

11371 School House Hollow Road, Huntingdon , PA 16652

Pet Types: cats, dogs

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Rescue

Mastiffs to Mutts - Eastern PA

Exton , PA 19341

Pet Types: dogs

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Rescue

Angel's Retreat

West Chester , PA 19382

Pet Types: dogs

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Rescue

To Love a Canine Rescue, Inc

PO Box 422, Kimberton , PA 19442

Pet Types: dogs

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If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog ?

We've got all the info you need on adopting and caring for a Mastiff puppy . Check out the links below for everything you ever wanted to know about Mastiff puppies and adults .

Mastiff information

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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