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Mastiff puppies and dogs in Harrisburg, Pennsylvania

Looking for a Mastiff puppy or dog in Harrisburg, Pennsylvania? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you in Harrisburg, Pennsylvania

These Mastiffs are available in Harrisburg, Pennsylvania.
We'll also keep you updated on Tiny Tim's adoption status with email updates.
Photo of Tiny Tim

Tiny Tim

English Mastiff

Male, Adult
Harrisburg, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
House-trained, Spayed or Neutered,
Story
You can fill out an adoption application online on our official website. Fill out an Adoption Application HEADLINER:  Tiny Tim “Tiny” PERSONALITY: Tiny can be on alert around people that are not regulars in the home however with some supervision and guidance he can warm up fast and become very loving. He has a bit of an “alpha” attitude and will occasionally have a low soft growl around small children. It is recommended he not be placed with any home that has pre teens or regular pack members that can over do it on attention. He is loyal and loving , he requires a lot of petting and attention. He does drool and will need help keeping his front legs cleaned often. FAVORITE ACTIVITIES: He likes being around other regular pack members and will bark at anything he deems a threat including door bells. MEDICAL ISSUES: He may have allergies as his eyes often have a mucus build up in both eyes but he enjoys getting his eyes wiped. WHAT WOULD BE THE BEST KIND OF HOME: No pre teens or no homes with a immature personality as he does not like to be teased. A home with a lot of love to give because he cant get enough. He will joyfully greet regular pack members when the return home from even the shortest trips and will follow you around as long as you can handle. Application Fees, Adoption Donations and Rescue Policy: Please know that 100% of our fees and donations pay for the costs of rescuing dogs. These include but are not limited to pull fees from shelters, veterinary examinations, vaccinations, medications and care, microchips, neuter/spay surgeries, heartworm treatments, behavior evaluations, and foster care, as needed. Important notes before applying. Approved adopters must have their primary residence in one of the following states: Delaware, Maryland, Michigan, New Jersey, Ohio, Pennsylvania, West Virginia, Virginia, and parts of North Carolina and Kentucky. You must be at least 21 years of age to apply and legally sign our contract for adoption. Applications must be completed by the homeowner.  We do not adopt giant breed dogs to renters. If you are renting, and you are applying to adopt a dog that is not a giant breed, permission to adopt an animal must be obtained from the landlord or property owner. We do not adopt giant breed dogs to homes with children under 6 years of age. Homes with children should have a fenced yard. Applications will be denied if anyone residing in the household has a record indicating drug/alcohol abuse, theft, or violence. Pets currently in the applicant's home must have a history of appropriate veterinary care. Homes with intact dogs will not be approved for adoption.  Proof of any of the following exceptions is required: The intact dog is a working member of a law enforcement, or search and rescue/recovery team. The intact dog is registered under the auspices of the American Kennel Club and is actively being shown. A veterinarian has determined the sterilization procedure would harm the intact dog.  We believe in Force Free Training Methods and do not approve of methods or devices using pain or force to control the dog, or to deter undesirable behavior.  Homes with highly varnished steps must have carpeting, securely fixed stair treads, or a non-skid surface. **We encourage you to remediate potential safety issues while your application is under review, prior to the home visit. &#226&#128&#139Any inside steps to which the dog(s) have access, must have carpeting, securely fixed stair treads, or a non-skid surface. Homes with highly varnished floors must have non-slip area rugs or mats wherever your animal walks or rests frequently.  For additional information please review our FAQs or contact mastiffstomutts@gmail.com **Mastiffs To Mutts Rescue reserves the right to approve or deny any adoption that occurs through this organization without disclosure.  We reserve the right to make exceptions for special circumstances. **PA Kennel License: 05845   Visit this organization's web site to see any additional information available about this pet. Application Fees, Adoption Donations and Rescue Policy: Please know that 100% of our fees and donations pay for the costs of rescuing dogs. These include but are not limited to pull fees from shelters, veterinary examinations, vaccinations, medications and care, microchips, neuter/spay surgeries, heartworm treatments, behavior evaluations, and foster care, as needed. Important notes before applying. Approved adopters must have their primary residence in one of the following states: Delaware, Maryland, Michigan, New Jersey, Ohio, Pennsylvania, West Virginia, Virginia, and parts of North Carolina and Kentucky. You must be at least 21 years of age to apply and legally sign our contract for adoption. Applications must be completed by the homeowner.  We do not adopt giant breed dogs to renters. If you are renting, and you are applying to adopt a dog that is not a giant breed, permission to adopt an animal must be obtained from the landlord or property owner. We do not adopt giant breed dogs to homes with children under 6 years of age. Homes with children should have a fenced yard. Applications will be denied if anyone residing in the household has a record indicating drug/alcohol abuse, theft, or violence. Pets currently in the applicant's home must have a history of appropriate veterinary care. Homes with intact dogs will not be approved for adoption.  Proof of any of the following exceptions is required: The intact dog is a working member of a law enforcement, or search and rescue/recovery team. The intact dog is registered under the auspices of the American Kennel Club and is actively being shown. A veterinarian has determined the sterilization procedure would harm the intact dog.  We believe in Force Free Training Methods and do not approve of methods or devices using pain or force to control the dog, or to deter undesirable behavior.  Homes with highly varnished steps must have carpeting, securely fixed stair treads, or a non-skid surface. **We encourage you to remediate potential safety issues while your application is under review, prior to the home visit. &#226&#128&#139Any inside steps to which the dog(s) have access, must have carpeting, securely fixed stair treads, or a non-skid surface. Homes with highly varnished floors must have non-slip area rugs or mats wherever your animal walks or rests frequently.  **Puppy Adoption Policy** To ensure proper house training and socialization, puppies will only be adopted to homes where an adult will not be away more than an hour per day, per month of age of the puppy, up to 6 months. Certain large-breed dogs should not be sterilized prior to 12 - 18 months of age.  If you adopt an intact puppy, you will sign an adoption contract agreeing to have the dog sterilized at your expense at the time your veterinarian recommends. Proof of sterilization must be provided to Mastiffs To Mutts Rescue as soon as the procedure is completed.  If the puppy is not sterilized as required, Mastiffs To Mutts Rescue reserves the right to claim legal ownership of the dog.  For additional information please review our FAQs or contact mastiffstomutts@gmail.com **Mastiffs To Mutts Rescue reserves the right to approve or deny any adoption that occurs through this organization without disclosure.  We reserve the right to make exceptions for special circumstances. **PA Kennel License: 05845   November 6, 2025, 8:17 pm
We'll also keep you updated on Izzabella's adoption status with email updates.
Photo of Izzabella

