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Mastiff puppies and dogs in Crystal City, Missouri

Looking for a Mastiff puppy or dog in Crystal City, Missouri? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near Crystal City, Missouri Other pups in Crystal City, Missouri Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in Crystal City, Missouri Mastiff shelters and rescues in Crystal City, Missouri Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Crystal City, Missouri

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Crystal City, Missouri

These Mastiffs are available for adoption close to Crystal City, Missouri.
We'll also keep you updated on Jax's adoption status with email updates.
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Jax

Mastiff

Male, 1 yr
Columbia, IL
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Jax is a lovable goofball who does not realize his own size! He is full of puppy energy, loves running and playing, and would do best in a home without small children. He is housebroken, dog selective, and looking for an experienced adopter who can give him structure, exercise, and lots of love.Jax is one year old and weighs 74 pounds.The adoption fee for adult dogs, seven months and older, is $250. All pets are microchipped, up to date on vaccines, and will be altered prior to adoption. If you are interested in meeting a dog, please stop by the shelter during open hours. Dogs may be in a foster home, therefore scheduling an appointment is recommended. If you have an existing dog at home, we recommend bringing it along to meet your possible new family member.helpingstrays.org

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We'll also keep you updated on Chili Mac's adoption status with email updates.
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Chili Mac

Mastiff

Male, Puppy
St Louis, MO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Chili Mac!    This 11-month-old Cane Corso is a big, lovable goofball with a heart as giant as his paws! Chili Mac is equal parts cuddle bug and class clown — he’ll make you laugh one minute and melt into your lap the next.   He can be a little shy when meeting new people, but once he decides you’re cool, he’s all in! He’s great with dogs big and small (seriously — from 6 lbs to 120 lbs!), crate and potty trained, and already knows some basic commands.   Due to Chili Mac's size and clumsiness, he would do best in a home with older children. He would also be best with someone who has breed/guardian experience given some mouthy behaviors which are normal for the breed.   Chili Mac would love an active home with another dog friend or a human adventure buddy. Whether you’re hiking, road-tripping, or just lounging on the couch- as long as you don’t mind a little drool, he’s ready to be your ride-or-die!    If interested, please  complete the  Adoption Application  on our website at  www.NeedyPaws.org  and we will contact you.  Adopters must live within an hour’s drive of St. Louis, MO. Our $295 adoption fee includes up-to-date vaccinations, heartworm testing and preventative, spay/neuter and microchip. We are a 100% foster-based rescue and all of our dogs live in approved foster homes. We are dedicated to finding the best Forever Homes, and will perform home visits and conduct veterinarian and reference checks for each potential adopter. Visit this organization's web site to see any additional information available about this pet.December 26, 2025, 1:09 pm

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We'll also keep you updated on Gus's adoption status with email updates.
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Gus

Mastiff Mixed Breed (Large)

Male, Adult
St. Louis, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Gus! Gus is a charming 3-year-old mastiff mix with a heart as big as his paws. This gentle giant is friendly, outgoing, and absolutely loves people. He gets along wonderfully with other dogs and kids—just be prepared for a little “bull in a china shop” energy when he gets excited! Gus is house-trained, kennel-trained, and making great progress with his leash skills. He’s also an excellent car buddy, happy to settle in and enjoy the ride. If you’re looking for a lovable, goofy companion who brings joy wherever he goes, Gus might just be your perfect match! https://www.shelterluv.com/matchme/adopt/NAF/Dog

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We'll also keep you updated on WALTER's adoption status with email updates.
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WALTER

Mastiff

Male, 5 yrs 1 mo
St. Louis, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
Walter is friendly, outgoing, and his happiness is contagious. He walks well on a leash and seems to be potty trained. He knows sit, loves to play with squeekie toys, and wants all the pets.