Izzabella

English Mastiff

Female, Senior
Harrisburg, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, House-trained, Spayed or Neutered,
Story
You can fill out an adoption application online on our official website. Fill out an Adoption Application HEADLINER: Izzabella aka Izzy. HISTORY: One owner who did not provide basic medical care so Izzy lived many year with out of control skin issues, ear infections, UTI’s, etc. PERSONALITY: Izzy is a sweet, friendly girl that loves meeting new people and welcoming them into the house. She loves attention and affection and will lean in hard for pets and ear scratches. She tends to spend her days snoozing away but when she gets the zoomies she takes them seriously and this girl can move despite her age.  She lives peacefully with a 60lb male mixed breed but is reactive when seeing dogs out on a walk. Izzy is a bit fearful of fireworks and thunderstorms and will sometimes get spooked by loud noises. Izzy likes things to happen on her own personal timeline and can be stubborn when they don’t. She will test limits by whining and carrying on (dancing around, stomping her feet, wagging her tail furiously while staring at you) to try to get her way. She’s learning that those things don’t work in our house but it’s hard not to laugh at her antics. She’ll do it to the other dog in the house too when he’s laying in a bed that she wants. She usually gets her way with the dog.  FAVORITE ACTIVITIES: Napping, soaking up love and attention, laying in the sun MEDICAL ISSUES: With vet care and a quality diet Izzy’s skin issues and ear infections have cleared up and she is no longer a big itchy mess. She did have a mammary tumor removed while being spayed. She is not currently on any medications. WHAT WOULD BE THE BEST KIND OF HOME: Izzy enjoys hanging out with her people, so a family that spends a lot of time around the house/yard/garden would be great for her. Once integrated with another dog she is very polite and respectful but she definitely needs slow introductions to new dogs.Visit this organization's web site to see any additional information available about this pet. Application Fees, Adoption Donations and Rescue Policy: Please know that 100% of our fees and donations pay for the costs of rescuing dogs. These include but are not limited to pull fees from shelters, veterinary examinations, vaccinations, medications and care, microchips, neuter/spay surgeries, heartworm treatments, behavior evaluations, and foster care, as needed. Important notes before applying. Approved adopters must have their primary residence in one of the following states: Delaware, Maryland, Michigan, New Jersey, Ohio, Pennsylvania, West Virginia, Virginia, and parts of North Carolina and Kentucky. You must be at least 21 years of age to apply and legally sign our contract for adoption. Applications must be completed by the homeowner.  We do not adopt giant breed dogs to renters. If you are renting, and you are applying to adopt a dog that is not a giant breed, permission to adopt an animal must be obtained from the landlord or property owner. We do not adopt giant breed dogs to homes with children under 6 years of age. Homes with children should have a fenced yard. Applications will be denied if anyone residing in the household has a record indicating drug/alcohol abuse, theft, or violence. Pets currently in the applicant's home must have a history of appropriate veterinary care. Homes with intact dogs will not be approved for adoption.  Proof of any of the following exceptions is required: The intact dog is a working member of a law enforcement, or search and rescue/recovery team. The intact dog is registered under the auspices of the American Kennel Club and is actively being shown. A veterinarian has determined the sterilization procedure would harm the intact dog.  We believe in Force Free Training Methods and do not approve of methods or devices using pain or force to control the dog, or to deter undesirable behavior.  Homes with highly varnished steps must have carpeting, securely fixed stair treads, or a non-skid surface. **We encourage you to remediate potential safety issues while your application is under review, prior to the home visit. &#226&#128&#139Any inside steps to which the dog(s) have access, must have carpeting, securely fixed stair treads, or a non-skid surface. Homes with highly varnished floors must have non-slip area rugs or mats wherever your animal walks or rests frequently.  **Puppy Adoption Policy** To ensure proper house training and socialization, puppies will only be adopted to homes where an adult will not be away more than an hour per day, per month of age of the puppy, up to 6 months. Certain large-breed dogs should not be sterilized prior to 12 - 18 months of age.  If you adopt an intact puppy, you will sign an adoption contract agreeing to have the dog sterilized at your expense at the time your veterinarian recommends. Proof of sterilization must be provided to Mastiffs To Mutts Rescue as soon as the procedure is completed.  If the puppy is not sterilized as required, Mastiffs To Mutts Rescue reserves the right to claim legal ownership of the dog.  For additional information please review our FAQs or contact mastiffstomutts@gmail.com **Mastiffs To Mutts Rescue reserves the right to approve or deny any adoption that occurs through this organization without disclosure.  We reserve the right to make exceptions for special circumstances. **PA Kennel License: 05845   December 14, 2025, 3:42 pm
We'll also keep you updated on Fernie *Courtesy Post*'s adoption status with email updates.
Photo of Fernie *Courtesy Post*

Fernie *Courtesy Post*

Mastiff

Female, Young
Harrisburg, PA
Size
(when grown) -
Details
Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
You can fill out an adoption application online on our official website. Fill out an Adoption Application Fern is now available please read her PetFinder post  https://www.petfinder.com/dog/fernie-d98ba9c5-c010-4bc0-b0e0-0e56e047e84b/pa/warrington/brookline-labrador-rescue-pa06/details/Click here to watch a video of Fernie *Courtesy Post*.Visit this organization's web site to see any additional information available about this pet. Application Fees, Adoption Donations and Rescue Policy: Please know that 100% of our fees and donations pay for the costs of rescuing dogs. These include but are not limited to pull fees from shelters, veterinary examinations, vaccinations, medications and care, microchips, neuter/spay surgeries, heartworm treatments, behavior evaluations, and foster care, as needed. Important notes before applying. Approved adopters must have their primary residence in one of the following states: Delaware, Maryland, Michigan, New Jersey, Ohio, Pennsylvania, West Virginia, Virginia, and parts of North Carolina and Kentucky. You must be at least 21 years of age to apply and legally sign our contract for adoption. Applications must be completed by the homeowner.  We do not adopt giant breed dogs to renters. If you are renting, and you are applying to adopt a dog that is not a giant breed, permission to adopt an animal must be obtained from the landlord or property owner. We do not adopt giant breed dogs to homes with children under 6 years of age. Homes with children should have a fenced yard. Applications will be denied if anyone residing in the household has a record indicating drug/alcohol abuse, theft, or violence. Pets currently in the applicant's home must have a history of appropriate veterinary care. Homes with intact dogs will not be approved for adoption.  Proof of any of the following exceptions is required: The intact dog is a working member of a law enforcement, or search and rescue/recovery team. The intact dog is registered under the auspices of the American Kennel Club and is actively being shown. A veterinarian has determined the sterilization procedure would harm the intact dog.  We believe in Force Free Training Methods and do not approve of methods or devices using pain or force to control the dog, or to deter undesirable behavior.  Homes with highly varnished steps must have carpeting, securely fixed stair treads, or a non-skid surface. **We encourage you to remediate potential safety issues while your application is under review, prior to the home visit. &#226&#128&#139Any inside steps to which the dog(s) have access, must have carpeting, securely fixed stair treads, or a non-skid surface. Homes with highly varnished floors must have non-slip area rugs or mats wherever your animal walks or rests frequently.  **Puppy Adoption Policy** To ensure proper house training and socialization, puppies will only be adopted to homes where an adult will not be away more than an hour per day, per month of age of the puppy, up to 6 months. Certain large-breed dogs should not be sterilized prior to 12 - 18 months of age.  If you adopt an intact puppy, you will sign an adoption contract agreeing to have the dog sterilized at your expense at the time your veterinarian recommends. Proof of sterilization must be provided to Mastiffs To Mutts Rescue as soon as the procedure is completed.  If the puppy is not sterilized as required, Mastiffs To Mutts Rescue reserves the right to claim legal ownership of the dog.  For additional information please review our FAQs or contact mastiffstomutts@gmail.com **Mastiffs To Mutts Rescue reserves the right to approve or deny any adoption that occurs through this organization without disclosure.  We reserve the right to make exceptions for special circumstances. **PA Kennel License: 05845   December 12, 2025, 6:57 pm
We'll also keep you updated on June's adoption status with email updates.
Photo of June