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We'll also keep you updated on WAYLON's adoption status with email updates.
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WAYLON

Mastiff

Male, 3 yrs 1 mo
St. Louis, MO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Spayed or Neutered,
Story
-

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We'll also keep you updated on Derek's adoption status with email updates.
Photo of Derek

Derek

Mastiff American Pit Bull Terrier

Male, 2 yrs 2 mos
Belleville, IL
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
Derek is a lovable 2-year-old mastiff mix with a big ol’ blocky build and an even bigger personality. This sweet, even-tempered dude is friendly, goofy, and always ready for fun. He’s got plenty of energy and absolutely lives for his zoomie sessions—watching him take off is guaranteed to make you smile. Derek is also great with other dogs and would love a furry friend to romp around with. If you’re looking for a joyful, silly, good-natured companion, Derek is your guy!

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Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Crystal City, Missouri.

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Mastiff puppies and dogs in nearby cities

Mastiff Puppies near me Mastiff in Arnold, MO Mastiff in Ballwin, MO Mastiff in Belleville, IL Mastiff in Bonne Terre, MO Mastiff in Brentwood, MO Mastiff in Cahokia, IL Mastiff in Centreville, IL Mastiff in Chesterfield, MO Mastiff in Clayton, MO Mastiff in Columbia, IL Mastiff in Creve Coeur, MO Mastiff in Desloge, MO Mastiff in De Soto, MO Mastiff in Des Peres, MO Mastiff in East Saint Louis, IL Mastiff in Ellisville, MO Mastiff in Eureka, MO Mastiff in Fairview Heights, IL Mastiff in Farmington, MO Mastiff in Festus, MO Mastiff in Hazelwood, MO Mastiff in Kirkwood, MO Mastiff in Manchester, MO Mastiff in Maryland Heights, MO Mastiff in O Fallon, IL Mastiff in Olivette, MO Mastiff in Overland, MO Mastiff in Pacific, MO Mastiff in Park Hills, MO Mastiff in Pevely, MO Mastiff in Richmond Heights, MO Mastiff in Saint Ann, MO Mastiff in Saint Louis, MO Mastiff in Shiloh, IL Mastiff in Swansea, IL Mastiff in Town and Country, MO Mastiff in University City, MO Mastiff in Valley Park, MO Mastiff in Washington Pk, IL Mastiff in Waterloo, IL Mastiff in Webster Groves, MO Mastiff in Wildwood, MO

Related breeds in Crystal City, Missouri

Bullmastiffs in Crystal City, Missouri Neapolitan Mastiffs in Crystal City, Missouri Saint Bernards in Crystal City, Missouri

Mastiff shelters & rescues in Crystal City, Missouri

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Crystal City, Missouri. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

17.3 miles

Helping Strays of Monroe County

4221 Hanover Rd., Columbia, IL 62236

Pet Types: cats, dogs

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Rescue

20.7 miles

Needy Paws Rescue

St Louis, MO 63125

Pet Types: dogs

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Rescue

26.6 miles

Nala and Friends Dog Rescue - ST. LOUIS transport

St. Louis, MO 63118

Pet Types: dogs

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Shelter

26.7 miles

Animal Protective Association of Missouri

1705 South Hanley Road, St. Louis, MO 63144

Pet Types: cats, dogs, rabbits, small animals

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Shelter

29.3 miles

Belleville Area Humane Society

1301 S. 11th St., Belleville, IL 62223

Pet Types: cats, dogs

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Shelter

29.3 miles

CARE STL

2700 Walnut Place, St. Louis, MO 63103

Pet Types: cats, birds, dogs, farm animals, rabbits, small animals

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Shelter

29.9 miles

Gateway Pet Guardians

725 N 15th St, East ST Louis, IL 62205

Pet Types: cats, dogs

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Rescue

31.1 miles

Is Today My Day Rescue

St. Louis, MO 63039

Pet Types: dogs

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Rescue

32.4 miles

Gods Dogs Rescue of TX for St Louis Transport Stop

St Louis, MO 63146

Pet Types: dogs

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Shelter

32.4 miles

Humane Society of Missouri - Maryland Heights

11660 Administration Dr., (Page Ave. and Schuetz Road), Maryland Heights, MO 63146

Pet Types: cats, birds, dogs, rabbits, small animals

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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