June

English Mastiff

Female, Adult
Harrisburg, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
You can fill out an adoption application online on our official website. Fill out an Adoption Application Headliner: Meet June - your soft and fluffy Mastiff who has so much lover to share. She came to us scared and timid but within days she came out of her shell and showed us how wonderful she is and how much she wants her forever family. She is 100% love and affection. In a few short weeks at her foster home she has quickly adapted to her new routine and housemates and has been a joy to have around. Personality: Large, happy, and typical Mastiff. She wants to be with her people and pack.  She is cheerful and full of love and very, very gentle. She has moderate to low drooling which is directly tied to eating, drinking or getting overly excited. She is a gentle giant. She approaches new situations with caution and looks to her people for assurance. She is quick to overcome her hesitations and reacts well to re-direction. She isn’t sketch; just aware and cautious.   Favorite Activities: Being near to her pack, being petted, napping, and going for walks. She likes treats too…she takes them with a very gentle mouth.     Medical: Small lump on her side that is scheduled to be checked otherwise appears in great health.   Best home: Great with kids, adults, and elderly people. She gets along very well with her two house mates - a bossy female Staffordshire terrier and a large and energetic male lab. Click here to watch a video of June.Visit this organization's web site to see any additional information available about this pet. Application Fees, Adoption Donations and Rescue Policy: Please know that 100% of our fees and donations pay for the costs of rescuing dogs. These include but are not limited to pull fees from shelters, veterinary examinations, vaccinations, medications and care, microchips, neuter/spay surgeries, heartworm treatments, behavior evaluations, and foster care, as needed. Important notes before applying. Approved adopters must have their primary residence in one of the following states: Delaware, Maryland, Michigan, New Jersey, Ohio, Pennsylvania, West Virginia, Virginia, and parts of North Carolina and Kentucky. You must be at least 21 years of age to apply and legally sign our contract for adoption. Applications must be completed by the homeowner.  We do not adopt giant breed dogs to renters. If you are renting, and you are applying to adopt a dog that is not a giant breed, permission to adopt an animal must be obtained from the landlord or property owner. We do not adopt giant breed dogs to homes with children under 6 years of age. Homes with children should have a fenced yard. Applications will be denied if anyone residing in the household has a record indicating drug/alcohol abuse, theft, or violence. Pets currently in the applicant's home must have a history of appropriate veterinary care. Homes with intact dogs will not be approved for adoption.  Proof of any of the following exceptions is required: The intact dog is a working member of a law enforcement, or search and rescue/recovery team. The intact dog is registered under the auspices of the American Kennel Club and is actively being shown. A veterinarian has determined the sterilization procedure would harm the intact dog.  We believe in Force Free Training Methods and do not approve of methods or devices using pain or force to control the dog, or to deter undesirable behavior.  Homes with highly varnished steps must have carpeting, securely fixed stair treads, or a non-skid surface. **We encourage you to remediate potential safety issues while your application is under review, prior to the home visit. &#226&#128&#139Any inside steps to which the dog(s) have access, must have carpeting, securely fixed stair treads, or a non-skid surface. Homes with highly varnished floors must have non-slip area rugs or mats wherever your animal walks or rests frequently.  **Puppy Adoption Policy** To ensure proper house training and socialization, puppies will only be adopted to homes where an adult will not be away more than an hour per day, per month of age of the puppy, up to 6 months. Certain large-breed dogs should not be sterilized prior to 12 - 18 months of age.  If you adopt an intact puppy, you will sign an adoption contract agreeing to have the dog sterilized at your expense at the time your veterinarian recommends. Proof of sterilization must be provided to Mastiffs To Mutts Rescue as soon as the procedure is completed.  If the puppy is not sterilized as required, Mastiffs To Mutts Rescue reserves the right to claim legal ownership of the dog.  For additional information please review our FAQs or contact mastiffstomutts@gmail.com **Mastiffs To Mutts Rescue reserves the right to approve or deny any adoption that occurs through this organization without disclosure.  We reserve the right to make exceptions for special circumstances. **PA Kennel License: 05845   December 26, 2025, 8:11 pm

Or, how about these Mastiffs in cities near Harrisburg, Pennsylvania

These Mastiffs are available for adoption close to Harrisburg, Pennsylvania.
We'll also keep you updated on Tiny Tim's adoption status with email updates.
Photo of Tiny Tim

Tiny Tim

English Mastiff

Male, Adult
Harrisburg, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
House-trained, Spayed or Neutered,
Story
You can fill out an adoption application online on our official website. Fill out an Adoption Application HEADLINER:  Tiny Tim “Tiny” PERSONALITY: Tiny can be on alert around people that are not regulars in the home however with some supervision and guidance he can warm up fast and become very loving. He has a bit of an “alpha” attitude and will occasionally have a low soft growl around small children. It is recommended he not be placed with any home that has pre teens or regular pack members that can over do it on attention. He is loyal and loving , he requires a lot of petting and attention. He does drool and will need help keeping his front legs cleaned often. FAVORITE ACTIVITIES: He likes being around other regular pack members and will bark at anything he deems a threat including door bells. MEDICAL ISSUES: He may have allergies as his eyes often have a mucus build up in both eyes but he enjoys getting his eyes wiped. WHAT WOULD BE THE BEST KIND OF HOME: No pre teens or no homes with a immature personality as he does not like to be teased. A home with a lot of love to give because he cant get enough. He will joyfully greet regular pack members when the return home from even the shortest trips and will follow you around as long as you can handle. Application Fees, Adoption Donations and Rescue Policy: Please know that 100% of our fees and donations pay for the costs of rescuing dogs. These include but are not limited to pull fees from shelters, veterinary examinations, vaccinations, medications and care, microchips, neuter/spay surgeries, heartworm treatments, behavior evaluations, and foster care, as needed. Important notes before applying. Approved adopters must have their primary residence in one of the following states: Delaware, Maryland, Michigan, New Jersey, Ohio, Pennsylvania, West Virginia, Virginia, and parts of North Carolina and Kentucky. You must be at least 21 years of age to apply and legally sign our contract for adoption. Applications must be completed by the homeowner.  We do not adopt giant breed dogs to renters. If you are renting, and you are applying to adopt a dog that is not a giant breed, permission to adopt an animal must be obtained from the landlord or property owner. We do not adopt giant breed dogs to homes with children under 6 years of age. Homes with children should have a fenced yard. Applications will be denied if anyone residing in the household has a record indicating drug/alcohol abuse, theft, or violence. Pets currently in the applicant's home must have a history of appropriate veterinary care. Homes with intact dogs will not be approved for adoption.  Proof of any of the following exceptions is required: The intact dog is a working member of a law enforcement, or search and rescue/recovery team. The intact dog is registered under the auspices of the American Kennel Club and is actively being shown. A veterinarian has determined the sterilization procedure would harm the intact dog.  We believe in Force Free Training Methods and do not approve of methods or devices using pain or force to control the dog, or to deter undesirable behavior.  Homes with highly varnished steps must have carpeting, securely fixed stair treads, or a non-skid surface. **We encourage you to remediate potential safety issues while your application is under review, prior to the home visit. &#226&#128&#139Any inside steps to which the dog(s) have access, must have carpeting, securely fixed stair treads, or a non-skid surface. Homes with highly varnished floors must have non-slip area rugs or mats wherever your animal walks or rests frequently.  For additional information please review our FAQs or contact mastiffstomutts@gmail.com **Mastiffs To Mutts Rescue reserves the right to approve or deny any adoption that occurs through this organization without disclosure.  We reserve the right to make exceptions for special circumstances. **PA Kennel License: 05845   Visit this organization's web site to see any additional information available about this pet. Application Fees, Adoption Donations and Rescue Policy: Please know that 100% of our fees and donations pay for the costs of rescuing dogs. These include but are not limited to pull fees from shelters, veterinary examinations, vaccinations, medications and care, microchips, neuter/spay surgeries, heartworm treatments, behavior evaluations, and foster care, as needed. Important notes before applying. Approved adopters must have their primary residence in one of the following states: Delaware, Maryland, Michigan, New Jersey, Ohio, Pennsylvania, West Virginia, Virginia, and parts of North Carolina and Kentucky. You must be at least 21 years of age to apply and legally sign our contract for adoption. Applications must be completed by the homeowner.  We do not adopt giant breed dogs to renters. If you are renting, and you are applying to adopt a dog that is not a giant breed, permission to adopt an animal must be obtained from the landlord or property owner. We do not adopt giant breed dogs to homes with children under 6 years of age. Homes with children should have a fenced yard. Applications will be denied if anyone residing in the household has a record indicating drug/alcohol abuse, theft, or violence. Pets currently in the applicant's home must have a history of appropriate veterinary care. Homes with intact dogs will not be approved for adoption.  Proof of any of the following exceptions is required: The intact dog is a working member of a law enforcement, or search and rescue/recovery team. The intact dog is registered under the auspices of the American Kennel Club and is actively being shown. A veterinarian has determined the sterilization procedure would harm the intact dog.  We believe in Force Free Training Methods and do not approve of methods or devices using pain or force to control the dog, or to deter undesirable behavior.  Homes with highly varnished steps must have carpeting, securely fixed stair treads, or a non-skid surface. **We encourage you to remediate potential safety issues while your application is under review, prior to the home visit. &#226&#128&#139Any inside steps to which the dog(s) have access, must have carpeting, securely fixed stair treads, or a non-skid surface. Homes with highly varnished floors must have non-slip area rugs or mats wherever your animal walks or rests frequently.  **Puppy Adoption Policy** To ensure proper house training and socialization, puppies will only be adopted to homes where an adult will not be away more than an hour per day, per month of age of the puppy, up to 6 months. Certain large-breed dogs should not be sterilized prior to 12 - 18 months of age.  If you adopt an intact puppy, you will sign an adoption contract agreeing to have the dog sterilized at your expense at the time your veterinarian recommends. Proof of sterilization must be provided to Mastiffs To Mutts Rescue as soon as the procedure is completed.  If the puppy is not sterilized as required, Mastiffs To Mutts Rescue reserves the right to claim legal ownership of the dog.  For additional information please review our FAQs or contact mastiffstomutts@gmail.com **Mastiffs To Mutts Rescue reserves the right to approve or deny any adoption that occurs through this organization without disclosure.  We reserve the right to make exceptions for special circumstances. **PA Kennel License: 05845   November 6, 2025, 8:17 pm
We'll also keep you updated on Izzabella's adoption status with email updates.
Photo of Izzabella

Izzabella

English Mastiff

Female, Senior
Harrisburg, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, House-trained, Spayed or Neutered,
Story
You can fill out an adoption application online on our official website. Fill out an Adoption Application HEADLINER: Izzabella aka Izzy. HISTORY: One owner who did not provide basic medical care so Izzy lived many year with out of control skin issues, ear infections, UTI’s, etc. PERSONALITY: Izzy is a sweet, friendly girl that loves meeting new people and welcoming them into the house. She loves attention and affection and will lean in hard for pets and ear scratches. She tends to spend her days snoozing away but when she gets the zoomies she takes them seriously and this girl can move despite her age.  She lives peacefully with a 60lb male mixed breed but is reactive when seeing dogs out on a walk. Izzy is a bit fearful of fireworks and thunderstorms and will sometimes get spooked by loud noises. Izzy likes things to happen on her own personal timeline and can be stubborn when they don’t. She will test limits by whining and carrying on (dancing around, stomping her feet, wagging her tail furiously while staring at you) to try to get her way. She’s learning that those things don’t work in our house but it’s hard not to laugh at her antics. She’ll do it to the other dog in the house too when he’s laying in a bed that she wants. She usually gets her way with the dog.  FAVORITE ACTIVITIES: Napping, soaking up love and attention, laying in the sun MEDICAL ISSUES: With vet care and a quality diet Izzy’s skin issues and ear infections have cleared up and she is no longer a big itchy mess. She did have a mammary tumor removed while being spayed. She is not currently on any medications. WHAT WOULD BE THE BEST KIND OF HOME: Izzy enjoys hanging out with her people, so a family that spends a lot of time around the house/yard/garden would be great for her. Once integrated with another dog she is very polite and respectful but she definitely needs slow introductions to new dogs.Visit this organization's web site to see any additional information available about this pet. Application Fees, Adoption Donations and Rescue Policy: Please know that 100% of our fees and donations pay for the costs of rescuing dogs. These include but are not limited to pull fees from shelters, veterinary examinations, vaccinations, medications and care, microchips, neuter/spay surgeries, heartworm treatments, behavior evaluations, and foster care, as needed. Important notes before applying. Approved adopters must have their primary residence in one of the following states: Delaware, Maryland, Michigan, New Jersey, Ohio, Pennsylvania, West Virginia, Virginia, and parts of North Carolina and Kentucky. You must be at least 21 years of age to apply and legally sign our contract for adoption. Applications must be completed by the homeowner.  We do not adopt giant breed dogs to renters. If you are renting, and you are applying to adopt a dog that is not a giant breed, permission to adopt an animal must be obtained from the landlord or property owner. We do not adopt giant breed dogs to homes with children under 6 years of age. Homes with children should have a fenced yard. Applications will be denied if anyone residing in the household has a record indicating drug/alcohol abuse, theft, or violence. Pets currently in the applicant's home must have a history of appropriate veterinary care. Homes with intact dogs will not be approved for adoption.  Proof of any of the following exceptions is required: The intact dog is a working member of a law enforcement, or search and rescue/recovery team. The intact dog is registered under the auspices of the American Kennel Club and is actively being shown. A veterinarian has determined the sterilization procedure would harm the intact dog.  We believe in Force Free Training Methods and do not approve of methods or devices using pain or force to control the dog, or to deter undesirable behavior.  Homes with highly varnished steps must have carpeting, securely fixed stair treads, or a non-skid surface. **We encourage you to remediate potential safety issues while your application is under review, prior to the home visit. &#226&#128&#139Any inside steps to which the dog(s) have access, must have carpeting, securely fixed stair treads, or a non-skid surface. Homes with highly varnished floors must have non-slip area rugs or mats wherever your animal walks or rests frequently.  **Puppy Adoption Policy** To ensure proper house training and socialization, puppies will only be adopted to homes where an adult will not be away more than an hour per day, per month of age of the puppy, up to 6 months. Certain large-breed dogs should not be sterilized prior to 12 - 18 months of age.  If you adopt an intact puppy, you will sign an adoption contract agreeing to have the dog sterilized at your expense at the time your veterinarian recommends. Proof of sterilization must be provided to Mastiffs To Mutts Rescue as soon as the procedure is completed.  If the puppy is not sterilized as required, Mastiffs To Mutts Rescue reserves the right to claim legal ownership of the dog.  For additional information please review our FAQs or contact mastiffstomutts@gmail.com **Mastiffs To Mutts Rescue reserves the right to approve or deny any adoption that occurs through this organization without disclosure.  We reserve the right to make exceptions for special circumstances. **PA Kennel License: 05845   December 14, 2025, 3:42 pm
We'll also keep you updated on Fernie *Courtesy Post*'s adoption status with email updates.
Photo of Fernie *Courtesy Post*

Fernie *Courtesy Post*

Mastiff

Female, Young
Harrisburg, PA
Size
(when grown) -
Details
Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
You can fill out an adoption application online on our official website. Fill out an Adoption Application Fern is now available please read her PetFinder post  https://www.petfinder.com/dog/fernie-d98ba9c5-c010-4bc0-b0e0-0e56e047e84b/pa/warrington/brookline-labrador-rescue-pa06/details/Click here to watch a video of Fernie *Courtesy Post*.Visit this organization's web site to see any additional information available about this pet. Application Fees, Adoption Donations and Rescue Policy: Please know that 100% of our fees and donations pay for the costs of rescuing dogs. These include but are not limited to pull fees from shelters, veterinary examinations, vaccinations, medications and care, microchips, neuter/spay surgeries, heartworm treatments, behavior evaluations, and foster care, as needed. Important notes before applying. Approved adopters must have their primary residence in one of the following states: Delaware, Maryland, Michigan, New Jersey, Ohio, Pennsylvania, West Virginia, Virginia, and parts of North Carolina and Kentucky. You must be at least 21 years of age to apply and legally sign our contract for adoption. Applications must be completed by the homeowner.  We do not adopt giant breed dogs to renters. If you are renting, and you are applying to adopt a dog that is not a giant breed, permission to adopt an animal must be obtained from the landlord or property owner. We do not adopt giant breed dogs to homes with children under 6 years of age. Homes with children should have a fenced yard. Applications will be denied if anyone residing in the household has a record indicating drug/alcohol abuse, theft, or violence. Pets currently in the applicant's home must have a history of appropriate veterinary care. Homes with intact dogs will not be approved for adoption.  Proof of any of the following exceptions is required: The intact dog is a working member of a law enforcement, or search and rescue/recovery team. The intact dog is registered under the auspices of the American Kennel Club and is actively being shown. A veterinarian has determined the sterilization procedure would harm the intact dog.  We believe in Force Free Training Methods and do not approve of methods or devices using pain or force to control the dog, or to deter undesirable behavior.  Homes with highly varnished steps must have carpeting, securely fixed stair treads, or a non-skid surface. **We encourage you to remediate potential safety issues while your application is under review, prior to the home visit. &#226&#128&#139Any inside steps to which the dog(s) have access, must have carpeting, securely fixed stair treads, or a non-skid surface. Homes with highly varnished floors must have non-slip area rugs or mats wherever your animal walks or rests frequently.  **Puppy Adoption Policy** To ensure proper house training and socialization, puppies will only be adopted to homes where an adult will not be away more than an hour per day, per month of age of the puppy, up to 6 months. Certain large-breed dogs should not be sterilized prior to 12 - 18 months of age.  If you adopt an intact puppy, you will sign an adoption contract agreeing to have the dog sterilized at your expense at the time your veterinarian recommends. Proof of sterilization must be provided to Mastiffs To Mutts Rescue as soon as the procedure is completed.  If the puppy is not sterilized as required, Mastiffs To Mutts Rescue reserves the right to claim legal ownership of the dog.  For additional information please review our FAQs or contact mastiffstomutts@gmail.com **Mastiffs To Mutts Rescue reserves the right to approve or deny any adoption that occurs through this organization without disclosure.  We reserve the right to make exceptions for special circumstances. **PA Kennel License: 05845   December 12, 2025, 6:57 pm
We'll also keep you updated on June's adoption status with email updates.
Photo of June

June

English Mastiff

Female, Adult
Harrisburg, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
You can fill out an adoption application online on our official website. Fill out an Adoption Application Headliner: Meet June - your soft and fluffy Mastiff who has so much lover to share. She came to us scared and timid but within days she came out of her shell and showed us how wonderful she is and how much she wants her forever family. She is 100% love and affection. In a few short weeks at her foster home she has quickly adapted to her new routine and housemates and has been a joy to have around. Personality: Large, happy, and typical Mastiff. She wants to be with her people and pack.  She is cheerful and full of love and very, very gentle. She has moderate to low drooling which is directly tied to eating, drinking or getting overly excited. She is a gentle giant. She approaches new situations with caution and looks to her people for assurance. She is quick to overcome her hesitations and reacts well to re-direction. She isn’t sketch; just aware and cautious.   Favorite Activities: Being near to her pack, being petted, napping, and going for walks. She likes treats too…she takes them with a very gentle mouth.     Medical: Small lump on her side that is scheduled to be checked otherwise appears in great health.   Best home: Great with kids, adults, and elderly people. She gets along very well with her two house mates - a bossy female Staffordshire terrier and a large and energetic male lab. Click here to watch a video of June.Visit this organization's web site to see any additional information available about this pet. Application Fees, Adoption Donations and Rescue Policy: Please know that 100% of our fees and donations pay for the costs of rescuing dogs. These include but are not limited to pull fees from shelters, veterinary examinations, vaccinations, medications and care, microchips, neuter/spay surgeries, heartworm treatments, behavior evaluations, and foster care, as needed. Important notes before applying. Approved adopters must have their primary residence in one of the following states: Delaware, Maryland, Michigan, New Jersey, Ohio, Pennsylvania, West Virginia, Virginia, and parts of North Carolina and Kentucky. You must be at least 21 years of age to apply and legally sign our contract for adoption. Applications must be completed by the homeowner.  We do not adopt giant breed dogs to renters. If you are renting, and you are applying to adopt a dog that is not a giant breed, permission to adopt an animal must be obtained from the landlord or property owner. We do not adopt giant breed dogs to homes with children under 6 years of age. Homes with children should have a fenced yard. Applications will be denied if anyone residing in the household has a record indicating drug/alcohol abuse, theft, or violence. Pets currently in the applicant's home must have a history of appropriate veterinary care. Homes with intact dogs will not be approved for adoption.  Proof of any of the following exceptions is required: The intact dog is a working member of a law enforcement, or search and rescue/recovery team. The intact dog is registered under the auspices of the American Kennel Club and is actively being shown. A veterinarian has determined the sterilization procedure would harm the intact dog.  We believe in Force Free Training Methods and do not approve of methods or devices using pain or force to control the dog, or to deter undesirable behavior.  Homes with highly varnished steps must have carpeting, securely fixed stair treads, or a non-skid surface. **We encourage you to remediate potential safety issues while your application is under review, prior to the home visit. &#226&#128&#139Any inside steps to which the dog(s) have access, must have carpeting, securely fixed stair treads, or a non-skid surface. Homes with highly varnished floors must have non-slip area rugs or mats wherever your animal walks or rests frequently.  **Puppy Adoption Policy** To ensure proper house training and socialization, puppies will only be adopted to homes where an adult will not be away more than an hour per day, per month of age of the puppy, up to 6 months. Certain large-breed dogs should not be sterilized prior to 12 - 18 months of age.  If you adopt an intact puppy, you will sign an adoption contract agreeing to have the dog sterilized at your expense at the time your veterinarian recommends. Proof of sterilization must be provided to Mastiffs To Mutts Rescue as soon as the procedure is completed.  If the puppy is not sterilized as required, Mastiffs To Mutts Rescue reserves the right to claim legal ownership of the dog.  For additional information please review our FAQs or contact mastiffstomutts@gmail.com **Mastiffs To Mutts Rescue reserves the right to approve or deny any adoption that occurs through this organization without disclosure.  We reserve the right to make exceptions for special circumstances. **PA Kennel License: 05845   December 26, 2025, 8:11 pm
We'll also keep you updated on Snubbull's adoption status with email updates.
Photo of Snubbull

Snubbull

Mastiff Mixed Breed (Large)

Female, 3 yrs 9 mos
York, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
Found on Penn St in York City
We'll also keep you updated on Bruno PPJ's adoption status with email updates.
Photo of Bruno PPJ

Bruno PPJ

Mastiff

Male, Young
York transport, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Spayed or Neutered, Shots are up-to-date,
Story
You can fill out an adoption application online on our official website.Thank you for checking out our wonderful orphans. If you would like to find out more please email or call Diane at...diane@ulpr.org or 870-577-3744.   Please email us at  diane@ulpr.org  and request an application.Visit this organization's web site to see any additional information available about this pet.December 11, 2025, 3:57 pm

These pups are in Harrisburg, Pennsylvania too!

Below are our newest added Mastiffs available for adoption in Harrisburg, Pennsylvania. To see more adoptable Mastiffs in Harrisburg, Pennsylvania, use the search tool below to enter specific criteria!
We'll also keep you updated on Johnny's adoption status with email updates.
Photo of Johnny

Johnny

Neapolitan Mastiff

Male, Adult
Harrisburg, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Spayed or Neutered, Shots are up-to-date,
Story
PLEASE NOTE! Unless stated otherwise, our dogs and puppies are located in Arkansas, and transported to the north/northeast once adopted. We do occasionally have dogs/puppies placed in foster homes in the north/northeast. In the cases where the pet is somewhere other than Arkansas, it will be noted beside the name of the pet.Johnny I dont know if I've ever seen a more beautiful dog. Johnny is a Neapolitan Mastiff (possibly mixed?) who is about 2 years old and weighs 120 lbs. He is the sweetest, big slobbery dummy! He thinks hes a 10 lb baby and wants to sit on your lap. He is super friendly with everyone he meets, but he has no idea how big he is, so probably wouldnt be the best choice for a family with toddler size humans. He is so kind hearted and wouldn't dream of hurting anyone on purpose. Hes just big and clumsy and hasn't had any training. We are gonna work on the training part as soon as he recovers from his neuter surgery, which was done today. Johnny was found as a starving stray in Arkansas. His stray hold is long over and no one ever came forward to claim him. He had no ID and no microchip. His rescue photo, which shows the condition he was in, is attached. He holds no grudges for his past neglect and hardships. He loves and trusts everyone. Since coming into rescue, he hasn't been introduced to many other dogs, but the limited exposure he has had was positive anf he gave no indication of aggression. We will be exploring that more now that he is neutered. I believe with proper introduction, he will do fine with other non aggressive dogs. Johnny was fully vetted today and thankfully he tested negative for heartworms. He does have the very loose skin typical of Neo Mastiffs, which may require surgery later in life. As of now, our vet didn't feel it was necessary. His eyelids droop but they don't cover his eyes and he is fully visual. But as he ages, this may need to be revisited. Johnny is definitely one of a kind, and he is not a dog that is found in rescue very often. I hope he will get adopted quickly so he can start to get adjusted to his new life and family of his own. Hes a total catch!Johnny is located in Arkansas. He can be adopted locally, but transport is available to the New England area as well. Adopter must be able to pick up or arrange for someone to pick up for them in PA, NY, or CT on Saturdays. To apply, please fill out the adoption app: https://form.jotform.com/212690945239059 Message us or email apps.aasr@gmail.com with any questions.Visit this organization's web site to see any additional information available about this pet.Our typical adoption fee for puppies younger than 6 months old is $400, and for older puppies and adults, the usual fee is $350. This includes microchip, spay/neuter,  up to date on age appropriate vaccinations, dewormings, flea/tick treatment, and heartworm test (if over 6 months old) as well as heartworm treatment if they test positive. There is a transport fee of $150 per dog, depending on the transporter. We use Pack Leaders Rescue Dog Transport most often, but also use Hearts Transport as well on occasion. Please visit our Facebook page too! https://www.facebook.com/adoptastrayrescueorg For more info regarding adopting, email apps.aasr@gmail.com Thank you for considering one of our rescue babies!December 29, 2025, 9:24 pm

Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Harrisburg, Pennsylvania.

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Mastiff shelters & rescues in Harrisburg, Pennsylvania

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Harrisburg, Pennsylvania. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Rescue

5.1 miles

Mastiffs To Mutts - Central PA

Harrisburg, PA 17109

Pet Types: dogs

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Shelter

22.5 miles

York County SPCA

3159 Susquehanna Trail North, York, PA 17406

Pet Types: cats, birds, dogs, rabbits, reptiles, small animals

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Rescue

23.3 miles

Pitter Pat Junction, York PA transport

York transport, PA 17403

Pet Types: dogs

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Shelter

35.8 miles

Brandywine Valley SPCA - Lancaster

2195 Lincoln Hwy E, Lancaster, PA 17602

Pet Types: dogs

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Rescue

44.1 miles

Reach Out Rescue & Resources

P. O. Box 542, Westminster, MD 21158

Pet Types: cats, dogs

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Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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